Scavidin: a fusion gene for the treatment of cancer

Informazioni relative al progetto

SCAVIDIN

ID dell’accordo di sovvenzione: QLK3-CT-2001-02166

Progetto chiuso

Data di avvio 1 Gennaio 2002

Data di completamento 31 Dicembre 2004

Finanziato da

• Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002

Costo totale € 1 341 000,00

Contributo UE € 1 072 000,00

Coordinato da

UNIVERSITY OF KUOPIO
Finland

Obiettivo

The main objective of the proposal is to develop a new target-specific delivery system for the treatment of malignant glioma. For that purpose we have cloned a new fusion gene "Cave-in" which contains intracellular and membrane-spanning domains of scavenger receptor legated to avid in which will form the extra cellular domain of the fusion protein. Cave-in will be transfixed to target tissue with local gene therapy via catheter delivery or during surgical operation with adenovirus or pseudotyped retrovirus technology. Targeted treatment is achieved by binding of biotinylated compounds to Cave-in, which will be only expressed in the transfixed tissue.

Campo scientifico

• medical and health sciences › medical biotechnology › genetic engineering › gene therapy
• natural sciences › biological sciences › biochemistry › biomolecules › proteins
• medical and health sciences › clinical medicine › oncology

Programma(i)

• FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002

Argomento(i)

• 1.1.1.-3. - Key action The "Cell factory"

Invito a presentare proposte

Data not available

Meccanismo di finanziamento

CSC - Cost-sharing contracts

Coordinatore

UNIVERSITY OF KUOPIO

• Contributo UE: Nessun dato
• Indirizzo: Savilahdentie 9 ; 1627 KUOPIO ; Finlandia
• Costo totale: Nessun dato

Partecipanti (3)

ARK THERAPEUTICS LTD.

Regno Unito

• Contributo UE: Nessun dato
• Indirizzo: Warren Mews 6 ; W1T 6AR LONDON
• Costo totale: Nessun dato

ISTITUTO EUROPEO DI ONCOLOGIA SRL

Italia

• Contributo UE: Nessun dato
• Indirizzo: Via Filodrammatici 8 ; 20121 MILANO
• Costo totale: Nessun dato

UNIVERSITY COLLEGE LONDON

Regno Unito

• Contributo UE: Nessun dato
• Indirizzo: Mortimer Street The Middlesex Hospital ; W1N 8AA London
• Costo totale: Nessun dato