Scavidin: a fusion gene for the treatment of cancer

Información del proyecto

SCAVIDIN

Identificador del acuerdo de subvención: QLK3-CT-2001-02166

Proyecto cerrado

Fecha de inicio 1 Enero 2002

Fecha de finalización 31 Diciembre 2004

Financiado con arreglo a

• Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002

Coste total € 1 341 000,00

Aportación de la UE € 1 072 000,00

Coordinado por

UNIVERSITY OF KUOPIO
Finland

Objetivo

The main objective of the proposal is to develop a new target-specific delivery system for the treatment of malignant glioma. For that purpose we have cloned a new fusion gene "Cave-in" which contains intracellular and membrane-spanning domains of scavenger receptor legated to avid in which will form the extra cellular domain of the fusion protein. Cave-in will be transfixed to target tissue with local gene therapy via catheter delivery or during surgical operation with adenovirus or pseudotyped retrovirus technology. Targeted treatment is achieved by binding of biotinylated compounds to Cave-in, which will be only expressed in the transfixed tissue.

Ámbito científico

• medical and health sciences › medical biotechnology › genetic engineering › gene therapy
• natural sciences › biological sciences › biochemistry › biomolecules › proteins
• medical and health sciences › clinical medicine › oncology

Programa(s)

• FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002

Tema(s)

• 1.1.1.-3. - Key action The "Cell factory"

Convocatoria de propuestas

Data not available

Régimen de financiación

CSC - Cost-sharing contracts

Coordinador

UNIVERSITY OF KUOPIO

• Aportación de la UE: Sin datos
• Dirección: Savilahdentie 9 ; 1627 KUOPIO ; Finlandia
• Coste total: Sin datos

Participantes (3)

ARK THERAPEUTICS LTD.

Reino Unido

• Aportación de la UE: Sin datos
• Dirección: Warren Mews 6 ; W1T 6AR LONDON
• Coste total: Sin datos

ISTITUTO EUROPEO DI ONCOLOGIA SRL

Italia

• Aportación de la UE: Sin datos
• Dirección: Via Filodrammatici 8 ; 20121 MILANO
• Coste total: Sin datos

UNIVERSITY COLLEGE LONDON

Reino Unido

• Aportación de la UE: Sin datos
• Dirección: Mortimer Street The Middlesex Hospital ; W1N 8AA London
• Coste total: Sin datos