Massive Reverse Genomics to Decipher Gene Regulatory Grammar

Resultado final

Project website for visibility, raising awareness and dissemination purposes. The website will be maintained throughout the execution and will stay alive at least 2 years after the project end.

Unnatural enhancer data-set and report

Natural enhancer data-set and report

Bottom-up data-set report

Top-down data-set report

Publicaciones

The interaction landscape between transcription factors and the nucleosome

Autores: Fangjie Zhu, Lucas Farnung, Eevi Kaasinen, Biswajyoti Sahu, Yimeng Yin, Bei Wei, Svetlana Dodonova, Patrick Cramer, Jussi Taipale
Publicado en: Nature, 2017, ISSN 2520-1158
Editor: Nature
DOI: 10.1101/240598

Gene expression variability across cells and species shapes innate immunity

Autores: Tzachi Hagai, Xi Chen, Ricardo J. Miragaia, Tomas Gomes, Raghd Rostom, Natalia Kunowska, Valentina Proserpio, Giacomo Donati, Lara Bossini-Castillo, Guy Naamati, Guy Emerton, Gosia Trynka, Ivanela Kondova, Mike Denis, Sarah A Teichmann
Publicado en: Nature, 2017, ISSN 2520-1158
Editor: Nature
DOI: 10.1101/137992

Genome-wide CRISPR screens in T helper cells reveal pervasive cross-talk between activation and differentiation

Autores: Johan Henriksson, Xi Chen, Tomás Gomes, Ubaid Ullah, Kerstin B Meyer, Ricardo Miragaia, Graham Duddy, Jhuma Pramanik, Kosuke Yusa, Riita Lahesmaa, Sarah A. Teichmann
Publicado en: Cell, 2017, ISSN 2073-4409
Editor: Cell
DOI: 10.1101/196022

A rapid and robust method for single cell chromatin accessibility profiling

Autores: Xi Chen, Kedar Nath Natarajan, Sarah A Teichmann
Publicado en: Nature Communiction, 2018, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1101/309831

Developmental enhancers and chromosome topology

Autores: Eileen E. M. Furlong, Michael Levine
Publicado en: Science, 2018, ISSN 1095-9203
Editor: Science Magazine
DOI: 10.1126/science.aau0320

A Synthetic Oligo Library and Sequencing Approach Reveals an Insulation Mechanism Encoded within Bacterial σ 54 Promoters

Autores: Lior Levy, Leon Anavy, Oz Solomon, Roni Cohen, Michal Brunwasser-Meirom, Shilo Ohayon, Orna Atar, Sarah Goldberg, Zohar Yakhini, Roee Amit
Publicado en: Cell Reports, Edición 21/3, 2017, Página(s) 845-858, ISSN 2211-1247
Editor: Cell Press
DOI: 10.1016/j.celrep.2017.09.063

Genome-wide analysis of fitness data and its application to improve metabolic models

Autores: Edward Vitkin, Oz Solomon, Sharon Sultan, Zohar Yakhini
Publicado en: BMC Bioinformatics, Edición 19/1, 2018, ISSN 1471-2105
Editor: BioMed Central
DOI: 10.1186/s12859-018-2341-9

Using synthetic bacterial enhancers to reveal a looping-based mechanism for quenching-like repression

Autores: Michal Brunwasser-Meirom, Yaroslav Pollak, Sarah Goldberg, Lior Levy, Orna Atar, Roee Amit
Publicado en: Nature Communications, Edición 7, 2016, Página(s) 10407, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/ncomms10407

A Looping-Based Model for Quenching Repression

Autores: Yaroslav Pollak, Sarah Goldberg, Roee Amit
Publicado en: PLOS, 2017
Editor: plos.org
DOI: 10.1371/journal.pcbi.1005337

Resultado final

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