Massive Reverse Genomics to Decipher Gene Regulatory Grammar

Informacje na temat projektu

MRG-GRammar

Identyfikator umowy o grant: 664918

DOI 10.3030/664918

Projekt został zamknięty

Data podpisania przez KE 31 Maja 2015

Data rozpoczęcia 1 Sierpnia 2015

Data zakończenia 31 Lipca 2018

Finansowanie w ramach

• EXCELLENT SCIENCE - Future and Emerging Technologies (FET)

Koszt całkowity € 3 999 661,00

Wkład UE € 3 999 661,00

Koordynowany przez

TECHNION - ISRAEL INSTITUTE OF TECHNOLOGY
Israel

Rezultaty

Other (1)

Website

Project website for visibility, raising awareness and dissemination purposes. The website will be maintained throughout the execution and will stay alive at least 2 years after the project end.

Documents, reports (4)

Unnatural enhancer data-set and report

Natural enhancer data-set and report

Bottom-up data-set report

Top-down data-set report

Publikacje

Peer reviewed articles (8)

The interaction landscape between transcription factors and the nucleosome

Autorzy: Fangjie Zhu, Lucas Farnung, Eevi Kaasinen, Biswajyoti Sahu, Yimeng Yin, Bei Wei, Svetlana Dodonova, Patrick Cramer, Jussi Taipale
Opublikowane w: Nature, 2017, ISSN 2520-1158
Wydawca: Nature
DOI: 10.1101/240598

Gene expression variability across cells and species shapes innate immunity

Autorzy: Tzachi Hagai, Xi Chen, Ricardo J. Miragaia, Tomas Gomes, Raghd Rostom, Natalia Kunowska, Valentina Proserpio, Giacomo Donati, Lara Bossini-Castillo, Guy Naamati, Guy Emerton, Gosia Trynka, Ivanela Kondova, Mike Denis, Sarah A Teichmann
Opublikowane w: Nature, 2017, ISSN 2520-1158
Wydawca: Nature
DOI: 10.1101/137992

Genome-wide CRISPR screens in T helper cells reveal pervasive cross-talk between activation and differentiation

Autorzy: Johan Henriksson, Xi Chen, Tomás Gomes, Ubaid Ullah, Kerstin B Meyer, Ricardo Miragaia, Graham Duddy, Jhuma Pramanik, Kosuke Yusa, Riita Lahesmaa, Sarah A. Teichmann
Opublikowane w: Cell, 2017, ISSN 2073-4409
Wydawca: Cell
DOI: 10.1101/196022

A rapid and robust method for single cell chromatin accessibility profiling

Autorzy: Xi Chen, Kedar Nath Natarajan, Sarah A Teichmann
Opublikowane w: Nature Communiction, 2018, ISSN 2041-1723
Wydawca: Nature Publishing Group
DOI: 10.1101/309831

Developmental enhancers and chromosome topology

Autorzy: Eileen E. M. Furlong, Michael Levine
Opublikowane w: Science, 2018, ISSN 1095-9203
Wydawca: Science Magazine
DOI: 10.1126/science.aau0320

A Synthetic Oligo Library and Sequencing Approach Reveals an Insulation Mechanism Encoded within Bacterial σ 54 Promoters

Autorzy: Lior Levy, Leon Anavy, Oz Solomon, Roni Cohen, Michal Brunwasser-Meirom, Shilo Ohayon, Orna Atar, Sarah Goldberg, Zohar Yakhini, Roee Amit
Opublikowane w: Cell Reports, Numer 21/3, 2017, Strona(/y) 845-858, ISSN 2211-1247
Wydawca: Cell Press
DOI: 10.1016/j.celrep.2017.09.063

Genome-wide analysis of fitness data and its application to improve metabolic models

Autorzy: Edward Vitkin, Oz Solomon, Sharon Sultan, Zohar Yakhini
Opublikowane w: BMC Bioinformatics, Numer 19/1, 2018, ISSN 1471-2105
Wydawca: BioMed Central
DOI: 10.1186/s12859-018-2341-9

Using synthetic bacterial enhancers to reveal a looping-based mechanism for quenching-like repression

Autorzy: Michal Brunwasser-Meirom, Yaroslav Pollak, Sarah Goldberg, Lior Levy, Orna Atar, Roee Amit
Opublikowane w: Nature Communications, Numer 7, 2016, Strona(/y) 10407, ISSN 2041-1723
Wydawca: Nature Publishing Group
DOI: 10.1038/ncomms10407

Other (1)

A Looping-Based Model for Quenching Repression

Autorzy: Yaroslav Pollak, Sarah Goldberg, Roee Amit
Opublikowane w: PLOS, 2017
Wydawca: plos.org
DOI: 10.1371/journal.pcbi.1005337