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Direct Alkylation of Saturated Cyclic Amines via catalytic C-H Functionalization

Objectif

"Direct conversion of C-H into C-C bonds is arguably indispensable in modern organic chemistry, as it allows for obtaining target compounds which are otherwise only accessible via lengthy procedures involving multi-step synthesis. Catalytic C-H functionalization is the most attractive approach to achieve this goal, as it does not require stoichiometric amounts of activating reagent. This research proposal aims to develop direct transition metal-catalyzed functionalizations of C(sp3)–H bonds in saturated nitrogen-based heterocycles, with a particular focus on compatibility with a very broad range of functional groups, regioselectivity and stereoselectivity. Towards this goal, insertion reactions with substituted alkenes featuring a variety of functional groups will be explored. The development of such a technology offers an important contribution to novel, improved and more sustainable synthetic pathways and is expected to be highly warranted for drug discovery purposes."

Appel à propositions

FP7-PEOPLE-2012-IIF
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Coordinateur

UNIVERSITEIT ANTWERPEN
Contribution de l’UE
€ 169 800,00
Adresse
PRINSSTRAAT 13
2000 Antwerpen
Belgique

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Région
Vlaams Gewest Prov. Antwerpen Arr. Antwerpen
Type d’activité
Higher or Secondary Education Establishments
Contact administratif
Anne Adams (Mrs.)
Liens
Coût total
Aucune donnée