Ziel
"Direct conversion of C-H into C-C bonds is arguably indispensable in modern organic chemistry, as it allows for obtaining target compounds which are otherwise only accessible via lengthy procedures involving multi-step synthesis. Catalytic C-H functionalization is the most attractive approach to achieve this goal, as it does not require stoichiometric amounts of activating reagent. This research proposal aims to develop direct transition metal-catalyzed functionalizations of C(sp3)–H bonds in saturated nitrogen-based heterocycles, with a particular focus on compatibility with a very broad range of functional groups, regioselectivity and stereoselectivity. Towards this goal, insertion reactions with substituted alkenes featuring a variety of functional groups will be explored. The development of such a technology offers an important contribution to novel, improved and more sustainable synthetic pathways and is expected to be highly warranted for drug discovery purposes."
Wissenschaftliches Gebiet
Aufforderung zur Vorschlagseinreichung
FP7-PEOPLE-2012-IIF
Andere Projekte für diesen Aufruf anzeigen
Finanzierungsplan
MC-IIF - International Incoming Fellowships (IIF)Koordinator
2000 Antwerpen
Belgien