Objetivo
"Direct conversion of C-H into C-C bonds is arguably indispensable in modern organic chemistry, as it allows for obtaining target compounds which are otherwise only accessible via lengthy procedures involving multi-step synthesis. Catalytic C-H functionalization is the most attractive approach to achieve this goal, as it does not require stoichiometric amounts of activating reagent. This research proposal aims to develop direct transition metal-catalyzed functionalizations of C(sp3)–H bonds in saturated nitrogen-based heterocycles, with a particular focus on compatibility with a very broad range of functional groups, regioselectivity and stereoselectivity. Towards this goal, insertion reactions with substituted alkenes featuring a variety of functional groups will be explored. The development of such a technology offers an important contribution to novel, improved and more sustainable synthetic pathways and is expected to be highly warranted for drug discovery purposes."
Ámbito científico
Not validated
Not validated
Convocatoria de propuestas
FP7-PEOPLE-2012-IIF
Consulte otros proyectos de esta convocatoria
Régimen de financiación
MC-IIF - International Incoming Fellowships (IIF)Coordinador
2000 Antwerpen
Bélgica