Multi-omics Interdisciplinary Research Integration to Address DEmentia diagnosis

Risultati finali

ESR recruitment: All 15 ESRs are recruited; individual contracts are signed

Management and overall coordination by VUMC will enable MIRIADE activities in all work packages to be performed timely coherently and efficiently One of these activities will be coordination of ESR recruitment

Project website: The project website (intranet as well as internet) is up and running

Secure efficient internal communication within the MIRIADE consortium

Pubblicazioni

A cell-free high throughput assay for assessment of SARS-CoV-2 neutralizing antibodies

Autori: Sara Mravinacova, Malin Jönsson, Wanda Christ, Jonas Klingström, Jamil Yousef, Cecilia Hellström, My Hedhammar, Sebastian Havervall, Charlotte Thålin, Elisa Pin, Hanna Tegel, Peter Nilsson, Anna Månberg, Sophia Hober
Pubblicato in: New Biotechnology, 2022, ISSN 1871-6784
Editore: Elsevier BV
DOI: 10.1016/j.nbt.2021.10.002

Association of Plasma p-tau181 and p-tau231 Concentrations With Cognitive Decline in Patients With Probable Dementia With Lewy Bodies

Autori: Maria C Gonzalez, Nicholas J Ashton, Bárbara Fernandes Gomes, Diego Alejandro Tovar-Rios, Frédéric Blanc, Thomas K Karikari, Brit Mollenhauer, Andrea Pilotto, Afina Lemstra, Claire Paquet, Carla Abdelnour, Milica G Kramberger, Laura Bonanni, Rik Vandenberghe, Abdul Hye, Kaj Blennow, Henrik Zetterberg, Dag Aarsland, European–Dementia With Lewy Bodies (E-DLB) Consortium
Pubblicato in: JAMA Neurology, 2022, ISSN 2168-6149
Editore: American Medical Association
DOI: 10.1001/jamaneurol.2021.4222

CSF and plasma Aβ42/40 across Alzheimer’s disease continuum: comparison of two ultrasensitive Simoa<sup>®</sup> assays targeting distinct amyloid regions

Autori: Anna Lidia Wojdała, Giovanni Bellomo, Andrea Toja, Lorenzo Gaetani, Lucilla Parnetti, Davide Chiasserini
Pubblicato in: Clinical Chemistry and Laboratory Medicine (CCLM), Numero 62, 2024, Pagina/e 332-340, ISSN 1434-6621
Editore: Walter de Gruyter GmbH & Co. KG
DOI: 10.1515/cclm-2023-0659

Phosphorylated tau181 in plasma as a potential biomarker for Alzheimer's disease in adults with Down syndrome

Autori: Alberto Lleó, Henrik Zetterberg, Jordi Pegueroles, Thomas K Karikari, María Carmona-Iragui, Nicholas J Ashton, Victor Montal, Isabel Barroeta, Juan Lantero-Rodríguez, Laura Videla, Miren Altuna, Bessy Benejam, Susana Fernandez, Silvia Valldeneu, Diana Garzón, Alexandre Bejanin, Maria Florencia Iulita, Valle Camacho, Santiago Medrano-Martorell, Olivia Belbin, Jordi Clarimon, Sylvain Lehmann, Da
Pubblicato in: Nature Communications, 2021, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-021-24319-x

Plasma p-tau231: a new biomarker for incipient Alzheimer's disease pathology

Autori: Nicholas J Ashton, Tharick A Pascoal, Thomas K Karikari, Andréa L Benedet, Juan Lantero-Rodriguez, Gunnar Brinkmalm, Anniina Snellman, Michael Schöll, Claire Troakes, Abdul Hye, Serge Gauthier, Eugeen Vanmechelen, Henrik Zetterberg, Pedro Rosa-Neto, Kaj Blennow
Pubblicato in: Acta Neuropathologica, 2021, ISSN 0001-6322
Editore: Springer Verlag
DOI: 10.1007/s00401-021-02275-6

Potential diagnostic value of CSF metabolism-related proteins across the Alzheimer’s disease continuum

Autori: Silvia Paciotti, Anna Lidia Wojdała, Giovanni Bellomo, Andrea Toja, Elena Chipi, Sander R. Piersma, Thang V. Pham, Lorenzo Gaetani, Connie R. Jimenez, Lucilla Parnetti, Davide Chiasserini
Pubblicato in: Alzheimer's Research & Therapy, Numero 15, 2023, ISSN 1758-9193
Editore: BioMed Central
DOI: 10.1186/s13195-023-01269-8

Investigating alpha‐synuclein co‐pathology in Alzheimer's disease by means of cerebrospinal fluid alpha‐synuclein seed amplification assay

Autori: Giovanni Bellomo, Andrea Toja, Federico Paolini Paoletti, Yihua Ma, Carly M. Farris, Lorenzo Gaetani, Nicola Salvadori, Davide Chiasserini, Anna Lidia Wojdaƚa, Luis Concha‐Marambio, Lucilla Parnetti
Pubblicato in: Alzheimer's & Dementia, Numero 20, 2024, Pagina/e 2444-2452, ISSN 1552-5260
Editore: Elsevier BV
DOI: 10.1002/alz.13658

Fluid biomarkers in frontotemporal dementia: past,present and future

Autori: Imogen Joanna Swift, Aitana Sogorb-Esteve, Carolin Heller, Matthis Synofzik, Markus Otto, Caroline Graff, Daniela Galimberti, Emily Todd, Amanda J Heslegrave, Emma Louise van der Ende, John Cornelis Van Swieten, Henrik Zetterberg, Jonathan Daniel Rohrer
Pubblicato in: Journal of neurology, neurosurgery, and psychiatry., 2021, ISSN 0022-3050
Editore: BMJ Publishing Group
DOI: 10.1136/jnnp-2020-323520

Fully automated measurement of plasma Aβ42/40 and p‐tau181: Analytical robustness and concordance with cerebrospinal fluid profile along the Alzheimer's disease continuum in two independent cohorts

Autori: Giovanni Bellomo, Sherif Bayoumy, Alfredo Megaro, Andrea Toja, Giovanna Nardi, Lorenzo Gaetani, Elena R. Blujdea, Federico Paolini Paoletti, Anna Lidia Wojdaƚa, Davide Chiasserini, Wiesje M. van der Flier, Inge M. W. Verberk, Charlotte Teunissen, Lucilla Parnetti
Pubblicato in: Alzheimer's & Dementia, Numero 20, 2024, Pagina/e 2453-2468, ISSN 1552-5260
Editore: Elsevier BV
DOI: 10.1002/alz.13687

Trajectories of CSF and plasma biomarkers across Alzheimer's disease continuum: disease staging by NF-L, p-tau181, and GFAP

Autori: Anna Lidia Wojdała, Giovanni Bellomo, Lorenzo Gaetani, Andrea Toja, Elena Chipi, Dandan Shan, Davide Chiasserini, Lucilla Parnetti
Pubblicato in: Neurobiology of Disease, Numero 189, 2023, Pagina/e 106356, ISSN 0969-9961
Editore: Academic Press
DOI: 10.1016/j.nbd.2023.106356

Blood-based biomarkers for Alzheimer's disease: towards clinical implementation

Autori: Charlotte E Teunissen, Inge M W Verberk, Elisabeth H Thijssen, Lisa Vermunt, Oskar Hansson, Henrik Zetterberg, Wiesje M van der Flier, Michelle M Mielke, Marta Del Campo
Pubblicato in: The Lancet Neurology, 2022, ISSN 1474-4422
Editore: The Lancet Publishing Group
DOI: 10.1016/s1474-4422(21)00361-6

Phosphatidylethanolamine Binding Protein 1 (PEBP1) in Alzheimer’s Disease: ELISA Development and Clinical Validation

Autori: Anna Lidia Wojdała, Davide Chiasserini, Giovanni Bellomo, Silvia Paciotti, Lorenzo Gaetani, Federico Paolini Paoletti, Lucilla Parnetti
Pubblicato in: Journal of Alzheimer's Disease, Numero 88, 2023, Pagina/e 1459-1468, ISSN 1387-2877
Editore: IOS Press
DOI: 10.3233/jad-220323

Use of plasma biomarkers for AT(N) classification of neurodegenerative dementias

Autori: Daniel Alcolea, Constance Delaby, Laia Muñoz, Soraya Torres, Teresa Estellés, Nuole Zhu, Isabel Barroeta , María Carmona-Iragui, Ignacio Illán-Gala, Miguel Ángel Santos-Santos, Miren Altuna, Isabel Sala, Mª Belén Sánchez-Saudinós, Laura Videla, Sílvia Valldeneu, Andrea Subirana, Jordi Pegueroles, Christophe Hirtz, Jérôme Vialaret, Sylvain Lehmann, Thomas K Karikari, Nicholas J Ashton,
Pubblicato in: Journal of Neurology, Neurosurgery and Psychiatry, 2021, ISSN 0022-3050
Editore: BMJ Publishing Group
DOI: 10.1136/jnnp-2021-326603

Multi-cohort profiling reveals elevated CSF levels of brain-enriched proteins in Alzheimer’s disease

Autori: Sofia Bergström, Julia Remnestål, Jamil Yousef, Jennie Olofsson, Ioanna Markaki, Stephanie Carvalho, Jean-Christophe Corvol, Kim Kultima, Lena Kilander, Malin Löwenmark, Martin Ingelsson, Kaj Blennow, Henrik Zetterberg, Bengt Nellgård, Frederic Brosseron, Michael T Heneka, Beatriz Bosch, Raquel Sanchez-Valle, Anna Månberg, Per Svenningsson, Peter Nilsson
Pubblicato in: Annals of Clinical and Translational Neurology, 2021, ISSN 2328-9503
Editore: John Wiley and Sons Inc.
DOI: 10.1002/acn3.51402

Neuronal pentraxins as biomarkers of synaptic activity: from physiological functions to pathological changes in neurodegeneration

Autori: Nerea Gómez de San José; Federico Massa; Steffen Halbgebauer; Patrick Oeckl; Petra Steinacker; Markus Otto
Pubblicato in: Neural Transmission, 2021, ISSN 0300-9564
Editore: Springer Verlag
DOI: 10.1007/s00702-021-02411-2

Association of Apolipoprotein E ɛ4 Allele With Clinical and Multimodal Biomarker Changes of Alzheimer Disease in Adults With Down Syndrome

Autori: Alexandre Bejanin, Maria Florencia Iulita, Eduard Vilaplana, Maria Carmona-Iragui, Bessy Benejam, Laura Videla, Isabel Barroeta, Susana Fernandez, Miren Altuna, Jordi Pegueroles, Victor Montal, Silvia Valldeneu, Sandra Giménez, Sofía González-Ortiz, Laia Muñoz, Concepción Padilla, Mateus Rozalem Aranha, Teresa Estellés, Ignacio Illán-Gala, Olivia Belbin, Valle Camacho, Liam Reese Wilson, Ti
Pubblicato in: JAMA Neurology, 2021, ISSN 2168-6149
Editore: American Medical Association
DOI: 10.1001/jamaneurol.2021.1893

Clinical reporting following the quantification of cerebrospinal fluid biomarkers in Alzheimer's disease: An international overview.

Autori: Constance Delaby, Charlotte E Teunissen, Kaj Blennow, Daniel Alcolea, Ivan Arisi, Elodie Bouaziz Amar, Anne Beaume, Aurélie Bedel, Giovanni Bellomo, Edith Bigot-Corbel, Maria Bjerke, Marie-Céline Blanc-Quintin, Mercè Boada, Olivier Bousiges, Miles D Chapman, Mari L DeMarco, Mara D'Onofrio, Julien Dumurgier, Diane Dufour-Rainfray, Sebastiaan Engelborghs, Hermann Esselmann, Anne Fogli, Audrey Gab
Pubblicato in: Alzheimer’s and Dementia, 2021, ISSN 1552-5279
Editore: John Wiley & Sons, Ltd
DOI: 10.1002/alz.12545

Characterization of pre-analytical sample handling effects on a panel of Alzheimer's disease-related blood-based biomarkers: Results from the Standardization of Alzheimer's Blood Biomarkers (SABB) working group.

Autori: Inge M W Verberk, Els O Misdorp, Jannet Koelewijn, Andrew J Ball, Kaj Blennow, Jeffrey L Dage, Noelia Fandos, Oskar Hansson, Christophe Hirtz, Shorena Janelidze, Sungmin Kang, Kristopher Kirmess, Jana Kindermans, Ryan Lee, Matthew R Meyer, Dandan Shan, Leslie M Shaw, Teresa Waligorska, Tim West, Henrik Zetterberg, Rebecca M Edelmayer, Charlotte E Teunissen
Pubblicato in: Alzheimer’s and Dementia, 2021, ISSN 1552-5279
Editore: John Wiley & Sons, Ltd
DOI: 10.1002/alz.12510

Clinical and analytical comparison of six Simoa assays for plasma P-tau isoforms P-tau181, P-tau217 and P-tau231

Autori: Sherif Bayoumy, Inge M W Verberk, Ben den Dulk, Zulaiga Hussainali, Marissa Zwan, Wiesje M van der Flier, Nicholas J Ashton, Henrik Zetterberg, Kaj Blennow, Jeroen Vanbrabant, Erik Stoops, Eugeen Vanmechelen, Jeffrey L Dage, Charlotte E Teunissen
Pubblicato in: Alzheimer's Research & Therapy, 2021, ISSN 1758-9193
Editore: BioMed Central
DOI: 10.1186/s13195-021-00939-9

Clinical and analytical comparison of three assays for plasma p-tau isoforms on an ultrasensitive platform

Autori: Sherif Bayoumy, Ben Den Dulk, Zulaiga Hussainali, Inge M.W. Verberk, Wiesje M van der Flier, Marissa D. Zwan, Jeffrey L. Dage, Charlotte E. Teunissen
Pubblicato in: Alzheimer’s and Dementia, 2021
Editore: John Wiley & Sons, Ltd
DOI: 10.1002/alz.054044

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