Multi-omics Interdisciplinary Research Integration to Address DEmentia diagnosis

Deliverables

ESR recruitment: All 15 ESRs are recruited; individual contracts are signed

Management and overall coordination by VUMC will enable MIRIADE activities in all work packages to be performed timely coherently and efficiently One of these activities will be coordination of ESR recruitment

Project website: The project website (intranet as well as internet) is up and running

Secure efficient internal communication within the MIRIADE consortium

Publications

A cell-free high throughput assay for assessment of SARS-CoV-2 neutralizing antibodies

Author(s): Sara Mravinacova, Malin Jönsson, Wanda Christ, Jonas Klingström, Jamil Yousef, Cecilia Hellström, My Hedhammar, Sebastian Havervall, Charlotte Thålin, Elisa Pin, Hanna Tegel, Peter Nilsson, Anna Månberg, Sophia Hober
Published in: New Biotechnology, 2022, ISSN 1871-6784
Publisher: Elsevier BV
DOI: 10.1016/j.nbt.2021.10.002

Association of Plasma p-tau181 and p-tau231 Concentrations With Cognitive Decline in Patients With Probable Dementia With Lewy Bodies

Author(s): Maria C Gonzalez, Nicholas J Ashton, Bárbara Fernandes Gomes, Diego Alejandro Tovar-Rios, Frédéric Blanc, Thomas K Karikari, Brit Mollenhauer, Andrea Pilotto, Afina Lemstra, Claire Paquet, Carla Abdelnour, Milica G Kramberger, Laura Bonanni, Rik Vandenberghe, Abdul Hye, Kaj Blennow, Henrik Zetterberg, Dag Aarsland, European–Dementia With Lewy Bodies (E-DLB) Consortium
Published in: JAMA Neurology, 2022, ISSN 2168-6149
Publisher: American Medical Association
DOI: 10.1001/jamaneurol.2021.4222

CSF and plasma Aβ42/40 across Alzheimer’s disease continuum: comparison of two ultrasensitive Simoa<sup>®</sup> assays targeting distinct amyloid regions

Author(s): Anna Lidia Wojdała, Giovanni Bellomo, Andrea Toja, Lorenzo Gaetani, Lucilla Parnetti, Davide Chiasserini
Published in: Clinical Chemistry and Laboratory Medicine (CCLM), Issue 62, 2024, Page(s) 332-340, ISSN 1434-6621
Publisher: Walter de Gruyter GmbH & Co. KG
DOI: 10.1515/cclm-2023-0659

Phosphorylated tau181 in plasma as a potential biomarker for Alzheimer's disease in adults with Down syndrome

Author(s): Alberto Lleó, Henrik Zetterberg, Jordi Pegueroles, Thomas K Karikari, María Carmona-Iragui, Nicholas J Ashton, Victor Montal, Isabel Barroeta, Juan Lantero-Rodríguez, Laura Videla, Miren Altuna, Bessy Benejam, Susana Fernandez, Silvia Valldeneu, Diana Garzón, Alexandre Bejanin, Maria Florencia Iulita, Valle Camacho, Santiago Medrano-Martorell, Olivia Belbin, Jordi Clarimon, Sylvain Lehmann, Da
Published in: Nature Communications, 2021, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-021-24319-x

Potential diagnostic value of CSF metabolism-related proteins across the Alzheimer’s disease continuum

Author(s): Silvia Paciotti, Anna Lidia Wojdała, Giovanni Bellomo, Andrea Toja, Elena Chipi, Sander R. Piersma, Thang V. Pham, Lorenzo Gaetani, Connie R. Jimenez, Lucilla Parnetti, Davide Chiasserini
Published in: Alzheimer's Research & Therapy, Issue 15, 2023, ISSN 1758-9193
Publisher: BioMed Central
DOI: 10.1186/s13195-023-01269-8

Investigating alpha‐synuclein co‐pathology in Alzheimer's disease by means of cerebrospinal fluid alpha‐synuclein seed amplification assay

Author(s): Giovanni Bellomo, Andrea Toja, Federico Paolini Paoletti, Yihua Ma, Carly M. Farris, Lorenzo Gaetani, Nicola Salvadori, Davide Chiasserini, Anna Lidia Wojdaƚa, Luis Concha‐Marambio, Lucilla Parnetti
Published in: Alzheimer's & Dementia, Issue 20, 2024, Page(s) 2444-2452, ISSN 1552-5260
Publisher: Elsevier BV
DOI: 10.1002/alz.13658

Fully automated measurement of plasma Aβ42/40 and p‐tau181: Analytical robustness and concordance with cerebrospinal fluid profile along the Alzheimer's disease continuum in two independent cohorts

Author(s): Giovanni Bellomo, Sherif Bayoumy, Alfredo Megaro, Andrea Toja, Giovanna Nardi, Lorenzo Gaetani, Elena R. Blujdea, Federico Paolini Paoletti, Anna Lidia Wojdaƚa, Davide Chiasserini, Wiesje M. van der Flier, Inge M. W. Verberk, Charlotte Teunissen, Lucilla Parnetti
Published in: Alzheimer's & Dementia, Issue 20, 2024, Page(s) 2453-2468, ISSN 1552-5260
Publisher: Elsevier BV
DOI: 10.1002/alz.13687

Trajectories of CSF and plasma biomarkers across Alzheimer's disease continuum: disease staging by NF-L, p-tau181, and GFAP

Author(s): Anna Lidia Wojdała, Giovanni Bellomo, Lorenzo Gaetani, Andrea Toja, Elena Chipi, Dandan Shan, Davide Chiasserini, Lucilla Parnetti
Published in: Neurobiology of Disease, Issue 189, 2023, Page(s) 106356, ISSN 0969-9961
Publisher: Academic Press
DOI: 10.1016/j.nbd.2023.106356

Phosphatidylethanolamine Binding Protein 1 (PEBP1) in Alzheimer’s Disease: ELISA Development and Clinical Validation

Author(s): Anna Lidia Wojdała, Davide Chiasserini, Giovanni Bellomo, Silvia Paciotti, Lorenzo Gaetani, Federico Paolini Paoletti, Lucilla Parnetti
Published in: Journal of Alzheimer's Disease, Issue 88, 2023, Page(s) 1459-1468, ISSN 1387-2877
Publisher: IOS Press
DOI: 10.3233/jad-220323

Use of plasma biomarkers for AT(N) classification of neurodegenerative dementias

Author(s): Daniel Alcolea, Constance Delaby, Laia Muñoz, Soraya Torres, Teresa Estellés, Nuole Zhu, Isabel Barroeta , María Carmona-Iragui, Ignacio Illán-Gala, Miguel Ángel Santos-Santos, Miren Altuna, Isabel Sala, Mª Belén Sánchez-Saudinós, Laura Videla, Sílvia Valldeneu, Andrea Subirana, Jordi Pegueroles, Christophe Hirtz, Jérôme Vialaret, Sylvain Lehmann, Thomas K Karikari, Nicholas J Ashton,
Published in: Journal of Neurology, Neurosurgery and Psychiatry, 2021, ISSN 0022-3050
Publisher: BMJ Publishing Group
DOI: 10.1136/jnnp-2021-326603

Neuronal pentraxins as biomarkers of synaptic activity: from physiological functions to pathological changes in neurodegeneration

Author(s): Nerea Gómez de San José; Federico Massa; Steffen Halbgebauer; Patrick Oeckl; Petra Steinacker; Markus Otto
Published in: Neural Transmission, 2021, ISSN 0300-9564
Publisher: Springer Verlag
DOI: 10.1007/s00702-021-02411-2

Association of Apolipoprotein E ɛ4 Allele With Clinical and Multimodal Biomarker Changes of Alzheimer Disease in Adults With Down Syndrome

Author(s): Alexandre Bejanin, Maria Florencia Iulita, Eduard Vilaplana, Maria Carmona-Iragui, Bessy Benejam, Laura Videla, Isabel Barroeta, Susana Fernandez, Miren Altuna, Jordi Pegueroles, Victor Montal, Silvia Valldeneu, Sandra Giménez, Sofía González-Ortiz, Laia Muñoz, Concepción Padilla, Mateus Rozalem Aranha, Teresa Estellés, Ignacio Illán-Gala, Olivia Belbin, Valle Camacho, Liam Reese Wilson, Ti
Published in: JAMA Neurology, 2021, ISSN 2168-6149
Publisher: American Medical Association
DOI: 10.1001/jamaneurol.2021.1893

Clinical reporting following the quantification of cerebrospinal fluid biomarkers in Alzheimer's disease: An international overview.

Author(s): Constance Delaby, Charlotte E Teunissen, Kaj Blennow, Daniel Alcolea, Ivan Arisi, Elodie Bouaziz Amar, Anne Beaume, Aurélie Bedel, Giovanni Bellomo, Edith Bigot-Corbel, Maria Bjerke, Marie-Céline Blanc-Quintin, Mercè Boada, Olivier Bousiges, Miles D Chapman, Mari L DeMarco, Mara D'Onofrio, Julien Dumurgier, Diane Dufour-Rainfray, Sebastiaan Engelborghs, Hermann Esselmann, Anne Fogli, Audrey Gab
Published in: Alzheimer’s and Dementia, 2021, ISSN 1552-5279
Publisher: John Wiley & Sons, Ltd
DOI: 10.1002/alz.12545

Characterization of pre-analytical sample handling effects on a panel of Alzheimer's disease-related blood-based biomarkers: Results from the Standardization of Alzheimer's Blood Biomarkers (SABB) working group.

Author(s): Inge M W Verberk, Els O Misdorp, Jannet Koelewijn, Andrew J Ball, Kaj Blennow, Jeffrey L Dage, Noelia Fandos, Oskar Hansson, Christophe Hirtz, Shorena Janelidze, Sungmin Kang, Kristopher Kirmess, Jana Kindermans, Ryan Lee, Matthew R Meyer, Dandan Shan, Leslie M Shaw, Teresa Waligorska, Tim West, Henrik Zetterberg, Rebecca M Edelmayer, Charlotte E Teunissen
Published in: Alzheimer’s and Dementia, 2021, ISSN 1552-5279
Publisher: John Wiley & Sons, Ltd
DOI: 10.1002/alz.12510

Clinical and analytical comparison of six Simoa assays for plasma P-tau isoforms P-tau181, P-tau217 and P-tau231

Author(s): Sherif Bayoumy, Inge M W Verberk, Ben den Dulk, Zulaiga Hussainali, Marissa Zwan, Wiesje M van der Flier, Nicholas J Ashton, Henrik Zetterberg, Kaj Blennow, Jeroen Vanbrabant, Erik Stoops, Eugeen Vanmechelen, Jeffrey L Dage, Charlotte E Teunissen
Published in: Alzheimer's Research & Therapy, 2021, ISSN 1758-9193
Publisher: BioMed Central
DOI: 10.1186/s13195-021-00939-9

Clinical and analytical comparison of three assays for plasma p-tau isoforms on an ultrasensitive platform

Author(s): Sherif Bayoumy, Ben Den Dulk, Zulaiga Hussainali, Inge M.W. Verberk, Wiesje M van der Flier, Marissa D. Zwan, Jeffrey L. Dage, Charlotte E. Teunissen
Published in: Alzheimer’s and Dementia, 2021
Publisher: John Wiley & Sons, Ltd
DOI: 10.1002/alz.054044

Deliverables

Publications

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