Multi-omics Interdisciplinary Research Integration to Address DEmentia diagnosis

Leistungen

ESR recruitment: All 15 ESRs are recruited; individual contracts are signed

Management and overall coordination by VUMC will enable MIRIADE activities in all work packages to be performed timely coherently and efficiently One of these activities will be coordination of ESR recruitment

Project website: The project website (intranet as well as internet) is up and running

Secure efficient internal communication within the MIRIADE consortium

Veröffentlichungen

A cell-free high throughput assay for assessment of SARS-CoV-2 neutralizing antibodies

Autoren: Sara Mravinacova, Malin Jönsson, Wanda Christ, Jonas Klingström, Jamil Yousef, Cecilia Hellström, My Hedhammar, Sebastian Havervall, Charlotte Thålin, Elisa Pin, Hanna Tegel, Peter Nilsson, Anna Månberg, Sophia Hober
Veröffentlicht in: New Biotechnology, 2022, ISSN 1871-6784
Herausgeber: Elsevier BV
DOI: 10.1016/j.nbt.2021.10.002

Association of Plasma p-tau181 and p-tau231 Concentrations With Cognitive Decline in Patients With Probable Dementia With Lewy Bodies

Autoren: Maria C Gonzalez, Nicholas J Ashton, Bárbara Fernandes Gomes, Diego Alejandro Tovar-Rios, Frédéric Blanc, Thomas K Karikari, Brit Mollenhauer, Andrea Pilotto, Afina Lemstra, Claire Paquet, Carla Abdelnour, Milica G Kramberger, Laura Bonanni, Rik Vandenberghe, Abdul Hye, Kaj Blennow, Henrik Zetterberg, Dag Aarsland, European–Dementia With Lewy Bodies (E-DLB) Consortium
Veröffentlicht in: JAMA Neurology, 2022, ISSN 2168-6149
Herausgeber: American Medical Association
DOI: 10.1001/jamaneurol.2021.4222

Phosphorylated tau181 in plasma as a potential biomarker for Alzheimer's disease in adults with Down syndrome

Autoren: Alberto Lleó, Henrik Zetterberg, Jordi Pegueroles, Thomas K Karikari, María Carmona-Iragui, Nicholas J Ashton, Victor Montal, Isabel Barroeta, Juan Lantero-Rodríguez, Laura Videla, Miren Altuna, Bessy Benejam, Susana Fernandez, Silvia Valldeneu, Diana Garzón, Alexandre Bejanin, Maria Florencia Iulita, Valle Camacho, Santiago Medrano-Martorell, Olivia Belbin, Jordi Clarimon, Sylvain Lehmann, Da
Veröffentlicht in: Nature Communications, 2021, ISSN 2041-1723
Herausgeber: Nature Publishing Group
DOI: 10.1038/s41467-021-24319-x

Plasma p-tau231: a new biomarker for incipient Alzheimer's disease pathology

Autoren: Nicholas J Ashton, Tharick A Pascoal, Thomas K Karikari, Andréa L Benedet, Juan Lantero-Rodriguez, Gunnar Brinkmalm, Anniina Snellman, Michael Schöll, Claire Troakes, Abdul Hye, Serge Gauthier, Eugeen Vanmechelen, Henrik Zetterberg, Pedro Rosa-Neto, Kaj Blennow
Veröffentlicht in: Acta Neuropathologica, 2021, ISSN 0001-6322
Herausgeber: Springer Verlag
DOI: 10.1007/s00401-021-02275-6

Fluid biomarkers in frontotemporal dementia: past,present and future

Autoren: Imogen Joanna Swift, Aitana Sogorb-Esteve, Carolin Heller, Matthis Synofzik, Markus Otto, Caroline Graff, Daniela Galimberti, Emily Todd, Amanda J Heslegrave, Emma Louise van der Ende, John Cornelis Van Swieten, Henrik Zetterberg, Jonathan Daniel Rohrer
Veröffentlicht in: Journal of neurology, neurosurgery, and psychiatry., 2021, ISSN 0022-3050
Herausgeber: BMJ Publishing Group
DOI: 10.1136/jnnp-2020-323520

Blood-based biomarkers for Alzheimer's disease: towards clinical implementation

Autoren: Charlotte E Teunissen, Inge M W Verberk, Elisabeth H Thijssen, Lisa Vermunt, Oskar Hansson, Henrik Zetterberg, Wiesje M van der Flier, Michelle M Mielke, Marta Del Campo
Veröffentlicht in: The Lancet Neurology, 2022, ISSN 1474-4422
Herausgeber: The Lancet Publishing Group
DOI: 10.1016/s1474-4422(21)00361-6

Use of plasma biomarkers for AT(N) classification of neurodegenerative dementias

Autoren: Daniel Alcolea, Constance Delaby, Laia Muñoz, Soraya Torres, Teresa Estellés, Nuole Zhu, Isabel Barroeta , María Carmona-Iragui, Ignacio Illán-Gala, Miguel Ángel Santos-Santos, Miren Altuna, Isabel Sala, Mª Belén Sánchez-Saudinós, Laura Videla, Sílvia Valldeneu, Andrea Subirana, Jordi Pegueroles, Christophe Hirtz, Jérôme Vialaret, Sylvain Lehmann, Thomas K Karikari, Nicholas J Ashton,
Veröffentlicht in: Journal of Neurology, Neurosurgery and Psychiatry, 2021, ISSN 0022-3050
Herausgeber: BMJ Publishing Group
DOI: 10.1136/jnnp-2021-326603

Multi-cohort profiling reveals elevated CSF levels of brain-enriched proteins in Alzheimer’s disease

Autoren: Sofia Bergström, Julia Remnestål, Jamil Yousef, Jennie Olofsson, Ioanna Markaki, Stephanie Carvalho, Jean-Christophe Corvol, Kim Kultima, Lena Kilander, Malin Löwenmark, Martin Ingelsson, Kaj Blennow, Henrik Zetterberg, Bengt Nellgård, Frederic Brosseron, Michael T Heneka, Beatriz Bosch, Raquel Sanchez-Valle, Anna Månberg, Per Svenningsson, Peter Nilsson
Veröffentlicht in: Annals of Clinical and Translational Neurology, 2021, ISSN 2328-9503
Herausgeber: John Wiley and Sons Inc.
DOI: 10.1002/acn3.51402

Neuronal pentraxins as biomarkers of synaptic activity: from physiological functions to pathological changes in neurodegeneration

Autoren: Nerea Gómez de San José; Federico Massa; Steffen Halbgebauer; Patrick Oeckl; Petra Steinacker; Markus Otto
Veröffentlicht in: Neural Transmission, 2021, ISSN 0300-9564
Herausgeber: Springer Verlag
DOI: 10.1007/s00702-021-02411-2

Association of Apolipoprotein E ɛ4 Allele With Clinical and Multimodal Biomarker Changes of Alzheimer Disease in Adults With Down Syndrome

Autoren: Alexandre Bejanin, Maria Florencia Iulita, Eduard Vilaplana, Maria Carmona-Iragui, Bessy Benejam, Laura Videla, Isabel Barroeta, Susana Fernandez, Miren Altuna, Jordi Pegueroles, Victor Montal, Silvia Valldeneu, Sandra Giménez, Sofía González-Ortiz, Laia Muñoz, Concepción Padilla, Mateus Rozalem Aranha, Teresa Estellés, Ignacio Illán-Gala, Olivia Belbin, Valle Camacho, Liam Reese Wilson, Ti
Veröffentlicht in: JAMA Neurology, 2021, ISSN 2168-6149
Herausgeber: American Medical Association
DOI: 10.1001/jamaneurol.2021.1893

Clinical reporting following the quantification of cerebrospinal fluid biomarkers in Alzheimer's disease: An international overview.

Autoren: Constance Delaby, Charlotte E Teunissen, Kaj Blennow, Daniel Alcolea, Ivan Arisi, Elodie Bouaziz Amar, Anne Beaume, Aurélie Bedel, Giovanni Bellomo, Edith Bigot-Corbel, Maria Bjerke, Marie-Céline Blanc-Quintin, Mercè Boada, Olivier Bousiges, Miles D Chapman, Mari L DeMarco, Mara D'Onofrio, Julien Dumurgier, Diane Dufour-Rainfray, Sebastiaan Engelborghs, Hermann Esselmann, Anne Fogli, Audrey Gab
Veröffentlicht in: Alzheimer’s and Dementia, 2021, ISSN 1552-5279
Herausgeber: John Wiley & Sons, Ltd
DOI: 10.1002/alz.12545

Characterization of pre-analytical sample handling effects on a panel of Alzheimer's disease-related blood-based biomarkers: Results from the Standardization of Alzheimer's Blood Biomarkers (SABB) working group.

Autoren: Inge M W Verberk, Els O Misdorp, Jannet Koelewijn, Andrew J Ball, Kaj Blennow, Jeffrey L Dage, Noelia Fandos, Oskar Hansson, Christophe Hirtz, Shorena Janelidze, Sungmin Kang, Kristopher Kirmess, Jana Kindermans, Ryan Lee, Matthew R Meyer, Dandan Shan, Leslie M Shaw, Teresa Waligorska, Tim West, Henrik Zetterberg, Rebecca M Edelmayer, Charlotte E Teunissen
Veröffentlicht in: Alzheimer’s and Dementia, 2021, ISSN 1552-5279
Herausgeber: John Wiley & Sons, Ltd
DOI: 10.1002/alz.12510

Clinical and analytical comparison of six Simoa assays for plasma P-tau isoforms P-tau181, P-tau217 and P-tau231

Autoren: Sherif Bayoumy, Inge M W Verberk, Ben den Dulk, Zulaiga Hussainali, Marissa Zwan, Wiesje M van der Flier, Nicholas J Ashton, Henrik Zetterberg, Kaj Blennow, Jeroen Vanbrabant, Erik Stoops, Eugeen Vanmechelen, Jeffrey L Dage, Charlotte E Teunissen
Veröffentlicht in: Alzheimer's Research & Therapy, 2021, ISSN 1758-9193
Herausgeber: BioMed Central
DOI: 10.1186/s13195-021-00939-9

Clinical and analytical comparison of three assays for plasma p-tau isoforms on an ultrasensitive platform

Autoren: Sherif Bayoumy, Ben Den Dulk, Zulaiga Hussainali, Inge M.W. Verberk, Wiesje M van der Flier, Marissa D. Zwan, Jeffrey L. Dage, Charlotte E. Teunissen
Veröffentlicht in: Alzheimer’s and Dementia, 2021
Herausgeber: John Wiley & Sons, Ltd
DOI: 10.1002/alz.054044

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