Creating Versatile Metallo-Enzyme Environments for Selective C-H Activation Chemistry: Lignocellulose Deconstruction and Beyond

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Pubblicazioni

Engineering an efficient and enantioselective enzyme for the Morita–Baylis–Hillman reaction

Autori: Rebecca Crawshaw, Amy E. Crossley, Linus Johannissen, Ashleigh J. Burke, Sam Hay, Colin Levy, David Baker, Sarah L. Lovelock, Anthony P. Green
Pubblicato in: Nature Chemistry, Numero 14, 2023, Pagina/e 313-320, ISSN 1755-4330
Editore: Nature Publishing Group
DOI: 10.1038/s41557-021-00833-9

Insights into the H2O2-driven catalytic mechanism of fungal lytic polysaccharide monooxygenases

Autori: Tobias M. Hedison; Erik Breslmayr; Erik Breslmayr; Muralidharan Shanmugam; Kwankao Karnpakdee; Derren J. Heyes; Anthony P. Green; Roland Ludwig; Nigel S. Scrutton; Daniel Kracher; Daniel Kracher
Pubblicato in: Hedison , T M , Breslmayr , E , Shanmugam , M , Karnpakdee , K , Heyes , D J , Green , A P , Ludwig , R , Scrutton , N S & Kracher , D 2020 , ' Insights into the H2O2 ‐driven catalytic mechanism of fungal lytic polysaccharide monooxygenases ' , The FEBS Journal . https://doi.org/10.1111/febs.15704, Numero 17424658, 2021, ISSN 1742-4658
Editore: Wiley
DOI: 10.1111/febs.15704

The road to fully programmable protein catalysis

Autori: Sarah L. Lovelock, Rebecca Crawshaw, Sophie Basler, Colin Levy, David Baker, Donald Hilvert, Anthony P. Green
Pubblicato in: Nature, Numero 606, 2022, Pagina/e 49-58, ISSN 0028-0836
Editore: Nature Publishing Group
DOI: 10.1038/s41586-022-04456-z

An efficient pyrrolysyl-tRNA synthetase for economical production of MeHis-containing enzymes

Autori: Amy E. Hutton, Jake Foster, James E. J. Sanders, Christopher J. Taylor, Stefan A. Hoffmann, Yizhi Cai, Sarah L. Lovelock, Anthony P. Green
Pubblicato in: Faraday Discussions, Numero 252, 2024, Pagina/e 295-305, ISSN 1359-6640
Editore: Royal Society of Chemistry
DOI: 10.1039/d4fd00019f

Enzymes with noncanonical amino acids

Autori: Jingming Zhao, Ashleigh J. Burke, Anthony P. Green
Pubblicato in: Current Opinion in Chemical Biology, Numero 55, 2020, Pagina/e 136-144, ISSN 1367-5931
Editore: Elsevier BV
DOI: 10.1016/j.cbpa.2020.01.006

Strategies for designing biocatalysts with new functions

Autori: Elizabeth L. Bell, Amy E. Hutton, Ashleigh J. Burke, Adam O’Connell, Amber Barry, Elaine O’Reilly, Anthony P. Green
Pubblicato in: Chemical Society Reviews, Numero 53, 2024, Pagina/e 2851-2862, ISSN 0306-0012
Editore: Royal Society of Chemistry
DOI: 10.1039/d3cs00972f

Noncanonical Amino Acids in Biocatalysis

Autori: Zachary Birch-Price, Florence J. Hardy, Thomas M. Lister, Anna R. Kohn, Anthony P. Green
Pubblicato in: Chemical Reviews, Numero 124, 2024, Pagina/e 8740-8786, ISSN 0009-2665
Editore: American Chemical Society
DOI: 10.1021/acs.chemrev.4c00120

A Noncanonical Tryptophan Analogue Reveals an Active Site Hydrogen Bond Controlling Ferryl Reactivity in a Heme Peroxidase.

Autori: Mary Ortmayer; Florence J. Hardy; Matthew G. Quesne; Matthew G. Quesne; Karl Fisher; Colin Levy; Derren J. Heyes; C. Richard A. Catlow; C. Richard A. Catlow; C. Richard A. Catlow; Sam P. de Visser; Stephen E. J. Rigby; Sam Hay; Anthony P. Green
Pubblicato in: 2691-3704, Numero 26913704, 2021, ISSN 2691-3704
Editore: American Chemical Society
DOI: 10.1021/jacsau.1c00145

Mapping the Initial Stages of a Protective Pathway that Enhances Catalytic Turnover by a Lytic Polysaccharide Monooxygenase

Autori: Jingming Zhao, Ying Zhuo, Daniel E. Diaz, Muralidharan Shanmugam, Abbey J. Telfer, Peter J. Lindley, Daniel Kracher, Takahiro Hayashi, Lisa S. Seibt, Florence J. Hardy, Oliver Manners, Tobias M. Hedison, Katherine A. Hollywood, Reynard Spiess, Kathleen M. Cain, Sofia Diaz-Moreno, Nigel S. Scrutton, Morten Tovborg, Paul H. Walton, Derren J. Heyes, Anthony P. Green
Pubblicato in: Journal of the American Chemical Society, Numero 145, 2023, Pagina/e 20672-20682, ISSN 0002-7863
Editore: American Chemical Society
DOI: 10.1021/jacs.3c06607

Rewiring the “Push-Pull” Catalytic Machinery of a Heme Enzyme Using an Expanded Genetic Code

Autori: Mary Ortmayer, Karl Fisher, Jaswir Basran, Emmanuel M. Wolde-Michael, Derren J. Heyes, Colin Levy, Sarah L. Lovelock, J. L. Ross Anderson, Emma L. Raven, Sam Hay, Stephen E. J. Rigby, Anthony P. Green
Pubblicato in: ACS Catalysis, Numero 10/4, 2020, Pagina/e 2735-2746, ISSN 2155-5435
Editore: American Chemical Society
DOI: 10.1021/acscatal.9b05129

Engineering enzyme activity using an expanded amino acid alphabet

Autori: Zachary Birch-Price, Christopher J Taylor, Mary Ortmayer, Anthony P Green
Pubblicato in: Protein Engineering, Design and Selection, Numero 36, 2023, ISSN 1741-0126
Editore: Oxford University Press
DOI: 10.1093/protein/gzac013

Engineered Metalloenzymes with Non‐Canonical Coordination Environments

Autori: Takahiro Hayashi, Donald Hilvert, Anthony P. Green
Pubblicato in: Chemistry – A European Journal, Numero 24/46, 2018, Pagina/e 11821-11830, ISSN 0947-6539
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/chem.201800975

Design and evolution of an enzyme with a non-canonical organocatalytic mechanism

Autori: Ashleigh J. Burke, Sarah L. Lovelock, Amina Frese, Rebecca Crawshaw, Mary Ortmayer, Mark Dunstan, Colin Levy, Anthony P. Green
Pubblicato in: Nature, Numero 570/7760, 2019, Pagina/e 219-223, ISSN 0028-0836
Editore: Nature Publishing Group
DOI: 10.1038/s41586-019-1262-8

A Noncanonical Proximal Heme Ligand Affords an Efficient Peroxidase in a Globin Fold

Autori: Moritz Pott, Takahiro Hayashi, Takahiro Mori, Peer R. E. Mittl, Anthony P. Green, Donald Hilvert
Pubblicato in: Journal of the American Chemical Society, Numero 140/4, 2018, Pagina/e 1535-1543, ISSN 0002-7863
Editore: American Chemical Society
DOI: 10.1021/jacs.7b12621

Chemo-Enzymatic Synthesis of Pyrazines and Pyrroles

Autori: Jin Xu, Anthony P. Green, Nicholas J. Turner
Pubblicato in: Angewandte Chemie International Edition, Numero 57/51, 2018, Pagina/e 16760-16763, ISSN 1433-7851
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/anie.201810555

A designed photoenzyme for enantioselective [2+2] cycloadditions

Autori: Jonathan S. Trimble, Rebecca Crawshaw, Florence J. Hardy, Colin W. Levy, Murray J. B. Brown, Douglas E. Fuerst, Derren J. Heyes, Richard Obexer, Anthony P. Green
Pubblicato in: Nature, Numero 611, 2022, Pagina/e 709-714, ISSN 0028-0836
Editore: Nature Publishing Group
DOI: 10.1038/s41586-022-05335-3

Design of Heme Enzymes with a Tunable Substrate Binding Pocket Adjacent to an Open Metal Coordination Site

Autori: Indrek Kalvet, Mary Ortmayer, Jingming Zhao, Rebecca Crawshaw, Nathan M. Ennist, Colin Levy, Anindya Roy, Anthony P. Green, David Baker
Pubblicato in: Journal of the American Chemical Society, Numero 145, 2023, Pagina/e 14307-14315, ISSN 0002-7863
Editore: American Chemical Society
DOI: 10.1021/jacs.3c02742

Engineering mutually orthogonal <scp>PylRS</scp>/<scp>tRNA</scp> pairs for dual encoding of functional histidine analogues

Autori: Christopher J. Taylor, Florence J. Hardy, Ashleigh J. Burke, Riley M. Bednar, Ryan A. Mehl, Anthony P. Green, Sarah L. Lovelock
Pubblicato in: Protein Science, Numero 32, 2023, ISSN 0961-8368
Editore: Cold Spring Harbor Laboratory Press
DOI: 10.1002/pro.4640

Biocatalysis

Autori: Elizabeth L. Bell, William Finnigan, Scott P. France, Anthony P. Green, Martin A. Hayes, Lorna J. Hepworth, Sarah L. Lovelock, Haruka Niikura, Sílvia Osuna, Elvira Romero, Katherine S. Ryan, Nicholas J. Turner, Sabine L. Flitsch
Pubblicato in: Nature Reviews Methods Primers, Numero 1, 2024, ISSN 2662-8449
Editore: Nature Publishing Group
DOI: 10.1038/s43586-021-00044-z

A non-canonical nucleophile unlocks a new mechanistic pathway in a designed enzyme

Autori: Amy E. Hutton, Jake Foster, Rebecca Crawshaw, Florence J. Hardy, Linus O. Johannissen, Thomas M. Lister, Emilie F. Gérard, Zachary Birch-Price, Richard Obexer, Sam Hay, Anthony P. Green
Pubblicato in: Nature Communications, Numero 15, 2024, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-024-46123-z

Probing Ferryl Reactivity in a Nonheme Iron Oxygenase Using an Expanded Genetic Code

Autori: Florence J. Hardy, Matthew G. Quesne, Emilie F. Gérard, Jingming Zhao, Mary Ortmayer, Christopher J. Taylor, Hafiz S. Ali, Jeffrey W. Slater, Colin W. Levy, Derren J. Heyes, J. Martin Bollinger, Sam P. de Visser, Anthony P. Green
Pubblicato in: ACS Catalysis, Numero 14, 2024, Pagina/e 11584-11590, ISSN 2155-5435
Editore: American Chemical Society
DOI: 10.1021/acscatal.4c02365

An Engineered Cytidine Deaminase for Biocatalytic Production of a Key Intermediate of the Covid-19 Antiviral Molnupiravir

Autori: Ashleigh J. Burke; William R. Birmingham; Ying Zhuo; Thomas W. Thorpe; Bruna Zucoloto da Costa; Rebecca Crawshaw; Ian Rowles; James D. Finnigan; Carl Young; Gregory M. Holgate; Mark P. Muldowney; Simon J. Charnock; Sarah L. Lovelock; Nicholas J. Turner; Anthony P. Green
Pubblicato in: Crossref, Numero 26913704, 2022, ISSN 2691-3704
Editore: American Chemical Society
DOI: 10.1021/jacs.1c11048

Directed evolution of an efficient and thermostable PET depolymerase

Autori: Elizabeth L. Bell, Ross Smithson, Siobhan Kilbride, Jake Foster, Florence J. Hardy, Saranarayanan Ramachandran, Aleksander A. Tedstone, Sarah J. Haigh, Arthur A. Garforth, Philip J. R. Day, Colin Levy, Michael P. Shaver, Anthony P. Green
Pubblicato in: Nature Catalysis, Numero 5, 2022, Pagina/e 673-681, ISSN 2520-1158
Editore: Nature Publishing
DOI: 10.1038/s41929-022-00821-3

A Designed Photoenzyme Promotes Enantioselective [2+2]-Cycloadditions via Triplet Energy Transfer

Autori: Anthony Green; Jonathan Trimble; Rebecca Crawshaw; Florence Hardy; Colin Levy; Murray Brown; Douglas Fuerst; Derren Heyes; Richard Obexer
Pubblicato in: Crossref, Numero 25732293, 2022, ISSN 2573-2293
Editore: Cambridge University Press
DOI: 10.21203/rs.3.rs-1650767/v1

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