Creating Versatile Metallo-Enzyme Environments for Selective C-H Activation Chemistry: Lignocellulose Deconstruction and Beyond

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Publicaciones

Engineering an efficient and enantioselective enzyme for the Morita–Baylis–Hillman reaction

Autores: Rebecca Crawshaw, Amy E. Crossley, Linus Johannissen, Ashleigh J. Burke, Sam Hay, Colin Levy, David Baker, Sarah L. Lovelock, Anthony P. Green
Publicado en: Nature Chemistry, Edición 14, 2023, Página(s) 313-320, ISSN 1755-4330
Editor: Nature Publishing Group
DOI: 10.1038/s41557-021-00833-9

Insights into the H2O2-driven catalytic mechanism of fungal lytic polysaccharide monooxygenases

Autores: Tobias M. Hedison; Erik Breslmayr; Erik Breslmayr; Muralidharan Shanmugam; Kwankao Karnpakdee; Derren J. Heyes; Anthony P. Green; Roland Ludwig; Nigel S. Scrutton; Daniel Kracher; Daniel Kracher
Publicado en: Hedison , T M , Breslmayr , E , Shanmugam , M , Karnpakdee , K , Heyes , D J , Green , A P , Ludwig , R , Scrutton , N S & Kracher , D 2020 , ' Insights into the H2O2 ‐driven catalytic mechanism of fungal lytic polysaccharide monooxygenases ' , The FEBS Journal . https://doi.org/10.1111/febs.15704, Edición 17424658, 2021, ISSN 1742-4658
Editor: Wiley
DOI: 10.1111/febs.15704

The road to fully programmable protein catalysis

Autores: Sarah L. Lovelock, Rebecca Crawshaw, Sophie Basler, Colin Levy, David Baker, Donald Hilvert, Anthony P. Green
Publicado en: Nature, Edición 606, 2022, Página(s) 49-58, ISSN 0028-0836
Editor: Nature Publishing Group
DOI: 10.1038/s41586-022-04456-z

An efficient pyrrolysyl-tRNA synthetase for economical production of MeHis-containing enzymes

Autores: Amy E. Hutton, Jake Foster, James E. J. Sanders, Christopher J. Taylor, Stefan A. Hoffmann, Yizhi Cai, Sarah L. Lovelock, Anthony P. Green
Publicado en: Faraday Discussions, Edición 252, 2024, Página(s) 295-305, ISSN 1359-6640
Editor: Royal Society of Chemistry
DOI: 10.1039/d4fd00019f

Enzymes with noncanonical amino acids

Autores: Jingming Zhao, Ashleigh J. Burke, Anthony P. Green
Publicado en: Current Opinion in Chemical Biology, Edición 55, 2020, Página(s) 136-144, ISSN 1367-5931
Editor: Elsevier BV
DOI: 10.1016/j.cbpa.2020.01.006

Strategies for designing biocatalysts with new functions

Autores: Elizabeth L. Bell, Amy E. Hutton, Ashleigh J. Burke, Adam O’Connell, Amber Barry, Elaine O’Reilly, Anthony P. Green
Publicado en: Chemical Society Reviews, Edición 53, 2024, Página(s) 2851-2862, ISSN 0306-0012
Editor: Royal Society of Chemistry
DOI: 10.1039/d3cs00972f

Noncanonical Amino Acids in Biocatalysis

Autores: Zachary Birch-Price, Florence J. Hardy, Thomas M. Lister, Anna R. Kohn, Anthony P. Green
Publicado en: Chemical Reviews, Edición 124, 2024, Página(s) 8740-8786, ISSN 0009-2665
Editor: American Chemical Society
DOI: 10.1021/acs.chemrev.4c00120

A Noncanonical Tryptophan Analogue Reveals an Active Site Hydrogen Bond Controlling Ferryl Reactivity in a Heme Peroxidase.

Autores: Mary Ortmayer; Florence J. Hardy; Matthew G. Quesne; Matthew G. Quesne; Karl Fisher; Colin Levy; Derren J. Heyes; C. Richard A. Catlow; C. Richard A. Catlow; C. Richard A. Catlow; Sam P. de Visser; Stephen E. J. Rigby; Sam Hay; Anthony P. Green
Publicado en: 2691-3704, Edición 26913704, 2021, ISSN 2691-3704
Editor: American Chemical Society
DOI: 10.1021/jacsau.1c00145

Mapping the Initial Stages of a Protective Pathway that Enhances Catalytic Turnover by a Lytic Polysaccharide Monooxygenase

Autores: Jingming Zhao, Ying Zhuo, Daniel E. Diaz, Muralidharan Shanmugam, Abbey J. Telfer, Peter J. Lindley, Daniel Kracher, Takahiro Hayashi, Lisa S. Seibt, Florence J. Hardy, Oliver Manners, Tobias M. Hedison, Katherine A. Hollywood, Reynard Spiess, Kathleen M. Cain, Sofia Diaz-Moreno, Nigel S. Scrutton, Morten Tovborg, Paul H. Walton, Derren J. Heyes, Anthony P. Green
Publicado en: Journal of the American Chemical Society, Edición 145, 2023, Página(s) 20672-20682, ISSN 0002-7863
Editor: American Chemical Society
DOI: 10.1021/jacs.3c06607

Rewiring the “Push-Pull” Catalytic Machinery of a Heme Enzyme Using an Expanded Genetic Code

Autores: Mary Ortmayer, Karl Fisher, Jaswir Basran, Emmanuel M. Wolde-Michael, Derren J. Heyes, Colin Levy, Sarah L. Lovelock, J. L. Ross Anderson, Emma L. Raven, Sam Hay, Stephen E. J. Rigby, Anthony P. Green
Publicado en: ACS Catalysis, Edición 10/4, 2020, Página(s) 2735-2746, ISSN 2155-5435
Editor: American Chemical Society
DOI: 10.1021/acscatal.9b05129

Engineering enzyme activity using an expanded amino acid alphabet

Autores: Zachary Birch-Price, Christopher J Taylor, Mary Ortmayer, Anthony P Green
Publicado en: Protein Engineering, Design and Selection, Edición 36, 2023, ISSN 1741-0126
Editor: Oxford University Press
DOI: 10.1093/protein/gzac013

Engineered Metalloenzymes with Non‐Canonical Coordination Environments

Autores: Takahiro Hayashi, Donald Hilvert, Anthony P. Green
Publicado en: Chemistry – A European Journal, Edición 24/46, 2018, Página(s) 11821-11830, ISSN 0947-6539
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/chem.201800975

Design and evolution of an enzyme with a non-canonical organocatalytic mechanism

Autores: Ashleigh J. Burke, Sarah L. Lovelock, Amina Frese, Rebecca Crawshaw, Mary Ortmayer, Mark Dunstan, Colin Levy, Anthony P. Green
Publicado en: Nature, Edición 570/7760, 2019, Página(s) 219-223, ISSN 0028-0836
Editor: Nature Publishing Group
DOI: 10.1038/s41586-019-1262-8

A Noncanonical Proximal Heme Ligand Affords an Efficient Peroxidase in a Globin Fold

Autores: Moritz Pott, Takahiro Hayashi, Takahiro Mori, Peer R. E. Mittl, Anthony P. Green, Donald Hilvert
Publicado en: Journal of the American Chemical Society, Edición 140/4, 2018, Página(s) 1535-1543, ISSN 0002-7863
Editor: American Chemical Society
DOI: 10.1021/jacs.7b12621

Chemo-Enzymatic Synthesis of Pyrazines and Pyrroles

Autores: Jin Xu, Anthony P. Green, Nicholas J. Turner
Publicado en: Angewandte Chemie International Edition, Edición 57/51, 2018, Página(s) 16760-16763, ISSN 1433-7851
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/anie.201810555

A designed photoenzyme for enantioselective [2+2] cycloadditions

Autores: Jonathan S. Trimble, Rebecca Crawshaw, Florence J. Hardy, Colin W. Levy, Murray J. B. Brown, Douglas E. Fuerst, Derren J. Heyes, Richard Obexer, Anthony P. Green
Publicado en: Nature, Edición 611, 2022, Página(s) 709-714, ISSN 0028-0836
Editor: Nature Publishing Group
DOI: 10.1038/s41586-022-05335-3

Design of Heme Enzymes with a Tunable Substrate Binding Pocket Adjacent to an Open Metal Coordination Site

Autores: Indrek Kalvet, Mary Ortmayer, Jingming Zhao, Rebecca Crawshaw, Nathan M. Ennist, Colin Levy, Anindya Roy, Anthony P. Green, David Baker
Publicado en: Journal of the American Chemical Society, Edición 145, 2023, Página(s) 14307-14315, ISSN 0002-7863
Editor: American Chemical Society
DOI: 10.1021/jacs.3c02742

Engineering mutually orthogonal <scp>PylRS</scp>/<scp>tRNA</scp> pairs for dual encoding of functional histidine analogues

Autores: Christopher J. Taylor, Florence J. Hardy, Ashleigh J. Burke, Riley M. Bednar, Ryan A. Mehl, Anthony P. Green, Sarah L. Lovelock
Publicado en: Protein Science, Edición 32, 2023, ISSN 0961-8368
Editor: Cold Spring Harbor Laboratory Press
DOI: 10.1002/pro.4640

Biocatalysis

Autores: Elizabeth L. Bell, William Finnigan, Scott P. France, Anthony P. Green, Martin A. Hayes, Lorna J. Hepworth, Sarah L. Lovelock, Haruka Niikura, Sílvia Osuna, Elvira Romero, Katherine S. Ryan, Nicholas J. Turner, Sabine L. Flitsch
Publicado en: Nature Reviews Methods Primers, Edición 1, 2024, ISSN 2662-8449
Editor: Nature Publishing Group
DOI: 10.1038/s43586-021-00044-z

A non-canonical nucleophile unlocks a new mechanistic pathway in a designed enzyme

Autores: Amy E. Hutton, Jake Foster, Rebecca Crawshaw, Florence J. Hardy, Linus O. Johannissen, Thomas M. Lister, Emilie F. Gérard, Zachary Birch-Price, Richard Obexer, Sam Hay, Anthony P. Green
Publicado en: Nature Communications, Edición 15, 2024, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-024-46123-z

Probing Ferryl Reactivity in a Nonheme Iron Oxygenase Using an Expanded Genetic Code

Autores: Florence J. Hardy, Matthew G. Quesne, Emilie F. Gérard, Jingming Zhao, Mary Ortmayer, Christopher J. Taylor, Hafiz S. Ali, Jeffrey W. Slater, Colin W. Levy, Derren J. Heyes, J. Martin Bollinger, Sam P. de Visser, Anthony P. Green
Publicado en: ACS Catalysis, Edición 14, 2024, Página(s) 11584-11590, ISSN 2155-5435
Editor: American Chemical Society
DOI: 10.1021/acscatal.4c02365

An Engineered Cytidine Deaminase for Biocatalytic Production of a Key Intermediate of the Covid-19 Antiviral Molnupiravir

Autores: Ashleigh J. Burke; William R. Birmingham; Ying Zhuo; Thomas W. Thorpe; Bruna Zucoloto da Costa; Rebecca Crawshaw; Ian Rowles; James D. Finnigan; Carl Young; Gregory M. Holgate; Mark P. Muldowney; Simon J. Charnock; Sarah L. Lovelock; Nicholas J. Turner; Anthony P. Green
Publicado en: Crossref, Edición 26913704, 2022, ISSN 2691-3704
Editor: American Chemical Society
DOI: 10.1021/jacs.1c11048

Directed evolution of an efficient and thermostable PET depolymerase

Autores: Elizabeth L. Bell, Ross Smithson, Siobhan Kilbride, Jake Foster, Florence J. Hardy, Saranarayanan Ramachandran, Aleksander A. Tedstone, Sarah J. Haigh, Arthur A. Garforth, Philip J. R. Day, Colin Levy, Michael P. Shaver, Anthony P. Green
Publicado en: Nature Catalysis, Edición 5, 2022, Página(s) 673-681, ISSN 2520-1158
Editor: Nature Publishing
DOI: 10.1038/s41929-022-00821-3

A Designed Photoenzyme Promotes Enantioselective [2+2]-Cycloadditions via Triplet Energy Transfer

Autores: Anthony Green; Jonathan Trimble; Rebecca Crawshaw; Florence Hardy; Colin Levy; Murray Brown; Douglas Fuerst; Derren Heyes; Richard Obexer
Publicado en: Crossref, Edición 25732293, 2022, ISSN 2573-2293
Editor: Cambridge University Press
DOI: 10.21203/rs.3.rs-1650767/v1

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