Creating Versatile Metallo-Enzyme Environments for Selective C-H Activation Chemistry: Lignocellulose Deconstruction and Beyond

Project Information

enzC-Hem

Grant agreement ID: 757991

DOI 10.3030/757991

Project closed

EC signature date 13 November 2017

Start date 1 January 2018

End date 31 December 2023

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 1 492 424,00

EU contribution € 1 492 424,00

Coordinated by

THE UNIVERSITY OF MANCHESTER
United Kingdom

Publications

Peer reviewed articles (9)

Insights into the H2O2-driven catalytic mechanism of fungal lytic polysaccharide monooxygenases

Author(s): Tobias M. Hedison; Erik Breslmayr; Erik Breslmayr; Muralidharan Shanmugam; Kwankao Karnpakdee; Derren J. Heyes; Anthony P. Green; Roland Ludwig; Nigel S. Scrutton; Daniel Kracher; Daniel Kracher
Published in: Hedison , T M , Breslmayr , E , Shanmugam , M , Karnpakdee , K , Heyes , D J , Green , A P , Ludwig , R , Scrutton , N S & Kracher , D 2020 , ' Insights into the H2O2 ‐driven catalytic mechanism of fungal lytic polysaccharide monooxygenases ' , The FEBS Journal . https://doi.org/10.1111/febs.15704, Issue 17424658, 2021, ISSN 1742-4658
Publisher: Wiley
DOI: 10.1111/febs.15704

Enzymes with noncanonical amino acids

Author(s): Jingming Zhao, Ashleigh J. Burke, Anthony P. Green
Published in: Current Opinion in Chemical Biology, Issue 55, 2020, Page(s) 136-144, ISSN 1367-5931
Publisher: Elsevier BV
DOI: 10.1016/j.cbpa.2020.01.006

A Noncanonical Tryptophan Analogue Reveals an Active Site Hydrogen Bond Controlling Ferryl Reactivity in a Heme Peroxidase.

Author(s): Mary Ortmayer; Florence J. Hardy; Matthew G. Quesne; Matthew G. Quesne; Karl Fisher; Colin Levy; Derren J. Heyes; C. Richard A. Catlow; C. Richard A. Catlow; C. Richard A. Catlow; Sam P. de Visser; Stephen E. J. Rigby; Sam Hay; Anthony P. Green
Published in: 2691-3704, Issue 26913704, 2021, ISSN 2691-3704
Publisher: American Chemical Society
DOI: 10.1021/jacsau.1c00145

Rewiring the “Push-Pull” Catalytic Machinery of a Heme Enzyme Using an Expanded Genetic Code

Author(s): Mary Ortmayer, Karl Fisher, Jaswir Basran, Emmanuel M. Wolde-Michael, Derren J. Heyes, Colin Levy, Sarah L. Lovelock, J. L. Ross Anderson, Emma L. Raven, Sam Hay, Stephen E. J. Rigby, Anthony P. Green
Published in: ACS Catalysis, Issue 10/4, 2020, Page(s) 2735-2746, ISSN 2155-5435
Publisher: American Chemical Society
DOI: 10.1021/acscatal.9b05129

Engineered Metalloenzymes with Non‐Canonical Coordination Environments

Author(s): Takahiro Hayashi, Donald Hilvert, Anthony P. Green
Published in: Chemistry – A European Journal, Issue 24/46, 2018, Page(s) 11821-11830, ISSN 0947-6539
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/chem.201800975

Design and evolution of an enzyme with a non-canonical organocatalytic mechanism

Author(s): Ashleigh J. Burke, Sarah L. Lovelock, Amina Frese, Rebecca Crawshaw, Mary Ortmayer, Mark Dunstan, Colin Levy, Anthony P. Green
Published in: Nature, Issue 570/7760, 2019, Page(s) 219-223, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-019-1262-8

A Noncanonical Proximal Heme Ligand Affords an Efficient Peroxidase in a Globin Fold

Author(s): Moritz Pott, Takahiro Hayashi, Takahiro Mori, Peer R. E. Mittl, Anthony P. Green, Donald Hilvert
Published in: Journal of the American Chemical Society, Issue 140/4, 2018, Page(s) 1535-1543, ISSN 0002-7863
Publisher: American Chemical Society
DOI: 10.1021/jacs.7b12621

Chemo-Enzymatic Synthesis of Pyrazines and Pyrroles

Author(s): Jin Xu, Anthony P. Green, Nicholas J. Turner
Published in: Angewandte Chemie International Edition, Issue 57/51, 2018, Page(s) 16760-16763, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/anie.201810555

An Engineered Cytidine Deaminase for Biocatalytic Production of a Key Intermediate of the Covid-19 Antiviral Molnupiravir

Author(s): Ashleigh J. Burke; William R. Birmingham; Ying Zhuo; Thomas W. Thorpe; Bruna Zucoloto da Costa; Rebecca Crawshaw; Ian Rowles; James D. Finnigan; Carl Young; Gregory M. Holgate; Mark P. Muldowney; Simon J. Charnock; Sarah L. Lovelock; Nicholas J. Turner; Anthony P. Green
Published in: Crossref, Issue 26913704, 2022, ISSN 2691-3704
Publisher: American Chemical Society
DOI: 10.1021/jacs.1c11048

Non-peer reviewed articles (1)

A Designed Photoenzyme Promotes Enantioselective [2+2]-Cycloadditions via Triplet Energy Transfer

Author(s): Anthony Green; Jonathan Trimble; Rebecca Crawshaw; Florence Hardy; Colin Levy; Murray Brown; Douglas Fuerst; Derren Heyes; Richard Obexer
Published in: Crossref, Issue 25732293, 2022, ISSN 2573-2293
Publisher: Cambridge University Press
DOI: 10.21203/rs.3.rs-1650767/v1