Creating Versatile Metallo-Enzyme Environments for Selective C-H Activation Chemistry: Lignocellulose Deconstruction and Beyond

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Odnośniki do rezultatów i publikacji związanych z poszczególnymi projektami 7PR, a także odnośniki do niektórych konkretnych kategorii wyników, takich jak zbiory danych i oprogramowanie, są dynamicznie pobierane z systemu OpenAIRE .

Publikacje

Engineering an efficient and enantioselective enzyme for the Morita–Baylis–Hillman reaction

Autorzy: Rebecca Crawshaw, Amy E. Crossley, Linus Johannissen, Ashleigh J. Burke, Sam Hay, Colin Levy, David Baker, Sarah L. Lovelock, Anthony P. Green
Opublikowane w: Nature Chemistry, Numer 14, 2023, Strona(/y) 313-320, ISSN 1755-4330
Wydawca: Nature Publishing Group
DOI: 10.1038/s41557-021-00833-9

Insights into the H2O2-driven catalytic mechanism of fungal lytic polysaccharide monooxygenases

Autorzy: Tobias M. Hedison; Erik Breslmayr; Erik Breslmayr; Muralidharan Shanmugam; Kwankao Karnpakdee; Derren J. Heyes; Anthony P. Green; Roland Ludwig; Nigel S. Scrutton; Daniel Kracher; Daniel Kracher
Opublikowane w: Hedison , T M , Breslmayr , E , Shanmugam , M , Karnpakdee , K , Heyes , D J , Green , A P , Ludwig , R , Scrutton , N S & Kracher , D 2020 , ' Insights into the H2O2 ‐driven catalytic mechanism of fungal lytic polysaccharide monooxygenases ' , The FEBS Journal . https://doi.org/10.1111/febs.15704, Numer 17424658, 2021, ISSN 1742-4658
Wydawca: Wiley
DOI: 10.1111/febs.15704

The road to fully programmable protein catalysis

Autorzy: Sarah L. Lovelock, Rebecca Crawshaw, Sophie Basler, Colin Levy, David Baker, Donald Hilvert, Anthony P. Green
Opublikowane w: Nature, Numer 606, 2022, Strona(/y) 49-58, ISSN 0028-0836
Wydawca: Nature Publishing Group
DOI: 10.1038/s41586-022-04456-z

An efficient pyrrolysyl-tRNA synthetase for economical production of MeHis-containing enzymes

Autorzy: Amy E. Hutton, Jake Foster, James E. J. Sanders, Christopher J. Taylor, Stefan A. Hoffmann, Yizhi Cai, Sarah L. Lovelock, Anthony P. Green
Opublikowane w: Faraday Discussions, Numer 252, 2024, Strona(/y) 295-305, ISSN 1359-6640
Wydawca: Royal Society of Chemistry
DOI: 10.1039/d4fd00019f

Enzymes with noncanonical amino acids

Autorzy: Jingming Zhao, Ashleigh J. Burke, Anthony P. Green
Opublikowane w: Current Opinion in Chemical Biology, Numer 55, 2020, Strona(/y) 136-144, ISSN 1367-5931
Wydawca: Elsevier BV
DOI: 10.1016/j.cbpa.2020.01.006

Strategies for designing biocatalysts with new functions

Autorzy: Elizabeth L. Bell, Amy E. Hutton, Ashleigh J. Burke, Adam O’Connell, Amber Barry, Elaine O’Reilly, Anthony P. Green
Opublikowane w: Chemical Society Reviews, Numer 53, 2024, Strona(/y) 2851-2862, ISSN 0306-0012
Wydawca: Royal Society of Chemistry
DOI: 10.1039/d3cs00972f

Noncanonical Amino Acids in Biocatalysis

Autorzy: Zachary Birch-Price, Florence J. Hardy, Thomas M. Lister, Anna R. Kohn, Anthony P. Green
Opublikowane w: Chemical Reviews, Numer 124, 2024, Strona(/y) 8740-8786, ISSN 0009-2665
Wydawca: American Chemical Society
DOI: 10.1021/acs.chemrev.4c00120

A Noncanonical Tryptophan Analogue Reveals an Active Site Hydrogen Bond Controlling Ferryl Reactivity in a Heme Peroxidase.

Autorzy: Mary Ortmayer; Florence J. Hardy; Matthew G. Quesne; Matthew G. Quesne; Karl Fisher; Colin Levy; Derren J. Heyes; C. Richard A. Catlow; C. Richard A. Catlow; C. Richard A. Catlow; Sam P. de Visser; Stephen E. J. Rigby; Sam Hay; Anthony P. Green
Opublikowane w: 2691-3704, Numer 26913704, 2021, ISSN 2691-3704
Wydawca: American Chemical Society
DOI: 10.1021/jacsau.1c00145

Mapping the Initial Stages of a Protective Pathway that Enhances Catalytic Turnover by a Lytic Polysaccharide Monooxygenase

Autorzy: Jingming Zhao, Ying Zhuo, Daniel E. Diaz, Muralidharan Shanmugam, Abbey J. Telfer, Peter J. Lindley, Daniel Kracher, Takahiro Hayashi, Lisa S. Seibt, Florence J. Hardy, Oliver Manners, Tobias M. Hedison, Katherine A. Hollywood, Reynard Spiess, Kathleen M. Cain, Sofia Diaz-Moreno, Nigel S. Scrutton, Morten Tovborg, Paul H. Walton, Derren J. Heyes, Anthony P. Green
Opublikowane w: Journal of the American Chemical Society, Numer 145, 2023, Strona(/y) 20672-20682, ISSN 0002-7863
Wydawca: American Chemical Society
DOI: 10.1021/jacs.3c06607

Rewiring the “Push-Pull” Catalytic Machinery of a Heme Enzyme Using an Expanded Genetic Code

Autorzy: Mary Ortmayer, Karl Fisher, Jaswir Basran, Emmanuel M. Wolde-Michael, Derren J. Heyes, Colin Levy, Sarah L. Lovelock, J. L. Ross Anderson, Emma L. Raven, Sam Hay, Stephen E. J. Rigby, Anthony P. Green
Opublikowane w: ACS Catalysis, Numer 10/4, 2020, Strona(/y) 2735-2746, ISSN 2155-5435
Wydawca: American Chemical Society
DOI: 10.1021/acscatal.9b05129

Engineering enzyme activity using an expanded amino acid alphabet

Autorzy: Zachary Birch-Price, Christopher J Taylor, Mary Ortmayer, Anthony P Green
Opublikowane w: Protein Engineering, Design and Selection, Numer 36, 2023, ISSN 1741-0126
Wydawca: Oxford University Press
DOI: 10.1093/protein/gzac013

Engineered Metalloenzymes with Non‐Canonical Coordination Environments

Autorzy: Takahiro Hayashi, Donald Hilvert, Anthony P. Green
Opublikowane w: Chemistry – A European Journal, Numer 24/46, 2018, Strona(/y) 11821-11830, ISSN 0947-6539
Wydawca: John Wiley & Sons Ltd.
DOI: 10.1002/chem.201800975

Design and evolution of an enzyme with a non-canonical organocatalytic mechanism

Autorzy: Ashleigh J. Burke, Sarah L. Lovelock, Amina Frese, Rebecca Crawshaw, Mary Ortmayer, Mark Dunstan, Colin Levy, Anthony P. Green
Opublikowane w: Nature, Numer 570/7760, 2019, Strona(/y) 219-223, ISSN 0028-0836
Wydawca: Nature Publishing Group
DOI: 10.1038/s41586-019-1262-8

A Noncanonical Proximal Heme Ligand Affords an Efficient Peroxidase in a Globin Fold

Autorzy: Moritz Pott, Takahiro Hayashi, Takahiro Mori, Peer R. E. Mittl, Anthony P. Green, Donald Hilvert
Opublikowane w: Journal of the American Chemical Society, Numer 140/4, 2018, Strona(/y) 1535-1543, ISSN 0002-7863
Wydawca: American Chemical Society
DOI: 10.1021/jacs.7b12621

Chemo-Enzymatic Synthesis of Pyrazines and Pyrroles

Autorzy: Jin Xu, Anthony P. Green, Nicholas J. Turner
Opublikowane w: Angewandte Chemie International Edition, Numer 57/51, 2018, Strona(/y) 16760-16763, ISSN 1433-7851
Wydawca: John Wiley & Sons Ltd.
DOI: 10.1002/anie.201810555

A designed photoenzyme for enantioselective [2+2] cycloadditions

Autorzy: Jonathan S. Trimble, Rebecca Crawshaw, Florence J. Hardy, Colin W. Levy, Murray J. B. Brown, Douglas E. Fuerst, Derren J. Heyes, Richard Obexer, Anthony P. Green
Opublikowane w: Nature, Numer 611, 2022, Strona(/y) 709-714, ISSN 0028-0836
Wydawca: Nature Publishing Group
DOI: 10.1038/s41586-022-05335-3

Design of Heme Enzymes with a Tunable Substrate Binding Pocket Adjacent to an Open Metal Coordination Site

Autorzy: Indrek Kalvet, Mary Ortmayer, Jingming Zhao, Rebecca Crawshaw, Nathan M. Ennist, Colin Levy, Anindya Roy, Anthony P. Green, David Baker
Opublikowane w: Journal of the American Chemical Society, Numer 145, 2023, Strona(/y) 14307-14315, ISSN 0002-7863
Wydawca: American Chemical Society
DOI: 10.1021/jacs.3c02742

Engineering mutually orthogonal <scp>PylRS</scp>/<scp>tRNA</scp> pairs for dual encoding of functional histidine analogues

Autorzy: Christopher J. Taylor, Florence J. Hardy, Ashleigh J. Burke, Riley M. Bednar, Ryan A. Mehl, Anthony P. Green, Sarah L. Lovelock
Opublikowane w: Protein Science, Numer 32, 2023, ISSN 0961-8368
Wydawca: Cold Spring Harbor Laboratory Press
DOI: 10.1002/pro.4640

Biocatalysis

Autorzy: Elizabeth L. Bell, William Finnigan, Scott P. France, Anthony P. Green, Martin A. Hayes, Lorna J. Hepworth, Sarah L. Lovelock, Haruka Niikura, Sílvia Osuna, Elvira Romero, Katherine S. Ryan, Nicholas J. Turner, Sabine L. Flitsch
Opublikowane w: Nature Reviews Methods Primers, Numer 1, 2024, ISSN 2662-8449
Wydawca: Nature Publishing Group
DOI: 10.1038/s43586-021-00044-z

A non-canonical nucleophile unlocks a new mechanistic pathway in a designed enzyme

Autorzy: Amy E. Hutton, Jake Foster, Rebecca Crawshaw, Florence J. Hardy, Linus O. Johannissen, Thomas M. Lister, Emilie F. Gérard, Zachary Birch-Price, Richard Obexer, Sam Hay, Anthony P. Green
Opublikowane w: Nature Communications, Numer 15, 2024, ISSN 2041-1723
Wydawca: Nature Publishing Group
DOI: 10.1038/s41467-024-46123-z

Probing Ferryl Reactivity in a Nonheme Iron Oxygenase Using an Expanded Genetic Code

Autorzy: Florence J. Hardy, Matthew G. Quesne, Emilie F. Gérard, Jingming Zhao, Mary Ortmayer, Christopher J. Taylor, Hafiz S. Ali, Jeffrey W. Slater, Colin W. Levy, Derren J. Heyes, J. Martin Bollinger, Sam P. de Visser, Anthony P. Green
Opublikowane w: ACS Catalysis, Numer 14, 2024, Strona(/y) 11584-11590, ISSN 2155-5435
Wydawca: American Chemical Society
DOI: 10.1021/acscatal.4c02365

An Engineered Cytidine Deaminase for Biocatalytic Production of a Key Intermediate of the Covid-19 Antiviral Molnupiravir

Autorzy: Ashleigh J. Burke; William R. Birmingham; Ying Zhuo; Thomas W. Thorpe; Bruna Zucoloto da Costa; Rebecca Crawshaw; Ian Rowles; James D. Finnigan; Carl Young; Gregory M. Holgate; Mark P. Muldowney; Simon J. Charnock; Sarah L. Lovelock; Nicholas J. Turner; Anthony P. Green
Opublikowane w: Crossref, Numer 26913704, 2022, ISSN 2691-3704
Wydawca: American Chemical Society
DOI: 10.1021/jacs.1c11048

Directed evolution of an efficient and thermostable PET depolymerase

Autorzy: Elizabeth L. Bell, Ross Smithson, Siobhan Kilbride, Jake Foster, Florence J. Hardy, Saranarayanan Ramachandran, Aleksander A. Tedstone, Sarah J. Haigh, Arthur A. Garforth, Philip J. R. Day, Colin Levy, Michael P. Shaver, Anthony P. Green
Opublikowane w: Nature Catalysis, Numer 5, 2022, Strona(/y) 673-681, ISSN 2520-1158
Wydawca: Nature Publishing
DOI: 10.1038/s41929-022-00821-3

A Designed Photoenzyme Promotes Enantioselective [2+2]-Cycloadditions via Triplet Energy Transfer

Autorzy: Anthony Green; Jonathan Trimble; Rebecca Crawshaw; Florence Hardy; Colin Levy; Murray Brown; Douglas Fuerst; Derren Heyes; Richard Obexer
Opublikowane w: Crossref, Numer 25732293, 2022, ISSN 2573-2293
Wydawca: Cambridge University Press
DOI: 10.21203/rs.3.rs-1650767/v1

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