Chronic Systemic Inflammation: Functional organ cross-talk in inflammatory disease and cancer

Dual therapeutic targeting of MYC and JUNB transcriptional programs for enhanced anti-myeloma activity

Autori: Judith Lind, Osman Aksoy, Michaela Prchal-Murphy, Fengjuan Fan, Mariateresa Fulciniti, Dagmar Stoiber, Latifa Bakiri, Erwin F. Wagner, Elisabeth Zwickl-Traxler, Martin Sattler, Karoline Kollmann, Sonia Vallet, Klaus Podar
Pubblicato in: Blood Cancer Journal, Numero 14, 2024, Pagina/e 138, ISSN 2044-5385
Editore: Nature Publishing Group
DOI: 10.1038/s41408-024-01117-4

Early Neutrophilia Marked by Aerobic Glycolysis Sustains Host Metabolism and Delays Cancer Cachexia

Autori: Michele Petruzzelli, Miriam Ferrer, Martijn J. Schuijs, Sam O. Kleeman, Nicholas Mourikis, Zoe Hall, David Perera, Shwethaa Raghunathan, Michele Vacca, Edoardo Gaude, Michael J. Lukey, Duncan I. Jodrell, Christian Frezza, Erwin F. Wagner, Ashok R. Venkitaraman, Timotheus Y. F. Halim,Tobias Janowitz
Pubblicato in: Cancers (Basel), Numero Feb 15;14(4), 2022, Pagina/e 963, ISSN 2072-6694
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers14040963

Sequestosome 1/p62 enhances chronic skin inflammation

Autori: Supawadee Sukseree, Latifa Bakiri, Marta Palomo-Irigoyen, Özge Uluçkan, Peter Petzelbauer, Erwin F. Wagner
Pubblicato in: Journal of Allergy and Clinical Immunology, Numero 147/6, 2021, Pagina/e 2386-2393.e4, ISSN 0091-6749
Editore: Mosby Inc.
DOI: 10.1016/j.jaci.2021.02.028

Topical application of an amygdalin analogue reduces inflammation and keratinocyte proliferation in a psoriasis mouse model

Autori: Nuria Gago‐López, Carmen Lagunas Arnal, Juan J. Perez, Erwin F. Wagner
Pubblicato in: Experimental Dermatology, 2021, ISSN 0906-6705
Editore: Blackwell Publishing Inc.
DOI: 10.1111/exd.14390

The AP-1 transcription factors c-Jun and JunB are essential for CD8α conventional dendritic cell identity

Autori: Philipp Novoszel, Barbara Drobits, Martin Holcmann, Cristiano De Sa Fernandes, Roland Tschismarov, Sophia Derdak, Thomas Decker, Erwin F. Wagner, Maria Sibilia
Pubblicato in: Cell Death & Differentiation, 2021, ISSN 1350-9047
Editore: Nature Publishing Group
DOI: 10.1038/s41418-021-00765-4

TPL-2 Inhibits IFN-β Expression via an ERK1/2-TCF-FOS Axis in TLR4-Stimulated Macrophages

Autori: Louise Blair, Michael J. Pattison, Probir Chakravarty, Stamatia Papoutsopoulou, Latifa Bakiri, Erwin F. Wagner, Stephen Smale, Steven C. Ley
Pubblicato in: J Immunol, Numero Feb 15; 208 (4), 2022, Pagina/e 941–954, ISSN 0022-1767
Editore: American Association of Immunologists
DOI: 10.4049/jimmunol.2100213

Wnt signaling and Loxl2 promote aggressive osteosarcoma

Autori: Kazuhiko Matsuoka, Latifa Bakiri, Lena I. Wolff, Markus Linder, Amanda Mikels-Vigdal, Ana Patiño-García, Fernando Lecanda, Christine Hartmann, Maria Sibilia, Erwin F. Wagner
Pubblicato in: Cell Research, Numero 30/10, 2020, Pagina/e 885-901, ISSN 1001-0602
Editore: Kexue Chubaneshe/Science Press
DOI: 10.1038/s41422-020-0370-1

Psoriatic skin inflammation is promoted by c‐Jun/AP‐1‐dependent CCL2 and IL‐23 expression in dendritic cells

Autori: Philipp Novoszel, Martin Holcmann, Gabriel Stulnig, Cristiano De Sa Fernandes, Victoria Zyulina, Izabela Borek, Markus Linder, Alexandra Bogusch, Barbara Drobits, Thomas Bauer, Carmen Tam‐Amersdorfer, Patrick M Brunner, Georg Stary, Latifa Bakiri, Erwin F Wagner, Herbert Strobl, Maria Sibilia
Pubblicato in: EMBO Molecular Medicine, Numero 13/4, 2021, ISSN 1757-4676
Editore: John Wiley & Sons Ltd.
DOI: 10.15252/emmm.202012409

Keratinocyte-derived S100A9 modulates neutrophil infiltration and affects psoriasis-like skin and joint disease

Autori: Liliana F Mellor; Nuria Gago-Lopez; Latifa Bakiri; Felix N Schmidt; Björn Busse; Simon Rauber; Maria Jimenez; Diego Megías; Sergio Oterino-Sogo; Ricardo Sanchez-Prieto; Sergei Grivennikov; Xinzhu Pu; Julia Oxford; Andreas Ramming; Georg Schett; Erwin F Wagner
Pubblicato in: Ann Rheum Dis, Numero 00034967, 2022, Pagina/e 1400-1408, ISSN 0003-4967
Editore: BMJ Publishing Group
DOI: 10.1136/annrheumdis-2022-222229

c-Jun and Fra-2 pair up to Myc-anistically drive HCC

Autori: Latifa Bakiri, Erwin F. Wagner
Pubblicato in: Cell Cycle, Numero Nov 24, Online ahead of print, 2024, Pagina/e 1–9, ISSN 1538-4101
Editore: Landes Bioscience
DOI: 10.1080/15384101.2024.2429968

Role of bulge epidermal stem cells and TSLP signaling in psoriasis

Autori: Nuria Gago‐Lopez, Liliana F Mellor, Diego Megías, Guillermo Martín‐Serrano, Ander Izeta, Francisco Jimenez, Erwin F Wagner
Pubblicato in: EMBO Molecular Medicine, Numero 11/11, 2019, ISSN 1757-4676
Editore: John Wiley & Sons Ltd.
DOI: 10.15252/emmm.201910697

EGFR controls bone development by negatively regulating mTOR-signaling during osteoblast differentiation

Autori: Markus Linder, Manfred Hecking, Elisabeth Glitzner, Karin Zwerina, Martin Holcmann, Latifa Bakiri, Maria Grazia Ruocco, Jan Tuckermann, Georg Schett, Erwin F. Wagner, Maria Sibilia
Pubblicato in: Cell Death & Differentiation, Numero 25/6, 2018, Pagina/e 1094-1106, ISSN 1350-9047
Editore: Nature Publishing Group
DOI: 10.1038/s41418-017-0054-7

Cutaneous Immune Cell-Microbiota Interactions Are Controlled by Epidermal JunB/AP-1

Autori: Özge Uluçkan, Maria Jiménez, Ben Roediger, Jakob Schnabl, Lucía T. Díez-Córdova, Kevin Troulé, Wolfgang Weninger, Erwin F. Wagner
Pubblicato in: Cell Reports, Numero 29/4, 2019, Pagina/e 844-859.e3, ISSN 2211-1247
Editore: Cell Press
DOI: 10.1016/j.celrep.2019.09.042

Fra-2 Expression in Osteoblasts Regulates Systemic Inflammation and Lung Injury through Osteopontin

Autori: Yubin Luo, Bettina Grötsch, Nicole Hannemann, Maria Jimenez, Natacha Ipseiz, Ozge Uluckan, Nengyu Lin, Georg Schett, Erwin F. Wagner, Aline Bozec
Pubblicato in: Molecular and Cellular Biology, Numero 38/22, 2018, ISSN 0270-7306
Editore: American Society for Microbiology
DOI: 10.1128/mcb.00022-18

Fra-2–expressing macrophages promote lung fibrosis

Autori: Alvaro C. Ucero, Latifa Bakiri, Ben Roediger, Masakatsu Suzuki, Maria Jimenez, Pratyusha Mandal, Paola Braghetta, Paolo Bonaldo, Luis Paz-Ares, Coral Fustero-Torre, Pilar Ximenez-Embun, Ana Isabel Hernandez, Diego Megias, Erwin F. Wagner
Pubblicato in: Journal of Clinical Investigation, Numero 129/8, 2019, Pagina/e 3293-3309, ISSN 0021-9738
Editore: American Society for Clinical Investigation
DOI: 10.1172/jci125366

EGFR is required for FOS‐dependent bone tumor development via RSK2/CREB signaling

Autori: Markus Linder, Elisabeth Glitzner, Sriram Srivatsa, Latifa Bakiri, Kazuhiko Matsuoka, Parastoo Shahrouzi, Monika Dumanic, Philipp Novoszel, Thomas Mohr, Oliver Langer, Thomas Wanek, Markus Mitterhauser, Erwin F Wagner, Maria Sibilia
Pubblicato in: EMBO Molecular Medicine, Numero 10/11, 2018, ISSN 1757-4676
Editore: John Wiley & Sons Ltd.
DOI: 10.15252/emmm.201809408

JunB is a key regulator of multiple myeloma bone marrow angiogenesis

Autori: Fengjuan Fan, Stefano Malvestiti, Sonia Vallet, Judith Lind, Jose Manuel Garcia-Manteiga, Eugenio Morelli, Qinyue Jiang, Anja Seckinger, Dirk Hose, Hartmut Goldschmidt, Andreas Stadlbauer, Chunyan Sun, Heng Mei, Martin Pecherstorfer, Latifa Bakiri, Erwin F. Wagner, Giovanni Tonon, Martin Sattler, Yu Hu, Pierfrancesco Tassone, Dirk Jaeger, Klaus Podar
Pubblicato in: Leukemia, 2021, ISSN 0887-6924
Editore: Nature Publishing Group
DOI: 10.1038/s41375-021-01271-9

Targeting AP-1 transcription factors by CRISPR in the prostate

Autori: Maria Riedel, Huiqiang Cai, Iben C Stoltze, Mikkel H Vendelbo, Erwin F Wagner, Latifa Bakiri, Martin K Thomsen
Pubblicato in: Oncotarget, Numero Sep 14;12(19), 2021, Pagina/e 1956-1961, ISSN 1949-2553
Editore: Impact Journals
DOI: 10.18632/oncotarget.27997

In vivo CRISPR inactivation of Fos promotes prostate cancer progression by altering the associated AP-1 subunit Jun

Autori: Maria Riedel, Martin F. Berthelsen, Huiqiang Cai, Jakob Haldrup, Michael Borre, Søren R. Paludan, Henrik Hager, Mikkel H. Vendelbo, Erwin F. Wagner, Latifa Bakiri, Martin K. Thomsen
Pubblicato in: Oncogene, Numero 40/13, 2021, Pagina/e 2437-2447, ISSN 0950-9232
Editore: Nature Publishing Group
DOI: 10.1038/s41388-021-01724-6

Interleukin-6 initiates muscle- and adipose tissue wasting in a novel C57BL/6 model of cancer-associated cachexia

Autori: Isabella Pototschnig, Ursula Feiler, Clemens Diwoky, Paul W. Vesely, Thomas Rauchenwald, Margret Paar, Latifa Bakiri, Laura Pajed, Peter Hofer, Karl Kashofer, Nyamdelger Sukhbaatar, Gabriele Schoiswohl, Thomas Weichhart, Gerald Hoefler, Christoph Bock, Martin Pichler, Erwin F. Wagner, Rudolf Zechner, Martina Schweiger
Pubblicato in: Journal of Cachexia, Sarcopenia and Muscle, Numero Nov 9, online ahead of print, 2022, ISSN 2190-5991
Editore: Springer Verlag
DOI: 10.1002/jcsm.13109

Liver cancer development driven by the AP-1/c-Jun~Fra-2 dimer through c-Myc.

Autori: Latifa Bakiri, Sebastian C Hasenfuss, Ana Guío-Carrión, Martin K Thomsen, Peter Hasselblatt, Erwin F Wagner.
Pubblicato in: Proc Natl Acad Sci U S A, Numero Apr 30;121(18) - Epub, 2024, Pagina/e e2404188121 (Epub), ISSN 0027-8424
Editore: National Academy of Sciences
DOI: 10.1073/pnas.2404188121

Metabolic rewiring controlled by c-Fos governs cartilage integrity in osteoarthritis

Autori: Kazuhiko Matsuoka, Latifa Bakiri, Martin Bilban, Stefan Toegel, Arvand Haschemi, Hao Yuan, Maria Kasper, Reinhard Windhager, Erwin F Wagner
Pubblicato in: Ann Rheum Dis, Numero Jun 21, 2023, Pagina/e ard-2023-224002, ISSN 0003-4967
Editore: BMJ Publishing Group
DOI: 10.1136/ard-2023-224002

An immune-sympathetic neuron communication axis guides adipose tissue browning in cancer-associated cachexia

Autori: Hao Xie, Christoph Heier, Xia Meng, Latifa Bakiri, Isabella Pototschnig, Zhiyuan Tang, Silvia Schauer, Vanessa J. Baumgartner, Gernot F. Grabner, Gernot Schabbauer, Heimo Wolinski, Graham R. Robertson, Gerald Hoefler, Wenwen Zeng, Erwin F. Wagner, Martina Schweiger, Rudolf Zechner
Pubblicato in: Proc Natl Acad Sci U S A, Numero Mar 1; 119(9), 2022, Pagina/e e2112840119, ISSN 0027-8424
Editore: National Academy of Sciences
DOI: 10.1073/pnas.2112840119

The role of S100A8, S100A9 and Calprotectin in skin inflammation

Autori: Marta Palomo Irigoyen, Latifa Bakiri, Erwin F Wagner
Pubblicato in: FEBS Open Bio, Numero 12 (Suppl. S1), 2022, Pagina/e 2–66, ISSN 2211-5463
Editore: John Wiley & Sons on behalf of the Federation of European Biochemical Societies
DOI: 10.1002/2211-5463.13442

Dissecting the progression of cardiac dysfunction in tumor-bearing mice

Autori: Dostal, LP Szabo, C Aioanei, D Abraham, K Zins, Latifa Bakiri, E Wagner, BK Podesser, A Kiss
Pubblicato in: Cardiovascular Research, Numero Vol 118, Supplement 1, 2022, Pagina/e cvac066.247, ISSN 1755-3245
Editore: Oxford Academic
DOI: 10.1093/cvr/cvac066.247

p62, a pro-inflammatory protein in atopic dermatitis has a protective role in a mouse model of psoriasis

Autori: Kamil Mieczkowski, Latifa Bakiri, Erwin F. Wagner
Pubblicato in: Journal of Investigative Dermatology, Numero 143 (11), Supplement, 2023, Pagina/e S355, ISSN 0022-202X
Editore: Elsevier
DOI: 10.1016/j.jid.2023.09.143

Cell-specific immune-modulatory functions of S100A8/A9 in Atopic Dermatitis

Autori: Marta Palomo Irigoyen, Tim Hendrikx, Latifa Bakiri, Silvia Hayer, Johanna Schaffenrath, Philipp Starkl, Silvia Knapp, Erwin F. Wagner
Pubblicato in: Journal of Investigative Dermatology, Numero 143 (11), Supplement, 2023, Pagina/e Page S356, ISSN 0022-202X
Editore: Elsevier
DOI: 10.1016/j.jid.2023.09.147

Dissecting the progression of cardiac dysfunction in tumor-bearing mice

Autori: C Dostal, LP Szabo, C Aioanei, D Abraham, K Zins, Latifa Bakiri, Erwin F Wagner, BK Podesser, Atilla Kiss.
Pubblicato in: The Wiener klinische Wochenschrift, Numero 134 (Suppl 2), 2022, Pagina/e 77–210
Editore: Springer-Verlag Wien
DOI: 10.1007/s00508-022-02035-w

Elucidating the molecular link between psoriasis and skin cancer

Autori: Panagiota Tsokkou, Martin Holcmann, Kamil Mieczkowski, Latifa Bakiri, Maria Sibilia, Erwin F. Wagner.
Pubblicato in: Journal of Investigative Dermatology, Numero 143 (11), Supplement, 2023, Pagina/e S350, ISSN 0022-202X
Editore: Elsevier
DOI: 10.1016/j.jid.2023.09.111

Skin deep and beyond: Function of Calprotectin (S100A8/A9)

Autori: Marta Palomo Irigoyen, Latifa Bakiri, Johanna Schaffenrath, Silvia Hayer, Philip Starkl, Silvia Knapp, Erwin F. Wagner.
Pubblicato in: Journal of Investigative Dermatology, Numero 142 (12), Supplement, 2022, Pagina/e S242, ISSN 0022-202X
Editore: Elsevier
DOI: 10.1016/j.jid.2022.09.372

How does inflammation spread through the body?

Autori: Latifa Bakiri, Erwin F Wagner
Pubblicato in: EU Research, Numero Spring issue, vol. (34), 2023, Pagina/e 17 - 19, ISSN 2752-4736
Editore: Blazon Publishing & Media Limited
DOI: 10.56181/fhju5543

Mechanismus der chronischen Entzündung bei atopischer Dermatitis

Autori: Supawadee Sukseree, Erwin F. Wagner
Pubblicato in: SPECTRUM Dermatologie, Numero SD 04|2021, Nov 18, 2021, ISSN 2223-0661
Editore: MedMedia Verlag und Mediaservice GmbH, Vienna

Open Thy Lattice Osteoclast, Resorb me!

Autori: Latifa Bakiri
Pubblicato in: J Cell Biol, Numero Volume 222, Numero 4,, 2023, Pagina/e e202302033, ISSN 0021-9525
Editore: Rockefeller University Press
DOI: 10.1083/jcb.202302033

Mechanism of chronic inflammation in psoriasis-like skin and joint disease

Autori: Latifa Bakiri, Georg Schett , Erwin F Wagner
Pubblicato in: SPECTRUM Dermatologie, Numero SD 04|2022, Nov 24, 2022, Pagina/e 94-95, ISSN 2223-0661
Editore: MedMedia Verlag und Mediaservice GmbH, Vienna

Novel therapeutic approaches for malignant bone cancer

Autori: Kazuhiko Matsuoka, Latifa Bakiri, Erwin F Wagner
Pubblicato in: SPECTRUM Onkologie, Numero SO 02|2021, April 15, 2021, ISSN 2223-0661
Editore: MedMedia Verlag

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