Chronic Systemic Inflammation: Functional organ cross-talk in inflammatory disease and cancer

Dual therapeutic targeting of MYC and JUNB transcriptional programs for enhanced anti-myeloma activity

Autores: Judith Lind, Osman Aksoy, Michaela Prchal-Murphy, Fengjuan Fan, Mariateresa Fulciniti, Dagmar Stoiber, Latifa Bakiri, Erwin F. Wagner, Elisabeth Zwickl-Traxler, Martin Sattler, Karoline Kollmann, Sonia Vallet, Klaus Podar
Publicado en: Blood Cancer Journal, Edición 14, 2024, Página(s) 138, ISSN 2044-5385
Editor: Nature Publishing Group
DOI: 10.1038/s41408-024-01117-4

Early Neutrophilia Marked by Aerobic Glycolysis Sustains Host Metabolism and Delays Cancer Cachexia

Autores: Michele Petruzzelli, Miriam Ferrer, Martijn J. Schuijs, Sam O. Kleeman, Nicholas Mourikis, Zoe Hall, David Perera, Shwethaa Raghunathan, Michele Vacca, Edoardo Gaude, Michael J. Lukey, Duncan I. Jodrell, Christian Frezza, Erwin F. Wagner, Ashok R. Venkitaraman, Timotheus Y. F. Halim,Tobias Janowitz
Publicado en: Cancers (Basel), Edición Feb 15;14(4), 2022, Página(s) 963, ISSN 2072-6694
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers14040963

Sequestosome 1/p62 enhances chronic skin inflammation

Autores: Supawadee Sukseree, Latifa Bakiri, Marta Palomo-Irigoyen, Özge Uluçkan, Peter Petzelbauer, Erwin F. Wagner
Publicado en: Journal of Allergy and Clinical Immunology, Edición 147/6, 2021, Página(s) 2386-2393.e4, ISSN 0091-6749
Editor: Mosby Inc.
DOI: 10.1016/j.jaci.2021.02.028

Topical application of an amygdalin analogue reduces inflammation and keratinocyte proliferation in a psoriasis mouse model

Autores: Nuria Gago‐López, Carmen Lagunas Arnal, Juan J. Perez, Erwin F. Wagner
Publicado en: Experimental Dermatology, 2021, ISSN 0906-6705
Editor: Blackwell Publishing Inc.
DOI: 10.1111/exd.14390

The AP-1 transcription factors c-Jun and JunB are essential for CD8α conventional dendritic cell identity

Autores: Philipp Novoszel, Barbara Drobits, Martin Holcmann, Cristiano De Sa Fernandes, Roland Tschismarov, Sophia Derdak, Thomas Decker, Erwin F. Wagner, Maria Sibilia
Publicado en: Cell Death & Differentiation, 2021, ISSN 1350-9047
Editor: Nature Publishing Group
DOI: 10.1038/s41418-021-00765-4

TPL-2 Inhibits IFN-β Expression via an ERK1/2-TCF-FOS Axis in TLR4-Stimulated Macrophages

Autores: Louise Blair, Michael J. Pattison, Probir Chakravarty, Stamatia Papoutsopoulou, Latifa Bakiri, Erwin F. Wagner, Stephen Smale, Steven C. Ley
Publicado en: J Immunol, Edición Feb 15; 208 (4), 2022, Página(s) 941–954, ISSN 0022-1767
Editor: American Association of Immunologists
DOI: 10.4049/jimmunol.2100213

Wnt signaling and Loxl2 promote aggressive osteosarcoma

Autores: Kazuhiko Matsuoka, Latifa Bakiri, Lena I. Wolff, Markus Linder, Amanda Mikels-Vigdal, Ana Patiño-García, Fernando Lecanda, Christine Hartmann, Maria Sibilia, Erwin F. Wagner
Publicado en: Cell Research, Edición 30/10, 2020, Página(s) 885-901, ISSN 1001-0602
Editor: Kexue Chubaneshe/Science Press
DOI: 10.1038/s41422-020-0370-1

Psoriatic skin inflammation is promoted by c‐Jun/AP‐1‐dependent CCL2 and IL‐23 expression in dendritic cells

Autores: Philipp Novoszel, Martin Holcmann, Gabriel Stulnig, Cristiano De Sa Fernandes, Victoria Zyulina, Izabela Borek, Markus Linder, Alexandra Bogusch, Barbara Drobits, Thomas Bauer, Carmen Tam‐Amersdorfer, Patrick M Brunner, Georg Stary, Latifa Bakiri, Erwin F Wagner, Herbert Strobl, Maria Sibilia
Publicado en: EMBO Molecular Medicine, Edición 13/4, 2021, ISSN 1757-4676
Editor: John Wiley & Sons Ltd.
DOI: 10.15252/emmm.202012409

Keratinocyte-derived S100A9 modulates neutrophil infiltration and affects psoriasis-like skin and joint disease

Autores: Liliana F Mellor; Nuria Gago-Lopez; Latifa Bakiri; Felix N Schmidt; Björn Busse; Simon Rauber; Maria Jimenez; Diego Megías; Sergio Oterino-Sogo; Ricardo Sanchez-Prieto; Sergei Grivennikov; Xinzhu Pu; Julia Oxford; Andreas Ramming; Georg Schett; Erwin F Wagner
Publicado en: Ann Rheum Dis, Edición 00034967, 2022, Página(s) 1400-1408, ISSN 0003-4967
Editor: BMJ Publishing Group
DOI: 10.1136/annrheumdis-2022-222229

c-Jun and Fra-2 pair up to Myc-anistically drive HCC

Autores: Latifa Bakiri, Erwin F. Wagner
Publicado en: Cell Cycle, Edición Nov 24, Online ahead of print, 2024, Página(s) 1–9, ISSN 1538-4101
Editor: Landes Bioscience
DOI: 10.1080/15384101.2024.2429968

Role of bulge epidermal stem cells and TSLP signaling in psoriasis

Autores: Nuria Gago‐Lopez, Liliana F Mellor, Diego Megías, Guillermo Martín‐Serrano, Ander Izeta, Francisco Jimenez, Erwin F Wagner
Publicado en: EMBO Molecular Medicine, Edición 11/11, 2019, ISSN 1757-4676
Editor: John Wiley & Sons Ltd.
DOI: 10.15252/emmm.201910697

EGFR controls bone development by negatively regulating mTOR-signaling during osteoblast differentiation

Autores: Markus Linder, Manfred Hecking, Elisabeth Glitzner, Karin Zwerina, Martin Holcmann, Latifa Bakiri, Maria Grazia Ruocco, Jan Tuckermann, Georg Schett, Erwin F. Wagner, Maria Sibilia
Publicado en: Cell Death & Differentiation, Edición 25/6, 2018, Página(s) 1094-1106, ISSN 1350-9047
Editor: Nature Publishing Group
DOI: 10.1038/s41418-017-0054-7

Cutaneous Immune Cell-Microbiota Interactions Are Controlled by Epidermal JunB/AP-1

Autores: Özge Uluçkan, Maria Jiménez, Ben Roediger, Jakob Schnabl, Lucía T. Díez-Córdova, Kevin Troulé, Wolfgang Weninger, Erwin F. Wagner
Publicado en: Cell Reports, Edición 29/4, 2019, Página(s) 844-859.e3, ISSN 2211-1247
Editor: Cell Press
DOI: 10.1016/j.celrep.2019.09.042

Fra-2 Expression in Osteoblasts Regulates Systemic Inflammation and Lung Injury through Osteopontin

Autores: Yubin Luo, Bettina Grötsch, Nicole Hannemann, Maria Jimenez, Natacha Ipseiz, Ozge Uluckan, Nengyu Lin, Georg Schett, Erwin F. Wagner, Aline Bozec
Publicado en: Molecular and Cellular Biology, Edición 38/22, 2018, ISSN 0270-7306
Editor: American Society for Microbiology
DOI: 10.1128/mcb.00022-18

Fra-2–expressing macrophages promote lung fibrosis

Autores: Alvaro C. Ucero, Latifa Bakiri, Ben Roediger, Masakatsu Suzuki, Maria Jimenez, Pratyusha Mandal, Paola Braghetta, Paolo Bonaldo, Luis Paz-Ares, Coral Fustero-Torre, Pilar Ximenez-Embun, Ana Isabel Hernandez, Diego Megias, Erwin F. Wagner
Publicado en: Journal of Clinical Investigation, Edición 129/8, 2019, Página(s) 3293-3309, ISSN 0021-9738
Editor: American Society for Clinical Investigation
DOI: 10.1172/jci125366

EGFR is required for FOS‐dependent bone tumor development via RSK2/CREB signaling

Autores: Markus Linder, Elisabeth Glitzner, Sriram Srivatsa, Latifa Bakiri, Kazuhiko Matsuoka, Parastoo Shahrouzi, Monika Dumanic, Philipp Novoszel, Thomas Mohr, Oliver Langer, Thomas Wanek, Markus Mitterhauser, Erwin F Wagner, Maria Sibilia
Publicado en: EMBO Molecular Medicine, Edición 10/11, 2018, ISSN 1757-4676
Editor: John Wiley & Sons Ltd.
DOI: 10.15252/emmm.201809408

JunB is a key regulator of multiple myeloma bone marrow angiogenesis

Autores: Fengjuan Fan, Stefano Malvestiti, Sonia Vallet, Judith Lind, Jose Manuel Garcia-Manteiga, Eugenio Morelli, Qinyue Jiang, Anja Seckinger, Dirk Hose, Hartmut Goldschmidt, Andreas Stadlbauer, Chunyan Sun, Heng Mei, Martin Pecherstorfer, Latifa Bakiri, Erwin F. Wagner, Giovanni Tonon, Martin Sattler, Yu Hu, Pierfrancesco Tassone, Dirk Jaeger, Klaus Podar
Publicado en: Leukemia, 2021, ISSN 0887-6924
Editor: Nature Publishing Group
DOI: 10.1038/s41375-021-01271-9

Targeting AP-1 transcription factors by CRISPR in the prostate

Autores: Maria Riedel, Huiqiang Cai, Iben C Stoltze, Mikkel H Vendelbo, Erwin F Wagner, Latifa Bakiri, Martin K Thomsen
Publicado en: Oncotarget, Edición Sep 14;12(19), 2021, Página(s) 1956-1961, ISSN 1949-2553
Editor: Impact Journals
DOI: 10.18632/oncotarget.27997

In vivo CRISPR inactivation of Fos promotes prostate cancer progression by altering the associated AP-1 subunit Jun

Autores: Maria Riedel, Martin F. Berthelsen, Huiqiang Cai, Jakob Haldrup, Michael Borre, Søren R. Paludan, Henrik Hager, Mikkel H. Vendelbo, Erwin F. Wagner, Latifa Bakiri, Martin K. Thomsen
Publicado en: Oncogene, Edición 40/13, 2021, Página(s) 2437-2447, ISSN 0950-9232
Editor: Nature Publishing Group
DOI: 10.1038/s41388-021-01724-6

Interleukin-6 initiates muscle- and adipose tissue wasting in a novel C57BL/6 model of cancer-associated cachexia

Autores: Isabella Pototschnig, Ursula Feiler, Clemens Diwoky, Paul W. Vesely, Thomas Rauchenwald, Margret Paar, Latifa Bakiri, Laura Pajed, Peter Hofer, Karl Kashofer, Nyamdelger Sukhbaatar, Gabriele Schoiswohl, Thomas Weichhart, Gerald Hoefler, Christoph Bock, Martin Pichler, Erwin F. Wagner, Rudolf Zechner, Martina Schweiger
Publicado en: Journal of Cachexia, Sarcopenia and Muscle, Edición Nov 9, online ahead of print, 2022, ISSN 2190-5991
Editor: Springer Verlag
DOI: 10.1002/jcsm.13109

Liver cancer development driven by the AP-1/c-Jun~Fra-2 dimer through c-Myc.

Autores: Latifa Bakiri, Sebastian C Hasenfuss, Ana Guío-Carrión, Martin K Thomsen, Peter Hasselblatt, Erwin F Wagner.
Publicado en: Proc Natl Acad Sci U S A, Edición Apr 30;121(18) - Epub, 2024, Página(s) e2404188121 (Epub), ISSN 0027-8424
Editor: National Academy of Sciences
DOI: 10.1073/pnas.2404188121

Metabolic rewiring controlled by c-Fos governs cartilage integrity in osteoarthritis

Autores: Kazuhiko Matsuoka, Latifa Bakiri, Martin Bilban, Stefan Toegel, Arvand Haschemi, Hao Yuan, Maria Kasper, Reinhard Windhager, Erwin F Wagner
Publicado en: Ann Rheum Dis, Edición Jun 21, 2023, Página(s) ard-2023-224002, ISSN 0003-4967
Editor: BMJ Publishing Group
DOI: 10.1136/ard-2023-224002

An immune-sympathetic neuron communication axis guides adipose tissue browning in cancer-associated cachexia

Autores: Hao Xie, Christoph Heier, Xia Meng, Latifa Bakiri, Isabella Pototschnig, Zhiyuan Tang, Silvia Schauer, Vanessa J. Baumgartner, Gernot F. Grabner, Gernot Schabbauer, Heimo Wolinski, Graham R. Robertson, Gerald Hoefler, Wenwen Zeng, Erwin F. Wagner, Martina Schweiger, Rudolf Zechner
Publicado en: Proc Natl Acad Sci U S A, Edición Mar 1; 119(9), 2022, Página(s) e2112840119, ISSN 0027-8424
Editor: National Academy of Sciences
DOI: 10.1073/pnas.2112840119

The role of S100A8, S100A9 and Calprotectin in skin inflammation

Autores: Marta Palomo Irigoyen, Latifa Bakiri, Erwin F Wagner
Publicado en: FEBS Open Bio, Edición 12 (Suppl. S1), 2022, Página(s) 2–66, ISSN 2211-5463
Editor: John Wiley & Sons on behalf of the Federation of European Biochemical Societies
DOI: 10.1002/2211-5463.13442

Dissecting the progression of cardiac dysfunction in tumor-bearing mice

Autores: Dostal, LP Szabo, C Aioanei, D Abraham, K Zins, Latifa Bakiri, E Wagner, BK Podesser, A Kiss
Publicado en: Cardiovascular Research, Edición Vol 118, Supplement 1, 2022, Página(s) cvac066.247, ISSN 1755-3245
Editor: Oxford Academic
DOI: 10.1093/cvr/cvac066.247

p62, a pro-inflammatory protein in atopic dermatitis has a protective role in a mouse model of psoriasis

Autores: Kamil Mieczkowski, Latifa Bakiri, Erwin F. Wagner
Publicado en: Journal of Investigative Dermatology, Edición 143 (11), Supplement, 2023, Página(s) S355, ISSN 0022-202X
Editor: Elsevier
DOI: 10.1016/j.jid.2023.09.143

Cell-specific immune-modulatory functions of S100A8/A9 in Atopic Dermatitis

Autores: Marta Palomo Irigoyen, Tim Hendrikx, Latifa Bakiri, Silvia Hayer, Johanna Schaffenrath, Philipp Starkl, Silvia Knapp, Erwin F. Wagner
Publicado en: Journal of Investigative Dermatology, Edición 143 (11), Supplement, 2023, Página(s) Page S356, ISSN 0022-202X
Editor: Elsevier
DOI: 10.1016/j.jid.2023.09.147

Dissecting the progression of cardiac dysfunction in tumor-bearing mice

Autores: C Dostal, LP Szabo, C Aioanei, D Abraham, K Zins, Latifa Bakiri, Erwin F Wagner, BK Podesser, Atilla Kiss.
Publicado en: The Wiener klinische Wochenschrift, Edición 134 (Suppl 2), 2022, Página(s) 77–210
Editor: Springer-Verlag Wien
DOI: 10.1007/s00508-022-02035-w

Elucidating the molecular link between psoriasis and skin cancer

Autores: Panagiota Tsokkou, Martin Holcmann, Kamil Mieczkowski, Latifa Bakiri, Maria Sibilia, Erwin F. Wagner.
Publicado en: Journal of Investigative Dermatology, Edición 143 (11), Supplement, 2023, Página(s) S350, ISSN 0022-202X
Editor: Elsevier
DOI: 10.1016/j.jid.2023.09.111

Skin deep and beyond: Function of Calprotectin (S100A8/A9)

Autores: Marta Palomo Irigoyen, Latifa Bakiri, Johanna Schaffenrath, Silvia Hayer, Philip Starkl, Silvia Knapp, Erwin F. Wagner.
Publicado en: Journal of Investigative Dermatology, Edición 142 (12), Supplement, 2022, Página(s) S242, ISSN 0022-202X
Editor: Elsevier
DOI: 10.1016/j.jid.2022.09.372

How does inflammation spread through the body?

Autores: Latifa Bakiri, Erwin F Wagner
Publicado en: EU Research, Edición Spring issue, vol. (34), 2023, Página(s) 17 - 19, ISSN 2752-4736
Editor: Blazon Publishing & Media Limited
DOI: 10.56181/fhju5543

Mechanismus der chronischen Entzündung bei atopischer Dermatitis

Autores: Supawadee Sukseree, Erwin F. Wagner
Publicado en: SPECTRUM Dermatologie, Edición SD 04|2021, Nov 18, 2021, ISSN 2223-0661
Editor: MedMedia Verlag und Mediaservice GmbH, Vienna

Open Thy Lattice Osteoclast, Resorb me!

Autores: Latifa Bakiri
Publicado en: J Cell Biol, Edición Volume 222, Edición 4,, 2023, Página(s) e202302033, ISSN 0021-9525
Editor: Rockefeller University Press
DOI: 10.1083/jcb.202302033

Mechanism of chronic inflammation in psoriasis-like skin and joint disease

Autores: Latifa Bakiri, Georg Schett , Erwin F Wagner
Publicado en: SPECTRUM Dermatologie, Edición SD 04|2022, Nov 24, 2022, Página(s) 94-95, ISSN 2223-0661
Editor: MedMedia Verlag und Mediaservice GmbH, Vienna

Novel therapeutic approaches for malignant bone cancer

Autores: Kazuhiko Matsuoka, Latifa Bakiri, Erwin F Wagner
Publicado en: SPECTRUM Onkologie, Edición SO 02|2021, April 15, 2021, ISSN 2223-0661
Editor: MedMedia Verlag

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