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A global alliance for Zika virus control and prevention

Descrizione del progetto

Unire le forze contro il virus Zika a livello globale

Il virus Zika (ZIKV) è un virus trasmesso dalle zanzare che ha destato preoccupazione a livello mondiale in seguito a una grave epidemia avvenuta nel 2015. Uno degli aspetti più preoccupanti dello ZIKV è la sua associazione con alcuni difetti alla nascita, e in particolare testa e cervello di dimensioni inferiori nei bambini nati da madri infettate durante la gravidanza. Lo scopo dell’iniziativa ZIKAlliance, finanziata dall’UE, è comprendere l’impatto dell’infezione trasmessa da ZIKV durante la gravidanza e studiarne la storia naturale negli esseri umani. Il consorzio adotterà un approccio multidisciplinare per studiare coorti nei Caraibi, in America centrale e in quella meridionale, paesi caratterizzati da diversi profili epidemiologici. L’obiettivo a lungo termine è sviluppare la capacità di ricerca e migliorare la preparazione per le future minacce epidemiche.

Obiettivo

"ZIKAlliance is a multidisciplinary project with a global ""One Health"" approach, built: on a multi-centric network of clinical cohorts in the Caribbean, Central & South America; research sites in countries where the virus has been or is currently circulating (Africa, Asia, Polynesia) or at risk for emergence (Reunion Island); a strong network of European and Brazilian clinical & basic research institutions; and multiple interfaces with other scientific and public health programmes. ZIKAlliance will addrees three key objectives relating to (i) impact of Zika virus (ZIKV) infection during pregnancy and short & medium term effects on newborns, (ii) associated natural history of ZIKV infection in humans and their environment in the context of other circulating arboviruses and (iii) building the overall capacity for preparedness research for future epidemic threats in Latin America & the Caribbean. The project will take advantage of large standardised clinical cohorts of pregnant women and febrile patients in regions of Latin America and the Caribbean were the virus is circulating, expanding a preexisting network established by the IDAMS EU project. I will also benefit of a very strong expertise in basic and environmental sciences, with access to both field work and sophisticated technological infrastructures to characterise virus replication and physiopathology mechanisms. To meet its 3 key objectives, the scientific project has been organised in 9 work packages, with WP2/3 dedicated to clinical research (cohorts, clinical biology, epidemiology & modeling), WP3/4 to basic research (virology & antivirals, pathophysiology & animal models), WP5/6 to environmental research (animal reservoirs, vectors & vector control) , WP7/8 to social sciences & communication, and WP9 to management. The broad consortium set-up allow gathering the necessary expertise for an actual interdisciplinary approach, and operating in a range of countries with contrasting ZIKV epidemiological status."

Invito a presentare proposte

H2020-SC1-2016-2017

Vedi altri progetti per questo bando

Bando secondario

H2020-SC1-2016-RTD-Zika

Meccanismo di finanziamento

RIA - Research and Innovation action

Coordinatore

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
Contribution nette de l'UE
€ 2 285 366,30
Indirizzo
RUE DE TOLBIAC 101
75654 Paris
Francia

Mostra sulla mappa

Regione
Ile-de-France Ile-de-France Paris
Tipo di attività
Research Organisations
Collegamenti
Costo totale
€ 2 285 366,30

Partecipanti (56)