Project description
Uniting global forces against the Zika virus
The Zika virus (ZIKV) is a mosquito-borne virus that raised global concern following a major outbreak in 2015. One of the most concerning aspects of ZIKV is its association with birth defects, particularly small head and brain in infants born to mothers infected during pregnancy. The scope of the EU-funded ZIKAlliance initiative is to understand the impact of ZIKV infection during pregnancy and study the natural history of ZIKV infection in humans. The consortium will undertake a multidisciplinary approach to study cohorts in the Caribbean, Central and South America in countries with different epidemiological profiles. The long-term aim is to build research capacity and enhance preparedness for future epidemic threats.
Objective
"ZIKAlliance is a multidisciplinary project with a global ""One Health"" approach, built: on a multi-centric network of clinical cohorts in the Caribbean, Central & South America; research sites in countries where the virus has been or is currently circulating (Africa, Asia, Polynesia) or at risk for emergence (Reunion Island); a strong network of European and Brazilian clinical & basic research institutions; and multiple interfaces with other scientific and public health programmes. ZIKAlliance will addrees three key objectives relating to (i) impact of Zika virus (ZIKV) infection during pregnancy and short & medium term effects on newborns, (ii) associated natural history of ZIKV infection in humans and their environment in the context of other circulating arboviruses and (iii) building the overall capacity for preparedness research for future epidemic threats in Latin America & the Caribbean. The project will take advantage of large standardised clinical cohorts of pregnant women and febrile patients in regions of Latin America and the Caribbean were the virus is circulating, expanding a preexisting network established by the IDAMS EU project. I will also benefit of a very strong expertise in basic and environmental sciences, with access to both field work and sophisticated technological infrastructures to characterise virus replication and physiopathology mechanisms. To meet its 3 key objectives, the scientific project has been organised in 9 work packages, with WP2/3 dedicated to clinical research (cohorts, clinical biology, epidemiology & modeling), WP3/4 to basic research (virology & antivirals, pathophysiology & animal models), WP5/6 to environmental research (animal reservoirs, vectors & vector control) , WP7/8 to social sciences & communication, and WP9 to management. The broad consortium set-up allow gathering the necessary expertise for an actual interdisciplinary approach, and operating in a range of countries with contrasting ZIKV epidemiological status."
Fields of science
- medical and health scienceshealth sciencespublic healthepidemiology
- medical and health sciencesbasic medicinephysiologypathophysiology
- medical and health sciencesbasic medicineimmunology
- medical and health sciencesclinical medicineobstetrics
- medical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsantivirals
Keywords
Programme(s)
Funding Scheme
RIA - Research and Innovation actionCoordinator
75654 Paris
France
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Participants (56)
69120 Heidelberg
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21040 900 Rio De Janeiro
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3015 GD Rotterdam
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2333 ZA Leiden
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3000 Leuven
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Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.
3001 Heverlee
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53127 Bonn
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75724 Paris
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OX1 2JD Oxford
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75015 PARIS
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13572 Marseille
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40110 160 Salvador
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75015 PARIS 15
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75794 Paris
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WC1E 7HT London
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1099 085 Lisboa
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13284 Marseille
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0456 Oslo
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53100 Siena
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62100 Cuernavaca Morelos
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06600 Mexico City
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1066 CX Amsterdam
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9713 GZ Groningen
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Bucaramanga
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Participation ended
80539 Munchen
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4000 Liege
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31270 901 Belo Horizonte Minas Gerais
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98713 Papeete
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3003 Bern
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08007 Barcelona
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30559 Hannover
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69117 Heidelberg
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2340 Beerse
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Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.
92787 Issy Les Moulineaux
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94700 Maisons Alfort
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090510 Guayaquil
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08140 Caldes De Montbui Barcelona
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8006 Zurich
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G12 8QQ Glasgow
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20359 Hamburg
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11300 La Habana
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38098 San Michele All'Adige
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69622 Villeurbanne Cedex
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35043 Rennes Cedex
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74001 970 Goiania
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6708 PB Wageningen
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6500 Bellinzona
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000 Phnom Penh
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DAKAR Dakar
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98845 Noumea
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200025 SHANGHAI
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05401 000 Sao Paulo
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25651-075 Petropolis
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39106 Magdeburg
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10117 Berlin
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31 LIMA
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