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A global alliance for Zika virus control and prevention

Descripción del proyecto

Aunar las iniciativas mundiales contra el virus de Zika

El virus de Zika (VZK) es un virus transmitido por mosquitos que, en 2015, suscitó preocupación mundial tras un gran brote. Uno de los aspectos más alarmantes del VZK es su capacidad para provocar defectos congénitos, en particular en la cabeza y el encéfalo de bebés de madres infectadas durante el embarazo. En el proyecto ZIKAlliance, financiado con fondos europeos, se aspira a comprender el efectos de la infección por el VZK durante el embarazo. así como estudiar la historia natural de la infección por el VZK en seres humanos. El consorcio adoptará un enfoque multidisciplinar para examinar cohortes de países del Caribe, Centroamérica y Sudamérica con diferentes perfiles epidemiológicos. El objetivo a largo plazo es mejorar la capacidad investigadora y la preparación ante futuras epidemias.

Objetivo

"ZIKAlliance is a multidisciplinary project with a global ""One Health"" approach, built: on a multi-centric network of clinical cohorts in the Caribbean, Central & South America; research sites in countries where the virus has been or is currently circulating (Africa, Asia, Polynesia) or at risk for emergence (Reunion Island); a strong network of European and Brazilian clinical & basic research institutions; and multiple interfaces with other scientific and public health programmes. ZIKAlliance will addrees three key objectives relating to (i) impact of Zika virus (ZIKV) infection during pregnancy and short & medium term effects on newborns, (ii) associated natural history of ZIKV infection in humans and their environment in the context of other circulating arboviruses and (iii) building the overall capacity for preparedness research for future epidemic threats in Latin America & the Caribbean. The project will take advantage of large standardised clinical cohorts of pregnant women and febrile patients in regions of Latin America and the Caribbean were the virus is circulating, expanding a preexisting network established by the IDAMS EU project. I will also benefit of a very strong expertise in basic and environmental sciences, with access to both field work and sophisticated technological infrastructures to characterise virus replication and physiopathology mechanisms. To meet its 3 key objectives, the scientific project has been organised in 9 work packages, with WP2/3 dedicated to clinical research (cohorts, clinical biology, epidemiology & modeling), WP3/4 to basic research (virology & antivirals, pathophysiology & animal models), WP5/6 to environmental research (animal reservoirs, vectors & vector control) , WP7/8 to social sciences & communication, and WP9 to management. The broad consortium set-up allow gathering the necessary expertise for an actual interdisciplinary approach, and operating in a range of countries with contrasting ZIKV epidemiological status."

Convocatoria de propuestas

H2020-SC1-2016-2017

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Convocatoria de subcontratación

H2020-SC1-2016-RTD-Zika

Régimen de financiación

RIA - Research and Innovation action

Coordinador

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
Aportación neta de la UEn
€ 2 285 366,30
Dirección
RUE DE TOLBIAC 101
75654 Paris
Francia

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Región
Ile-de-France Ile-de-France Paris
Tipo de actividad
Research Organisations
Enlaces
Coste total
€ 2 285 366,30

Participantes (56)