INfraStructure in Proton International REsearch

Rezultaty

Report Recalculation of treatment plans performed assuming a constant RBE=1.1, with two different models for variable RBE, including dependencies on beam quality, dose fractionation, OER and tissue type

Study of the effects of using a variable RBE on treatment planning and how factors such as fractionation, OER and beam quality affect this plan. Combination of experimental and theoretical studies. Due Date (in months): 36

TNA providers have QA documentation in place

All TNA providers have QA documentation in place on their experimental protocols and operational procedures. For example for dosimetry, spot scanning, energy verification. Due Date (in months): 12

Benchmark radiobiological models of hypoxia against experimental data; prepare paper for publication

Compare experimental and simulation studies on the effects of tumour cell growth in hypoxic environments and the effects of PBT and how this differs to photons Prepare paper for publicationDue Date in months 58

Evaluate detectors for measuring range uncertainties and evaluate opportunities of using nanoparticles to enhance signals

Use nanoparticles to enhance prompt gamma signal for range verification. Evaluate the use of nanoparticles to enhance detector signal. Due Date (in months): 40

Public Engagement factsheets & other information available in a number of languages on Open Access Gateway

Factsheets on PBT will be available for the general public and policy makers in a number of languages through the part of the INSPIRE Access Gateway aimed at engaging stakeholders.Due Date (in months): 12

6 monthly INSPIRE Newsletter

Electronic Newsletter to describe NA TNA and JRA achievements of INSPIRE This will be compiled every 6 monthsDue Date in months 12 18 24 30 36 42 48 54

Report on post-treatment assessment of actually delivered dose in patients

IC will oversee the analysis of the analytical and MC planning systems comparing the different models and their performance and evaluate the incidence of biological models on virtual planning and then report on their findingsDue Date in months 58

Definition of key parameters for NTCP based patient selection and tumour sites

Discussion of key tumour sites and development of NTCP models for those sites. Sharing of results between interested partners. Due Date (in months): 12

Mid term & Final Report on Innovation Gateway with toolkit of Activities

Reports on the activities of the Innovation Gateway Outlining industrial involvement and participation within INSPIRE through use of the toolkit of activitiesDue Date in months 24 58

Sustainability Report for INSPIRE

Report on the sustainability of INSPIRE. Development of INSPIRE and positioning it to become an advanced research community.Due Date (in months): 58

Reports to management boards on TNA provision

QA for TNA will be provided to management meetings in terms of TNA provided turnaround times user feedback benchmarking and interoperability experiments quantity and quality of outputs including publications grants patents etc user engagement including industry and hospitals training courses placement and secondments use of the Innovation Gateway This will allow the performance of each TNA provider to be monitored and measured against INSPIREs deliverables and Milestones Due Date in months 6 12 18 24 30 36 42 48 54 58

Protocols for in vitro analysis of dose response of radio sensitising agents with protons; prepare paper for publication

Establish protocols for in vitro studies of PBT in combination with radio sensitising agents. Prepare paper for publication. Due Date (in months): 36

Preliminary experiments to investigate radio-protective effects of hibernation on small animals, prepare paper for publication

Develop experiments to test the hypothesis that there are radio-protective effects due to hibernation. Prepare paper for publication. Due Date (in months): 40

Data Management Plan & Dissemination & Exploitation Plan

A comprehensive data management plan (DMP) will be drawn up for INSPIRE. A draft of INSPIRE’s dissemination and exploitation plan can be found in section 2.2(a) and its roadmap is shown in Figure 7. Due Date (in months): 5

Deliver training courses outlined in table 3.1.1

A series of Training Courses will be established for New Users. This will use a combination of established courses such as the PSI Proton Winter School in PBT and new courses where we have established from a “gap analysis” that there is a new user need. These are described in shown Table 3.1.1 in Annex A. Where possible we would seek to run these courses in conjunction with other EU projects. Due Date (in months): 58

Annual INSPIRE Information Day in participating countries and other EU member states on request

Every year, each participant will hold an INSPIRE Information Day. This will bring those interested in PBT together, provide a training opportunity on PBT and promote the TNA and NA opportunities within INSPIRE as well as giving the latest updates on JRA. Due Date (in months): 6, 18, 30, 42, 54

User selection Panel appointed

Independent reviewers of proposals for TNA appointed and given information on how they expected to review proposals. Due Date (in months): 6

INSPIRE delivers 612 hrs of TNA by month 48

Monitoring of TNA delivery to ensure 612 hours of TNA are delivered by month 48.Due Date (in months): 58

Open Nights programme commenced

INSPIRE will have an “Open Nights” programme for all of the PBT centres who wish to participate. This is an idea that has been pioneered by IFJPAN and allows the opportunity for the public to see around both the research room and the clinical facilities, ask questions and hear about the research being conducted within INSPIRE. Due Date (in months): 12

15 Discipline Hops and summer placements have taken place

Early career researchers (ECR) will also be offered the opportunity of “Discipline Hops” which will enable them to spend a period of 2 to 3 months at a PBT centre, either in the clinical environment or in clinical medical physics (or both), where they will also have the opportunity to take part in the JRA activities in that centre. “Discipline Hops” will also be available for ECRs who wish to experience the PBT industrial environment. Due Date (in months): 58

Development and testing of advanced radiobiological phantoms / end-stations for RBE experiments along the Bragg peak using spot scanning or passive scattering

Development of equipment / phantoms to study the change in relative biological effectiveness along the Bragg peak.Due Date (in months): 58

Incorporation of PBT indications into Malthus decision trees

Incorporating decision trees for UK PBT indications in to Malthus model for modelling radiotherapy demand. Due Date (in months): 12

Develop tissue equivalent phantoms for monitoring dosimetry and changes in RBE along the Bragg peak

Develop materials which can be used as tissue equivalent for PBT and use 3D printing technology to build phantoms which can be used in round-robin experiments.Due Date (in months): 42

INSPIRE Access Gateway, Knowledge Hub, Help Desk and Open Access Portal

INSPIRE web portal now includes a Knowledge Hub for those interested in finding out more about PBT and for sharing best practice. Open Access Portal developed for sharing results and publications and information about INSPIRE through NA.Due Date (in months): 8

Access Gateway designed and launched

INSPIRE web portal which comprises INSPIRE Access Gateway (for NA, TNA and JRA) and is specified, designed, tested using a proto-type and then launched so it can be used by partners and the wider EU community. Due Date (in months): 6

Open Access to Research data

Open access to research data pilot

Publikacje

Proton therapy and the European Particle Therapy Network: The past, present and future

Autorzy: D C Weber, J A Langendijk, C Grau, J Thariat
Opublikowane w: Cancer Radiotherapie, 2020, ISSN 1278-3218
Wydawca: Elsevier Masson

Shortening delivery times for intensity-modulated proton therapy by reducing the number of proton spots: an experimental verification

Autorzy: van de Water, Steven; Belosi, Maria F; Albertini, Francesca; Winterhalter, Carla; Weber, Damien C; Lomax, Antony J
Opublikowane w: Physics in Medicine & Biology, Numer 21, 2020, ISSN 0031-9155
Wydawca: Institute of Physics Publishing

Development of advanced preselection tools to reduce redundant plan comparisons in model-based selection of head and neck cancer patients for proton therapy

Autorzy: Makbule Tambas, Hans P. van der Laan, Wouter Rutgers, Johanna G.M. van den Hoek, Edwin Oldehinkel, Tineke W.H. Meijer, Arjen van der Schaaf, Daniel Scandurra, Jeffrey Free, Stefan Both, Roel J.H.M. Steenbakkers, Johannes A. Langendijk
Opublikowane w: Radiotherapy and Oncology, Numer 160, 2021, Strona(/y) 61-68, ISSN 0167-8140
Wydawca: Elsevier BV
DOI: 10.1016/j.radonc.2021.04.012

Carbon Ion Radiobiology

Autorzy: Walter Tinganelli, Marco Durante
Opublikowane w: Cancers, Numer 12/10, 2020, Strona(/y) 3022, ISSN 2072-6694
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers12103022

Late Side Effects in Normal Mouse Brain Tissue After Proton Irradiation

Autorzy: Theresa Suckert, Elke Beyreuther, Johannes Müller, Behnam Azadegan, Matthias Meinhardt, Felix Raschke, Elisabeth Bodenstein, Cläre von Neubeck, Armin Lühr, Mechthild Krause, Antje Dietrich
Opublikowane w: Frontiers in Oncology, Numer 10, 2021, ISSN 2234-943X
Wydawca: Frontiers Media S. A.
DOI: 10.3389/fonc.2020.598360

Ultra-high dose rate (FLASH) carbon ion irradiation: dosimetry and first cell experiments.

Autorzy: Walter Tinganelli; Olga Sokol; Martina Quartieri; Anggraeini Puspitasari; Ivana Dokic; Ivana Dokic; Amir Abdollahi; Amir Abdollahi; Marco Durante; Thomas Haberer; Jürgen Debus; Jürgen Debus; Daria Boscolo; Bernd Voss; Stephan Brons; Christoph Schuy; Felix Horst; Ulrich Weber
Opublikowane w: International Journal of Radiation Oncology*Biology*Physics, Numer 9, 2022, ISSN 0360-3016
Wydawca: Elsevier BV
DOI: 10.1016/j.ijrobp.2021.11.020

Multi-modality bedding platform for combined imaging and irradiation of mice

Autorzy: Johannes Müller, Michael Schürer, Christian Neubert, Falk Tillner, Elke Beyreuther, Theresa Suckert, Nils Peters, Cläre von Neubeck, Armin Lühr, Mechthild Krause, Rebecca Bütof, Antje Dietrich
Opublikowane w: Biomedical Physics & Engineering Express, Numer 6/3, 2020, Strona(/y) 037003, ISSN 2057-1976
Wydawca: IOP Publishing
DOI: 10.1088/2057-1976/ab79f1

Heavy charged particle beam therapy and related new radiotherapy technologies: The clinical potential, physics and technical developments required to deliver benefit for patients with cancer.

Autorzy: Karen J. Kirkby; Karen J. Kirkby; Norman F. Kirkby; Norman F. Kirkby; Neil G. Burnet; Neil G. Burnet; Hywel Owen; Ranald I Mackay; Ranald I Mackay; Adrian Crellin; Adrian Crellin; Stuart Green
Opublikowane w: The British Journal of Radiobiology, Numer 1, 2020, Strona(/y) Vol 93, No. 1116, ISSN 1748-880X
Wydawca: The British Institute of Radiobiology
DOI: 10.1259/bjr.20200247

Neutron Radiation Dose Measurements in a Scanning Proton Therapy Room: Can Parents Remain Near Their Children During Treatment?

Autorzy: Mares V, Farah J, De Saint-Hubert M, Domański S, Domingo C, Dommert M, Kłodowska M, Krzempek K, Kuć M, Martínez-Rovira I, Michaś E, Mojżeszek N, Murawski Ł, Ploc O, Romero-Expósito M, Tisi M, Trompier F, Van Hoey O, Van Ryckeghem L, Wielunski M, Harrison RM, Stolarczyk L, Olko P
Opublikowane w: Front Oncol, Numer 2234943X, 2022, Strona(/y) 903706, ISSN 2234-943X
Wydawca: Frontiers Media S. A.
DOI: 10.3389/fonc.2022.903706

Clinically relevant nanodosimetric simulation of DNA damage complexity from photons and protons

Autorzy: N. T. Henthorn, J. W. Warmenhoven, M. Sotiropoulos, A. H. Aitkenhead, E. A. K. Smith, S. P. Ingram, N. F. Kirkby, A. L. Chadwick, N. G. Burnet, R. I. Mackay, K. J. Kirkby, M. J. Merchant
Opublikowane w: RSC Advances, Numer 9/12, 2019, Strona(/y) 6845-6858, ISSN 2046-2069
Wydawca: Royal Society of Chemistry
DOI: 10.1039/c8ra10168j

Gold Nanopeanuts as Prospective Support for Cisplatin in Glioblastoma Nano-Chemo-Radiotherapy

Autorzy: Joanna Depciuch, Justyna Miszczyk, Alexey Maximenko, Piotr M. Zielinski, Kamila Rawojć, Agnieszka Panek, Pawel Olko, Magdalena Parlinska-Wojtan
Opublikowane w: International Journal of Molecular Sciences, Numer 21/23, 2020, Strona(/y) 9082, ISSN 1422-0067
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms21239082

Modeling Radioimmune Response—Current Status and Perspectives

Autorzy: Thomas Friedrich, Nicholas Henthorn, Marco Durante
Opublikowane w: Frontiers in Oncology, Numer 11, 2021, ISSN 2234-943X
Wydawca: Frontiers Media S. A.
DOI: 10.3389/fonc.2021.647272

Cancer risk after breast proton therapy considering physiological and radiobiological uncertainties

Autorzy: Apostolos Raptis, Jakob Ödén, Oscar Ardenfors, Anna M. Flejmer, Iuliana Toma-Dasu, Alexandru Dasu
Opublikowane w: Physica Medica, Numer 76, 2020, Strona(/y) 1-6, ISSN 1120-1797
Wydawca: Istituti Editoriali e Poligrafici Internazionali
DOI: 10.1016/j.ejmp.2020.06.012

Oxygen Depletion in Proton Spot Scanning: A Tool for Exploring the Conditions Needed for FLASH

Autorzy: Bethany C. Rothwell, Matthew Low, Norman F. Kirkby, ,Michael J. Merchant, Amy L. Chadwick, Ranald I. Mackay, Jolyon H. Hendry and Karen J. Kirkby
Opublikowane w: Radiation 2021, 2021, ISSN 2673-592X
Wydawca: MDPI
DOI: 10.3390/radiation1040024

Out-of-field measurements and simulations of a proton pencil beam in a wide range of dose rates using a Timepix3 detector: Dose rate, flux and LET

Autorzy: Cristina Oancea, Carlos Granja, Lukas Marek, Jan Jakubek, Jaroslav Šolc, Elisabeth Bodenstein, Sebastian Gantz, Jorg Pawelke, Jiri Pivec
Opublikowane w: Physica Medica, Numer Vol 106, 2023, ISSN 1120-1797
Wydawca: Istituti Editoriali e Poligrafici Internazionali
DOI: 10.1016/j.ejmp.2023.102529

An Update to the Malthus Model for Radiotherapy Utilisation in England

Autorzy: S. Heritage, S. Sundaram, N.F. Kirkby , K.J. Kirkby, T. Mee , R. Jena
Opublikowane w: Clinical Oncolgy, Numer Vol 35, Numer 1, 2023, ISSN 0936-6555
Wydawca: W. B. Saunders Co., Ltd.
DOI: 10.1016/j.clon.2022.06.006

Commentary: RBE in proton therapy – where is the experimental in vivo data?

Autorzy: Brita Singers Sørensen
Opublikowane w: Acta Oncologica, Numer 58/10, 2019, Strona(/y) 1337-1339, ISSN 0284-186X
Wydawca: Taylor & Francis
DOI: 10.1080/0284186x.2019.1669819

Simultaneous Measurements of Dose and Microdosimetric Spectra in a Clinical Proton Beam Using a scCVD Diamond Membrane Microdosimeter

Autorzy: Oluwasayo Loto, Izabella Zahradnik, Amelia Maia Leite, Ludovic De Marzi, Dominique Tromson, Michal Pomorski
Opublikowane w: Sensors, Numer 21/4, 2021, Strona(/y) 1314, ISSN 1424-8220
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/s21041314

Combined proton radiography and irradiation for high-precision preclinical studies in small animals

Autorzy: Moritz Schneider, Elisabeth Bodenstein, Johanna Bock, Antje Dietrich, Sebastian Gantz, Lena Heuchel, Mechthild Krause, Armin Lühr, Cläre von Neubeck, Sindi Nexhipi, Michael Schürer, Falk Tillner, Elke Beyreuther, Theresa Suckert, Johannes Richard Müller
Opublikowane w: Frontiers in Oncology, 2022, ISSN 0000-0000
Wydawca: Frontiers
DOI: 10.3389/fonc.2022.982417

Proton beam therapy: perspectives on the National Health Service England clinical service and research programme

Autorzy: Neil G Burnet, Ranald I Mackay, Ed Smith, Amy L Chadwick, Gillian A Whitfield, David J Thomson, Matthew Lowe, Norman F Kirkby, Adrian M Crellin, Karen J Kirkby
Opublikowane w: The British Journal of Radiology, Numer 93/1107, 2020, Strona(/y) 20190873, ISSN 0007-1285
Wydawca: British Institute of Radiology
DOI: 10.1259/bjr.20190873

Ultra-fast pencil beam scanning proton therapy for locally advanced non-small-cell lung cancers: Field delivery within a single breath-hold

Autorzy: VivekMaradia, Steven van de Water, David Meer, Damien C.Weber, Antony J.Lomax, SerenaPsoroulas
Opublikowane w: Radiotherapy and Oncology, 2022, Strona(/y) 23-29, ISSN 0167-8140
Wydawca: Elsevier BV
DOI: 10.1016/j.radonc.2022.06.018

The Effects of Combined Exposure to Simulated Microgravity, Ionizing Radiation, and Cortisol on the In Vitro Wound Healing Process

Autorzy: Radstake, W.E.; Gautam, K.; Miranda, S.; Vermeesen, R.; Tabury, K.; Rehnberg, E.; Buset, J.; Janssen, A.; Leysen, L.; Neefs, M.; Verslegers, M.; Claesen, J.; van Goethem, M.-J.; Weber, U.; Fournier, C.; Parisi, A.; Brandenburg, S.; Durante, M.; Baselet, B.; Baatout, S.
Opublikowane w: Cells, 2023, ISSN 2073-4409
Wydawca: MDPI
DOI: 10.3390/cells12020246

Proton Radiographs Using Position-Sensitive Silicon Detectors and High-Resolution Scintillators

Autorzy: J. A. Briz et al
Opublikowane w: IEEE Transactions on Nuclear Science, Numer Volume 69 Numer 4, 2022, ISSN 0018-9499
Wydawca: Institute of Electrical and Electronics Engineers
DOI: 10.1109/tns.2022.3142618

A Monte Carlo study of different LET definitions and calculation parameters for proton beam therapy

Autorzy: Edward A K Smith, Carla Winterhalter, Tracy S A Underwood, Adam H Aitkenhead, Jenny C Richardson, Michael J Merchant, Norman F Kirkby, Karen J Kirby and Ranald I Mackay
Opublikowane w: Biomedical Physics & Engineering Express, Numer Vol 8, 1, 2021, ISSN 2057-1976
Wydawca: Institute of Physics
DOI: 10.1088/2057-1976/ac3f50

Spatial correlation of linear energy transfer and relative biological effectiveness with suspected treatment‐related toxicities following proton therapy for intracranial tumors

Autorzy: Jakob Ödén, Iuliana Toma‐Dasu, Petra Witt Nyström, Erik Traneus, Alexandru Dasu
Opublikowane w: Medical Physics, Numer 47/2, 2020, Strona(/y) 342-351, ISSN 0094-2405
Wydawca: American Association of Physicists in Medicine
DOI: 10.1002/mp.13911

Simulation and experimental validation of a prototype electron beam linear accelerator for preclinical studies

Autorzy: Pierre Lansonneur, Vincent Favaudon, Sophie Heinrich, Charles Fouillade, Pierre Verrelle, Ludovic De Marzi
Opublikowane w: Physica Medica, Numer 60, 2019, Strona(/y) 50-57, ISSN 1120-1797
Wydawca: Istituti Editoriali e Poligrafici Internazionali
DOI: 10.1016/j.ejmp.2019.03.016

Biomedical Research Programs at Present and Future High-Energy Particle Accelerators

Autorzy: Vincenzo Patera, Yolanda Prezado, Faical Azaiez, Giuseppe Battistoni, Diego Bettoni, Sytze Brandenburg, Aleksandr Bugay, Giacomo Cuttone, Denis Dauvergne, Gilles de France, Christian Graeff, Thomas Haberer, Taku Inaniwa, Sebastien Incerti, Elena Nasonova, Alahari Navin, Marco Pullia, Sandro Rossi, Charlot Vandevoorde, Marco Durante
Opublikowane w: Frontiers in Physics, Numer 8, 2020, ISSN 2296-424X
Wydawca: Frontiers Media
DOI: 10.3389/fphy.2020.00380

Mechanistic Modelling of Slow and Fast NHEJ DNA Repair Pathways Following Radiation for G0/G1 Normal Tissue Cells

Autorzy: Yaping Qi,John William Warmenhoven,Nicholas Thomas Henthorn, Samuel Peter Ingram,Xie George Xu,Karen Joy Kirkby and Michael John Merchant
Opublikowane w: Cancers 2021, Numer 13 (9), 2021, ISSN 2072-6694
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers13092202

Biological Impact of Target Fragments on Proton Treatment Plans: An Analysis Based on the Current Cross-Section Data and a Full Mixed Field Approach.

Autorzy: Elettra Valentina Bellinzona; Leszek Grzanka; Andrea Attili; Francesco Tommasino; Thomas Friedrich; Michael Kramer; Michael Scholz; Giuseppe Battistoni; A. Embriaco; Davide Chiappara; G.A.P. Cirrone; Giada Petringa; Marco Durante; Emanuele Scifoni
Opublikowane w: Cancers, Numer 1, 2021, ISSN 2072-6694
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers13194768

Hi-C implementation of genome structure for in silico models of radiation-induced DNA damage

Autorzy: Samuel P. Ingram, Nicholas T. Henthorn, John W. Warmenhoven, Norman F. Kirkby, Ranald I. Mackay, Karen J. Kirkby, Michael J. Merchant
Opublikowane w: PLOS Computational Biology, Numer 16/12, 2020, Strona(/y) e1008476, ISSN 1553-7358
Wydawca: PLOS
DOI: 10.1371/journal.pcbi.1008476

High-precision image-guided proton irradiation of mouse brain sub-volumes

Autorzy: Theresa Suckert, Johannes Müller, Elke Beyreuther, Behnam Azadegan, Anja Brüggemann, Rebecca Bütof, Antje Dietrich, Malte Gotz, Robert Haase, Michael Schürer, Falk Tillner, Cläre von Neubeck, Mechthild Krause, Armin Lühr
Opublikowane w: Radiotherapy and Oncology, Numer 146, 2020, Strona(/y) 205-212, ISSN 0167-8140
Wydawca: Elsevier BV
DOI: 10.1016/j.radonc.2020.02.023

RBE for proton radiation therapy – a Nordic view in the international perspective

Autorzy: Iuliana Toma-Dasu, Alexandru Dasu, Anne Vestergaard, Petra Witt Nyström, Håkan Nyström
Opublikowane w: Acta Oncologica, Numer 59/10, 2020, Strona(/y) 1151-1156, ISSN 0284-186X
Wydawca: Taylor & Francis
DOI: 10.1080/0284186x.2020.1826573

Predicting late magnetic resonance image changes in glioma patients after proton therapy

Autorzy: J. Eulitz, E.G.C. Troost, F. Raschke, E. Schulz, B. Lutz, A. Dutz, S. Löck, P. Wohlfahrt, W. Enghardt, C. Karpowitz, M. Krause, A. Lühr
Opublikowane w: Acta Oncologica, Numer 58/10, 2019, Strona(/y) 1536-1539, ISSN 0284-186X
Wydawca: Taylor & Francis
DOI: 10.1080/0284186x.2019.1631477

Beam pulse structure and dose rate as determinants for the flash effect observed in zebrafish embryo

Autorzy: Leonhard Karsch, Jörg Pawelke, Michael Brand, Stefan Hans, Katalin Hideghéty, Jeannette Jansen, Elisabeth Lessmann, Steffen Löck, Michael Schürer, Rico Schurig, Joao Seco, Emília Rita Szabó, Elke Beyreuther
Opublikowane w: Radiotherapy and Oncology, 2022, Strona(/y) 49-54, ISSN 0167-8140
Wydawca: Elsevier BV
DOI: 10.1016/j.radonc.2022.05.025

Does the uncertainty in relative biological effectiveness affect patient treatment in proton therapy?

Autorzy: Brita S. Sørensen, Jörg Pawelke, Julia Bauer, Neil G. Burnet, Alexandru Dasu, Morten Høyer, Christian P. Karger, Mechthild Krause, Marco Schwarz, Tracy S.A. Underwood, Dirk Wagenaar, Gillian A. Whitfield, Armin Lühr
Opublikowane w: Radiotherapy and Oncology, Numer 163, 2021, Strona(/y) 177-184, ISSN 0167-8140
Wydawca: Elsevier BV
DOI: 10.1016/j.radonc.2021.08.016

Mapping the Future of Particle Radiobiology in Europe: The INSPIRE Project

Autorzy: Nicholas T. Henthorn, Olga Sokol, Marco Durante, Ludovic De Marzi, Frederic Pouzoulet, Justyna Miszczyk, Pawel Olko, Sytze Brandenburg, Marc Jan van Goethem, Lara Barazzuol, Makbule Tambas, Johannes A. Langendijk, Marie Davídková, Vladimír Vondráĉek, Elisabeth Bodenstein, Joerg Pawelke, Antony J. Lomax, Damien C. Weber, Alexandru Dasu, Bo Stenerlöw, Per R. Poulsen, Brita S. Sørensen, Cai Gr
Opublikowane w: Frontiers in Physics, Numer 8, 2020, ISSN 2296-424X
Wydawca: Frontiers Media
DOI: 10.3389/fphy.2020.565055

Determining the parameter space for effective oxygen depletion for FLASH radiation therapy

Autorzy: B C Rothwell, N F Kirkby, M J Merchant, A L Chadwick, M Lowe, R I Mackay, J H Hendry, K J Kirkby
Opublikowane w: Physics in Medicine & Biology, Numer 66/5, 2021, Strona(/y) 055020, ISSN 0031-9155
Wydawca: Institute of Physics Publishing
DOI: 10.1088/1361-6560/abe2ea

A computational approach to quantifying miscounting of radiation-induced double-strand break immunofluorescent foci

Autorzy: Samuel P. Ingram; John-William Warmenhoven; Nicholas T. Henthorn; Amy L. Chadiwck; Elham E. Santina; Stephen J. McMahon; Jan Schuemann; Norman F. Kirkby; Ranald I. Mackay; Karen J. Kirkby; Michael J. Merchant
Opublikowane w: Communications Biology, Numer 1, 2022, Strona(/y) 5 Article number: 700 (2022), ISSN 2399-3642
Wydawca: Communications Biology
DOI: 10.1038/s42003-022-03585-5

Estimating the percentage of patients who might benefit from proton beam therapy instead of X-ray radiotherapy

Autorzy: Neil G Burnet, Thomas Mee, Simona Gaito, Norman F Kirkby, Adam H Aitkenhead, Carmel N Anandadas, Marianne C Aznar, Lisa H Barraclough, Gerben Borst, Frances C Charlwood, Matthew Clarke, Rovel J Colaco, Adrian M Crellin, Noemie N Defourney, Christina J Hague, Margaret Harris, Nicholas T Henthorn, Kirsten I Hopkins, E Hwang, Sam P Ingram, Karen J Kirkby, Lip W Lee, David Lines, Zoe Lingard, Matthew
Opublikowane w: British Journal of Radiology, Numer Br J Radiol 2022; 95: 20211175, 2022, ISSN 0007-1285
Wydawca: British Institute of Radiology
DOI: 10.1259/bjr.20211175

Comparative Proton and Photon Irradiation Combined with Pharmacological Inhibitors in 3D Pancreatic Cancer Cultures

Autorzy: Josephine Görte, Elke Beyreuther, Erik H. J. Danen, Nils Cordes
Opublikowane w: Cancers, Numer 12/11, 2020, Strona(/y) 3216, ISSN 2072-6694
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers12113216

3D high resolution clonogenic survival measurement of xrs-5 cells in low-dose region of carbon ion plans

Autorzy: Dea Kartini, Olga Sokol, Chutima Talabnin, Chinorat Kobdaj, Marco Durante, Michael Krämer, Martina Fuss
Opublikowane w: International Journal of Radiation Biology, 2022, ISSN 0955-3002
Wydawca: Taylor & Francis
DOI: 10.1080/09553002.2022.2110318

Spread-out Bragg Peak in Spatially Fractionated Proton Therapy

Autorzy: A.Toboła, J. Swakoń, P. Olko
Opublikowane w: Acta Phys. Pol. B, 2022, Strona(/y) Proc. Suppl. 15, 4-A3, ISSN 2082-7865
Wydawca: Jagiellonian University
DOI: 10.5506/aphyspolbsupp.15.4-a3

Simulation and experimental verification of ambient neutron doses in a pencil beam scanning proton therapy room as function of treatment plan parameters

Autorzy: Van Hoey O, Stolarczyk L, Lillhök J, Eliasson L, Mojzeszek N, Liszka M, Alkhiat A, Mares V, Trompier F, Trinkl S, Martínez-Rovira I, Romero-Expósito M, Ploc O, Harrison R, Olko P
Opublikowane w: Front Oncol, Numer 2234943X, 2022, Strona(/y) 903537, ISSN 2234-943X
Wydawca: Frontiers Media S. A.
DOI: 10.3389/fonc.2022.903537

Harnessing radiation to improve immunotherapy: better with particles?

Autorzy: Marco Durante, Silvia Formenti
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Combined Systemic Drug Treatment with Proton Therapy: Investigations on Patient-Derived Organoids

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Virus Irradiation and COVID-19 Disease

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Water Equivalence of Various 3D Printed Materials for Proton Therapy --- Monte Carlo Simulation, Treatment Planning Modelling and Validation by Measurements

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First experimental measurements of 2D microdosimetry maps in proton therapy

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Metallic Nanoparticles: A Useful Prompt Gamma Emitter for Range Monitoring in Proton Therapy?

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Does FLASH deplete oxygen? Experimental evaluation for photons, protons, and carbon ions

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Beam Monitor Calibration for Radiobiological Experiments With Scanned High Energy Heavy Ion Beams at FAIR

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Nanomaterials as Ultrasound Theragnostic Tools for Heart Disease Treatment/Diagnosis

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OC-0563 First experience with the model-based selection of head and neck cancer patients for proton therapy

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A quantitative FLASH effectiveness model to reveal potentials and pitfalls of high dose rate proton therapy

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Proposing a Clinical Model for RBE Based on Proton Track-End Counts

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Influence of Therapeutic Proton Beam on Glioblastoma Multiforme Proliferation Index — A Preliminary Study

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First experience with model-based selection of head and neck cancer patients for proton therapy

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The European Joint Research Project UHDpulse - Metrology for advanced radiotherapy using particle beams with ultra-high pulse dose rates.

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Current practice in proton therapy delivery in adult cancer patients across Europe

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In vivo validation and tissue sparing factor for acute damage of pencil beam scanning proton FLASH

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Cellular plasticity upon proton irradiation determines tumor cell radiosensitivity

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Towards harmonizing clinical linear energy transfer (LET) reporting in proton radiotherapy: a European multi-centric study

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In Silico Models of DNA Damage and Repair in Proton Treatment Planning: A Proof of Concept

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Flash modalities track (oral presentations) flat panel proton radiography in high-precision image-guided mouse brain proton irradiation

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Spatially fractionated proton therapy of eye cancer: Feasibility studies

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INSPIRE: Infrastructure in proton international research – A new horizon 2020 network

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Protontherapy Therapeutic Window Widening By Pbct And Flash Modalities - Epd020

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FLASH Modalities Track (Oral Presentations) SPECTRAL- AND INTENSITY-SENSITIVE CHARACTERIZATION OF PULSED FLASH PROTON FIELDS WITH THE PIXEL DETECTOR TIMEPIX3

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Dosimetry of primary beam and scattered radiation in proton therapy

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Flash modalities track (oral presentations) ultra-high dose rate beam monitoring and control for a varian probeam system

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Opublikowane w: Physica Medica, 2022, Strona(/y) S56, ISSN 1120-1797
Wydawca: Istituti Editoriali e Poligrafici Internazionali
DOI: 10.1016/s1120-1797(22)01560-5

Does FLASH deplete Oxygen? Experimental Evaluation for Photons, Protons and Carbon Ions

Autorzy: Jansen, Jeannette; Knoll, Jan; Beyreuther, Elke; Pawelke, Jörg; Skuza, Raphael; Hanley, Rachel; Brons, Stephan; Pagliari, Francesca; Seco, Joao
Opublikowane w: Numer 3, 2021
Wydawca: Cornell University

Using Comprehensive Relative-Biological-Effectiveness Simulations to Assess the Potential Clinical Gain of FLASH Proton Therapy

Autorzy: S van de Water, S Fabiano, N Bizzocchi, S Safai, D Weber, A Mazal, J Unkelbach, A Lomax
Opublikowane w: 2020 Joint APPM/Comp Meeting, 2020
Wydawca: APPM

An ion chamber array for easy assessment of flash proton fields

Autorzy: L.StolarczykM.SitarzI.HuthP.PoulsenT.Pfeiler
Opublikowane w: Physica Medica, 2022, Strona(/y) S79, ISSN 1120-1797
Wydawca: Istituti Editoriali e Poligrafici Internazionali
DOI: 10.1016/s1120-1797(22)01613-1

Flash modalities track (oral presentations) preliminary results of dosimetry audit of active scanning proton beam

Autorzy: M. Davídková, A. Dasu, C. De Angelis, L. De Marzi, M. De Saint-Hubert, D. Ekendahl, A. Jelínek Michaelidesová, Ž. Knežević, P. Kukolowicz, M. Liszka, S. Lorentini, A. Maia Leite, M. Majer, B. Michalec, M. Navrátil, B. Reniers, M.J. Van Goethem, A. Vestergaard, G. Vilches-Freixas, V. Vondráček, L. Stolarczyk, P. Olko
Opublikowane w: Physica Medica, 2022, Strona(/y) S57, ISSN 1120-1797
Wydawca: Istituti Editoriali e Poligrafici Internazionali
DOI: 10.1016/s1120-1797(22)01562-9

Assessment of the Probability of Tumour Control for Prescribed Doses Based on Imaging of Oxygen Partial Pressure

Autorzy: Ana Ureba, Emely Kjellsson Lindblom, Iuliana Toma-Dasu, Alexandru Dasu, Marta Lazzeroni
Opublikowane w: Oxygen Transport to Tissue XLII, Numer 1269, 2021, Strona(/y) 185-190, ISBN 978-3-030-48236-7
Wydawca: Springer International Publishing
DOI: 10.1007/978-3-030-48238-1_29

Extending of the pytrip software package for biologically optimized proton radiotherapy

Autorzy: Leszek Grzanka, Kinga Jeleń1, Łukasz Jeleń, Arkadiusz Ćwikła, Michał Krawczyk, Joanna Fortuna, Mateusz Łaszczyk, Paweł Olko
Opublikowane w: 2021
Wydawca: The Henryk Niewodniczański INSTITUTE OF NUCLEAR PHYSICS Polish Academy of Sciences

An In Silico Model of DNA Repair for Investigation of Mechanisms in Non-Homologous End Joining

Autorzy: Ranald I Mackay; Nicholas T. Henthorn; Marios Sotiropoulos; J.W. Warmenhoven; Karen J. Kirkby; Sergei Fedotov; Michael J. Merchant; Nickolay Korabel
Opublikowane w: Numer 1, 2018
Wydawca: bioRxiv
DOI: 10.1101/318139

Towards incorporation of RBE uncertainty in proton therapy planning systems

Autorzy: Leszek Grzanka , Kinga Jeleń, Michael P.R. Waligórski
Opublikowane w: 2019
Wydawca: The Henryk Niewodniczański INSTITUTE OF NUCLEAR PHYSICS Polish Academy of Sciences

An Industry/Academic Partnership Yields Fruit: An Ultra-High Dose Rate Beam Monitoring Tool for FLASH Trials

Autorzy: Varian Medical Systems, Inc.
Opublikowane w: 2021
Wydawca: 12

Cell responses to ionizing radiation: current research at Lithuania University of Health Sciences and future perspectives with “Inspire” project

Autorzy: Juozaitytė, Elona;Bartnykaitė, Agnė;Laukaitienė, Danguolė;Ugenskienė, Rasa
Opublikowane w: Rīga Stradiņš University International conference on Medical and Health Care Sciences, Numer Knowledge for Use in Practice: abstracts, 2019, Strona(/y) Conference Section Oncology and Haematology
Wydawca: Rīga Stradiņš University

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