INfraStructure in Proton International REsearch

Risultati finali

Report Recalculation of treatment plans performed assuming a constant RBE=1.1, with two different models for variable RBE, including dependencies on beam quality, dose fractionation, OER and tissue type

Study of the effects of using a variable RBE on treatment planning and how factors such as fractionation, OER and beam quality affect this plan. Combination of experimental and theoretical studies. Due Date (in months): 36

TNA providers have QA documentation in place

All TNA providers have QA documentation in place on their experimental protocols and operational procedures. For example for dosimetry, spot scanning, energy verification. Due Date (in months): 12

Benchmark radiobiological models of hypoxia against experimental data; prepare paper for publication

Compare experimental and simulation studies on the effects of tumour cell growth in hypoxic environments and the effects of PBT and how this differs to photons Prepare paper for publicationDue Date in months 58

Evaluate detectors for measuring range uncertainties and evaluate opportunities of using nanoparticles to enhance signals

Use nanoparticles to enhance prompt gamma signal for range verification. Evaluate the use of nanoparticles to enhance detector signal. Due Date (in months): 40

Public Engagement factsheets & other information available in a number of languages on Open Access Gateway

Factsheets on PBT will be available for the general public and policy makers in a number of languages through the part of the INSPIRE Access Gateway aimed at engaging stakeholders.Due Date (in months): 12

6 monthly INSPIRE Newsletter

Electronic Newsletter to describe NA TNA and JRA achievements of INSPIRE This will be compiled every 6 monthsDue Date in months 12 18 24 30 36 42 48 54

Report on post-treatment assessment of actually delivered dose in patients

IC will oversee the analysis of the analytical and MC planning systems comparing the different models and their performance and evaluate the incidence of biological models on virtual planning and then report on their findingsDue Date in months 58

Definition of key parameters for NTCP based patient selection and tumour sites

Discussion of key tumour sites and development of NTCP models for those sites. Sharing of results between interested partners. Due Date (in months): 12

Mid term & Final Report on Innovation Gateway with toolkit of Activities

Reports on the activities of the Innovation Gateway Outlining industrial involvement and participation within INSPIRE through use of the toolkit of activitiesDue Date in months 24 58

Sustainability Report for INSPIRE

Report on the sustainability of INSPIRE. Development of INSPIRE and positioning it to become an advanced research community.Due Date (in months): 58

Reports to management boards on TNA provision

QA for TNA will be provided to management meetings in terms of TNA provided turnaround times user feedback benchmarking and interoperability experiments quantity and quality of outputs including publications grants patents etc user engagement including industry and hospitals training courses placement and secondments use of the Innovation Gateway This will allow the performance of each TNA provider to be monitored and measured against INSPIREs deliverables and Milestones Due Date in months 6 12 18 24 30 36 42 48 54 58

Protocols for in vitro analysis of dose response of radio sensitising agents with protons; prepare paper for publication

Establish protocols for in vitro studies of PBT in combination with radio sensitising agents. Prepare paper for publication. Due Date (in months): 36

Preliminary experiments to investigate radio-protective effects of hibernation on small animals, prepare paper for publication

Develop experiments to test the hypothesis that there are radio-protective effects due to hibernation. Prepare paper for publication. Due Date (in months): 40

Data Management Plan & Dissemination & Exploitation Plan

A comprehensive data management plan (DMP) will be drawn up for INSPIRE. A draft of INSPIRE’s dissemination and exploitation plan can be found in section 2.2(a) and its roadmap is shown in Figure 7. Due Date (in months): 5

Deliver training courses outlined in table 3.1.1

A series of Training Courses will be established for New Users. This will use a combination of established courses such as the PSI Proton Winter School in PBT and new courses where we have established from a “gap analysis” that there is a new user need. These are described in shown Table 3.1.1 in Annex A. Where possible we would seek to run these courses in conjunction with other EU projects. Due Date (in months): 58

Annual INSPIRE Information Day in participating countries and other EU member states on request

Every year, each participant will hold an INSPIRE Information Day. This will bring those interested in PBT together, provide a training opportunity on PBT and promote the TNA and NA opportunities within INSPIRE as well as giving the latest updates on JRA. Due Date (in months): 6, 18, 30, 42, 54

User selection Panel appointed

Independent reviewers of proposals for TNA appointed and given information on how they expected to review proposals. Due Date (in months): 6

INSPIRE delivers 612 hrs of TNA by month 48

Monitoring of TNA delivery to ensure 612 hours of TNA are delivered by month 48.Due Date (in months): 58

Open Nights programme commenced

INSPIRE will have an “Open Nights” programme for all of the PBT centres who wish to participate. This is an idea that has been pioneered by IFJPAN and allows the opportunity for the public to see around both the research room and the clinical facilities, ask questions and hear about the research being conducted within INSPIRE. Due Date (in months): 12

15 Discipline Hops and summer placements have taken place

Early career researchers (ECR) will also be offered the opportunity of “Discipline Hops” which will enable them to spend a period of 2 to 3 months at a PBT centre, either in the clinical environment or in clinical medical physics (or both), where they will also have the opportunity to take part in the JRA activities in that centre. “Discipline Hops” will also be available for ECRs who wish to experience the PBT industrial environment. Due Date (in months): 58

Development and testing of advanced radiobiological phantoms / end-stations for RBE experiments along the Bragg peak using spot scanning or passive scattering

Development of equipment / phantoms to study the change in relative biological effectiveness along the Bragg peak.Due Date (in months): 58

Incorporation of PBT indications into Malthus decision trees

Incorporating decision trees for UK PBT indications in to Malthus model for modelling radiotherapy demand. Due Date (in months): 12

Develop tissue equivalent phantoms for monitoring dosimetry and changes in RBE along the Bragg peak

Develop materials which can be used as tissue equivalent for PBT and use 3D printing technology to build phantoms which can be used in round-robin experiments.Due Date (in months): 42

INSPIRE Access Gateway, Knowledge Hub, Help Desk and Open Access Portal

INSPIRE web portal now includes a Knowledge Hub for those interested in finding out more about PBT and for sharing best practice. Open Access Portal developed for sharing results and publications and information about INSPIRE through NA.Due Date (in months): 8

Access Gateway designed and launched

INSPIRE web portal which comprises INSPIRE Access Gateway (for NA, TNA and JRA) and is specified, designed, tested using a proto-type and then launched so it can be used by partners and the wider EU community. Due Date (in months): 6

Open Access to Research data

Open access to research data pilot

Pubblicazioni

Proton therapy and the European Particle Therapy Network: The past, present and future

Autori: D C Weber, J A Langendijk, C Grau, J Thariat
Pubblicato in: Cancer Radiotherapie, 2020, ISSN 1278-3218
Editore: Elsevier Masson

Shortening delivery times for intensity-modulated proton therapy by reducing the number of proton spots: an experimental verification

Autori: van de Water, Steven; Belosi, Maria F; Albertini, Francesca; Winterhalter, Carla; Weber, Damien C; Lomax, Antony J
Pubblicato in: Physics in Medicine & Biology, Numero 21, 2020, ISSN 0031-9155
Editore: Institute of Physics Publishing

Development of advanced preselection tools to reduce redundant plan comparisons in model-based selection of head and neck cancer patients for proton therapy

Autori: Makbule Tambas, Hans P. van der Laan, Wouter Rutgers, Johanna G.M. van den Hoek, Edwin Oldehinkel, Tineke W.H. Meijer, Arjen van der Schaaf, Daniel Scandurra, Jeffrey Free, Stefan Both, Roel J.H.M. Steenbakkers, Johannes A. Langendijk
Pubblicato in: Radiotherapy and Oncology, Numero 160, 2021, Pagina/e 61-68, ISSN 0167-8140
Editore: Elsevier BV
DOI: 10.1016/j.radonc.2021.04.012

Carbon Ion Radiobiology

Autori: Walter Tinganelli, Marco Durante
Pubblicato in: Cancers, Numero 12/10, 2020, Pagina/e 3022, ISSN 2072-6694
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers12103022

Late Side Effects in Normal Mouse Brain Tissue After Proton Irradiation

Autori: Theresa Suckert, Elke Beyreuther, Johannes Müller, Behnam Azadegan, Matthias Meinhardt, Felix Raschke, Elisabeth Bodenstein, Cläre von Neubeck, Armin Lühr, Mechthild Krause, Antje Dietrich
Pubblicato in: Frontiers in Oncology, Numero 10, 2021, ISSN 2234-943X
Editore: Frontiers Media S. A.
DOI: 10.3389/fonc.2020.598360

Ultra-high dose rate (FLASH) carbon ion irradiation: dosimetry and first cell experiments.

Autori: Walter Tinganelli; Olga Sokol; Martina Quartieri; Anggraeini Puspitasari; Ivana Dokic; Ivana Dokic; Amir Abdollahi; Amir Abdollahi; Marco Durante; Thomas Haberer; Jürgen Debus; Jürgen Debus; Daria Boscolo; Bernd Voss; Stephan Brons; Christoph Schuy; Felix Horst; Ulrich Weber
Pubblicato in: International Journal of Radiation Oncology*Biology*Physics, Numero 9, 2022, ISSN 0360-3016
Editore: Elsevier BV
DOI: 10.1016/j.ijrobp.2021.11.020

Multi-modality bedding platform for combined imaging and irradiation of mice

Autori: Johannes Müller, Michael Schürer, Christian Neubert, Falk Tillner, Elke Beyreuther, Theresa Suckert, Nils Peters, Cläre von Neubeck, Armin Lühr, Mechthild Krause, Rebecca Bütof, Antje Dietrich
Pubblicato in: Biomedical Physics & Engineering Express, Numero 6/3, 2020, Pagina/e 037003, ISSN 2057-1976
Editore: IOP Publishing
DOI: 10.1088/2057-1976/ab79f1

Heavy charged particle beam therapy and related new radiotherapy technologies: The clinical potential, physics and technical developments required to deliver benefit for patients with cancer.

Autori: Karen J. Kirkby; Karen J. Kirkby; Norman F. Kirkby; Norman F. Kirkby; Neil G. Burnet; Neil G. Burnet; Hywel Owen; Ranald I Mackay; Ranald I Mackay; Adrian Crellin; Adrian Crellin; Stuart Green
Pubblicato in: The British Journal of Radiobiology, Numero 1, 2020, Pagina/e Vol 93, No. 1116, ISSN 1748-880X
Editore: The British Institute of Radiobiology
DOI: 10.1259/bjr.20200247

Neutron Radiation Dose Measurements in a Scanning Proton Therapy Room: Can Parents Remain Near Their Children During Treatment?

Autori: Mares V, Farah J, De Saint-Hubert M, Domański S, Domingo C, Dommert M, Kłodowska M, Krzempek K, Kuć M, Martínez-Rovira I, Michaś E, Mojżeszek N, Murawski Ł, Ploc O, Romero-Expósito M, Tisi M, Trompier F, Van Hoey O, Van Ryckeghem L, Wielunski M, Harrison RM, Stolarczyk L, Olko P
Pubblicato in: Front Oncol, Numero 2234943X, 2022, Pagina/e 903706, ISSN 2234-943X
Editore: Frontiers Media S. A.
DOI: 10.3389/fonc.2022.903706

Clinically relevant nanodosimetric simulation of DNA damage complexity from photons and protons

Autori: N. T. Henthorn, J. W. Warmenhoven, M. Sotiropoulos, A. H. Aitkenhead, E. A. K. Smith, S. P. Ingram, N. F. Kirkby, A. L. Chadwick, N. G. Burnet, R. I. Mackay, K. J. Kirkby, M. J. Merchant
Pubblicato in: RSC Advances, Numero 9/12, 2019, Pagina/e 6845-6858, ISSN 2046-2069
Editore: Royal Society of Chemistry
DOI: 10.1039/c8ra10168j

Gold Nanopeanuts as Prospective Support for Cisplatin in Glioblastoma Nano-Chemo-Radiotherapy

Autori: Joanna Depciuch, Justyna Miszczyk, Alexey Maximenko, Piotr M. Zielinski, Kamila Rawojć, Agnieszka Panek, Pawel Olko, Magdalena Parlinska-Wojtan
Pubblicato in: International Journal of Molecular Sciences, Numero 21/23, 2020, Pagina/e 9082, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms21239082

Modeling Radioimmune Response—Current Status and Perspectives

Autori: Thomas Friedrich, Nicholas Henthorn, Marco Durante
Pubblicato in: Frontiers in Oncology, Numero 11, 2021, ISSN 2234-943X
Editore: Frontiers Media S. A.
DOI: 10.3389/fonc.2021.647272

Cancer risk after breast proton therapy considering physiological and radiobiological uncertainties

Autori: Apostolos Raptis, Jakob Ödén, Oscar Ardenfors, Anna M. Flejmer, Iuliana Toma-Dasu, Alexandru Dasu
Pubblicato in: Physica Medica, Numero 76, 2020, Pagina/e 1-6, ISSN 1120-1797
Editore: Istituti Editoriali e Poligrafici Internazionali
DOI: 10.1016/j.ejmp.2020.06.012

Oxygen Depletion in Proton Spot Scanning: A Tool for Exploring the Conditions Needed for FLASH

Autori: Bethany C. Rothwell, Matthew Low, Norman F. Kirkby, ,Michael J. Merchant, Amy L. Chadwick, Ranald I. Mackay, Jolyon H. Hendry and Karen J. Kirkby
Pubblicato in: Radiation 2021, 2021, ISSN 2673-592X
Editore: MDPI
DOI: 10.3390/radiation1040024

Out-of-field measurements and simulations of a proton pencil beam in a wide range of dose rates using a Timepix3 detector: Dose rate, flux and LET

Autori: Cristina Oancea, Carlos Granja, Lukas Marek, Jan Jakubek, Jaroslav Šolc, Elisabeth Bodenstein, Sebastian Gantz, Jorg Pawelke, Jiri Pivec
Pubblicato in: Physica Medica, Numero Vol 106, 2023, ISSN 1120-1797
Editore: Istituti Editoriali e Poligrafici Internazionali
DOI: 10.1016/j.ejmp.2023.102529

An Update to the Malthus Model for Radiotherapy Utilisation in England

Autori: S. Heritage, S. Sundaram, N.F. Kirkby , K.J. Kirkby, T. Mee , R. Jena
Pubblicato in: Clinical Oncolgy, Numero Vol 35, Numero 1, 2023, ISSN 0936-6555
Editore: W. B. Saunders Co., Ltd.
DOI: 10.1016/j.clon.2022.06.006

Commentary: RBE in proton therapy – where is the experimental in vivo data?

Autori: Brita Singers Sørensen
Pubblicato in: Acta Oncologica, Numero 58/10, 2019, Pagina/e 1337-1339, ISSN 0284-186X
Editore: Taylor & Francis
DOI: 10.1080/0284186x.2019.1669819

Simultaneous Measurements of Dose and Microdosimetric Spectra in a Clinical Proton Beam Using a scCVD Diamond Membrane Microdosimeter

Autori: Oluwasayo Loto, Izabella Zahradnik, Amelia Maia Leite, Ludovic De Marzi, Dominique Tromson, Michal Pomorski
Pubblicato in: Sensors, Numero 21/4, 2021, Pagina/e 1314, ISSN 1424-8220
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/s21041314

Combined proton radiography and irradiation for high-precision preclinical studies in small animals

Autori: Moritz Schneider, Elisabeth Bodenstein, Johanna Bock, Antje Dietrich, Sebastian Gantz, Lena Heuchel, Mechthild Krause, Armin Lühr, Cläre von Neubeck, Sindi Nexhipi, Michael Schürer, Falk Tillner, Elke Beyreuther, Theresa Suckert, Johannes Richard Müller
Pubblicato in: Frontiers in Oncology, 2022, ISSN 0000-0000
Editore: Frontiers
DOI: 10.3389/fonc.2022.982417

Proton beam therapy: perspectives on the National Health Service England clinical service and research programme

Autori: Neil G Burnet, Ranald I Mackay, Ed Smith, Amy L Chadwick, Gillian A Whitfield, David J Thomson, Matthew Lowe, Norman F Kirkby, Adrian M Crellin, Karen J Kirkby
Pubblicato in: The British Journal of Radiology, Numero 93/1107, 2020, Pagina/e 20190873, ISSN 0007-1285
Editore: British Institute of Radiology
DOI: 10.1259/bjr.20190873

Ultra-fast pencil beam scanning proton therapy for locally advanced non-small-cell lung cancers: Field delivery within a single breath-hold

Autori: VivekMaradia, Steven van de Water, David Meer, Damien C.Weber, Antony J.Lomax, SerenaPsoroulas
Pubblicato in: Radiotherapy and Oncology, 2022, Pagina/e 23-29, ISSN 0167-8140
Editore: Elsevier BV
DOI: 10.1016/j.radonc.2022.06.018

The Effects of Combined Exposure to Simulated Microgravity, Ionizing Radiation, and Cortisol on the In Vitro Wound Healing Process

Autori: Radstake, W.E.; Gautam, K.; Miranda, S.; Vermeesen, R.; Tabury, K.; Rehnberg, E.; Buset, J.; Janssen, A.; Leysen, L.; Neefs, M.; Verslegers, M.; Claesen, J.; van Goethem, M.-J.; Weber, U.; Fournier, C.; Parisi, A.; Brandenburg, S.; Durante, M.; Baselet, B.; Baatout, S.
Pubblicato in: Cells, 2023, ISSN 2073-4409
Editore: MDPI
DOI: 10.3390/cells12020246

Proton Radiographs Using Position-Sensitive Silicon Detectors and High-Resolution Scintillators

Autori: J. A. Briz et al
Pubblicato in: IEEE Transactions on Nuclear Science, Numero Volume 69 Numero 4, 2022, ISSN 0018-9499
Editore: Institute of Electrical and Electronics Engineers
DOI: 10.1109/tns.2022.3142618

A Monte Carlo study of different LET definitions and calculation parameters for proton beam therapy

Autori: Edward A K Smith, Carla Winterhalter, Tracy S A Underwood, Adam H Aitkenhead, Jenny C Richardson, Michael J Merchant, Norman F Kirkby, Karen J Kirby and Ranald I Mackay
Pubblicato in: Biomedical Physics & Engineering Express, Numero Vol 8, 1, 2021, ISSN 2057-1976
Editore: Institute of Physics
DOI: 10.1088/2057-1976/ac3f50

Spatial correlation of linear energy transfer and relative biological effectiveness with suspected treatment‐related toxicities following proton therapy for intracranial tumors

Autori: Jakob Ödén, Iuliana Toma‐Dasu, Petra Witt Nyström, Erik Traneus, Alexandru Dasu
Pubblicato in: Medical Physics, Numero 47/2, 2020, Pagina/e 342-351, ISSN 0094-2405
Editore: American Association of Physicists in Medicine
DOI: 10.1002/mp.13911

Simulation and experimental validation of a prototype electron beam linear accelerator for preclinical studies

Autori: Pierre Lansonneur, Vincent Favaudon, Sophie Heinrich, Charles Fouillade, Pierre Verrelle, Ludovic De Marzi
Pubblicato in: Physica Medica, Numero 60, 2019, Pagina/e 50-57, ISSN 1120-1797
Editore: Istituti Editoriali e Poligrafici Internazionali
DOI: 10.1016/j.ejmp.2019.03.016

Biomedical Research Programs at Present and Future High-Energy Particle Accelerators

Autori: Vincenzo Patera, Yolanda Prezado, Faical Azaiez, Giuseppe Battistoni, Diego Bettoni, Sytze Brandenburg, Aleksandr Bugay, Giacomo Cuttone, Denis Dauvergne, Gilles de France, Christian Graeff, Thomas Haberer, Taku Inaniwa, Sebastien Incerti, Elena Nasonova, Alahari Navin, Marco Pullia, Sandro Rossi, Charlot Vandevoorde, Marco Durante
Pubblicato in: Frontiers in Physics, Numero 8, 2020, ISSN 2296-424X
Editore: Frontiers Media
DOI: 10.3389/fphy.2020.00380

Mechanistic Modelling of Slow and Fast NHEJ DNA Repair Pathways Following Radiation for G0/G1 Normal Tissue Cells

Autori: Yaping Qi,John William Warmenhoven,Nicholas Thomas Henthorn, Samuel Peter Ingram,Xie George Xu,Karen Joy Kirkby and Michael John Merchant
Pubblicato in: Cancers 2021, Numero 13 (9), 2021, ISSN 2072-6694
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers13092202

Biological Impact of Target Fragments on Proton Treatment Plans: An Analysis Based on the Current Cross-Section Data and a Full Mixed Field Approach.

Autori: Elettra Valentina Bellinzona; Leszek Grzanka; Andrea Attili; Francesco Tommasino; Thomas Friedrich; Michael Kramer; Michael Scholz; Giuseppe Battistoni; A. Embriaco; Davide Chiappara; G.A.P. Cirrone; Giada Petringa; Marco Durante; Emanuele Scifoni
Pubblicato in: Cancers, Numero 1, 2021, ISSN 2072-6694
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers13194768

Hi-C implementation of genome structure for in silico models of radiation-induced DNA damage

Autori: Samuel P. Ingram, Nicholas T. Henthorn, John W. Warmenhoven, Norman F. Kirkby, Ranald I. Mackay, Karen J. Kirkby, Michael J. Merchant
Pubblicato in: PLOS Computational Biology, Numero 16/12, 2020, Pagina/e e1008476, ISSN 1553-7358
Editore: PLOS
DOI: 10.1371/journal.pcbi.1008476

High-precision image-guided proton irradiation of mouse brain sub-volumes

Autori: Theresa Suckert, Johannes Müller, Elke Beyreuther, Behnam Azadegan, Anja Brüggemann, Rebecca Bütof, Antje Dietrich, Malte Gotz, Robert Haase, Michael Schürer, Falk Tillner, Cläre von Neubeck, Mechthild Krause, Armin Lühr
Pubblicato in: Radiotherapy and Oncology, Numero 146, 2020, Pagina/e 205-212, ISSN 0167-8140
Editore: Elsevier BV
DOI: 10.1016/j.radonc.2020.02.023

RBE for proton radiation therapy – a Nordic view in the international perspective

Autori: Iuliana Toma-Dasu, Alexandru Dasu, Anne Vestergaard, Petra Witt Nyström, Håkan Nyström
Pubblicato in: Acta Oncologica, Numero 59/10, 2020, Pagina/e 1151-1156, ISSN 0284-186X
Editore: Taylor & Francis
DOI: 10.1080/0284186x.2020.1826573

Predicting late magnetic resonance image changes in glioma patients after proton therapy

Autori: J. Eulitz, E.G.C. Troost, F. Raschke, E. Schulz, B. Lutz, A. Dutz, S. Löck, P. Wohlfahrt, W. Enghardt, C. Karpowitz, M. Krause, A. Lühr
Pubblicato in: Acta Oncologica, Numero 58/10, 2019, Pagina/e 1536-1539, ISSN 0284-186X
Editore: Taylor & Francis
DOI: 10.1080/0284186x.2019.1631477

Beam pulse structure and dose rate as determinants for the flash effect observed in zebrafish embryo

Autori: Leonhard Karsch, Jörg Pawelke, Michael Brand, Stefan Hans, Katalin Hideghéty, Jeannette Jansen, Elisabeth Lessmann, Steffen Löck, Michael Schürer, Rico Schurig, Joao Seco, Emília Rita Szabó, Elke Beyreuther
Pubblicato in: Radiotherapy and Oncology, 2022, Pagina/e 49-54, ISSN 0167-8140
Editore: Elsevier BV
DOI: 10.1016/j.radonc.2022.05.025

Does the uncertainty in relative biological effectiveness affect patient treatment in proton therapy?

Autori: Brita S. Sørensen, Jörg Pawelke, Julia Bauer, Neil G. Burnet, Alexandru Dasu, Morten Høyer, Christian P. Karger, Mechthild Krause, Marco Schwarz, Tracy S.A. Underwood, Dirk Wagenaar, Gillian A. Whitfield, Armin Lühr
Pubblicato in: Radiotherapy and Oncology, Numero 163, 2021, Pagina/e 177-184, ISSN 0167-8140
Editore: Elsevier BV
DOI: 10.1016/j.radonc.2021.08.016

Mapping the Future of Particle Radiobiology in Europe: The INSPIRE Project

Autori: Nicholas T. Henthorn, Olga Sokol, Marco Durante, Ludovic De Marzi, Frederic Pouzoulet, Justyna Miszczyk, Pawel Olko, Sytze Brandenburg, Marc Jan van Goethem, Lara Barazzuol, Makbule Tambas, Johannes A. Langendijk, Marie Davídková, Vladimír Vondráĉek, Elisabeth Bodenstein, Joerg Pawelke, Antony J. Lomax, Damien C. Weber, Alexandru Dasu, Bo Stenerlöw, Per R. Poulsen, Brita S. Sørensen, Cai Gr
Pubblicato in: Frontiers in Physics, Numero 8, 2020, ISSN 2296-424X
Editore: Frontiers Media
DOI: 10.3389/fphy.2020.565055

Determining the parameter space for effective oxygen depletion for FLASH radiation therapy

Autori: B C Rothwell, N F Kirkby, M J Merchant, A L Chadwick, M Lowe, R I Mackay, J H Hendry, K J Kirkby
Pubblicato in: Physics in Medicine & Biology, Numero 66/5, 2021, Pagina/e 055020, ISSN 0031-9155
Editore: Institute of Physics Publishing
DOI: 10.1088/1361-6560/abe2ea

A computational approach to quantifying miscounting of radiation-induced double-strand break immunofluorescent foci

Autori: Samuel P. Ingram; John-William Warmenhoven; Nicholas T. Henthorn; Amy L. Chadiwck; Elham E. Santina; Stephen J. McMahon; Jan Schuemann; Norman F. Kirkby; Ranald I. Mackay; Karen J. Kirkby; Michael J. Merchant
Pubblicato in: Communications Biology, Numero 1, 2022, Pagina/e 5 Article number: 700 (2022), ISSN 2399-3642
Editore: Communications Biology
DOI: 10.1038/s42003-022-03585-5

Estimating the percentage of patients who might benefit from proton beam therapy instead of X-ray radiotherapy

Autori: Neil G Burnet, Thomas Mee, Simona Gaito, Norman F Kirkby, Adam H Aitkenhead, Carmel N Anandadas, Marianne C Aznar, Lisa H Barraclough, Gerben Borst, Frances C Charlwood, Matthew Clarke, Rovel J Colaco, Adrian M Crellin, Noemie N Defourney, Christina J Hague, Margaret Harris, Nicholas T Henthorn, Kirsten I Hopkins, E Hwang, Sam P Ingram, Karen J Kirkby, Lip W Lee, David Lines, Zoe Lingard, Matthew
Pubblicato in: British Journal of Radiology, Numero Br J Radiol 2022; 95: 20211175, 2022, ISSN 0007-1285
Editore: British Institute of Radiology
DOI: 10.1259/bjr.20211175

Comparative Proton and Photon Irradiation Combined with Pharmacological Inhibitors in 3D Pancreatic Cancer Cultures

Autori: Josephine Görte, Elke Beyreuther, Erik H. J. Danen, Nils Cordes
Pubblicato in: Cancers, Numero 12/11, 2020, Pagina/e 3216, ISSN 2072-6694
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers12113216

3D high resolution clonogenic survival measurement of xrs-5 cells in low-dose region of carbon ion plans

Autori: Dea Kartini, Olga Sokol, Chutima Talabnin, Chinorat Kobdaj, Marco Durante, Michael Krämer, Martina Fuss
Pubblicato in: International Journal of Radiation Biology, 2022, ISSN 0955-3002
Editore: Taylor & Francis
DOI: 10.1080/09553002.2022.2110318

Spread-out Bragg Peak in Spatially Fractionated Proton Therapy

Autori: A.Toboła, J. Swakoń, P. Olko
Pubblicato in: Acta Phys. Pol. B, 2022, Pagina/e Proc. Suppl. 15, 4-A3, ISSN 2082-7865
Editore: Jagiellonian University
DOI: 10.5506/aphyspolbsupp.15.4-a3

Simulation and experimental verification of ambient neutron doses in a pencil beam scanning proton therapy room as function of treatment plan parameters

Autori: Van Hoey O, Stolarczyk L, Lillhök J, Eliasson L, Mojzeszek N, Liszka M, Alkhiat A, Mares V, Trompier F, Trinkl S, Martínez-Rovira I, Romero-Expósito M, Ploc O, Harrison R, Olko P
Pubblicato in: Front Oncol, Numero 2234943X, 2022, Pagina/e 903537, ISSN 2234-943X
Editore: Frontiers Media S. A.
DOI: 10.3389/fonc.2022.903537

Harnessing radiation to improve immunotherapy: better with particles?

Autori: Marco Durante, Silvia Formenti
Pubblicato in: The British Journal of Radiology, Numero 93/1107, 2020, Pagina/e 20190224, ISSN 0007-1285
Editore: British Institute of Radiology
DOI: 10.1259/bjr.20190224

Applying Tissue Slice Culture in Cancer Research—Insights from Preclinical Proton Radiotherapy

Autori: Theresa Suckert, Treewut Rassamegevanon, Johannes Müller, Antje Dietrich, Antonia Graja, Michael Reiche, Steffen Löck, Mechthild Krause, Elke Beyreuther, Cläre von Neubeck
Pubblicato in: Cancers, Numero 12/6, 2020, Pagina/e 1589, ISSN 2072-6694
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
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Secondary neutron dose contribution from pencil beam scanning, scattered and spatially fractionated proton therapy.

Autori: A. M. M. Leite; A. M. M. Leite; M G Ronga; M Giorgi; Y Ristic; Yann Perrot; François Trompier; Yolanda Prezado; G Créhange; L. De Marzi; L. De Marzi
Pubblicato in: Physics in Medicine & Biology, Numero 1, 2021, ISSN 0031-9155
Editore: Institute of Physics Publishing
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Hibernation and Radioprotection: Gene Expression in the Liver and Testicle of Rats Irradiated under Synthetic Torpor

Autori: Walter Tinganelli, Timna Hitrec, Fabrizio Romani, Palma Simoniello, Fabio Squarcio, Agnese Stanzani, Emiliana Piscitiello, Valentina Marchesano, Marco Luppi, Maximiliano Sioli, Alexander Helm, Gaetano Compagnone, Alessio Morganti, Roberto Amici, Matteo Negrini, Antonio Zoccoli, Marco Durante, Matteo Cerri
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Editore: Multidisciplinary Digital Publishing Institute (MDPI)
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In Vitro Comparison of Passive and Active Clinical Proton Beams

Autori: Anna Michaelidesová, Jana Vachelová, Jana Klementová, Tomáš Urban, Kateřina Pachnerová Brabcová, Stanislav Kaczor, Martin Falk, Iva Falková, Daniel Depeš, Vladimír Vondráček, Marie Davídková
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Editore: Multidisciplinary Digital Publishing Institute (MDPI)
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Combined Systemic Drug Treatment with Proton Therapy: Investigations on Patient-Derived Organoids

Autori: Max Naumann, Tabea Czempiel, Anna Jana Lößner, Kristin Pape, Elke Beyreuther, Steffen Löck, Stephan Drukewitz, Alexander Hennig, Cläre von Neubeck, Barbara Klink, Mechthild Krause, Doreen William, Daniel E. Stange, Rebecca Bütof, Antje Dietrich
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Editore: Multidisciplinary Digital Publishing Institute (MDPI)
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A Decision Support Tool to Optimize Selection of Head and Neck Cancer Patients for Proton Therapy

Autori: Makbule Tambas,Hans Paul van der Laan, Arjen van der Schaaf, Roel J. H. M. Steenbakkers and Johannes Albertus Langendijk
Pubblicato in: Cancers, 2022, ISSN 2072-6694
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
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Radiomics-based tumor phenotype determination based on medical imaging and tumor microenvironment in a preclinical setting

Autori: Johannes Müller, Stefan Leger, Alex Zwanenburg, Theresa Suckert, Armin Lühr, Elke Beyreuther, Cläre von Neubeck, Mechthild Krause, Steffen Löck, Antje Dietrich, Rebecca Bütof
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Pencil beam scanning proton FLASH maintains tumor control while normal tissue damage is reduced in a mouse model

Autori: Brita Singers Sørensen, Mateusz Krzysztof Sitarz, Christina Ankjærgaard, Jacob G. Johansen, Claus E. Andersen, Eleni Kanouta, Cai Grau, Per Poulsen
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The suitability of micronuclei as markers of relative biological effect

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Editore: Oxford University Press
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Evaluating very high energy electron RBE from nanodosimetric pBR322 plasmid DNA damage

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Virus Irradiation and COVID-19 Disease

Autori: Marco Durante, Kai Schulze, Sebastien Incerti, Ziad Francis, Sara Zein, Carlos Alberto Guzmán
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Reduction of Lung Metastases in a Mouse Osteosarcoma Model Treated With Carbon Ions and Immune Checkpoint Inhibitors

Autori: Alexander Helm, Walter Tinganelli, Palma Simoniello, Fuki Kurosawa, Claudia Fournier, Takashi Shimokawa, Marco Durante
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Advanced Sandwich Composite Cores for Patient Support in Advanced Clinical Imaging and Oncology Treatment

Autori: Robert H. Morris, Nicasio R. Geraldi, Lucy C. Pike, Jörg Pawelke, Aswin L. Hoffmann, Nicola Doy, Johanna L. Stafford, Abi Spicer, Michael I. Newton
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Uncertainty of RBE Model in Proton Radiotherapy Based on $\frac {\alpha }{\beta }$ Ratio and Linear Energy Transfer

Autori: K. Jeleń, L. Grzanka, P. Olko
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Experimental characterisation of a proton kernel model for pencil beam scanning techniques

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Impact of spot reduction on the effectiveness of rescanning in pencil beam scanned proton therapyfor mobile tumours

Autori: Stefanie Bertschi6, Miriam Krieger, Damien C Weber, Antony J Lomax and Steven van de Water
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Editore: Institute of Physics Publishing
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Characterization of 2D Al2O3:C,Mg radiophotoluminescence films in charged particle beams

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Water Equivalence of Various 3D Printed Materials for Proton Therapy --- Monte Carlo Simulation, Treatment Planning Modelling and Validation by Measurements

Autori: A. Wochnik, J. Swakoń, P. Olko
Pubblicato in: Acta Physica Polonica B, Numero 51/1, 2020, Pagina/e 409, ISSN 0587-4254
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Out-of-field doses for scanning proton radiotherapy of shallowly located paediatric tumours—a comparison of range shifter and 3D printed compensator

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Editore: Institute of Physics Publishing
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First experimental measurements of 2D microdosimetry maps in proton therapy

Autori: Consuelo Guardiola, Diana Bachiller-Perea, Emmanuel M. Mate Kole, Celeste Fleta, David Quirion, Ludovic De Marzi, Faustino Gómez
Pubblicato in: European Journal of Medical Physics, Numero Vol 50, Numero 1, 2022, ISSN 2473-4209
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Tumour irradiation in mice with a laser-accelerated proton beam

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Metallic Nanoparticles: A Useful Prompt Gamma Emitter for Range Monitoring in Proton Therapy?

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Editore: Multidisciplinary Digital Publishing Institute (MDPI)
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Does FLASH deplete oxygen? Experimental evaluation for photons, protons, and carbon ions

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Editore: American Association of Physicists in Medicine
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Beam Monitor Calibration for Radiobiological Experiments With Scanned High Energy Heavy Ion Beams at FAIR

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Validation of a pseudo-3D phantom for radiobiological treatment plan verifications

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Editore: IOP Science
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Particle therapy in Europe

Autori: Cai Grau, Marco Durante, Dietmar Georg, Johannes A. Langendijk, Damien C. Weber
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Nanomaterials as Ultrasound Theragnostic Tools for Heart Disease Treatment/Diagnosis

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OC-0563 First experience with the model-based selection of head and neck cancer patients for proton therapy

Autori: M. Tambas, H.P. Van der Laan, J.G.M. Van den Hoek, H.P. Bijl, M. Dieters, R.G.J. Kierkels, D. Scandurra, S. Both, R.J.H.M. Steenbakkers, J.A. Langendijk
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A quantitative FLASH effectiveness model to reveal potentials and pitfalls of high dose rate proton therapy

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Proposing a Clinical Model for RBE Based on Proton Track-End Counts

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Influence of Therapeutic Proton Beam on Glioblastoma Multiforme Proliferation Index — A Preliminary Study

Autori: A.M. Bogdali-Suślik, K. Rawojć, J. Miszczyk, A. Panek, M. Woźniak, K. Szewczyk, T. Książek, M. Bik-Multanowski, J. Swakoń, W. Komenda, N. Mojżeszek, T. Kajdrowicz, R. Kopeć, P. Olko
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Evolution of the hypoxic compartment on sequential oxygen partial pressure maps during radiochemotherapy in advanced head and neck cancer

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First experience with model-based selection of head and neck cancer patients for proton therapy

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Towards FLASH proton therapy: the impact of treatment planning and machine characteristics on achievable dose rates

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Insights into the non-homologous end joining pathway and double strand break end mobility provided by mechanistic in silico modelling

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The European Joint Research Project UHDpulse - Metrology for advanced radiotherapy using particle beams with ultra-high pulse dose rates.

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Current practice in proton therapy delivery in adult cancer patients across Europe

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In vivo validation and tissue sparing factor for acute damage of pencil beam scanning proton FLASH

Autori: Brita Singers Sørensen, Mateusz Krzysztof Sitarz, Christina Ankjærgaard, Jacob Johansen, Claus E Andersen, Eleni Kanouta, Cathrine Overgaard, Cai Grau, Per Poulsen
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Cellular plasticity upon proton irradiation determines tumor cell radiosensitivity

Autori: Iñaki Schniewind, Wahyu Wijaya Hadiwikarta, JuliaGrajek, Jan Poleszczuk, Susan Richter, Mirko Peitzsch, Johannes Müller, Daria Klusa, Elke Beyreuther, Steffen Löck, Armin Lühr, Susanne Frosch, Christer Groeben, Ulrich Sommer, Mechthild Krause, Anna Dubrovska, Cläre von Neubeck, Ina Kurth, Claudia Peitzsch
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Towards harmonizing clinical linear energy transfer (LET) reporting in proton radiotherapy: a European multi-centric study

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In Silico Models of DNA Damage and Repair in Proton Treatment Planning: A Proof of Concept

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The Effect of Ionizing Radiation on MCF-7 Breast Cancer Cell Line

Autori: Agnė Bartnykaitė, Rasa Ugenskienė, Arturas Inčiūra, Elona Juozaitytė
Pubblicato in: 2020
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Patient-specific 3D printed compensators for proton pencil beam scanning of shallow situated tumours

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Pubblicato in: 2018
Editore: ENLIGHT

Optimization of Preselection Process in Model-based Selection for Proton Therapy in Head & Neck Cancer

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Flash modalities track (oral presentations) flat panel proton radiography in high-precision image-guided mouse brain proton irradiation

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Spatially fractionated proton therapy of eye cancer: Feasibility studies

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INSPIRE: Infrastructure in proton international research – A new horizon 2020 network

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Modelling framework for FMISO and FDG PET imaging tailored dose prescription

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Editore: ESTRO38

In vitro measurements of proton rbe: a multi-centric comparison of experimental procedures and results

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Protontherapy Therapeutic Window Widening By Pbct And Flash Modalities - Epd020

Autori: Pavel Bláha, Lorenzo Manti, Ludovic de Marzi, Frédérique Mégnin-Chanet, Amélia Maia Leite, Annalisa Patriarca, Valerio Ricciardi, Katarína Michaličková
Pubblicato in: European Journal of Medical Physics, 2022, ISSN 1120-1797
Editore: Physica Medica
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FLASH Modalities Track (Oral Presentations) SPECTRAL- AND INTENSITY-SENSITIVE CHARACTERIZATION OF PULSED FLASH PROTON FIELDS WITH THE PIXEL DETECTOR TIMEPIX3

Autori: C. Oancea E. Bodenstein C. Granja J. Jakubek L. Marek J. Pawelke J. Pivec S. Polansky J. Šolc
Pubblicato in: Physics Medica, European Journal of Medical Physics, 2022, ISSN 1120-1797
Editore: Istituti Editoriali e Poligrafici Internazionali
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Dosimetry of primary beam and scattered radiation in proton therapy

Autori: Pawel Olko
Pubblicato in: IFJ Pan, 2020
Editore: IFJ Pan

Flash modalities track (oral presentations) ultra-high dose rate beam monitoring and control for a varian probeam system

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Editore: Istituti Editoriali e Poligrafici Internazionali
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Does FLASH deplete Oxygen? Experimental Evaluation for Photons, Protons and Carbon Ions

Autori: Jansen, Jeannette; Knoll, Jan; Beyreuther, Elke; Pawelke, Jörg; Skuza, Raphael; Hanley, Rachel; Brons, Stephan; Pagliari, Francesca; Seco, Joao
Pubblicato in: Numero 3, 2021
Editore: Cornell University

Using Comprehensive Relative-Biological-Effectiveness Simulations to Assess the Potential Clinical Gain of FLASH Proton Therapy

Autori: S van de Water, S Fabiano, N Bizzocchi, S Safai, D Weber, A Mazal, J Unkelbach, A Lomax
Pubblicato in: 2020 Joint APPM/Comp Meeting, 2020
Editore: APPM

An ion chamber array for easy assessment of flash proton fields

Autori: L.StolarczykM.SitarzI.HuthP.PoulsenT.Pfeiler
Pubblicato in: Physica Medica, 2022, Pagina/e S79, ISSN 1120-1797
Editore: Istituti Editoriali e Poligrafici Internazionali
DOI: 10.1016/s1120-1797(22)01613-1

Flash modalities track (oral presentations) preliminary results of dosimetry audit of active scanning proton beam

Autori: M. Davídková, A. Dasu, C. De Angelis, L. De Marzi, M. De Saint-Hubert, D. Ekendahl, A. Jelínek Michaelidesová, Ž. Knežević, P. Kukolowicz, M. Liszka, S. Lorentini, A. Maia Leite, M. Majer, B. Michalec, M. Navrátil, B. Reniers, M.J. Van Goethem, A. Vestergaard, G. Vilches-Freixas, V. Vondráček, L. Stolarczyk, P. Olko
Pubblicato in: Physica Medica, 2022, Pagina/e S57, ISSN 1120-1797
Editore: Istituti Editoriali e Poligrafici Internazionali
DOI: 10.1016/s1120-1797(22)01562-9

Assessment of the Probability of Tumour Control for Prescribed Doses Based on Imaging of Oxygen Partial Pressure

Autori: Ana Ureba, Emely Kjellsson Lindblom, Iuliana Toma-Dasu, Alexandru Dasu, Marta Lazzeroni
Pubblicato in: Oxygen Transport to Tissue XLII, Numero 1269, 2021, Pagina/e 185-190, ISBN 978-3-030-48236-7
Editore: Springer International Publishing
DOI: 10.1007/978-3-030-48238-1_29

Extending of the pytrip software package for biologically optimized proton radiotherapy

Autori: Leszek Grzanka, Kinga Jeleń1, Łukasz Jeleń, Arkadiusz Ćwikła, Michał Krawczyk, Joanna Fortuna, Mateusz Łaszczyk, Paweł Olko
Pubblicato in: 2021
Editore: The Henryk Niewodniczański INSTITUTE OF NUCLEAR PHYSICS Polish Academy of Sciences

An In Silico Model of DNA Repair for Investigation of Mechanisms in Non-Homologous End Joining

Autori: Ranald I Mackay; Nicholas T. Henthorn; Marios Sotiropoulos; J.W. Warmenhoven; Karen J. Kirkby; Sergei Fedotov; Michael J. Merchant; Nickolay Korabel
Pubblicato in: Numero 1, 2018
Editore: bioRxiv
DOI: 10.1101/318139

Towards incorporation of RBE uncertainty in proton therapy planning systems

Autori: Leszek Grzanka , Kinga Jeleń, Michael P.R. Waligórski
Pubblicato in: 2019
Editore: The Henryk Niewodniczański INSTITUTE OF NUCLEAR PHYSICS Polish Academy of Sciences

An Industry/Academic Partnership Yields Fruit: An Ultra-High Dose Rate Beam Monitoring Tool for FLASH Trials

Autori: Varian Medical Systems, Inc.
Pubblicato in: 2021
Editore: 12

Cell responses to ionizing radiation: current research at Lithuania University of Health Sciences and future perspectives with “Inspire” project

Autori: Juozaitytė, Elona;Bartnykaitė, Agnė;Laukaitienė, Danguolė;Ugenskienė, Rasa
Pubblicato in: Rīga Stradiņš University International conference on Medical and Health Care Sciences, Numero Knowledge for Use in Practice: abstracts, 2019, Pagina/e Conference Section Oncology and Haematology
Editore: Rīga Stradiņš University

Diritti di proprietà intellettuale

Method of obtaining a system containing gold nanomolecules and application of such system in anticancer therapy

Numero candidatura/pubblicazione: 43 199619
Data: 2019-11-28
Candidato/i: THE HENRYK NIEWODNICZANSKI INSTITUTE OF NUCLEAR PHYSICS, POLISH ACADEMY OF SCIENCES

DEVICE FOR CONTAINING ANIMALS DURING IRRADIATION BY A PROTON BEAM

Numero candidatura/pubblicazione: 20 22065951
Data: 2022-06-13
Candidato/i: UNIVERSITE DE NAMUR ASBL

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