Targeting TGF-β activation, likely the core mechanism of immunosuppression by human regulatory T cells.

Publicaciones

Cutting Edge: Active TGF-β1 Released from GARP/TGF-β1 Complexes on the Surface of Stimulated Human B Lymphocytes Increases Class-Switch Recombination and Production of IgA

Autores: Olivier Dedobbeleer, Julie Stockis, Bas van der Woning, Pierre G. Coulie, Sophie Lucas
Publicado en: The Journal of Immunology, Edición 199/2, 2017, Página(s) 391-396, ISSN 0022-1767
Editor: American Association of Immunologists
DOI: 10.4049/jimmunol.1601882

Blocking immunosuppression by human Tregs in vivo with antibodies targeting integrin αVβ8

Autores: Julie Stockis, Stéphanie Liénart, Didier Colau, Amandine Collignon, Stephen L. Nishimura, Dean Sheppard, Pierre G. Coulie, Sophie Lucas
Publicado en: Proceedings of the National Academy of Sciences, Edición 114/47, 2017, Página(s) E10161-E10168, ISSN 0027-8424
Editor: National Academy of Sciences
DOI: 10.1073/pnas.1710680114

Structural basis of latent TGF-β1 presentation and activation by GARP on human regulatory T cells

Autores: Stéphanie Liénart, Romain Merceron, Christophe Vanderaa, Fanny Lambert, Didier Colau, Julie Stockis, Bas van der Woning, Hans De Haard, Michael Saunders, Pierre G. Coulie, Savvas N. Savvides, Sophie Lucas
Publicado en: Science, Edición 362/6417, 2018, Página(s) 952-956, ISSN 0036-8075
Editor: American Association for the Advancement of Science
DOI: 10.1126/science.aau2909

Selective inhibition of TGF-β1 produced by GARP-expressing Tregs overcomes resistance to PD-1/PD-L1 blockade in cancer

Autores: Grégoire de Streel, Charlotte Bertrand, Nicolas Chalon, Stéphanie Liénart, Orian Bricard, Sara Lecomte, Julien Devreux, Mélanie Gaignage, Gitte De Boeck, Lore Mariën, Inge Van De Walle, Bas van der Woning, Michael Saunders, Hans de Haard, Elien Vermeersch, Wim Maes, Hans Deckmyn, Pierre G. Coulie, Nicolas van Baren, Sophie Lucas
Publicado en: Nature Communications, Edición 11/1, 2020, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-020-17811-3

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