Targeting TGF-β activation, likely the core mechanism of immunosuppression by human regulatory T cells.

Informazioni relative al progetto

TARG-SUP

ID dell’accordo di sovvenzione: 682818

DOI 10.3030/682818

Progetto chiuso

Data della firma CE 21 Marzo 2016

Data di avvio 1 Aprile 2016

Data di completamento 31 Marzo 2021

Finanziato da

• EXCELLENT SCIENCE - European Research Council (ERC)

Costo totale € 1 993 125,00

Contributo UE € 1 993 125,00

Coordinato da

UNIVERSITE CATHOLIQUE DE LOUVAIN
Belgium

Pubblicazioni

Peer reviewed articles (4)

Cutting Edge: Active TGF-β1 Released from GARP/TGF-β1 Complexes on the Surface of Stimulated Human B Lymphocytes Increases Class-Switch Recombination and Production of IgA

Autori: Olivier Dedobbeleer, Julie Stockis, Bas van der Woning, Pierre G. Coulie, Sophie Lucas
Pubblicato in: The Journal of Immunology, Numero 199/2, 2017, Pagina/e 391-396, ISSN 0022-1767
Editore: American Association of Immunologists
DOI: 10.4049/jimmunol.1601882

Blocking immunosuppression by human Tregs in vivo with antibodies targeting integrin αVβ8

Autori: Julie Stockis, Stéphanie Liénart, Didier Colau, Amandine Collignon, Stephen L. Nishimura, Dean Sheppard, Pierre G. Coulie, Sophie Lucas
Pubblicato in: Proceedings of the National Academy of Sciences, Numero 114/47, 2017, Pagina/e E10161-E10168, ISSN 0027-8424
Editore: National Academy of Sciences
DOI: 10.1073/pnas.1710680114

Structural basis of latent TGF-β1 presentation and activation by GARP on human regulatory T cells

Autori: Stéphanie Liénart, Romain Merceron, Christophe Vanderaa, Fanny Lambert, Didier Colau, Julie Stockis, Bas van der Woning, Hans De Haard, Michael Saunders, Pierre G. Coulie, Savvas N. Savvides, Sophie Lucas
Pubblicato in: Science, Numero 362/6417, 2018, Pagina/e 952-956, ISSN 0036-8075
Editore: American Association for the Advancement of Science
DOI: 10.1126/science.aau2909

Selective inhibition of TGF-β1 produced by GARP-expressing Tregs overcomes resistance to PD-1/PD-L1 blockade in cancer

Autori: Grégoire de Streel, Charlotte Bertrand, Nicolas Chalon, Stéphanie Liénart, Orian Bricard, Sara Lecomte, Julien Devreux, Mélanie Gaignage, Gitte De Boeck, Lore Mariën, Inge Van De Walle, Bas van der Woning, Michael Saunders, Hans de Haard, Elien Vermeersch, Wim Maes, Hans Deckmyn, Pierre G. Coulie, Nicolas van Baren, Sophie Lucas
Pubblicato in: Nature Communications, Numero 11/1, 2020, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-020-17811-3