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Novel biocontrol agents for insect pests from neuroendocrinology

Objetivo

Insects are the most diverse Class of life on earth, and different insects can be essential for, or highly damaging to, agriculture, horticulture and forestry. There is a pressing need, not just for new insecticides to combat resistance, but more specific, “greener” insecticides that target deleterious insects while sparing beneficial ones. This proposal aims to identify such insecticides by turning the insects’ own hormones against them, both by designing artificial neuropeptide “mimetic” analogs as candidate compounds, and by generating transgenic insects that carry deleterious neuropeptide payloads within them, that can propagate through a population and impact on survival at times of stress.

We have assembled an international multi-actor consortium from EU member and associated member states, as well as a third country partner, with unparalleled experience in insect functional genomics, neuropeptide physiology, synthetic chemistry and synthetic biology, and in field-testing of candidates. Established links to agricultural, horticultural and forestry end-users, agencies/advisors and our SME partners ensure relevance to user need; and set out a pathway to exploitation and implementation of our results, for impact across three major economic sectors in the EU and globally.

We will deliver novel, ‘green’ neuropeptide-based insect pest biocontrol tools by:
• utilising ‘beyond the State-of-the-Art’ technologies based on two approaches: rational design of neuropeptide hormone analogues; and development of genetically-encoded neuropeptides for translational insect synthetic biology in genetic pest management.
• bridging outstanding research and technology in neuroendocrinology and genetics to end user need, to ultimately produce neuropeptide hormone analogues and genetic pest management biocontrol tools.
• validating and demonstrating these novel insect biocontrol agents in laboratory, field and forest applications, based on user need and a market-driven approach.

Convocatoria de propuestas

H2020-SFS-2014-2015

Consulte otros proyectos de esta convocatoria

Convocatoria de subcontratación

H2020-SFS-2014-2

Régimen de financiación

RIA - Research and Innovation action

Coordinador

UNIVERSITY OF GLASGOW
Aportación neta de la UEn
€ 2 318 875,00
Dirección
UNIVERSITY AVENUE
G12 8QQ Glasgow
Reino Unido

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Región
Scotland West Central Scotland Glasgow City
Tipo de actividad
Higher or Secondary Education Establishments
Enlaces
Coste total
€ 2 318 875,00

Participantes (13)