Ziel
Despite the increasing number of macromolecules with potential impact in the treatment of devastating systemic diseases, these therapies have failed to deliver on their expectations because they cannot be administered in the fashion which is most cost efficient and has the highest patient compliance: the oral route. The availability of an oral form of administration could lead to a great improvement of classical therapies and it would also make a high number of new therapies feasible. To make this happen, the final objective of Trans-INT is to design nanocarriers specifically adapted to deal with the gastrointestinal ecosystem and use them for the development of new oral nanomedicines for diseases with high socioeconomic impact (i.e. metabolic diseases, pain medication).
The concept behind TRANS-INT is the rational design of oral nanomedicines based on safety, mechanistic, bioengineering (multifunctional nanocarriers: high payload, drug protection, efficient drug transport, controlled release) and pharmaceutical technology criteria (scalable technology and stability). The project will start with nanocarrier platforms on which the partners have IPR and freedom to operate: nanocapsules, nanoparticles, micelles made of combinations of lipids, polypeptides and polysaccharides, continue with the optimization and redefinition of selected nanocarriers. It is expected to end with (i) at least one oral nanocarrier prototype with a comprehensive GLP-tox package, which could be applied for the delivery of a high number of peptide molecules, (ii) at least one nanomedicine fulfilling target product profile criteria, with a comprehensive preclinical evaluation package, (iii) substantial integrative knowledge on the feasibility and potential of oral nanocarriers and nanopharmaceuticals. TRANS-INT is expected to have a great impact no only from the new therapies/patients perspective but also from the innovation and EU industrial development perspective.
Wissenschaftliches Gebiet
- medical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugs
- natural sciencesbiological sciencesbiochemistrybiomoleculeslipids
- medical and health sciencesmedical biotechnologynanomedicine
- natural sciencesbiological sciencesbiochemistrybiomoleculescarbohydrates
- engineering and technologynanotechnologynano-materials
Programm/Programme
Aufforderung zur Vorschlagseinreichung
FP7-NMP-2011-LARGE-5
Andere Projekte für diesen Aufruf anzeigen
Finanzierungsplan
CP-IP - Large-scale integrating projectKoordinator
15782 Santiago De Compostela
Spanien
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Beteiligte (17)
4 Dublin
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1348 Louvain La Neuve
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75015 PARIS 15
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WC1E 6BT LONDON
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08028 Barcelona
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35131 Padova
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9 DUBLIN
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49035 Angers Cedex 01
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30625 Hannover
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08028 Barcelona
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751 05 Uppsala
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35128 Padova
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1125 Budapest
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94250 GENTILLY
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4070 Basel
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T12 YN60 Cork
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36030 Monte Di Malo
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