New Oral Nanomedicines: Transporting Therapeutic Macromolecules across the Intestinal Barrier

Project Information

TRANS-INT

Grant agreement ID: 281035

Project closed

Start date 1 May 2012

End date 30 April 2017

Funded under

• Specific Programme "Cooperation": Nanosciences, Nanotechnologies, Materials and new Production Technologies

Total cost € 10 748 102,64

EU contribution € 8 000 000,00

Coordinated by

UNIVERSIDAD DE SANTIAGO DE COMPOSTELA
Spain

Objective

Despite the increasing number of macromolecules with potential impact in the treatment of devastating systemic diseases, these therapies have failed to deliver on their expectations because they cannot be administered in the fashion which is most cost efficient and has the highest patient compliance: the oral route. The availability of an oral form of administration could lead to a great improvement of classical therapies and it would also make a high number of new therapies feasible. To make this happen, the final objective of Trans-INT is to design nanocarriers specifically adapted to deal with the gastrointestinal ecosystem and use them for the development of new oral nanomedicines for diseases with high socioeconomic impact (i.e. metabolic diseases, pain medication).

The concept behind TRANS-INT is the rational design of oral nanomedicines based on safety, mechanistic, bioengineering (multifunctional nanocarriers: high payload, drug protection, efficient drug transport, controlled release) and pharmaceutical technology criteria (scalable technology and stability). The project will start with nanocarrier platforms on which the partners have IPR and freedom to operate: nanocapsules, nanoparticles, micelles made of combinations of lipids, polypeptides and polysaccharides, continue with the optimization and redefinition of selected nanocarriers. It is expected to end with (i) at least one oral nanocarrier prototype with a comprehensive GLP-tox package, which could be applied for the delivery of a high number of peptide molecules, (ii) at least one nanomedicine fulfilling target product profile criteria, with a comprehensive preclinical evaluation package, (iii) substantial integrative knowledge on the feasibility and potential of oral nanocarriers and nanopharmaceuticals. TRANS-INT is expected to have a great impact no only from the new therapies/patients perspective but also from the innovation and EU industrial development perspective.

Fields of science

Not validated

• medical and health sciences › basic medicine › pharmacology and pharmacy › pharmaceutical drugs
• natural sciences › biological sciences › biochemistry › biomolecules › lipids
• medical and health sciences › medical biotechnology › nanomedicine
• natural sciences › biological sciences › biochemistry › biomolecules › carbohydrates
• engineering and technology › nanotechnology › nano-materials

Programme(s)

• FP7-NMP - Specific Programme "Cooperation": Nanosciences, Nanotechnologies, Materials and new Production Technologies

Topic(s)

• NMP.2011.1.2-2 - New targeted therapy using nanotechnology for transport of macro-molecules across biological barriers

Call for proposal

FP7-NMP-2011-LARGE-5
See other projects for this call

Funding Scheme

CP-IP - Large-scale integrating project

Coordinator

UNIVERSIDAD DE SANTIAGO DE COMPOSTELA

• EU contribution: € 1 665 013,76
• Address: COLEXIO DE SAN XEROME PRAZA DO OBRADOIRO S/N ; 15782 Santiago De Compostela ; Spain
• Region: Noroeste › Galicia › A Coruña
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Martin Cacheiro Martinez (Mr.)
• Total cost: No data

Participants (17)

UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN

Ireland

• EU contribution: € 654 159,40
• Address: BELFIELD ; 4 Dublin
• Region: Ireland › Eastern and Midland › Dublin
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Donal Doolan (Mr.)
• Total cost: No data

UNIVERSITE CATHOLIQUE DE LOUVAIN

Belgium

• EU contribution: € 506 920,00
• Address: PLACE DE L UNIVERSITE 1 ; 1348 Louvain La Neuve
• Region: Région wallonne › Prov. Brabant Wallon › Arr. Nivelles
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Véronique Préat (Prof.)
• Total cost: No data

COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES

France

• EU contribution: € 355 755,23
• Address: RUE LEBLANC 25 ; 75015 PARIS 15
• Region: Ile-de-France › Ile-de-France › Paris
• Activity type: Research Organisations
• Administrative Contact: Aloïse Mabondzo (Dr.)
• Total cost: No data

UNIVERSITY COLLEGE LONDON

• EU contribution: € 699 576,00
• Address: GOWER STREET ; WC1E 6BT LONDON
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Greta Borg-Carbott (Ms.)
• Total cost: No data

ADVANCELL ADVANCED IN VITRO CELL TECHNOLOGIES S.A

Participation ended

Spain

• EU contribution: No data
• Address: CALLE BALDARI I REIXACH 10 ; 08028 Barcelona
• Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Administrative Contact: Vila Pena Ana Isabel (Dr.)
• Total cost: No data

VENETO NANOTECH SOCIETA CONSORTILEPER AZIONI

Participation ended

Italy

• EU contribution: € 117 477,29
• Address: PIAZZA SALVEMINI 13 ; 35131 Padova
• Region: Nord-Est › Veneto › Padova
• Activity type: Research Organisations
• Administrative Contact: Roberta Mitidieri (Ms.)
• Total cost: No data

SUBLIMITY THERAPEUTICS LIMITED

Ireland

• EU contribution: € 390 900,00
• Address: INVENT CENTRE DUBLIN CITY UNIVERSITY ; 9 DUBLIN
• Region: Ireland › Eastern and Midland › Dublin
• Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Administrative Contact: Ivan S Coulter (Dr.)
• Total cost: No data

UNIVERSITE D'ANGERS

France

• EU contribution: € 558 305,22
• Address: RUE DE RENNES 40 ; 49035 Angers Cedex 01
• Region: Pays de la Loire › Pays de la Loire › Maine-et-Loire
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Jean-Pierre Benoit (Prof.)
• Total cost: No data

MEDIZINISCHE HOCHSCHULE HANNOVER

Germany

• EU contribution: € 434 880,00
• Address: Carl-Neuberg-Strasse 1 ; 30625 Hannover
• Region: Niedersachsen › Hannover › Region Hannover
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Frank Dittrich (Mr.)
• Total cost: No data

FUNDACIO INSTITUT DE RECERCA BIOMEDICA (IRB BARCELONA)

Spain

• EU contribution: € 302 040,00
• Address: CARRER BALDIRI REIXAC 10-12 PARC SCIENTIFIC DE BARCELONA ; 08028 Barcelona
• Region: Este › Cataluña › Barcelona
• Activity type: Research Organisations
• Administrative Contact: Alexandre Puerto Valdivieso (Mr.)
• Total cost: No data

UPPSALA UNIVERSITET

Sweden

• EU contribution: € 449 436,40
• Address: VON KRAEMERS ALLE 4 ; 751 05 Uppsala
• Region: Östra Sverige › Östra Mellansverige › Uppsala län
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Eva Nises Ahlgren (Ms.)
• Total cost: No data

ISTITUTO ONCOLOGICO VENETO

Italy

• EU contribution: € 301 400,00
• Address: VIA GATTAMELATA 64 ; 35128 Padova
• Region: Nord-Est › Veneto › Padova
• Activity type: Research Organisations
• Administrative Contact: Manuela Mtanis (Ms.)
• Total cost: No data

SEROSCIENCE KUTATO FEJLESZTO ES KERESKEDELMI KORLATOLT FELELOSSEGU TARSASAG

Hungary

• EU contribution: € 346 320,00
• Address: LORANT UTCA 10 B EP FSZT 2 ; 1125 Budapest
• Region: Közép-Magyarország › Budapest › Budapest
• Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Administrative Contact: Janos Csukás (Mr.)
• Total cost: No data

SANOFI-AVENTIS RECHERCHE & DEVELOPPEMENT

France

• EU contribution: € 616 154,00
• Address: 82 AVENUE RASPAIL ; 94250 GENTILLY
• Region: Ile-de-France › Ile-de-France › Val-de-Marne
• Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Administrative Contact: Denis Croisat (Dr.)
• Total cost: No data

F. HOFFMANN-LA ROCHE AG

Participation ended

Switzerland

• EU contribution: No data
• Address: GRENZACHERSTRASSE 124 ; 4070 Basel
• Region: Schweiz/Suisse/Svizzera › Nordwestschweiz › Basel-Stadt
• Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Administrative Contact: Barbara Lueckel (Dr.)
• Total cost: No data

UNIVERSITY COLLEGE CORK - NATIONAL UNIVERSITY OF IRELAND, CORK

Ireland

• EU contribution: € 459 100,00
• Address: WESTERN ROAD ; T12 YN60 Cork
• Region: Ireland › Southern › South-East
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: David O'connell (Dr.)
• Total cost: No data

ECAMRICERT SRL

Italy

• EU contribution: € 142 562,70
• Address: VIALE DEL LAVORO 6 ; 36030 Monte Di Malo
• Region: Nord-Est › Veneto › Vicenza
• Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Administrative Contact: Nicola Dalle Molle (Dr.)
• Total cost: No data