Obiettivo
The main purpose of the EVINCI-study is to test the impact of combined “anatomo-functional” non invasive cardiac imaging for detection and characterization of Ischemic Heart Disease (IHD). The EVINCI-study is a prospective clinical European multicenter trial performed in a cohort of 700 patients with suspected IHD. Patients with intermediate pre-test probability will undergo clinical and biohumoral characterization, including novel circulating markers of cardiovascular risk. They will be admitted to a non-invasive cardiac evaluation, consisting of “anatomic” imaging, by multislice computerized tomography, combined with “functional” tests among radionuclide, magnetic resonance and ultrasound imaging. Heart catheterization will be performed to validate non-invasive diagnosis and follow-up to assess outcome. The diagnostic accuracy of combined non-invasive “anatomo-functional” imaging will be tested against reference methods for diagnosing epicardial coronary lesions (coronary angiography), vessel wall atherosclerosis (intracoronary ultrasound) and impaired coronary flow reserve (intracoronary doppler/pressure wire). The individual profiles from “anatomo-functional” cardiac imaging and “clinical-biohumoral” data will be combined and tested against outcome. A cost-benefit analysis (including an estimate of procedural/radiological risks) of the new diagnostic work-up will also be performed. A relevant part of the EVINCI-study will be dedicated to the development, in cooperation with the industry, of an advanced informatics’ platform able to synthetically present to the end-user (patients, physicians, etc.) the integrated cardiological diagnostic profile of the individual patient as resulting from clinical-biohumoral and multi-imaging assessment. Overall results will be disseminated in cooperation with the European Society of Cardiology (ESC) and will guide the work of a dedicated ESC Commission which will release specific European Recommendations.
Campo scientifico
Not validated
Not validated
Parole chiave
Argomento(i)
Invito a presentare proposte
FP7-HEALTH-2007-B
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Meccanismo di finanziamento
CP-FP - Small or medium-scale focused research projectCoordinatore
00185 Roma
Italia
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Partecipanti (21)
20014 Turku
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8006 ZURICH
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2333 ZA Leiden
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Partecipazione conclusa
80333 Muenchen
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08041 Barcelona
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04 628 Warszawa
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SW3 6NP LONDON
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75012 Paris
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16126 Genova
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28046 MADRID
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80138 Napoli
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08007 Barcelona
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06903 Biot Sophia Antipolis
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Partecipazione conclusa
W6 7JP London
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20154 Milano
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56126 Pisa
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81675 Muenchen
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E1 4NS London
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50134 Firenze
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55041 Lucca
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73035 GOPPINGEN
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