Evaluation of Integrated Cardiac Imaging for the Detection and Characterization of Ischemic Heart Disease

Project Information

EVINCI-STUDY

Grant agreement ID: 222915

Project closed

Start date 1 January 2009

End date 30 June 2012

Funded under

• Specific Programme "Cooperation": Health

Total cost € 3 432 418,46

EU contribution € 2 695 402,00

Coordinated by

CONSIGLIO NAZIONALE DELLE RICERCHE
Italy

Objective

The main purpose of the EVINCI-study is to test the impact of combined “anatomo-functional” non invasive cardiac imaging for detection and characterization of Ischemic Heart Disease (IHD). The EVINCI-study is a prospective clinical European multicenter trial performed in a cohort of 700 patients with suspected IHD. Patients with intermediate pre-test probability will undergo clinical and biohumoral characterization, including novel circulating markers of cardiovascular risk. They will be admitted to a non-invasive cardiac evaluation, consisting of “anatomic” imaging, by multislice computerized tomography, combined with “functional” tests among radionuclide, magnetic resonance and ultrasound imaging. Heart catheterization will be performed to validate non-invasive diagnosis and follow-up to assess outcome. The diagnostic accuracy of combined non-invasive “anatomo-functional” imaging will be tested against reference methods for diagnosing epicardial coronary lesions (coronary angiography), vessel wall atherosclerosis (intracoronary ultrasound) and impaired coronary flow reserve (intracoronary doppler/pressure wire). The individual profiles from “anatomo-functional” cardiac imaging and “clinical-biohumoral” data will be combined and tested against outcome. A cost-benefit analysis (including an estimate of procedural/radiological risks) of the new diagnostic work-up will also be performed. A relevant part of the EVINCI-study will be dedicated to the development, in cooperation with the industry, of an advanced informatics’ platform able to synthetically present to the end-user (patients, physicians, etc.) the integrated cardiological diagnostic profile of the individual patient as resulting from clinical-biohumoral and multi-imaging assessment. Overall results will be disseminated in cooperation with the European Society of Cardiology (ESC) and will guide the work of a dedicated ESC Commission which will release specific European Recommendations.

Fields of science

CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques.

• medical and health sciences › clinical medicine › cardiology › cardiovascular diseases › arteriosclerosis
• natural sciences › chemical sciences › nuclear chemistry › radiation chemistry
• natural sciences › physical sciences › acoustics › ultrasound

Keywords

• coronary heart disease
• echocardiography
• imaging
• magnetic resonance imaging
• positron emission tomography
• scintigraphy

Programme(s)

• FP7-HEALTH - Specific Programme "Cooperation": Health

Topic(s)

• HEALTH-2007-2.4.2-6 - Organ imaging in CVD

Call for proposal

FP7-HEALTH-2007-B
See other projects for this call

Funding Scheme

CP-FP - Small or medium-scale focused research project

Coordinator

CONSIGLIO NAZIONALE DELLE RICERCHE

• EU contribution: € 632 071,00
• Address: PIAZZALE ALDO MORO 7 ; 00185 Roma ; Italy
• Region: Centro (IT) › Lazio › Roma
• Activity type: Research Organisations
• Administrative Contact: Marco Borbotti (Mr.)
• Total cost: No data

Participants (21)

TURUN YLIOPISTO

Finland

• EU contribution: € 450 023,09
• Address: YLIOPISTONMAKI ; 20014 Turku
• Region: Manner-Suomi › Etelä-Suomi › Varsinais-Suomi
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Eliisa Särkilahti (Dr.)
• Total cost: No data

University of Zurich

Switzerland

• EU contribution: € 92 706,00
• Address: RAMISTRASSE 71 ; 8006 ZURICH
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Philipp Kaufmann (Prof.)
• Total cost: No data

ACADEMISCH ZIEKENHUIS LEIDEN

Netherlands

• EU contribution: € 199 115,02
• Address: ALBINUSDREEF 2 ; 2333 ZA Leiden
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Sietske Hoekstra-Byvank (Ms.)
• Total cost: No data

TECHNISCHE UNIVERSITAET MUENCHEN

Participation ended

Germany

• EU contribution: No data
• Address: Arcisstrasse 21 ; 80333 Muenchen
• Region: Bayern › Oberbayern › München, Kreisfreie Stadt
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Inge Linder (Ms.)
• Total cost: No data

INSTITUT DE RECERCA DE L'HOSPITAL DE LA SANTA CREU I SANT PAU FUNDACION

Spain

• EU contribution: € 12 883,59
• Address: C SANT QUINTI 77-79 ; 08041 Barcelona
• Region: Este › Cataluña › Barcelona
• Activity type: Research Organisations
• Administrative Contact: Hilda Herrero (Ms.)
• Total cost: No data

NARODOWY INSTYTUT KARDIOLOGII STEFANA KARDYNALA WYSZYNSKIEGO - PANSTWOWY INSTYTUT BADAWCZY

Poland

• EU contribution: € 89 980,81
• Address: UL. ALPEJSKA 42 ; 04 628 Warszawa
• Region: Makroregion województwo mazowieckie › Warszawski stołeczny › Miasto Warszawa
• Activity type: Research Organisations
• Administrative Contact: Liliana Chojnacka (Ms.)
• Total cost: No data

ROYAL BROMPTON AND HAREFIELD NATIONAL HEALTH SERVICE TRUST

United Kingdom

• EU contribution: € 95 272,12
• Address: SYDNEY STREET ; SW3 6NP LONDON
• Region: London › Inner London — West › Kensington & Chelsea and Hammersmith & Fulham
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: George Karagiannis (Mr.)
• Total cost: No data

ASSISTANCE PUBLIQUE HOPITAUX DE PARIS

France

• EU contribution: € 84 513,16
• Address: 55 BOULEVARD DIDEROT ; 75012 Paris
• Region: Ile-de-France › Ile-de-France › Paris
• Activity type: Research Organisations
• Administrative Contact: Christophe Misse (Mr.)
• Total cost: No data

UNIVERSITA DEGLI STUDI DI GENOVA

Italy

• EU contribution: € 112 821,36
• Address: VIA BALBI 5 ; 16126 Genova
• Region: Nord-Ovest › Liguria › Genova
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Maria Angela Ferrera (Ms.)
• Total cost: No data

SERVICIO MADRILENO DE SALUD

Spain

• EU contribution: € 107 893,24
• Address: Paseo De la Castellana, 280 ; 28046 MADRID
• Region: Comunidad de Madrid › Comunidad de Madrid › Madrid
• Activity type: Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
• Administrative Contact: José Francisco Soto Bonel (Mr.)
• Total cost: No data

UNIVERSITA DEGLI STUDI DI NAPOLI FEDERICO II

Italy

• EU contribution: € 45 032,36
• Address: CORSO UMBERTO I, 40 ; 80138 Napoli
• Region: Sud › Campania › Napoli
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Renata D'amico (Ms.)
• Total cost: No data

INSTITUT CATALA DE LA SALUT

Spain

• EU contribution: € 56 265,54
• Address: GRAN VIA DE LES CORTS CATALANES 587 ; 08007 Barcelona
• Region: Este › Cataluña › Barcelona
• Activity type: Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
• Administrative Contact: Santiago Aguade (Dr.)
• Total cost: No data

SOCIETE EUROPEENNE DE CARDIOLOGIE

France

• EU contribution: € 28 180,00
• Address: ROUTE DES COLLES 2035 ; 06903 Biot Sophia Antipolis
• Region: Provence-Alpes-Côte d’Azur › Provence-Alpes-Côte d’Azur › Alpes-Maritimes
• Activity type: Other
• Administrative Contact: Francoise Heraud (Ms.)
• Total cost: No data

INFORSENSE LIMITED

Participation ended

United Kingdom

• EU contribution: € 46 740,90
• Address: HAMMERSMITH ROAD COLET COURT 100 ; W6 7JP London
• Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Administrative Contact: Martin Naughalty (Mr.)
• Total cost: No data

CF CONSULTING FINANZIAMENTI UNIONE EUROPEA SRL

Italy

• EU contribution: € 79 661,10
• Address: Via Giuseppe Mussi 1 ; 20154 Milano
• Region: Nord-Ovest › Lombardia › Milano
• Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Administrative Contact: Carla Finocchiaro (Ms.)
• Total cost: No data

FONDAZIONE TOSCANA GABRIELE MONASTERIO PER LA RICERCA MEDICA E DI SANITA PUBBLICA

Italy

• EU contribution: € 233 031,84
• Address: VIA TRIESTE 41 ; 56126 Pisa
• Region: Centro (IT) › Toscana › Pisa
• Activity type: Research Organisations
• Administrative Contact: Luciano Ciucci (Dr.)
• Total cost: No data

KLINIKUM RECHTS DER ISAR DER TECHNISCHEN UNIVERSITAT MUNCHEN

Germany

• EU contribution: € 98 962,99
• Address: ISMANINGER STRASSE 22 ; 81675 Muenchen
• Region: Bayern › Oberbayern › München, Kreisfreie Stadt
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Renate Rädlein (Ms.)
• Total cost: No data

QUEEN MARY UNIVERSITY OF LONDON

United Kingdom

• EU contribution: € 120 247,88
• Address: 327 MILE END ROAD ; E1 4NS London
• Region: London › Inner London — West › Camden and City of London
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Tanya Szendeffy (Ms.)
• Total cost: No data

AZIENDA OSPEDALIERO-UNIVERSITARIA CAREGGI

Italy

• EU contribution: € 40 000,00
• Address: LARGO G.A. BRAMBILLA 3 ; 50134 Firenze
• Region: Centro (IT) › Toscana › Firenze
• Activity type: Research Organisations
• Administrative Contact: Mariagrazia Catania (Ms.)
• Total cost: No data

Azienda U.S.L. N. 12 di Viareggio

Italy

• EU contribution: € 30 000,00
• Address: Via Aurelia 335 ; 55041 Lucca
• Activity type: Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
• Administrative Contact: Claudio Rapalini (Dr.)
• Total cost: No data

KLINIKEN DES LANDKREISES GOPPINGEN GGMBH

Germany

• EU contribution: € 40 000,00
• Address: EICHERTSTRASSE 3 ; 73035 GOPPINGEN
• Activity type: Research Organisations
• Administrative Contact: Jörg Martin (Prof.)
• Total cost: No data