Numerical modeling of cardiac electrophysiology at the cellular scale

Información del proyecto

MICROCARD

Identificador del acuerdo de subvención: 955495

DOI 10.3030/955495

Proyecto cerrado

Fecha de la firma de la CE 18 Diciembre 2020

Fecha de inicio 1 Abril 2021

Fecha de finalización 30 Septiembre 2024

Financiado con arreglo a

• INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies - Information and Communication Technologies (ICT)

Coste total € 5 858 546,25

Aportación de la UE € 2 777 053,32

Coordinado por

UNIVERSITE DE BORDEAUX
France

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Resultado final

Documents, reports (9)

Report on task-based parallelization

Publication of a report on task-based parallelization.

Report on MPI communication optimization

Publication of a report on optimization of MPI communication in the code.

Report on the sustainable roadmap for MICROCARD platform and software

Publication of a report on the sustainable roadmap for the MICROCARD platform and software.

A Software Management Plan for the HPC simulation platform μ CARP

Creation of a Software Management Plan for the HPC simulation platform CARP

Results of the surveys conducted in M18 and M36 on ease of use of the cloud-based web platform

Publication of a report on the results of the surveys conducted in M18 and M36 on ease of use of the cloud-based web platform

Linear solver development and performance assessment report

Publication of a report on the development of linear solvers and an assessment of their performance

Report on High-Performance Data Output

Publication of a report on High-Performance Data Output

Report on automatic checkpoint placement strategy

Publication of a report on automatic checkpoint placement strategy in the code

Report on the implemented DevOps toolchain as a best-practice example

Demonstrators, pilots, prototypes (2)

Linear solver application integration proof

Demonstration of the application of the newly integrated linear solver(s).

Resilient parallelization support

Prototype of the code with task-based parallellization that is resilient to hardware failures.

Open Research Data Pilot (1)

Online publication of the use cases

Posts on the use cases intended for a large audience, on the project website.

Publicaciones

Peer reviewed articles (19)

A comparison of Algebraic Multigrid Bidomain solvers on hybrid CPU–GPU architectures

Autores: Edoardo Centofanti, Simone Scacchi
Publicado en: Computer Methods in Applied Mechanics and Engineering, Edición 423, 2024, Página(s) 116875, ISSN 0045-7825
Editor: Elsevier BV
DOI: 10.1016/j.cma.2024.116875

Robust parallel nonlinear solvers for implicit time discretizations of the Bidomain equations with staggered ionic models

Autores: Nicolás A. Barnafi, Ngoc Mai Monica Huynh, Luca F. Pavarino, Simone Scacchi
Publicado en: Computers & Mathematics with Applications, Edición 167, 2024, Página(s) 134-149, ISSN 0898-1221
Editor: Pergamon Press Ltd.
DOI: 10.1016/j.camwa.2024.04.014

Explicit stabilized multirate methods for the monodomain model in cardiac electrophysiology

Autores: Giacomo Rosilho de Souza, Marcus Grote, Simone Pezzuto, Rolf Krause
Publicado en: ESAIM: Mathematical Modelling and Numerical Analysis, 2024, ISSN 2822-7840
Editor: edpsciences
DOI: 10.1051/m2an/2024030

A Review of Healthy and Fibrotic Myocardium Microstructure Modeling and Corresponding Intracardiac Electrograms

Autores: Sánchez, J.; Loewe, A.
Publicado en: Frontiers in Physiology, 2022, ISSN 1664-042X
Editor: Frontiers Research Foundation
DOI: 10.3389/fphys.2022.908069

Scalable and Robust Dual-Primal Newton–Krylov Deluxe Solvers for Cardiac Electrophysiology with Biophysical Ionic Models

Autores: Ngoc Mai Monica Huynh; Luca F. Pavarino; Simone Scacchi
Publicado en: Vietnam Journal of Mathematics, Edición 50, 2022, ISSN 2305-221X
Editor: Springer Science + Business Media
DOI: 10.1007/s10013-022-00576-1

Boundary integral formulation of the cell-by-cell model of cardiac electrophysiology

Autores: Giacomo Rosilho de Souza, Rolf Krause, Simone Pezzuto
Publicado en: Engineering Analysis with Boundary Elements, Edición 158, 2023, Página(s) 239-251, ISSN 0955-7997
Editor: Pergamon Press Ltd.
DOI: 10.1016/j.enganabound.2023.10.021

Characterization of the pace-and-drive capacity of the human sinoatrial node: A 3D in silico study

Autores: Antoine Amsaleg; Jorge Sánchez; Ralf Mikut; Axel Loewe
Publicado en: Biophysical Journal, Edición 121, 2022, Página(s) 4247–4259, ISSN 0006-3495
Editor: Biophysical Society
DOI: 10.1016/j.bpj.2022.10.020

Unexpected impairment of INa underpins reentrant arrhythmias in a knock-in swine model of Timothy syndrome

Autores: Andreu Porta-Sánchez, Andrea Mazzanti, Carmen Tarifa, Deni Kukavica, Alessandro Trancuccio, Muhammad Mohsin, Elisa Zanfrini, Andrea Perota, Roberto Duchi, Kevin Hernandez-Lopez, Miguel Eduardo Jáuregui-Abularach, Valerio Pergola, Eugenio Fernandez, Rossana Bongianino, Elisa Tavazzani, Patrick Gambelli, Mirella Memmi, Simone Scacchi, Luca F. Pavarino, Piero Colli Franzone, Giovanni Lentini, David
Publicado en: Nature Cardiovascular Research, Edición 2, 2023, Página(s) 1291-1309, ISSN 2731-0590
Editor: Springer Nature
DOI: 10.1038/s44161-023-00393-w

A Survey of General-purpose Polyhedral Compilers

Autores: Arun Thangamani, Vincent Loechner, Stéphane Genaud
Publicado en: ACM Transactions on Architecture and Code Optimization, 2024, ISSN 1544-3566
Editor: Association for Computing Machinary, Inc.
DOI: 10.1145/3674735

Epicardial Dispersion of Repolarization Promotes the Onset of Reentry in Brugada Syndrome: A Numerical Simulation Study

Autores: Simone Scacchi, Piero Colli Franzone, Luca F. Pavarino, Vincenzo Gionti, Cesare Storti
Publicado en: Bulletin of Mathematical Biology, Edición 85, 2023, ISSN 0092-8240
Editor: Academic Press
DOI: 10.1007/s11538-023-01124-9

The openCARP CDEConcept for and implementation of a sustainable collaborativedevelopment environment for research software

Autores: Felix Bach, Jochen Klar, Axel Loewe, Jorge Sánchez, Gunnar Seemann, Yung-Lin Huang, Robert Ulrich
Publicado en: Bausteine Forschungsdatenmanagement, Edición Nr.1, 2022, ISSN 2626-7489
Editor: Marburg: Philipps-Universität
DOI: 10.17192/bfdm.2022.1.8368

À quoi servent les ordinateurs les plus puissants au monde ? Un exemple en cardiologie.

Autores: Emmanuelle Saillard; Mark Potse
Publicado en: The Conversation, 2022, ISSN 2431-2134
Editor: The Conversation Media Group

The role of pulse timing in cardiac defibrillation

Autores: Joshua Steyer, Thomas Lilienkamp, Stefan Luther, Ulrich Parlitz
Publicado en: Frontiers in Network Physiology, Edición 2, 2023, ISSN 2674-0109
Editor: Frontiers
DOI: 10.3389/fnetp.2022.1007585

Attractor selection in nonlinear oscillators by temporary dual-frequency driving

Autores: Péter Krähling, Joshua Steyer, Ulrich Parlitz, Ferenc Hegedűs
Publicado en: Nonlinear Dynamics, Edición 111, 2024, Página(s) 19209-19224, ISSN 0924-090X
Editor: Kluwer Academic Publishers
DOI: 10.1007/s11071-023-08855-3

Evaluating computational efforts and physiological resolution of mathematical models of cardiac tissue

Autores: Karoline Horgmo Jæger, James D. Trotter, Xing Cai, Hermenegild Arevalo, Aslak Tveito
Publicado en: Scientific Reports, Edición 14, 2024, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-024-67431-w

Editorial: Atrial Fibrillation: Technology for Diagnosis, Monitoring, and Treatment

Autores: Omer Berenfeld, Valentina D. A. Corino, Axel Loewe, Juan Pablo Martínez and Jose F. Rodriguez Matas
Publicado en: Frontiers in Physiology, 2022, ISSN 1664-042X
Editor: Frontiers Research Foundation
DOI: 10.3389/fphys.2022.848096

Resource-Efficient Use of Modern Processor Architectures For Numerically Solving Cardiac Ionic Cell Models

Autores: Kristian Gregorius Hustad; Xing Cai
Publicado en: Frontiers in Physiology, 2022, ISSN 1664-042X
Editor: Frontiers Research Foundation
DOI: 10.3389/fphys.2022.904648

Convergence Analysis of BDDC Preconditioners for Composite DG Discretizations of the Cardiac Cell-By-Cell Model

Autores: Ngoc Mai Monica Huynh, Fatemeh Chegini, Luca Franco Pavarino, Martin Weiser, Simone Scacchi
Publicado en: SIAM Journal on Scientific Computing, Edición 45, 2023, Página(s) A2836-A2857, ISSN 1064-8275
Editor: Society for Industrial and Applied Mathematics
DOI: 10.1137/22m1542532

Fibrotic Remodeling during Persistent Atrial Fibrillation: In Silico Investigation of the Role of Calcium for Human Atrial Myofibroblast Electrophysiology

Autores: Jorge Sánchez , Beatriz Trenor, Javier Saiz, Olaf Dössel and Axel Loewe
Publicado en: Cells, Edición 10, 2021, ISSN 2073-4409
Editor: MDPI
DOI: 10.3390/cells10112852

Conference proceedings (2)

Parallel nonlinear solvers in computational cardiac electrophysiology

Autores: Nicolas Alejandro BARNAFI; Ngoc Mai Monica HUYNH; Luca Franco PAVARINO; Simone SCACCHI
Publicado en: IFAC-PapersOnLine, 2022
Editor: Elsevier
DOI: 10.1016/j.ifacol.2022.09.093

Combining Uncore Frequency and Dynamic Power Capping to Improve Power Savings

Autores: Amina Guermouche
Publicado en: 2022 IEEE International Parallel and Distributed Processing Symposium Workshops (IPDPSW), 2022, ISBN 978-1-6654-9748-0
Editor: IEEE
DOI: 10.1109/ipdpsw55747.2022.00164