Stratification of Obesity Phenotypes to Optimize Future Therapy

Deliverables

Dataset profiles handbook
Needs and challenges communication package

Publications

Clinical characteristics and outcomes of children, adolescents and young adults with overweight or obesity and mental health disorders

Author(s): Angela Galler, Angelika Thönnes, Jens Joas, Christine Joisten, Antje Körner, Thomas Reinehr, Markus Röbl, Gerd Schauerte, Wolfgang Siegfried, Daniel Weghuber, Susann Weihrauch-Blüher, Susanna Wiegand, Reinhard W. Holl, Nicole Prinz, null null
Published in: International Journal of Obesity, Issue 48, 2024, Page(s) 423-432, ISSN 0307-0565
Publisher: Nature Publishing Group
DOI: 10.1038/s41366-023-01449-4

Who benefits most from outpatient lifestyle intervention? An IMI‐SOPHIA study on pediatric individuals living with overweight and obesity

Author(s): Prinz, Nicole; Pomares‐Millan, Hugo; Dannemann, Almut; Giordano, Giuseppe N.; Joisten, Christine; Körner, Antje; Weghuber, Daniel; Weihrauch‐Blüher, Susann; Wiegand, Susanna; Holl, Reinhard W.; Lanzinger, Stefanie; APV initiative; Stratification of Obesity Phenotypes to Optimize Future Therapy (SOPHIA) consortium
Published in: Obesity, Issue 2, 2023, ISSN 1930-739X
Publisher: Wiley

Genetic evidence that high BMI in childhood has a protective effect on intermediate diabetes traits, including measures of insulin sensitivity and secretion, after accounting for BMI in adulthood

Author(s): Gareth Hawkes; Robin N. Beaumont; Jessica Tyrrell; Grace M. Power; Andrew Wood; Markku Laakso; Lilian Fernandes Silva; Michael Boehnke; Xianyong Yin; Tom G. Richardson; George Davey Smith; Timothy M. Frayling
Published in: Diabetologia, 2023, ISSN 1949-2448
Publisher: Springer link
DOI: 10.1007/s00125-023-05923-6

Is COVID-19 to Blame? Trends of Incidence and Sex Ratio in Youth-Onset Type 2 Diabetes in Germany

Author(s): Christian Denzer; Christian Denzer; Daniela Klose; Antje Korner; Thomas Reinehr; Christina Baechle; Carmen Schroder; Susanna Wiegand; Reinhard W. Holl; Nicole Prinz
Published in: Diabetes care, 2023, ISSN 0012-1797
Publisher: American Diabetes Association
DOI: 10.2337/dc22-2257

The emergence of obesity in type 1 diabetes

Author(s): Martin T. W. Kueh, Nicholas W. S. Chew, Ebaa Al-Ozairi, Carel W. le Roux
Published in: International Journal of Obesity, Issue 48, 2024, Page(s) 289-301, ISSN 0307-0565
Publisher: Nature Publishing Group
DOI: 10.1038/s41366-023-01429-8

Cardiovascular health, genetic predisposition, and lifetime risk of type 2 diabetes

Author(s): Kan Wang; Maryam Kavousi; Trudy Voortman; M. Arfan Ikram; Mohsen Ghanbari; Fariba Ahmadizar;
Published in: European Journal of Preventive Cardiology, 2021, ISSN 2047-4873
Publisher: SAGE Publications Ltd
DOI: 10.1093/eurjpc/zwab141

A phenome-wide comparative analysis of genetic discordance between obesity and type 2 diabetes

Author(s): Daniel E. Coral; Juan Fernandez-Tajes; Neli Tsereteli; Hugo Pomares-Millan; Hugo Fitipaldi; Pascal M. Mutie; Naeimeh Atabaki-Pasdar; Sebastian Kalamajski; Alaitz Poveda; Tyne W. Miller-Fleming; Xue Zhong; Giuseppe N. Giordano; Ewan R. Pearson; Nancy J. Cox; Paul W. Franks
Published in: Nature Metabolism, 2023, ISSN 2522-5812
Publisher: Nature Metabolism
DOI: 10.1038/s42255-022-00731-5

Comparison of cardiovascular risk factors between children and adolescents with classes III and IV obesity: findings from the APV cohort

Author(s): Thomas Reinehr, Sascha R. Tittel, Rolf Holle, Susanna Wiegand, Ines Gellhaus, Johannes Hebebrand, Susanne Greber-Platzer, Christian Denzer, Sabine Linke, Wieland Kiess, Reinhard W. Holl
Published in: International Journal of Obesity, Issue 45/5, 2021, Page(s) 1061-1073, ISSN 0307-0565
Publisher: Nature Publishing Group
DOI: 10.1038/s41366-021-00773-x

Clinical characteristics and cardiovascular risk profile in children and adolescents with latent autoimmune diabetes: Results from the German/Austrian prospective diabetes follow‐up registry

Author(s): Alena Welters, Sascha R. Tittel, Thomas Reinehr, Daniel Weghuber, Susanna Wiegand, Wolfram Karges, Clemens Freiberg, Thomas Meissner, Nanette C. Schloot, Reinhard W. Holl
Published in: Pediatric Diabetes, Issue 23, 2022, Page(s) 1602-1612, ISSN 1399-543X
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/pedi.13450

“You Are Always at War With Yourself” The Perceptions and Beliefs of People With Obesity Regarding Obesity as a Disease

Author(s): Andrew Grannell; Carel W. le Roux; Deirdre McGillicuddy;
Published in: Qualitative Health Research, 2021, ISSN 1049-7323
Publisher: SAGE Publications
DOI: 10.1177/10497323211040767

BMI Z-Score (SDS) versus Calculated Body Fat Percentage: Association with Cardiometabolic Risk Factors in Obese Children and Adolescents

Author(s): Christine Joisten, Stefanie Wessely, Nicole Prinz, Susanna Wiegand, Bettina Gohlke, Sabine Keiser, Paula Moliterno, Jens Nielinger, Gabriel Torbahn, Hagen Wulff, Reinhard W. Holl, null null
Published in: Annals of Nutrition and Metabolism, Issue 80, 2024, Page(s) 29-36, ISSN 0250-6807
Publisher: S. Karger AG
DOI: 10.1159/000535216

The lived experience of people with obesity: study protocol for a systematic review and synthesis of qualitative studies

Author(s): Emma Farrell, Marta Bustillo, Carel W. le Roux, Joe Nadglowski, Eva Hollmann & Deirdre McGillicuddy
Published in: Systematic Reviews, 2021, ISSN 2046-4053
Publisher: BioMed Central
DOI: 10.1186/s13643-021-01706-5

The double burden: Navigating type 1 diabetes and obesity

Author(s): Nele Steenackers, Alix Nessa Feldman, Chantal Mathieu, Jonathan Rosen, Jeannette Soderberg, Ebaa Al‐Ozairi, Carel W. le Roux, Bart Van der Schueren
Published in: Clinical Obesity, Issue 14, 2024, ISSN 1758-8103
Publisher: Wiley
DOI: 10.1111/cob.12645

Altered Insulin Clearance after Gastric Bypass and Sleeve Gastrectomy in the Fasting and Prandial Conditions

Author(s): Marzieh Salehi, Ralph DeFronzo, and Amalia Gastaldelli
Published in: Molecular Sciences, 2022, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms23147667

Exposome-wide ranking of modifiable risk factors for cardiometabolic disease traits

Author(s): Alaitz Poveda; Hugo Pomares-Millan; Yan Chen; Azra Kurbasic; Chirag J. Patel; Frida Renström; Göran Hallmans,; Ingegerd Johansson; Paul W. Franks
Published in: Sci Rep, 2022, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-022-08050-1

Precision medicine in diabetes: a Consensus Report from the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD)

Author(s): Wendy K. Chung, Karel Erion, Jose C. Florez, Andrew T. Hattersley, Marie-France Hivert, Christine G. Lee, Mark I. McCarthy, John J. Nolan, Jill M. Norris, Ewan R. Pearson, Louis Philipson, Allison T. McElvaine, William T. Cefalu, Stephen S. Rich, Paul W. Franks
Published in: Diabetologia, Issue 63, 2021, Page(s) 1671-1693, ISSN 0012-186X
Publisher: Springer Verlag
DOI: 10.1007/s00125-020-05181-w

Not All Type-2-Diabetes Patients Increase Body Mass Index After Initiating Insulin: Results of Latent Class Analysis from the DPV Registry

Author(s): Nicole Prinz; Anke Schwandt; Bernadette Borgert; Bettina Hartmann; Hans-Peter Kempe; Julia K. Mader; Sigrund Merger; Rosmarie Weber-Lauffer; Frank-Jürgen Wosch; Reinhard W. Holl;
Published in: Diabetes Technology & Therapeutics, 2021, ISSN 1520-9156
Publisher: Mary Ann Liebert Inc.
DOI: 10.1089/dia.2021.0144

Who benefits most from outpatient lifestyle intervention? An <scp>IMI‐SOPHIA</scp> study on pediatric individuals living with overweight and obesity

Author(s): Nicole Prinz, Hugo Pomares‐Millan, Almut Dannemann, Giuseppe N. Giordano, Christine Joisten, Antje Körner, Daniel Weghuber, Susann Weihrauch‐Blüher, Susanna Wiegand, Reinhard W. Holl, Stefanie Lanzinger, null null
Published in: Obesity, Issue 31, 2024, Page(s) 2375-2385, ISSN 1930-7381
Publisher: Wiley-Blackwell
DOI: 10.1002/oby.23844

The lived experience of patients with obesity: A systematic review and qualitative synthesis

Author(s): Emma Farrell, Eva Hollmann, Carel W. le Roux, Marta Bustillo, Joe Nadglowski, Deirdre McGillicuddy
Published in: Obesity Reviews, 2021, ISSN 1467-7881
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/obr.13334

Body Mass Index's influence on arterial hypertension in Type 1 diabetes – A brief report from IMI-SOPHIA study

Author(s): Laurence D. Petty, Enrique Soto-Pedre, Rory J. McCrimmon, Ewan R. Pearson
Published in: Journal of Diabetes and its Complications, Issue 38, 2024, Page(s) 108747, ISSN 1056-8727
Publisher: Elsevier BV
DOI: 10.1016/j.jdiacomp.2024.108747

Accurate liquid biopsy for the diagnosis of non-alcoholic steatohepatitis and liver fibrosis

Author(s): Giulia Angelini, Simona Panunzi, Lidia Castagneto-Gissey, Francesca Pellicanò, Andrea De Gaetano, Maurizio Pompili, Laura Riccardi, Matteo Garcovich, Marco Raffaelli, Luigi Ciccoritti, Ornella Verrastro, Maria Francesca Russo, Fabio Maria Vecchio, Giovanni Casella, James Casella-Mariolo, Luigi Papa, Pier Luigi Marini, Francesco Rubino, Carel W le Roux, Stefan Bornstein, Geltrude Mingrone
Published in: Gut, Issue 72, 2023, Page(s) 392-403, ISSN 0017-5749
Publisher: BMJ Publishing Group
DOI: 10.1136/gutjnl-2022-327498

Disease heterogeneity of adult diabetes based on routine clinical variables at diagnosis: Results from the German/Austrian Diabetes Follow-up Registry

Author(s): Julia M. Grimsmann; Sascha R. Tittel; Peter Bramlage; Benjamin Mayer; Andreas Fritsche; Jochen Seufert; Markus Laimer; Stefan Zimny; Sebastian M. Meyhoefer; Michael Hummel; Reinhard W. Holl
Published in: Diabetes, Obesity and Metabolism, 2022, ISSN 1463-1326
Publisher: Diabetes, Obesity and Metabolism
DOI: 10.1111/dom.14812

Characterisation and clinical outcomes in children and adolescents with diabetes according to newly defined subgroups: a cohort study from the DPV registry

Author(s): Katharina Warncke, Alexander Eckert, Ezio Bonifacio, Peter Achenbach, Olga Kordonouri, Thomas Meissner, Ute Ohlenschläger, Walter Bonfig, Anette-G. Ziegler, Reinhard W. Holl
Published in: eClinicalMedicine, Issue 64, 2024, Page(s) 102208, ISSN 2589-5370
Publisher: eClinicalMedicine
DOI: 10.1016/j.eclinm.2023.102208

Access to Healthcare for Children and Adolescents with a Chronic Health Condition during the COVID-19 Pandemic: First Results from the KICK-COVID Study in Germany

Author(s): Julia M. Göldel, Clemens Kamrath, Kirsten Minden, Susanna Wiegand, Stefanie Lanzinger, Claudia Sengler, Susann Weihrauch-Blüher, Reinhard W. Holl, Sascha R. Tittel, Petra Warschburger
Published in: Children, Issue 10, 2024, Page(s) 10, ISSN 2227-9067
Publisher: Children
DOI: 10.3390/children10010010

Special diet in type 1 diabetes: do gender and BMI-SDS differ?

Author(s): Alena Gerlinde Thiele; Nicole Prinz; Monika Flury; Melanie Hess; Daniela Klose; Thomas Meissner; Klemens Raile; Klemens Raile; Sabine Wenzel; Sascha Tittel; Thomas Kapellen; Reinhard Holl
Published in: Child and Adolescent Obesity, 2021, ISSN 2227-9067
Publisher: Taylor & Francis
DOI: 10.1080/2574254x.2021.2002061

Plasma circulating microRNAs associated with obesity, body fat distribution, and fat mass: the Rotterdam Study

Author(s): Yasir J. Abozaid; Xiaofang Zhang; Michelle M. J. Mens; Fariba Ahmadizar; Marlou Limpens; M. Arfan Ikram; Fernando Rivadeneira; Trudy Voortman; Maryam Kavousi; Mohsen Ghanbari
Published in: International Journal of Obesity, 2022, ISSN 1476-4687
Publisher: Nature
DOI: 10.1038/s41366-022-01227-8

BMI variability and cardiovascular outcomes within clinical trial and real-world environments in type 2 diabetes: an IMI2 SOPHIA study

Author(s): Robert J. Massey, Yu Chen, Marina Panova-Noeva, Michaela Mattheus, Moneeza K. Siddiqui, Nanette C. Schloot, Antonio Ceriello, Ewan R. Pearson, Adem Y. Dawed
Published in: Cardiovascular Diabetology, Issue 23, 2024, ISSN 1475-2840
Publisher: BioMed Central
DOI: 10.1186/s12933-024-02299-8

Achieving consensus on the language of obesity: a modified Delphi study

Author(s): Cecilie Heerdegen Jepsen, Jacqueline Bowman-Busato, Thomas Allvin, Niamh Arthurs, Gijs H. Goossens, Elisabeth Govers, Benjamin Assad Jaghutriz, Vicki Mooney, Bart Van der Schueren, Carel W. le Roux
Published in: eClinicalMedicine, Issue 62, 2024, Page(s) 102061, ISSN 2589-5370
Publisher: eClinical Medicine
DOI: 10.1016/j.eclinm.2023.102061

Fetal alleles predisposing to metabolically favorable adiposity are associated with higher birth weight

Author(s): William D Thompson, Robin N Beaumont, Alan Kuang, Nicole M Warrington, Yingjie Ji, Jessica Tyrrell, Andrew R Wood, Denise M Scholtens, Bridget A Knight, David M Evans, William L Lowe Jr, Gillian Santorelli, Raq Azad, Dan Mason, Andrew T Hattersley, Timothy M Frayling, Hanieh Yaghootkar, Maria Carolina Borges, Deborah A Lawlor, Rachel M Freathy
Published in: Human Molecular Genetics, Issue 31, 2022, Page(s) 1762-1775, ISSN 0964-6906
Publisher: Oxford University Press
DOI: 10.1093/hmg/ddab356

Upper gut heat shock proteins HSP70 and GRP78 promote insulin resistance, hyperglycemia, and non-alcoholic steatohepatitis

Author(s): Giulia Angelini; Lidia Castagneto-Gissey; Serenella Salinari; Alessandro Bertuzzi; Danila Anello; Meenakshi Pradhan; Marlen Zschätzsch; Paul Ritter; CarelW. Le Roux; Francesco Rubino; Nicola Basso; Giovanni Casella; Stefan R. Bornstein; Valentina Tremaroli; Geltrude Mingrone
Published in: Nature Communications, 2022, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-022-35310-5

Three‐variate trajectories of metabolic control, body mass index, and insulin dose: Heterogeneous response to initiation of pump therapy in youth with type 1 diabetes

Author(s): Martin Tauschmann, Anke Schwandt, Nicole Prinz, Marianne Becker, Torben Biester, Melanie Hess, Martin Holder, Beate Karges, Andrea Näke, Oliver Kuss, Simone Sengbusch, Reinhard W. Holl, null null
Published in: Pediatric Diabetes, Issue 23, 2022, Page(s) 330-340, ISSN 1399-543X
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/pedi.13320

Comparison of BMI and HbA1c changes before and during the COVID-19 pandemic in type 1 diabetes: a longitudinal population-based study

Author(s): Marie Auzanneau, Dorothee M. Kieninger, Katharina Laubner, Christian Renner, Joaquina Mirza, Gerhard Däublin, Kirsten Praedicow, Holger Haberland, Claudia Steigleder-Schweiger, Bettina Gohlke, Angela Galler, Reinhard W. Holl, null null
Published in: Journal of Diabetes & Metabolic Disorders, Issue 23, 2024, Page(s) 573-583, ISSN 2251-6581
Publisher: BioMed Central
DOI: 10.1007/s40200-023-01316-z

The association between perinatal factors and cardiometabolic risk factors in children and adolescents with overweight or obesity: A retrospective two-cohort study

Author(s): Nicole Prinz, Resthie R. Putri, Thomas Reinehr, Pernilla Danielsson, Daniel Weghuber, Mikael Norman, Niels Rochow, Claude Marcus, Reinhard W. Holl, Emilia Hagman
Published in: PLOS Medicine, Issue 20, 2023, Page(s) e1004165, ISSN 1549-1676
Publisher: PLoS Med
DOI: 10.1371/journal.pmed.1004165

Disease heterogeneity of adult diabetes based on routine clinical parameters at diagnosis: Results from the German/Austrian DPV registry.

Author(s): Grimsmann, Julia M; Tittel, Sascha R; Bramlage, Peter; Mayer, Benjamin; Fritsche, Andreas; Seufert, Jochen; Laimer, Markus; Zimny, Stefan; Meyhoefer, Sebastian M; Hummel, Michael; Holl, Reinhard W
Published in: Grimsmann, Julia M; Tittel, Sascha R; Bramlage, Peter; Mayer, Benjamin; Fritsche, Andreas; Seufert, Jochen; Laimer, Markus; Zimny, Stefan; Meyhoefer, Sebastian M; Hummel, Michael; Holl, Reinhard W (2022). Disease heterogeneity of adult diabetes based on routine clinical parameters at diagnosis: Results from the German/Austrian DPV registry. Diabetes, obesity & metabolism, 24(11), pp. 2253-2262. Wi, Issue 1, 2022, ISSN 1463-1326
Publisher: Diabetes, obesity & metabolism
DOI: 10.48350/171154

Obesity in people living with type 1 diabetes

Author(s): Bart Van der Schueren Darcy Ellis Raquel NFaradji Eeba Al-Ozairi Jonathan Rosen Chantal Mathieu
Published in: The Lancet Diabetes & Endocrinology, 2021, ISSN 2213-8587
Publisher: Elsevier BV
DOI: 10.1016/s2213-8587(21)00246-1

Combining diabetes, sex, and menopause as meaningful clinical features associated with NASH and liver fibrosis in individuals with class II and III obesity: A retrospective cohort study

Author(s): Violeta Raverdy, Estelle Chatelain, Guillaume Lasailly, Robert Caiazzo, Jimmy Vandel, Helene Verkindt, Camille Marciniak, Benjamin Legendre, Pierre Bauvin, Naima Oukhouya‐Daoud, Gregory Baud, Mikael Chetboun, Marie‐Christine Vantyghem, Viviane Gnemmi, Emmanuelle Leteurtre, Bart Staels, Philippe Lefebvre, Philippe Mathurin, Guillemette Marot, Francois Pattou
Published in: Obesity, Issue 31, 2024, Page(s) 3066-3076, ISSN 1930-7381
Publisher: Wiley-Blackwell
DOI: 10.1002/oby.23904

Development and validation of an interpretable machine learning-based calculator for predicting 5-year weight trajectories after bariatric surgery: a multinational retrospective cohort SOPHIA study

Author(s): Patrick Saux, Pierre Bauvin, Violeta Raverdy, Julien Teigny, Hélène Verkindt, Tomy Soumphonphakdy, Maxence Debert, Anne Jacobs, Daan Jacobs, Valerie Monpellier, Phong Ching Lee, Chin Hong Lim, Johanna C Andersson-Assarsson, Lena Carlsson, Per-Arne Svensson, Florence Galtier, Guelareh Dezfoulian, Mihaela Moldovanu, Severine Andrieux, Julien Couster, Marie Lepage, Erminia Lembo, Ornella Verrastro,
Published in: The Lancet Digital Health, Issue 5, 2023, Page(s) e692-e702, ISSN 2589-7500
Publisher: Lancet Digital Health
DOI: 10.1016/s2589-7500(23)00135-8

At home and at risk: The experiences of Irish adults living with obesity during the COVID-19 pandemic

Author(s): Emma Farrell; Eva Hollmann; Carel Le Roux; Joe Nadglowski; Deirdre McGillicuddy
Published in: EClinicalMedicine, 2022, ISSN 2589-5370
Publisher: Elsevier
DOI: 10.1016/j.eclinm.2022.101568

“I am terrified of something happening to me” The lived experience of people with obesity during the COVID ‐19 pandemic

Author(s): Andrew Grannell, Carel W. Roux, Deirdre McGillicuddy
Published in: Clinical Obesity, Issue 10/6, 2020, ISSN 1758-8103
Publisher: Clinical Obesity
DOI: 10.1111/cob.12406

Association between arterial stiffness/remodeling and new-onset type 2 diabetes mellitus in general population

Author(s): Fariba Ahmadizar; Kan Wang; Maurits Roos; Maxime Bos; Francesco Mattace- Raso; Maryam Kavousi
Published in: Diabetes Research and Clinical Practice, 2023, ISSN 0168-8227
Publisher: Elsevier BV
DOI: 10.1016/j.diabres.2023.110237

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