Project description
Optimising obesity treatment through sorting into relevant groups
Obesity is often perceived as a lack of self control rather than a disease. The EU-funded SOPHIA project aims to challenge this misconception by providing evidence for disease heterogeneity and create a shared value where all the stakeholders can do well by doing good. Researchers will identify predictors of risks of obesity complications as well as the subpopulations who are at risk of specific complications (e.g. type 2 diabetes, T2D, cardiovascular disease, CVD, cancers and osteoarthritis). The project will also identify predictors of response to different obesity treatments. The outcomes of this research will allow patients to receive higher quality information which in turn will empower them to make decisions together with their healthcare professionals in regards to their treatment.
Objective
SOPHIA will optimise the future treatment of obesity. The challenge is that clinicians, payers and patients view obesity as a failure of self-control, rather than a disease. We will change this perspective by defining subpopulations in terms of (a) the risks of complications linked to obesity, (b) response to various obesity treatments. The subpopulations will be characterised in terms of operational variables (phenotypic, genetic, behavioural, environmental, and omics). These predictive variables will facilitate diagnosis and underpin personalised and protocolised obesity care.
Patient priorities regarding risk and response will influence all aspects of our work. SOPHIA will create a federated database of premier EU cohorts to identify operational variables that are predictive of risk and treatment response in people with and without diabetes. We will validate the predictive value of these variables before creating clinically-useful algorithms to decide “when-to-treat” and “how-to-treat”. Biomarker variables will feed into innovative assays, tests and research targets. We will interpret and analyse our results, to identify shared value across all stakeholders (patients, clinicians, industry, payers).
SOPHIA will change attitudes and experience of obesity by (1) demonstrating the heterogeneity of the disease, (2) identifying people at risk of complications, (3) identifying the best treatment for each individual, (4) delivering a common vocabulary and shared understanding of obesity, (5) demonstrating shared value, which combines commercial opportunity with societal benefit.
Our ambition will only be realised if (a) payers agree to fund treatment, (b) industry generate effective treatments, (c) clinicians are prepared to prescribe treatments, and (d) patients are prepared to take treatments. The evidence base does not currently exist. SOPHIA will deliver this evidence and the shared value analysis to drive this revolution in obesity care.
Fields of science
Keywords
Programme(s)
Funding Scheme
RIA - Research and Innovation actionCoordinator
4 Dublin
Ireland
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Participants (38)
DD1 4HN Dundee
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22100 Lund
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EX4 4QJ Exeter
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3015 GD Rotterdam
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6200 MD Maastricht
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89081 Ulm
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405 30 Goeteborg
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T12 YN60 Cork
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A96 E8H2 DUBLIN
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
01307 Dresden
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
20052 Washington Dc
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1206 Geneve
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3000 Leuven
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1000 Bruxelles / Brussel
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
20123 Milano
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Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.
00133 Roma
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00185 Roma
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17190 Girona
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Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.
08007 Barcelona
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Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.
31080 Pamplona
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72074 Tuebingen
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85399 Hallbergmoos
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
59037 Lille
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D02 N820 Dublin
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2880 Bagsvaerd
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55218 Ingelheim
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10281 NEW YORK
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02111 Boston
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33614 Tampa Fl
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1131 Tolochenaz
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Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.
3712BA Huis Ter Heide
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RG21 4FA Basingstoke
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CT13 9NJ Sandwich
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68125 Tel Aviv
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1011 Lausanne
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15462 SHARQ
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75012 Paris
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BS8 1QU Bristol
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