Stratification of Obesity Phenotypes to Optimize Future Therapy

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Dataset profiles handbook
Needs and challenges communication package

Pubblicazioni

Genetic evidence that high BMI in childhood has a protective effect on intermediate diabetes traits, including measures of insulin sensitivity and secretion, after accounting for BMI in adulthood

Autori: Gareth Hawkes; Robin N. Beaumont; Jessica Tyrrell; Grace M. Power; Andrew Wood; Markku Laakso; Lilian Fernandes Silva; Michael Boehnke; Xianyong Yin; Tom G. Richardson; George Davey Smith; Timothy M. Frayling
Pubblicato in: Diabetologia, 2023, ISSN 1949-2448
Editore: Springer link
DOI: 10.1007/s00125-023-05923-6

Is COVID-19 to Blame? Trends of Incidence and Sex Ratio in Youth-Onset Type 2 Diabetes in Germany

Autori: Christian Denzer; Christian Denzer; Daniela Klose; Antje Korner; Thomas Reinehr; Christina Baechle; Carmen Schroder; Susanna Wiegand; Reinhard W. Holl; Nicole Prinz
Pubblicato in: Diabetes care, 2023, ISSN 0012-1797
Editore: American Diabetes Association
DOI: 10.2337/dc22-2257

Cardiovascular health, genetic predisposition, and lifetime risk of type 2 diabetes

Autori: Kan Wang; Maryam Kavousi; Trudy Voortman; M. Arfan Ikram; Mohsen Ghanbari; Fariba Ahmadizar;
Pubblicato in: European Journal of Preventive Cardiology, 2021, ISSN 2047-4873
Editore: SAGE Publications Ltd
DOI: 10.1093/eurjpc/zwab141

A phenome-wide comparative analysis of genetic discordance between obesity and type 2 diabetes

Autori: Daniel E. Coral; Juan Fernandez-Tajes; Neli Tsereteli; Hugo Pomares-Millan; Hugo Fitipaldi; Pascal M. Mutie; Naeimeh Atabaki-Pasdar; Sebastian Kalamajski; Alaitz Poveda; Tyne W. Miller-Fleming; Xue Zhong; Giuseppe N. Giordano; Ewan R. Pearson; Nancy J. Cox; Paul W. Franks
Pubblicato in: Nature Metabolism, 2023, ISSN 2522-5812
Editore: Nature Metabolism
DOI: 10.1038/s42255-022-00731-5

Comparison of cardiovascular risk factors between children and adolescents with classes III and IV obesity: findings from the APV cohort

Autori: Thomas Reinehr, Sascha R. Tittel, Rolf Holle, Susanna Wiegand, Ines Gellhaus, Johannes Hebebrand, Susanne Greber-Platzer, Christian Denzer, Sabine Linke, Wieland Kiess, Reinhard W. Holl
Pubblicato in: International Journal of Obesity, Numero 45/5, 2021, Pagina/e 1061-1073, ISSN 0307-0565
Editore: Nature Publishing Group
DOI: 10.1038/s41366-021-00773-x

Clinical characteristics and cardiovascular risk profile in children and adolescents with latent autoimmune diabetes: Results from the German/Austrian prospective diabetes follow‐up registry

Autori: Alena Welters, Sascha R. Tittel, Thomas Reinehr, Daniel Weghuber, Susanna Wiegand, Wolfram Karges, Clemens Freiberg, Thomas Meissner, Nanette C. Schloot, Reinhard W. Holl
Pubblicato in: Pediatric Diabetes, Numero 23, 2022, Pagina/e 1602-1612, ISSN 1399-543X
Editore: Blackwell Publishing Inc.
DOI: 10.1111/pedi.13450

“You Are Always at War With Yourself” The Perceptions and Beliefs of People With Obesity Regarding Obesity as a Disease

Autori: Andrew Grannell; Carel W. le Roux; Deirdre McGillicuddy;
Pubblicato in: Qualitative Health Research, 2021, ISSN 1049-7323
Editore: SAGE Publications
DOI: 10.1177/10497323211040767

BMI Z-Score (SDS) versus Calculated Body Fat Percentage: Association with Cardiometabolic Risk Factors in Obese Children and Adolescents

Autori: Christine Joisten, Stefanie Wessely, Nicole Prinz, Susanna Wiegand, Bettina Gohlke, Sabine Keiser, Paula Moliterno, Jens Nielinger, Gabriel Torbahn, Hagen Wulff, Reinhard W. Holl, null null
Pubblicato in: Annals of Nutrition and Metabolism, Numero 80, 2024, Pagina/e 29-36, ISSN 0250-6807
Editore: S. Karger AG
DOI: 10.1159/000535216

The lived experience of people with obesity: study protocol for a systematic review and synthesis of qualitative studies

Autori: Emma Farrell, Marta Bustillo, Carel W. le Roux, Joe Nadglowski, Eva Hollmann & Deirdre McGillicuddy
Pubblicato in: Systematic Reviews, 2021, ISSN 2046-4053
Editore: BioMed Central
DOI: 10.1186/s13643-021-01706-5

The double burden: Navigating type 1 diabetes and obesity

Autori: Nele Steenackers, Alix Nessa Feldman, Chantal Mathieu, Jonathan Rosen, Jeannette Soderberg, Ebaa Al‐Ozairi, Carel W. le Roux, Bart Van der Schueren
Pubblicato in: Clinical Obesity, Numero 14, 2024, ISSN 1758-8103
Editore: Wiley
DOI: 10.1111/cob.12645

Altered Insulin Clearance after Gastric Bypass and Sleeve Gastrectomy in the Fasting and Prandial Conditions

Autori: Marzieh Salehi, Ralph DeFronzo, and Amalia Gastaldelli
Pubblicato in: Molecular Sciences, 2022, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms23147667

Exposome-wide ranking of modifiable risk factors for cardiometabolic disease traits

Autori: Alaitz Poveda; Hugo Pomares-Millan; Yan Chen; Azra Kurbasic; Chirag J. Patel; Frida Renström; Göran Hallmans,; Ingegerd Johansson; Paul W. Franks
Pubblicato in: Sci Rep, 2022, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-022-08050-1

Precision medicine in diabetes: a Consensus Report from the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD)

Autori: Wendy K. Chung, Karel Erion, Jose C. Florez, Andrew T. Hattersley, Marie-France Hivert, Christine G. Lee, Mark I. McCarthy, John J. Nolan, Jill M. Norris, Ewan R. Pearson, Louis Philipson, Allison T. McElvaine, William T. Cefalu, Stephen S. Rich, Paul W. Franks
Pubblicato in: Diabetologia, Numero 63, 2021, Pagina/e 1671-1693, ISSN 0012-186X
Editore: Springer Verlag
DOI: 10.1007/s00125-020-05181-w

Not All Type-2-Diabetes Patients Increase Body Mass Index After Initiating Insulin: Results of Latent Class Analysis from the DPV Registry

Autori: Nicole Prinz; Anke Schwandt; Bernadette Borgert; Bettina Hartmann; Hans-Peter Kempe; Julia K. Mader; Sigrund Merger; Rosmarie Weber-Lauffer; Frank-Jürgen Wosch; Reinhard W. Holl;
Pubblicato in: Diabetes Technology & Therapeutics, 2021, ISSN 1520-9156
Editore: Mary Ann Liebert Inc.
DOI: 10.1089/dia.2021.0144

Who benefits most from outpatient lifestyle intervention? An <scp>IMI‐SOPHIA</scp> study on pediatric individuals living with overweight and obesity

Autori: Nicole Prinz, Hugo Pomares‐Millan, Almut Dannemann, Giuseppe N. Giordano, Christine Joisten, Antje Körner, Daniel Weghuber, Susann Weihrauch‐Blüher, Susanna Wiegand, Reinhard W. Holl, Stefanie Lanzinger, null null
Pubblicato in: Obesity, Numero 31, 2024, Pagina/e 2375-2385, ISSN 1930-7381
Editore: Wiley-Blackwell
DOI: 10.1002/oby.23844

The lived experience of patients with obesity: A systematic review and qualitative synthesis

Autori: Emma Farrell, Eva Hollmann, Carel W. le Roux, Marta Bustillo, Joe Nadglowski, Deirdre McGillicuddy
Pubblicato in: Obesity Reviews, 2021, ISSN 1467-7881
Editore: Blackwell Publishing Inc.
DOI: 10.1111/obr.13334

Body Mass Index's influence on arterial hypertension in Type 1 diabetes – A brief report from IMI-SOPHIA study

Autori: Laurence D. Petty, Enrique Soto-Pedre, Rory J. McCrimmon, Ewan R. Pearson
Pubblicato in: Journal of Diabetes and its Complications, Numero 38, 2024, Pagina/e 108747, ISSN 1056-8727
Editore: Elsevier BV
DOI: 10.1016/j.jdiacomp.2024.108747

Accurate liquid biopsy for the diagnosis of non-alcoholic steatohepatitis and liver fibrosis

Autori: Giulia Angelini, Simona Panunzi, Lidia Castagneto-Gissey, Francesca Pellicanò, Andrea De Gaetano, Maurizio Pompili, Laura Riccardi, Matteo Garcovich, Marco Raffaelli, Luigi Ciccoritti, Ornella Verrastro, Maria Francesca Russo, Fabio Maria Vecchio, Giovanni Casella, James Casella-Mariolo, Luigi Papa, Pier Luigi Marini, Francesco Rubino, Carel W le Roux, Stefan Bornstein, Geltrude Mingrone
Pubblicato in: Gut, Numero 72, 2023, Pagina/e 392-403, ISSN 0017-5749
Editore: BMJ Publishing Group
DOI: 10.1136/gutjnl-2022-327498

Disease heterogeneity of adult diabetes based on routine clinical variables at diagnosis: Results from the German/Austrian Diabetes Follow-up Registry

Autori: Julia M. Grimsmann; Sascha R. Tittel; Peter Bramlage; Benjamin Mayer; Andreas Fritsche; Jochen Seufert; Markus Laimer; Stefan Zimny; Sebastian M. Meyhoefer; Michael Hummel; Reinhard W. Holl
Pubblicato in: Diabetes, Obesity and Metabolism, 2022, ISSN 1463-1326
Editore: Diabetes, Obesity and Metabolism
DOI: 10.1111/dom.14812

Characterisation and clinical outcomes in children and adolescents with diabetes according to newly defined subgroups: a cohort study from the DPV registry

Autori: Katharina Warncke, Alexander Eckert, Ezio Bonifacio, Peter Achenbach, Olga Kordonouri, Thomas Meissner, Ute Ohlenschläger, Walter Bonfig, Anette-G. Ziegler, Reinhard W. Holl
Pubblicato in: eClinicalMedicine, Numero 64, 2024, Pagina/e 102208, ISSN 2589-5370
Editore: eClinicalMedicine
DOI: 10.1016/j.eclinm.2023.102208

Access to Healthcare for Children and Adolescents with a Chronic Health Condition during the COVID-19 Pandemic: First Results from the KICK-COVID Study in Germany

Autori: Julia M. Göldel, Clemens Kamrath, Kirsten Minden, Susanna Wiegand, Stefanie Lanzinger, Claudia Sengler, Susann Weihrauch-Blüher, Reinhard W. Holl, Sascha R. Tittel, Petra Warschburger
Pubblicato in: Children, Numero 10, 2024, Pagina/e 10, ISSN 2227-9067
Editore: Children
DOI: 10.3390/children10010010

Special diet in type 1 diabetes: do gender and BMI-SDS differ?

Autori: Alena Gerlinde Thiele; Nicole Prinz; Monika Flury; Melanie Hess; Daniela Klose; Thomas Meissner; Klemens Raile; Klemens Raile; Sabine Wenzel; Sascha Tittel; Thomas Kapellen; Reinhard Holl
Pubblicato in: Child and Adolescent Obesity, 2021, ISSN 2227-9067
Editore: Taylor & Francis
DOI: 10.1080/2574254x.2021.2002061

Plasma circulating microRNAs associated with obesity, body fat distribution, and fat mass: the Rotterdam Study

Autori: Yasir J. Abozaid; Xiaofang Zhang; Michelle M. J. Mens; Fariba Ahmadizar; Marlou Limpens; M. Arfan Ikram; Fernando Rivadeneira; Trudy Voortman; Maryam Kavousi; Mohsen Ghanbari
Pubblicato in: International Journal of Obesity, 2022, ISSN 1476-4687
Editore: Nature
DOI: 10.1038/s41366-022-01227-8

BMI variability and cardiovascular outcomes within clinical trial and real-world environments in type 2 diabetes: an IMI2 SOPHIA study

Autori: Robert J. Massey, Yu Chen, Marina Panova-Noeva, Michaela Mattheus, Moneeza K. Siddiqui, Nanette C. Schloot, Antonio Ceriello, Ewan R. Pearson, Adem Y. Dawed
Pubblicato in: Cardiovascular Diabetology, Numero 23, 2024, ISSN 1475-2840
Editore: BioMed Central
DOI: 10.1186/s12933-024-02299-8

Achieving consensus on the language of obesity: a modified Delphi study

Autori: Cecilie Heerdegen Jepsen, Jacqueline Bowman-Busato, Thomas Allvin, Niamh Arthurs, Gijs H. Goossens, Elisabeth Govers, Benjamin Assad Jaghutriz, Vicki Mooney, Bart Van der Schueren, Carel W. le Roux
Pubblicato in: eClinicalMedicine, Numero 62, 2024, Pagina/e 102061, ISSN 2589-5370
Editore: eClinical Medicine
DOI: 10.1016/j.eclinm.2023.102061

Fetal alleles predisposing to metabolically favorable adiposity are associated with higher birth weight

Autori: William D Thompson, Robin N Beaumont, Alan Kuang, Nicole M Warrington, Yingjie Ji, Jessica Tyrrell, Andrew R Wood, Denise M Scholtens, Bridget A Knight, David M Evans, William L Lowe Jr, Gillian Santorelli, Raq Azad, Dan Mason, Andrew T Hattersley, Timothy M Frayling, Hanieh Yaghootkar, Maria Carolina Borges, Deborah A Lawlor, Rachel M Freathy
Pubblicato in: Human Molecular Genetics, Numero 31, 2022, Pagina/e 1762-1775, ISSN 0964-6906
Editore: Oxford University Press
DOI: 10.1093/hmg/ddab356

Upper gut heat shock proteins HSP70 and GRP78 promote insulin resistance, hyperglycemia, and non-alcoholic steatohepatitis

Autori: Giulia Angelini; Lidia Castagneto-Gissey; Serenella Salinari; Alessandro Bertuzzi; Danila Anello; Meenakshi Pradhan; Marlen Zschätzsch; Paul Ritter; CarelW. Le Roux; Francesco Rubino; Nicola Basso; Giovanni Casella; Stefan R. Bornstein; Valentina Tremaroli; Geltrude Mingrone
Pubblicato in: Nature Communications, 2022, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-022-35310-5

Three‐variate trajectories of metabolic control, body mass index, and insulin dose: Heterogeneous response to initiation of pump therapy in youth with type 1 diabetes

Autori: Martin Tauschmann, Anke Schwandt, Nicole Prinz, Marianne Becker, Torben Biester, Melanie Hess, Martin Holder, Beate Karges, Andrea Näke, Oliver Kuss, Simone Sengbusch, Reinhard W. Holl, null null
Pubblicato in: Pediatric Diabetes, Numero 23, 2022, Pagina/e 330-340, ISSN 1399-543X
Editore: Blackwell Publishing Inc.
DOI: 10.1111/pedi.13320

Comparison of BMI and HbA1c changes before and during the COVID-19 pandemic in type 1 diabetes: a longitudinal population-based study

Autori: Marie Auzanneau, Dorothee M. Kieninger, Katharina Laubner, Christian Renner, Joaquina Mirza, Gerhard Däublin, Kirsten Praedicow, Holger Haberland, Claudia Steigleder-Schweiger, Bettina Gohlke, Angela Galler, Reinhard W. Holl, null null
Pubblicato in: Journal of Diabetes & Metabolic Disorders, Numero 23, 2024, Pagina/e 573-583, ISSN 2251-6581
Editore: BioMed Central
DOI: 10.1007/s40200-023-01316-z

The association between perinatal factors and cardiometabolic risk factors in children and adolescents with overweight or obesity: A retrospective two-cohort study

Autori: Nicole Prinz, Resthie R. Putri, Thomas Reinehr, Pernilla Danielsson, Daniel Weghuber, Mikael Norman, Niels Rochow, Claude Marcus, Reinhard W. Holl, Emilia Hagman
Pubblicato in: PLOS Medicine, Numero 20, 2023, Pagina/e e1004165, ISSN 1549-1676
Editore: PLoS Med
DOI: 10.1371/journal.pmed.1004165

Disease heterogeneity of adult diabetes based on routine clinical parameters at diagnosis: Results from the German/Austrian DPV registry.

Autori: Grimsmann, Julia M; Tittel, Sascha R; Bramlage, Peter; Mayer, Benjamin; Fritsche, Andreas; Seufert, Jochen; Laimer, Markus; Zimny, Stefan; Meyhoefer, Sebastian M; Hummel, Michael; Holl, Reinhard W
Pubblicato in: Grimsmann, Julia M; Tittel, Sascha R; Bramlage, Peter; Mayer, Benjamin; Fritsche, Andreas; Seufert, Jochen; Laimer, Markus; Zimny, Stefan; Meyhoefer, Sebastian M; Hummel, Michael; Holl, Reinhard W (2022). Disease heterogeneity of adult diabetes based on routine clinical parameters at diagnosis: Results from the German/Austrian DPV registry. Diabetes, obesity & metabolism, 24(11), pp. 2253-2262. Wi, Numero 1, 2022, ISSN 1463-1326
Editore: Diabetes, obesity & metabolism
DOI: 10.48350/171154

Obesity in people living with type 1 diabetes

Autori: Bart Van der Schueren Darcy Ellis Raquel NFaradji Eeba Al-Ozairi Jonathan Rosen Chantal Mathieu
Pubblicato in: The Lancet Diabetes & Endocrinology, 2021, ISSN 2213-8587
Editore: Elsevier BV
DOI: 10.1016/s2213-8587(21)00246-1

Combining diabetes, sex, and menopause as meaningful clinical features associated with NASH and liver fibrosis in individuals with class II and III obesity: A retrospective cohort study

Autori: Violeta Raverdy, Estelle Chatelain, Guillaume Lasailly, Robert Caiazzo, Jimmy Vandel, Helene Verkindt, Camille Marciniak, Benjamin Legendre, Pierre Bauvin, Naima Oukhouya‐Daoud, Gregory Baud, Mikael Chetboun, Marie‐Christine Vantyghem, Viviane Gnemmi, Emmanuelle Leteurtre, Bart Staels, Philippe Lefebvre, Philippe Mathurin, Guillemette Marot, Francois Pattou
Pubblicato in: Obesity, Numero 31, 2024, Pagina/e 3066-3076, ISSN 1930-7381
Editore: Wiley-Blackwell
DOI: 10.1002/oby.23904

Development and validation of an interpretable machine learning-based calculator for predicting 5-year weight trajectories after bariatric surgery: a multinational retrospective cohort SOPHIA study

Autori: Patrick Saux, Pierre Bauvin, Violeta Raverdy, Julien Teigny, Hélène Verkindt, Tomy Soumphonphakdy, Maxence Debert, Anne Jacobs, Daan Jacobs, Valerie Monpellier, Phong Ching Lee, Chin Hong Lim, Johanna C Andersson-Assarsson, Lena Carlsson, Per-Arne Svensson, Florence Galtier, Guelareh Dezfoulian, Mihaela Moldovanu, Severine Andrieux, Julien Couster, Marie Lepage, Erminia Lembo, Ornella Verrastro,
Pubblicato in: The Lancet Digital Health, Numero 5, 2023, Pagina/e e692-e702, ISSN 2589-7500
Editore: Lancet Digital Health
DOI: 10.1016/s2589-7500(23)00135-8

At home and at risk: The experiences of Irish adults living with obesity during the COVID-19 pandemic

Autori: Emma Farrell; Eva Hollmann; Carel Le Roux; Joe Nadglowski; Deirdre McGillicuddy
Pubblicato in: EClinicalMedicine, 2022, ISSN 2589-5370
Editore: Elsevier
DOI: 10.1016/j.eclinm.2022.101568

“I am terrified of something happening to me” The lived experience of people with obesity during the COVID ‐19 pandemic

Autori: Andrew Grannell, Carel W. Roux, Deirdre McGillicuddy
Pubblicato in: Clinical Obesity, Numero 10/6, 2020, ISSN 1758-8103
Editore: Clinical Obesity
DOI: 10.1111/cob.12406

Association between arterial stiffness/remodeling and new-onset type 2 diabetes mellitus in general population

Autori: Fariba Ahmadizar; Kan Wang; Maurits Roos; Maxime Bos; Francesco Mattace- Raso; Maryam Kavousi
Pubblicato in: Diabetes Research and Clinical Practice, 2023, ISSN 0168-8227
Editore: Elsevier BV
DOI: 10.1016/j.diabres.2023.110237

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