Advancing Tools for Human Early Lifecourse Exposome Research and Translation

Deliverables

E-learning materials, R packages and shiny apps for exposome and cross-omics data analysis

E-learning materials, R packages and shiny apps for exposome and cross-omics data analysis as developed by task 3.6

DataSHIELD platform for exposome and omic data analysis

Co-lead UNEW and ISGlobal.DataSHIELD platform for exposome and omic data analysis as developed by task 3.5

Co-lead Bettair and ISGlobal.This deliverable contains the App that study participants can install on their own phones for geolocalisation and physical activity data collection (task 2.3.1).

Harmonization mapping system

Harmonization mapping system – project members can define and share interoperability algorithms.This report will describe all harmonisation protocols developed for the ATHLETE cohort data.

Report describing strategies for exposome-health statistical analyses

This report will contain the statistical strategies and protocols developed by task 3.1 and 3.2.

Report comparing advanced statistical data integration strategies for cross-omics analysis

Co-Lead CNRS and USC.This task will contain the statistical strategies and protocols developed by task 3.3.

Data access protocols

D1.5 Data access protocols – cohorts and other data providers can make their data securely accessible. This deliverable will describe the data access approaches and procedures within and outside the consortium.

Intervention priorities and briefing notes for policy makers

Intervention priorities and briefing notes for policy makers with prioritised interventions.This deliverable will report the priorities resulting from task 7.4 with briefing notes.

Dissemination and engagement plan

This document will contain a guide on how to disseminate activities and outcomes in clear and accessible formats to reach the scientific, environmental health, urban and transport planning, clinical and public health community, and the general public.

Publication policy

This document will contain the publication policy for the whole project during the first year, agreed between all partners of the consortium. It will contain open access guidelines, authorship policy, and a pipeline to obtain the centralised funding for publications.

AOPs and aggregate exposure variables for use in analyses

AOPs and aggregate exposure variables for use in analyses linking the exposome to health outcomes.This report will describe the AOP methods used and indices developed by task 4.5.

Report describing strategies for incorporating external knowledge

Co-Lead ISGlobal and CNRS.This report will contain the statistical strategies and protocols developed by task 3.4.

Policy strategy

Update Joint policy strategy for the network

Data Management Plan

Co-lead ISGlobal and UMCG. This report will contain: 1) handling of research data during and after the end of the project, 2) what data will be collected, processed or generated, 3) which methodology and standards will be applied, 4) whether data will be shared/made open access and, 5) how data will be curated and preserved (including after the end of the project).

Publications

Applying the exposome concept in birth cohort research: a review of statistical approaches

Author(s): Susana Santos, Léa Maitre, Charline Warembourg, Lydiane Agier, Lorenzo Richiardi, Xavier Basagaña, Martine Vrijheid
Published in: European Journal of Epidemiology, Issue 35/3, 2020, Page(s) 193-204, ISSN 0393-2990
Publisher: Kluwer Academic Publishers
DOI: 10.1007/s10654-020-00625-4

Prenatal environmental exposures associated with sex differences in childhood obesity and neurodevelopment

Author(s): Alejandro Cáceres, Natàlia Carreras-Gallo, Sandra Andrusaityte, Mariona Bustamante, Ángel Carracedo, Leda Chatzi, Varun B. Dwaraka, Regina Grazuleviciene, Kristine Bjerve Gutzkow, Johanna Lepeule, Léa Maitre, Tavis L. Mendez, Mark Nieuwenhuijsen, Remy Slama, Ryan Smith, Nikos Stratakis, Cathrine Thomsen, Jose Urquiza, Hannah Went, John Wright, Tiffany Yang, Maribel Casas, Martine Vrijheid, Jua
Published in: BMC Medicine, Issue 21, 2023, ISSN 1741-7015
Publisher: BioMed Central
DOI: 10.1186/s12916-023-02815-9

Childhood exposure to non-persistent endocrine disrupting chemicals and multi-omic profiles: A panel study

Author(s): Lorenzo Fabbri, Ronan Garlantézec, Karine Audouze, Mariona Bustamante, Ángel Carracedo, Leda Chatzi, Juan Ramón González, Regina Gražulevičienė, Hector Keun, Chung-Ho E Lau, Eduard Sabidó, Alexandros P Siskos, Rémy Slama, Cathrine Thomsen, John Wright, Wen Lun Yuan, Maribel Casas, Martine Vrijheid, Léa Maitre
Published in: Environment International, Issue 173, 2024, Page(s) 107856, ISSN 0160-4120
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.envint.2023.107856

First trimester fetal proportion volumetric measurements using a Virtual Reality approach.

Author(s): Clarissa J. Wiertsema; Jan S. Erkamp; A. Mulders; Eric A.P. Steegers; Liesbeth Duijts; Anton H. J. Koning; Anton H. J. Koning; Romy Gaillard; Vincent W. V. Jaddoe
Published in: Prenatal Diagnosis, Issue 41(7), 2021, ISSN 0197-3851
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/pd.5947

Multi-omics signatures of the human early life exposome

Author(s): Léa Maitre, Mariona Bustamante, Carles Hernández-Ferrer, Denise Thiel, Chung-Ho E. Lau, Alexandros P. Siskos, Marta Vives-Usano, Carlos Ruiz-Arenas, Dolors Pelegrí-Sisó, Oliver Robinson, Dan Mason, John Wright, Solène Cadiou, Rémy Slama, Barbara Heude, Maribel Casas, Jordi Sunyer, Eleni Z. Papadopoulou, Kristine B. Gutzkow, Sandra Andrusaityte, Regina Grazuleviciene, Marina Vafeiadi, Leda Ch
Published in: Nature Communications, Issue 13:7024, 2022, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-022-34422-2

Bisphenol and phthalate exposure during pregnancy and the development of childhood lung function and asthma. The Generation R Study

Author(s): Tarik Karramass, Chalana Sol, Kurunthachalam Kannan, Leonardo Trasande, Vincent Jaddoe, Liesbeth Duijts
Published in: Environmental Pollution, Issue 332, 2023, Page(s) 121853, ISSN 0269-7491
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.envpol.2023.121853

Nitrogen dioxide exposure, attentional function, and working memory in children from 4 to 8 years: Periods of susceptibility from pregnancy to childhood

Author(s): Kellie L.H.A. Crooijmans, Carmen Iñiguez, Kristina W. Withworth, Marisa Estarlich, Aitana Lertxundi, Ana Fernández-Somoano, Adonina Tardón, Jesús Ibarluzea, Jordi Sunyer, Mònica Guxens, Anne-Claire Binter
Published in: Environment International, Issue 186, 2024, Page(s) 108604, ISSN 0160-4120
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.envint.2024.108604

State-of-the-Art Methods for Exposure-Health Studies: results from the Exposome Data Challenge Event

Author(s): Maitre, Léa; Guimbaud, Jean-Baptiste; Warembourg, Charline; Güil-Oumrait, Nuria; Consortium, The Exposome Data Challenge Participant; Petrone, Paula Marcela; Chadeau-Hyam, Marc; Vrijheid, Martine; Gonzalez, Juan R.; Basagaña, Xavier
Published in: Environment International, Issue 168, 2022, ISSN 0160-4120
Publisher: Pergamon Press Ltd.
DOI: 10.48550/arxiv.2202.01680

A host–gut microbial amino acid co-metabolite, <i>p</i>-cresol glucuronide, promotes blood–brain barrier integrity <i>in vivo</i>

Author(s): Andrew V. Stachulski; Tobias B-A Knausenberger; Sita N. Shah; Lesley Hoyles; Simon McArthur
Published in: Tissue Barriers, Issue 11(1), 2022, ISSN 2168-8362
Publisher: Taylor & Francis
DOI: 10.1080/21688370.2022.2073175

Fully exploiting SNP arrays: a systematic review on the tools to extract underlying genomic structure

Author(s): Laura Balagué-Dobón, Alejandro Cáceres, Juan R González
Published in: Briefings in Bioinformatics, Issue bbac043, 2022, ISSN 1467-5463
Publisher: Oxford University Press
DOI: 10.1093/bib/bbac043

Integrating -omics approaches into population-based studies of endocrine disrupting chemicals: A scoping review

Author(s): Léa Maitre, Paulina Jedynak, Marta Gallego, Laura Ciaran, Karine Audouze, Maribel Casas, Martine Vrijheid
Published in: Environmental Research, Issue 228, 2023, Page(s) 115788, ISSN 0013-9351
Publisher: Academic Press
DOI: 10.1016/j.envres.2023.115788

Associations of physical condition with lung function and asthma in adolescents from the general population

Author(s): Sara M. Mensink‐Bout, Marc R. Jahangir, Johan C. de Jongste, Hein Raat, Vincent W. V. Jaddoe, Liesbeth Duijts
Published in: Pediatric Allergy and Immunology, Issue 33, 2023, ISSN 0905-6157
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/pai.13811

A case study of neurodevelopmental risks from combined exposures to lead, methyl-mercury, inorganic arsenic, polychlorinated biphenyls, polybrominated diphenyl ethers and fluoride

Author(s): Corinne Sprong, Jan Dirk te Biesebeek, Mousumi Chatterjee, Gerrit Wolterink, Annick van den Brand, Urska Blaznik, Despo Christodoulou, Amélie Crépet, Bodil Hamborg Jensen, Darja Sokolić, Elke Rauscher-Gabernig, Jiri Ruprich, Andreas Kortenkamp, Jacob van Klaveren
Published in: International Journal of Hygiene and Environmental Health, Issue 251, 2023, Page(s) 114167, ISSN 1438-4639
Publisher: Elsevier BV
DOI: 10.1016/j.ijheh.2023.114167

Common genetic variants associated with urinary phthalate levels in children: A genome-wide study

Author(s): Mariona Bustamante, Laura Balagué-Dobón, Zsanett Buko, Amrit Kaur Sakhi, Maribel Casas, Lea Maitre, Sandra Andrusaityte, Regina Grazuleviciene, Kristine B. Gützkow, Anne-Lise Brantsæter, Barbara Heude, Claire Philippat, Leda Chatzi, Marina Vafeiadi, Tiffany C. Yang, John Wright, Amy Hough, Carlos Ruiz-Arenas, Ramil N. Nurtdinov, Geòrgia Escaramís, Juan R. González, Cathrine Thomsen, Martine
Published in: Environment International, Issue 190, 2024, Page(s) 108845, ISSN 0160-4120
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.envint.2024.108845

Association of exposure to mixture of chemicals during pregnancy with cognitive abilities and fine motor function of children

Author(s): Pavla Brennan Kearns, Michiel A. van den Dries, Jordi Julvez, Mariza Kampouri, Mónica López-Vicente, Lea Maitre, Claire Philippat, Line Småstuen Haug, Marina Vafeiadi, Cathrine Thomsen, Tiffany C Yang, Martine Vrijheid, Henning Tiemeier, Mònica Guxens
Published in: Environment International, Issue 185, 2024, Page(s) 108490, ISSN 0160-4120
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.envint.2024.108490

A Deterministic Approach for Protecting Privacy in Sensitive Personal Data

Author(s): Demetris Avraam; Elinor Jones; Paul Burton
Published in: BMC Medical Informatics and Decision Making, Issue 22(24), 2022, ISSN 1472-6947
Publisher: BioMed Central
DOI: 10.21203/rs.3.rs-344334/v1

Maternal bisphenol urine concentrations, fetal growth and adverse birth outcomes: A population-based prospective cohort

Author(s): Chalana M. Sol, Charissa van Zwol - Janssens, Elise M. Philips, Alexandros G. Asimakopoulos, Maria-Pilar Martinez-Moral, Kurunthachalam Kannan, Vincent W. V. Jaddoe, Leonardo Trasande, Susana Santos
Published in: Environmental Health, Issue 20/1, 2021, ISSN 1476-069X
Publisher: BioMed Central
DOI: 10.1186/s12940-021-00747-6

Prenatal Urban Environment and Blood Pressure Trajectories From Childhood to Early Adulthood

Author(s): Ana Gonçalves Soares, Susana Santos, Emie Seyve, Rozenn Nedelec, Soile Puhakka, Aino-Maija Eloranta, Santtu Mikkonen, Wen Lun Yuan, Deborah A. Lawlor, Jon Heron, Martine Vrijheid, Johanna Lepeule, Mark Nieuwenhuijsen, Serena Fossati, Vincent W.V. Jaddoe, Timo Lakka, Sylvain Sebert, Barbara Heude, Janine F. Felix, Ahmed Elhakeem, Nicholas J. Timpson
Published in: JACC: Advances, Issue 3, 2024, Page(s) 100808, ISSN 2772-963X
Publisher: Elsevier
DOI: 10.1016/j.jacadv.2023.100808

Integrating Multi-Omics with environmental data for precision health: A novel analytic framework and case study on prenatal mercury induced childhood fatty liver disease

Author(s): Jesse A. Goodrich, Hongxu Wang, Qiran Jia, Nikos Stratakis, Yinqi Zhao, Léa Maitre, Mariona Bustamante, Marina Vafeiadi, Max Aung, Sandra Andrušaitytė, Xavier Basagana, Shohreh F. Farzan, Barbara Heude, Hector Keun, Rob McConnell, Tiffany C. Yang, Alexandros P. Siskos, Jose Urquiza, Damaskini Valvi, Nerea Varo, Line Småstuen Haug, Bente M. Oftedal, Regina Gražulevičienė, Claire Philippat, J
Published in: Environment International, Issue 190, 2024, Page(s) 108930, ISSN 0160-4120
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.envint.2024.108930

Performance of approaches relying on multidimensional intermediary data to decipher causal relationships between the exposome and health: A simulation study under various causal structures

Author(s): Solène Cadiou, Xavier Basagaña, Juan R. Gonzalez, Johanna Lepeule, Martine Vrijheid, Valérie Siroux, Rémy Slama
Published in: Environment International, Issue 153, 2021, Page(s) 106509, ISSN 0160-4120
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.envint.2021.106509

Prenatal exposure to common plasticizers: a longitudinal study on phthalates, brain volumetric measures, and IQ in youth

Author(s): Akhgar Ghassabian, Michiel van den Dries, Leonardo Trasande, Sander Lamballais, Suzanne Spaan, Maria-Pilar Martinez-Moral, Kurunthachalam Kannan, Vincent W. V. Jaddoe, Stephanie M. Engel, Anjoeka Pronk, Tonya White, Henning Tiemeier, Mònica Guxens
Published in: Molecular Psychiatry, Issue 28, 2024, Page(s) 4814-4822, ISSN 1359-4184
Publisher: Nature Publishing Group
DOI: 10.1038/s41380-023-02225-6

Interventions to Reduce Exposure to Synthetic Phenols and Phthalates from Dietary Intake and Personal Care Products: a Scoping Review

Author(s): Tiffany C. Yang, Nicolas Jovanovic, Felisha Chong, Meegan Worcester, Amrit K. Sakhi, Cathrine Thomsen, Ronan Garlantézec, Cécile Chevrier, Génon Jensen, Natacha Cingotti, Maribel Casas, Rosemary RC McEachan, Martine Vrijheid, Claire Philippat
Published in: Current Environmental Health Reports, Issue 10, 2023, Page(s) 184-214, ISSN 2196-5412
Publisher: Springer
DOI: 10.1007/s40572-023-00394-8

Associations of Early Pregnancy Metabolite Profiles with Gestational Blood Pressure Development

Author(s): Sophia M. Blaauwendraad; Rama J. Wahab; Bas B. van Rijn; Berthold Koletzko; Vincent W. V. Jaddoe; Romy Gaillard
Published in: Metabolites, Issue 12(12), 2022, ISSN 2218-1989
Publisher: MDPI
DOI: 10.3390/metabo12121169

The effects of heavy metal exposure on brain and gut microbiota: A systematic review of animal studies

Author(s): Simona Porru, Ana Esplugues, Sabrina Llop, Juana María Delgado-Saborit
Published in: Environmental Pollution, Issue 348, 2024, Page(s) 123732, ISSN 0269-7491
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.envpol.2024.123732

Green spaces and respiratory, cardiometabolic, and neurodevelopmental outcomes: An individual-participant data meta-analysis of >35.000 European children

Author(s): Amanda Fernandes, Demetris Avraam, Tim Cadman, Payam Dadvand, Mònica Guxens, Anne-Claire Binter, Angela Pinot de Moira, Mark Nieuwenhuijsen, Liesbeth Duijts, Jordi Julvez, Montserrat De Castro, Serena Fossati, Sandra Márquez, Tanja Vrijkotte, Ahmed Elhakeem, Rosemary McEachan, Tiffany Yang, Marie Pedersen, Johan Vinther, Johanna Lepeule, Barbara Heude, Vincent W.V. Jaddoe, Susana Santos, Marieke
Published in: Environment International, Issue 190, 2024, Page(s) 108853, ISSN 0160-4120
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.envint.2024.108853

Maternal iron status in early pregnancy and childhood body fat measures and cardiometabolic risk factors: A population-based prospective cohort

Author(s): Hugo G. Quezada-Pinedo, Vincent Jaddoe, Liesbeth Duijts, Taulant Muka, Marijn J. Vermeulen, Irwin K.M. Reiss, Susana Santos
Published in: The American Journal of Clinical Nutrition, Issue 117, 2024, Page(s) 191-198, ISSN 0002-9165
Publisher: American Society for Clinical Nutrition, Inc.
DOI: 10.1016/j.ajcnut.2022.10.006

Urban environment during pregnancy and childhood and white matter microstructure in preadolescence in two European birth cohorts

Author(s): Anne-Claire Binter, Laura Granés, Elise Bannier, Montserrat de Castro, Sami Petricola, Serena Fossati, Martine Vrijheid, Cécile Chevrier, Hanan El Marroun, Mark Nieuwenhuijsen, Dave Saint-Amour, Henning Tiemeier, Mònica Guxens
Published in: Environmental Pollution, Issue 346, 2024, Page(s) 123612, ISSN 0269-7491
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.envpol.2024.123612

Association of prenatal exposure to phthalates and synthetic phenols with pubertal development in three European cohorts

Author(s): Carmen Freire, Francesca Castiello, Izaro Babarro, Augusto Anguita-Ruiz, Maribel Casas, Martine Vrijheid, Blanca Sarzo, Andrea Beneito, Manik Kadawathagedara, Claire Philippat, Cathrine Thomsen, Amrit Kaur Sakhi, Maria-Jose Lopez-Espinosa
Published in: International Journal of Hygiene and Environmental Health, Issue 261, 2024, Page(s) 114418, ISSN 1438-4639
Publisher: Elsevier BV
DOI: 10.1016/j.ijheh.2024.114418

Urinary metabolic biomarkers of diet quality in European children are associated with metabolic health

Author(s): Nikos Stratakis, Alexandros P Siskos, Eleni Papadopoulou, Anh N Nguyen, Yinqi Zhao, Katerina Margetaki, Chung-Ho E Lau, Muireann Coen, Lea Maitre, Silvia Fernández-Barrés, Lydiane Agier, Sandra Andrusaityte, Xavier Basagaña, Anne Lise Brantsaeter, Maribel Casas, Serena Fossati, Regina Grazuleviciene, Barbara Heude, Rosemary RC McEachan, Helle Margrete Meltzer, Christopher Millett, Fernanda Raub
Published in: eLife, Issue 11, 2022, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.71332

Blurred lines: Crossing the boundaries between the chemical exposome and the metabolome

Author(s): Cristina Balcells, Yitao Xu, Rubén Gil-Solsona, Léa Maitre, Pablo Gago-Ferrero, Hector C. Keun
Published in: Current Opinion in Chemical Biology, Issue 78, 2024, Page(s) 102407, ISSN 1367-5931
Publisher: Elsevier BV
DOI: 10.1016/j.cbpa.2023.102407

Influence of genetic polymorphisms on arsenic methylation efficiency during pregnancy: Evidence from a Spanish birth cohort

Author(s): Raquel Soler-Blasco, Florencia Harari, Gabriel Riutort-Mayol, Mario Murcia, Manuel Lozano, Amaia Irizar, Loreto Santa Marina, Miren Begoña Zubero, Nora Fernández-Jimenez, Simone Braeuer, Ferran Ballester, Sabrina Llop
Published in: Science of The Total Environment, Issue 900, 2024, Page(s) 165740, ISSN 0048-9697
Publisher: Elsevier BV
DOI: 10.1016/j.scitotenv.2023.165740

Privacy preserving data visualizations

Author(s): Demetris Avraam, Rebecca Wilson, Oliver Butters, Thomas Burton, Christos Nicolaides, Elinor Jones, Andy Boyd, Paul Burton
Published in: EPJ Data Science, Issue 10/1, 2021, ISSN 2193-1127
Publisher: Springer
DOI: 10.1140/epjds/s13688-020-00257-4

Associations of green and blue space exposure in pregnancy with epigenetic gestational age acceleration

Author(s): Irene Marques, Susana Santos, Giulietta S. Monasso, Serena Fossati, Martine Vrijheid, Mark Nieuwenhuijsen, Vincent W. V. Jaddoe, Janine F. Felix
Published in: Epigenetics, Issue 18, 2023, ISSN 1559-2294
Publisher: Landes Bioscience
DOI: 10.1080/15592294.2023.2165321

Green space exposure and blood DNA methylation at birth and in childhood – A multi-cohort study

Author(s): Sofia Aguilar-Lacasaña, Irene Fontes Marques, Montserrat de Castro, Payam Dadvand, Xavier Escribà, Serena Fossati, Juan R González, Mark Nieuwenhuijsen, Rossella Alfano, Isabella Annesi-Maesano, Sonia Brescianini, Kimberley Burrows, Lucinda Calas, Ahmed Elhakeem, Barbara Heude, Amy Hough, Elena Isaevska, Vincent W V Jaddoe, Deborah A Lawlor, Genevieve Monaghan, Tim Nawrot, Michelle Plusquin, Lo
Published in: Environment International, Issue 188, 2024, Page(s) 108684, ISSN 0160-4120
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.envint.2024.108684

Prenatal exposure to PM10 and changes in DNA methylation and telomere length in cord blood

Author(s): Elena Isaevska, Valentina Fiano, Federica Asta, Massimo Stafoggia, Giovenale Moirano, Maja Popovic, Costanza Pizzi, Morena Trevisan, Laura De Marco, Silvia Polidoro, Luigi Gagliardi, Franca Rusconi, Sonia Brescianini, Lorenza Nistico, Maria Antonietta Stazi, Luca Ronfani, Daniela Porta, Lorenzo Richiardi
Published in: Environmental Research, Issue 209: 112717, 2022, ISSN 0013-9351
Publisher: Academic Press
DOI: 10.1016/j.envres.2022.112717

The Exposome Approach to Decipher the Role of Multiple Environmental and Lifestyle Determinants in Asthma

Author(s): Alicia Guillien, Solène Cadiou, Rémy Slama, Valérie Siroux
Published in: International Journal of Environmental Research and Public Health, Issue 18/3, 2021, Page(s) 1138, ISSN 1660-4601
Publisher: MDPI
DOI: 10.3390/ijerph18031138

Identification of autosomal cis expression quantitative trait methylation (cis eQTMs) in children’s blood

Author(s): Carlos Ruiz-Arenas; Carles Hernandez-Ferrer; Marta Vives-Usano; Sergi Mari; Inés Quintela; Dan Mason; Solène Cadiou; Maribel Casas; Sandra Andrusaityte; Kristine B. Gutzkow; Marina Vafeiadi; John Wright; Johanna Lepeule; Regina Grazuleviciene; Leda Chatzi; Angel Carracedo; Xavier Estivill; Eulàlia Martí; Geòrgia Escaramís; Martine Vrijheid; Juan R. González; Mariona Bustamante
Published in: eLife, Issue 11:e65310, 2022, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.1101/2020.11.05.368076

Associations between synthetic phenols, phthalates, and placental growth/function: a longitudinal cohort with exposure assessment in early pregnancy

Author(s): Nicolas Jovanovic, Vicente Mustieles, Marc Althuser, Sarah Lyon-Caen, Nadia Alfaidy, Cathrine Thomsen, Amrit Kaur Sakhi, Azemira Sabaredzovic, Sam Bayat, Anne Couturier-Tarrade, Rémy Slama, Claire Philippat
Published in: Human Reproduction Open, Issue 2024, 2024, ISSN 2399-3529
Publisher: Oxford Academic
DOI: 10.1093/hropen/hoae018

Associations of four biological age markers with child development: A multi-omic analysis in the European HELIX cohort

Author(s): Oliver Robinson, ChungHo E Lau, Sungyeon Joo, Sandra Andrusaityte, Eva Borras, Paula de Prado-Bert, Lida Chatzi, Hector C Keun, Regina Grazuleviciene, Kristine B Gutzkow, Lea Maitre, Dries S Martens, Eduard Sabido, Valérie Siroux, Jose Urquiza, Marina Vafeiadi, John Wright, Tim S Nawrot, Mariona Bustamante, Martine Vrijheid
Published in: eLife, Issue 12, 2023, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.85104

Availability, accessibility, and use of green spaces and cognitive development in primary school children

Author(s): Amanda Fernandes, Norun Hjertager Krog, Rosemary McEachan, Mark Nieuwenhuijsen, Jordi Julvez, Sandra Márquez, Montserrat de Castro, José Urquiza, Barbara Heude, Marina Vafeiadi, Regina Gražulevičienė, Rémy Slama, Audrius Dedele, Gunn Marit Aasvang, Jorunn Evandt, Sandra Andrusaityte, Mariza Kampouri, Martine Vrijheid
Published in: Environmental Pollution, Issue 334, 2024, Page(s) 122143, ISSN 0269-7491
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.envpol.2023.122143

Socioeconomic position, family context, and child cognitive development

Author(s): Llúcia González, Maja Popovic, Marisa Rebagliato, Marisa Estarlich, Giovenale Moirano, Florencia Barreto-Zarza, Lorenzo Richiardi, Enrique Arranz, Loreto Santa-Marina, Daniela Zugna, Jesús Ibarluzea, Costanza Pizzi
Published in: European Journal of Pediatrics, Issue 183, 2024, Page(s) 2571-2585, ISSN 1432-1076
Publisher: Springer
DOI: 10.1007/s00431-024-05482-x

Associations of maternal phthalate and bisphenol urine concentrations during pregnancy with childhood blood pressure in a population-based prospective cohort study

Author(s): Chalana M. Sol, Susana Santos, Alexandros G. Asimakopoulos, Maria-Pilar Martinez-Moral, Liesbeth Duijts, Kurunthachalam Kannan, Leonardo Trasande, Vincent W.V. Jaddoe
Published in: Environment International, Issue 138, 2020, Page(s) 105677, ISSN 0160-4120
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.envint.2020.105677

Cadmium exposures and deteriorations of cognitive abilities: estimation of a reference dose for mixture risk assessments based on a systematic review and confidence rating.

Author(s): Andreas Kortenkamp; Mousumi Chatterjee
Published in: Environmental Health, Issue 9, 2022, ISSN 1476-069X
Publisher: BioMed Central
DOI: 10.1186/s12940-022-00881-9

A population-based study on associations of stool microbiota with atopic diseases in school-age children

Author(s): Chen Hu; Evelien R. van Meel; Carolina Medina-Gomez; Robert Kraaij; Monica Barroso; Jessica C. Kiefte-de Jong; Jessica C. Kiefte-de Jong; Djawad Radjabzadeh; Suzanne G.M.A. Pasmans; Nicolette W. de Jong; Johan C. de Jongste; Henriëtte A. Moll; Tamar Nijsten; Fernando Rivadeneira; Luba M. Pardo; Liesbeth Duijts
Published in: The Journal of Allergy and Clinical Immunology, Issue 10, 2021, ISSN 0091-6749
Publisher: Mosby Inc.
DOI: 10.1016/j.jaci.2021.04.001

Associations between combined urban and lifestyle factors and respiratory health in European children

Author(s): Alicia Guillien, Rémy Slama, Sandra Andrusaityte, Maribel Casas, Leda Chatzi, Montserrat de Castro, Blandine de Lauzon-Guillain, Berit Granum, Regina Grazuleviciene, Jordi Julvez, Norun Hjertager Krog, Johanna Lepeule, Léa Maitre, Rosemary McEachan, Mark Nieuwenhuijsen, Bente Oftedal, Jose Urquiza, Marina Vafeiadi, John Wright, Martine Vrijheid, Xavier Basagaña, Valérie Siroux
Published in: Environmental Research, Issue 242, 2024, Page(s) 117774, ISSN 0013-9351
Publisher: Academic Press
DOI: 10.1016/j.envres.2023.117774

Orchestrating privacy-protected big data analyses of data from different resources with R and DataSHIELD

Author(s): Yannick Marcon, Tom Bishop, Demetris Avraam, Xavier Escriba-Montagut, Patricia Ryser-Welch, Stuart Wheater, Paul Burton, Juan R. González
Published in: PLOS Computational Biology, Issue 17/3, 2021, Page(s) e1008880, ISSN 1553-7358
Publisher: PLOS
DOI: 10.1371/journal.pcbi.1008880

Association between household cleaning product profiles evaluated by the Ménag’Score® index and asthma symptoms among women from the SEPAGES cohort

Author(s): Lemire, Pierre; Chevallier, Emmanuel; Lyon-Caen, Sarah; Sévin, Etienne; Boudier, Anne; da Silva, Emilie Pacheco; de Thuin, Christian; Slama, Rémy; Dumas, Orianne; Siroux, Valérie; Le Moual, Nicole
Published in: International Archives of Occupational and Environmental Health, Issue 95, 2022, ISSN 1432-1246
Publisher: Springer
DOI: 10.1007/s00420-022-01860-w

Urban environment during pregnancy and lung function, wheezing, and asthma in school-age children. The generation R study

Author(s): Alicia Abellan, Charline Warembourg, Sara M. Mensink-Bout, Albert Ambros, Montserrat de Castro, Serena Fossati, Mònica Guxens, Vincent WV. Jaddoe, Mark J. Nieuwenhuijsen, Martine Vrijheid, Susana Santos, Maribel Casas, Liesbeth Duijts
Published in: Environmental Pollution, Issue 344, 2024, Page(s) 123345, ISSN 0269-7491
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.envpol.2024.123345

Ambient air temperature exposure and foetal size and growth in three European birth cohorts

Author(s): Esmée Essers, Laura Granés, Scott Delaney, Joan Ballester, Susana Santos, Sami Petricola, Tiffany C Yang, Ana Fernández-Somoano, Ainhoa Bereziartua, Ferran Ballester, Adonina Tardón, Martine Vrijheid, Aitana Lertxundi, Rosemary R.C. McEachan, Hanan El Marroun, Henning Tiemeier, Carmen Iñiguez, Mònica Guxens
Published in: Environment International, Issue 186, 2024, Page(s) 108619, ISSN 0160-4120
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.envint.2024.108619

Pre-natal exposure to NO2 and PM2.5 and newborn lung function: An approach based on repeated personal exposure measurements

Author(s): Johanna Lepeule, Isabelle Pin, Anne Boudier, Joane Quentin, Sarah Lyon-Caen, Karine Supernant, Emie Seyve, Ryan Chartier, Remy Slama, Valérie Siroux
Published in: Environmental Research, Issue 226, 2024, Page(s) 115656, ISSN 0013-9351
Publisher: Academic Press
DOI: 10.1016/j.envres.2023.115656

Study of the combined effect of maternal tobacco smoking and polygenic risk scores on birth weight and body mass index in childhood

Author(s): Georgina Fuentes-Paez; Geòrgia Escaramís; Sofía Aguilar-Lacasaña; Sandra Andrusaityte; Anne Lise Brantsæter; Maribel Casas; Marie-Aline Charles; Leda Chatzi; Johanna Lepeule; Regina Grazuleviciene; Kristine B. Gützkow; Barbara Heude; Léa Maitre; Carlos Ruiz-Arenas; Jordi Sunyer; Jose Urquiza; Tiffany C. Yang; John Wright; Martine Vrijheid; Natàlia Vilor-Tejedor; Mariona Bustamante
Published in: Frontiers in Genetics, Issue 13, 2022, ISSN 1664-8021
Publisher: Frontiers Media
DOI: 10.3389/fgene.2022.867611

Software application profile: exposomeShiny—a toolbox for exposome data analysis

Author(s): Xavier Escriba-Montagut; Xavier Basagaña; Martine Vrijheid; Juan R. González
Published in: International Journal of Epidemiology, Issue 51(1), 2021, ISSN 0300-5771
Publisher: Oxford University Press
DOI: 10.1093/ije/dyab220

A plausibility database summarizing the level of evidence regarding the hazards induced by the exposome on children health

Author(s): Colzin Stacy, Crépet Amélie, Wies Blanche, Rocabois Audrey, Sanchez Margaux, Perreau Simon, Jean Julien, Redaelli Matteo, Kortenkamp Andreas, Rousselle Christophe, Vrijheid Martine, Nieuwenhuijsen Mark, Slama Rémy, Angeli Karine
Published in: International Journal of Hygiene and Environmental Health, Issue 256, 2024, Page(s) 114311, ISSN 1438-4639
Publisher: Elsevier BV
DOI: 10.1016/j.ijheh.2023.114311

A review of statistical strategies to integrate biomarkers of chemical exposure with biomarkers of effect applied in omic-scale environmental epidemiology

Author(s): Étienne Babin, German Cano-Sancho, Evelyne Vigneau, Jean-Philippe Antignac
Published in: Environmental Pollution, Issue 330, 2023, Page(s) 121741, ISSN 0269-7491
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.envpol.2023.121741

Machine learning-based health environmental-clinical risk scores in European children

Author(s): Jean-Baptiste Guimbaud, Alexandros P. Siskos, Amrit Kaur Sakhi, Barbara Heude, Eduard Sabidó, Eva Borràs, Hector Keun, John Wright, Jordi Julvez, Jose Urquiza, Kristine Bjerve Gützkow, Leda Chatzi, Maribel Casas, Mariona Bustamante, Mark Nieuwenhuijsen, Martine Vrijheid, Mónica López-Vicente, Montserrat de Castro Pascual, Nikos Stratakis, Oliver Robinson, Regina Grazuleviciene, Remy Slama, Si
Published in: Communications Medicine, Issue 4, 2024, ISSN 2730-664X
Publisher: Springer Nature
DOI: 10.1038/s43856-024-00513-y

Early life exposure to mercury and relationships with telomere length and mitochondrial DNA content in European children

Author(s): Manuel Lozano, Rosemary R.C. McEachan, John Wright, Tiffany C. Yang, Courtney Dow, Manik Kadawathagedara, Johanna Lepeule, Mariona Bustamante, Lea Maitre, Martine Vrijheid, Anne Lise Brantsæter, Helle Margrete Meltzer, Vasiliki Bempi, Theano Roumeliotaki, Cathrine Thomsen, Tim Nawrot, Karin Broberg, Sabrina Llop
Published in: Science of The Total Environment, Issue 932, 2024, Page(s) 173014, ISSN 0048-9697
Publisher: Elsevier BV
DOI: 10.1016/j.scitotenv.2024.173014

Statistical Approaches to Study Exposome-Health Associations in the Context of Repeated Exposure Data: A Simulation Study

Author(s): Charline Warembourg, Augusto Anguita-Ruiz, Valérie Siroux, Rémy Slama, Martine Vrijheid, Lorenzo Richiardi, Xavier Basagaña
Published in: Environmental Science & Technology, Issue 57, 2023, Page(s) 16232-16243, ISSN 0013-936X
Publisher: American Chemical Society
DOI: 10.1021/acs.est.3c04805

Maternal pesticides exposure in pregnancy and the risk of wheezing in infancy: A prospective cohort study

Author(s): Silvia Maritano; Giovenale Moirano; Maja Popovic; Antonio D'Errico; Franca Rusconi; Milena Maule; Lorenzo Richiardi
Published in: Environment International, Issue 163, 2022, ISSN 0160-4120
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.envint.2022.107229

Environmental exposures in early-life and general health in childhood

Author(s): Ines Amine, Alicia Guillien, Claire Philippat, Augusto Anguita-Ruiz, Maribel Casas, Montserrat de Castro, Audrius Dedele, Judith Garcia-Aymerich, Berit Granum, Regina Grazuleviciene, Barbara Heude, Line Småstuen Haug, Jordi Julvez, Mónica López-Vicente, Léa Maitre, Rosemary McEachan, Mark Nieuwenhuijsen, Nikos Stratakis, Marina Vafeiadi, John Wright, Tiffany Yang, Wen Lun Yuan, Xavier Basagañ
Published in: Environmental Health, Issue 22, 2023, ISSN 1476-069X
Publisher: BioMed Central
DOI: 10.1186/s12940-023-01001-x

A roadmap to advance exposomics through federation of data

Author(s): Charles P Schmitt, Jeanette A Stingone, Arcot Rajasekar, Yuxia Cui, Xiuxia Du, Chris Duncan, Michelle Heacock, Hui Hu, Juan R Gonzalez, Paul D Juarez, Alex I Smirnov
Published in: Exposome, Issue 3, 2024, ISSN 2635-2265
Publisher: Oxford
DOI: 10.1093/exposome/osad010

Blood miRNA levels associated with ADHD traits in children across six European birth cohorts

Author(s): Lene B. Dypås, Nur Duale, Ann-Karin Olsen, Mariona Bustamante, Lea Maitre, Geòrgia Escaramis, Jordi Julvez, Sofia Aguilar-Lacasaña, Sandra Andrusaityte, Maribel Casas, Marina Vafeiadi, Regina Grazuleviciene, Barbara Heude, Johanna Lepeule, Jose Urquiza, John Wright, Tiffany C. Yang, Martine Vrijheid, Kristine B. Gützkow
Published in: BMC Psychiatry, Issue 23, 2023, ISSN 1471-244X
Publisher: BioMed Central
DOI: 10.1186/s12888-023-05199-5

The exposome concept: how has it changed our understanding of environmental causes of chronic respiratory diseases?

Author(s): Alicia Guillien, Manosij Ghosh, Thomas Gille, Orianne Dumas
Published in: Breathe, Issue 19, 2023, Page(s) 230044, ISSN 1810-6838
Publisher: European Respiratory Society
DOI: 10.1183/20734735.0044-2023

The early-life exposome modulates the effect of polymorphic inversions on DNA methylation

Author(s): Natàlia Carreras-Gallo; Alejandro Cáceres; Laura Balagué-Dobón; Carlos Ruiz-Arenas; Sandra Andrusaityte; Ángel Carracedo; Maribel Casas; Leda Chatzi; Regina Grazuleviciene; Kristine Bjerve Gutzkow; Johanna Lepeule; Léa Maitre; Mark Nieuwenhuijsen; Remy Slama; Nikos Stratakis; Cathrine Thomsen; Jose Urquiza; John Wright; Tiffany Yang; Geòrgia Escaramís; Mariona Bustamante; Martine Vrijheid;
Published in: Communications Biology, Issue 455, 2022, ISSN 2399-3642
Publisher: Springer Nature
DOI: 10.1038/s42003-022-03380-2

Urban environment in pregnancy and postpartum depression: An individual participant data meta-analysis of 12 European birth cohorts

Author(s): Tim Cadman, Katrine Strandberg-Larsen, Lucinda Calas, Malina Christiansen, Iryna Culpin, Payam Dadvand, Montserrat de Castro, Maria Foraster, Serena Fossati, Mònica Guxens, Jennifer R. Harris, Manon Hillegers, Vincent Jaddoe, Yunsung Lee, Johanna Lepeule, Hanan el Marroun, Milena Maule, Rosie McEachen, Chiara Moccia, Johanna Nader, Mark Nieuwenhuijsen, Anne-Marie Nybo Andersen, Rebecca Pearson, M
Published in: Environment International, Issue 185, 2024, Page(s) 108453, ISSN 0160-4120
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.envint.2024.108453

Prenatal maternal smoke, DNA methylation, and multi-omics of tissues and child health

Author(s): Marta Cosin-Tomas; Ariadna Cilleros-Portet; Sofía Aguilar-Lacasaña; Nora Fernandez-Jimenez; Mariona Bustamante
Published in: Current Environmental Health Reports, Issue 9, 2022, ISSN 2196-5412
Publisher: Springer
DOI: 10.1007/s40572-022-00361-9

Fetal Organophosphate Pesticide Exposure and Child Adiposity Measures at 10 Years of Age in the General Dutch Population

Author(s): Sophia M. Blaauwendraad, Danielle R. Stevens, Michiel A. van den Dries, Romy Gaillard, Anjoeka Pronk, Suzanne Spaan, Kelly K. Ferguson, Vincent W.V. Jaddoe
Published in: Environmental Health Perspectives, Issue 131, 2023, ISSN 0091-6765
Publisher: US Department of Health and Human Services
DOI: 10.1289/ehp12267

Towards an Interoperable Ecosystem of Research Cohort andReal-world Data Catalogues Enabling Multi-center Studies

Author(s): Morris Swertz, Esther van Enckevort , José Luis Oliveira , Isabel Fortier , Julie Bergeron , Nicolas H. Thurin , Eleanor Hyde , Alexander Kellmann , Romin Pahoueshnja , Miriam Sturkenboom , Marianne Cunnington , Anne-Marie Nybo Andersen , Yannick Marcon , Gonçalo Gonçalves , Rosa Gini
Published in: Yearbook of medical informatics, Issue 31(01), 2022, ISSN 2364-0502
Publisher: Thieme Medical Publishers Inc.
DOI: 10.1055/s-0042-1742522

Variability of multi-omics profiles in a population-based child cohort

Author(s): Marta Gallego-Paüls, Carles Hernández-Ferrer, Mariona Bustamante, Xavier Basagaña, Jose Barrera-Gómez, Chung-Ho E. Lau, Alexandros P. Siskos, Marta Vives-Usano, Carlos Ruiz-Arenas, John Wright, Remy Slama, Barbara Heude, Maribel Casas, Regina Grazuleviciene, Leda Chatzi, Eva Borràs, Eduard Sabidó, Ángel Carracedo, Xavier Estivill, Jose Urquiza, Muireann Coen, Hector C. Keun, Juan R. Gonzál
Published in: BMC Medicine, Issue 19/1, 2021, ISSN 1741-7015
Publisher: BioMed Central
DOI: 10.1186/s12916-021-02027-z

Lifestyle patterns in European preschoolers: Associations with socio‐demographic factors and body mass index

Author(s): Alexandra Descarpentrie, Lucinda Calas, Maxime Cornet, Barbara Heude, Marie‐Aline Charles, Demetris Avraam, Sonia Brescianini, Tim Cadman, Ahmed Elhakeem, Sílvia Fernández‐Barrés, Jennifer R. Harris, Hazel Inskip, Jordi Julvez, Sabrina Llop, Katerina Margetaki, Silvia Maritano, Johanna Lucia Thorbjornsrud Nader, Theano Roumeliotaki, Theodosia Salika, Mikel Subiza‐Pérez, Marina Vafeiadi,
Published in: Pediatric Obesity, Issue 18, 2023, ISSN 2047-6310
Publisher: Wiley-Blackwell for the International Association for the Study of Obesity
DOI: 10.1111/ijpo.13079

Abdominal fat and risk of impaired lung function and asthma in children: A population‐based prospective cohort study

Author(s): Tong Wu, Tarik Karramass, Vincent W. V. Jaddoe, Stefan Klein, Edwin H. G. Oei, Liesbeth Duijts
Published in: Pediatric Allergy and Immunology, Issue 35, 2024, ISSN 0905-6157
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/pai.14079

School‐Based Interventions to Support Healthy Indoor and Outdoor Environments for Children: A Systematic Review

Author(s): Amanda Fernandes, Mònica Ubalde-López, Tiffany C Yang, Rosemary R C McEachan, Rukhsana Rashid, Léa Maitre, Mark J Nieuwenhuijsen, Martine Vrijheid
Published in: International Journal of Environmental Research and Public Health, Issue 20(3), 2023, ISSN 1660-4601
Publisher: MDPI
DOI: 10.3390/ijerph20031746

In utero exposure to bisphenols and asthma, wheeze, and lung function in school-age children: a prospective meta-analysis of 8 European birth cohorts

Author(s): Alicia Abellan, Sara M Mensink-Bout, Raquel Garcia-Esteban, Andrea Beneito, Leda Chatzi, Talita Duarte-Salles, Mariana F Fernandez, Judith Garcia-Aymerich, Berit Granum, Carmen Iñiguez, Vincent W V Jaddoe, Kurunthachalam Kannan, Aitana Lertxundi, Maria-Jose Lopez-Espinosa, Claire Philippat, Amrit K Sakhi, Susana Santos, Valérie Siroux, Jordi Sunyer, Leonardo Trasande, Marina Vafeiadi, Fernando V
Published in: Environment International, Issue 162, 2022, ISSN 0160-4120
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.envint.2022.107178

The impact of prenatal mercury on neurobehavioral functioning longitudinally assessed from a young age to pre-adolescence in a Spanish birth cohort

Author(s): Blanca Sarzo, Ferran Ballester, Raquel Soler-Blasco, Jordi Sunyer, Maria-Jose Lopez-Espinosa, Jesus Ibarluzea, Manuel Lozano, Jordi Julvez, Gorka Iriarte, Mikel Subiza-Perez, Llúcia González-Safont, Ana Fernández-Somoano, Jorge Vallejo-Ortega, Mònica Guxens, Ulises-Alfredo López-González, Isolina Riaño-Galán, Gabriel Riutort-Mayol, Mario Murcia, Sabrina Llop
Published in: Environmental Research, Issue 252, 2024, Page(s) 118954, ISSN 0013-9351
Publisher: Academic Press
DOI: 10.1016/j.envres.2024.118954

Prenatal Exposure to Multiple Endocrine-Disrupting Chemicals and Childhood BMI Trajectories in the INMA Cohort Study

Author(s): Parisa Montazeri, Nuria Güil-Oumrait, Sandra Marquez, Lourdes Cirugeda, Andrea Beneito, Mònica Guxens, Aitana Lertxundi, Maria-Jose Lopez-Espinosa, Loreto Santa-Marina, Jordi Sunyer, Maribel Casas, Martine Vrijheid
Published in: Environmental Health Perspectives, Issue 131, 2023, ISSN 0091-6765
Publisher: US Department of Health and Human Services
DOI: 10.1289/ehp11103

Concentrations of per- and polyfluoroalkyl substances (PFAS) in paired tap water and blood samples during pregnancy

Author(s): Dora Cserbik, Maribel Casas, Cintia Flores, Alexandra Paraian, Line Småstuen Haug, Ioar Rivas, Mariona Bustamante, Payam Dadvand, Jordi Sunyer, Martine Vrijheid, Cristina M. Villanueva
Published in: Journal of Exposure Science & Environmental Epidemiology, Issue 34, 2024, Page(s) 90-96, ISSN 1559-0631
Publisher: Nature Publishing Group
DOI: 10.1038/s41370-023-00581-7

The early-life exposome and epigenetic age acceleration in children

Author(s): Paula de Prado-Bert, Carlos Ruiz-Arenas, Marta Vives-Usano, Sandra Andrusaityte, Solène Cadiou, Ángel Carracedo, Maribel Casas, Leda Chatzi, Payam Dadvand, Juan R. González, Regina Grazuleviciene, Kristine B. Gutzkow, Line S. Haug, Carles Hernandez-Ferrer, Hector C. Keun, Johanna Lepeule, Léa Maitre, Rosie McEachan, Mark J. Nieuwenhuijsen, Dolors Pelegrí, Oliver Robinson, Rémy Slama, Marina
Published in: Environment International, Issue 155, 2021, Page(s) 106683, ISSN 0160-4120
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.envint.2021.106683

Advancing tools for human early lifecourse exposome research and translation (ATHLETE)

Author(s): Vrijheid, Martine; Basagaña, Xavier; Gonzalez, Juan; Jaddoe, Vincent; Jensen, Genon; Keun, Hector; Mceachan, Rosemary; Porcel, Joana; Siroux, Valerie; Swertz, Morris; Thomsen, Cathrine; Aasvang, Gunn Marit; Andrušaitytė, Sandra; Angeli, Karine; Avraam, Demetris; Ballester, Ferran; Burton, Paul; Bustamante, Mariona; Casas, Maribel; Chatzi, Leda; Chevrier, Cécile; Cingotti, Natacha; Conti, David
Published in: Environmental Epidemiology, Issue 5 (5), 2021, ISSN 2474-7882
Publisher: Lippincott
DOI: 10.1097/ee9.0000000000000166

Arterial Health Markers in Relation to Behavior and Cognitive Outcomes at School Age

Author(s): Romy Gonçalves, Romy Gaillard, Charlotte Cecil, Serena Defina, Eric. A. P. Steegers, Vincent W. V. Jaddoe
Published in: Journal of the American Heart Association, Issue 13, 2024, ISSN 2047-9980
Publisher: Wiley-Blackwell
DOI: 10.1161/jaha.123.029771

Regulation of blood–brain barrier integrity by microbiome-associated methylamines and cognition by trimethylamine N-oxide

Author(s): Lesley Hoyles, Matthew G. Pontifex, Ildefonso Rodriguez-Ramiro, M. Areeb Anis-Alavi, Khadija S. Jelane, Tom Snelling, Egle Solito, Sonia Fonseca, Ana L. Carvalho, Simon R. Carding, Michael Müller, Robert C. Glen, David Vauzour & Simon McArthur
Published in: Microbiome, Issue 9:235, 2021, ISSN 2049-2618
Publisher: BioMed Central
DOI: 10.1186/s40168-021-01181-z

Short- and medium-term air pollution exposure, plasmatic protein levels and blood pressure in children

Author(s): Paula de Prado-Bert; Charline Warembourg; Audrius Dedele; Barbara Heude; Eva Borràs; Eduard Sabidó; Gunn Marit Aasvang; Johanna Lepeule; John Wright; Jose Urquiza; Kristine B. Gützkow; Léa Maitre; Leda Chatzi; Maribel Casas; Marina Vafeiadi; Mark J. Nieuwenhuijsen; Montserrat de Castro; Regina Grazuleviciene; Rosemary R.C. McEachan; Xavier Basagaña; Martine Vrijheid; Jordi Sunyer; Mariona Bus
Published in: Environmental Research, Issue 2011, 2022, ISSN 0013-9351
Publisher: Academic Press
DOI: 10.1016/j.envres.2022.113109

Latent Childhood Exposure to Mixtures of Metals and Neurodevelopmental Outcomes in 4–5-Year-Old Children Living in Spain

Author(s): L. Notario-Barandiaran, S. Díaz-Coto, N. Jimenez-Redondo, M. Guxens, M. Vrijheid, A. Andiarena, A. Irizar, I. Riaño-Galan, A. Fernández-Somoano, S. Llop, M. Lozano, M. R. Karagas, A. Meharg, M. Carey, C. Meharg, K. Ralphs, C. McCreanor, J. Vioque, P. Martinez-Camblor, A. J. Signes-Pastor
Published in: Exposure and Health, Issue 16, 2024, Page(s) 1053-1066, ISSN 2451-9766
Publisher: Springer Nature
DOI: 10.1007/s12403-023-00610-8

Neuronal differentiation pathways and compound-induced developmental neurotoxicity in the human neural progenitor cell test (hNPT) revealed by RNA-seq

Author(s): Victoria C. de Leeuw, Conny T.M. van Oostrom, Paul F.K. Wackers, Jeroen L.A. Pennings, Hennie M. Hodemaekers, Aldert H. Piersma, Ellen V.S. Hessel
Published in: Chemosphere, Issue 304: 135298, 2022, ISSN 0045-6535
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.chemosphere.2022.135298

Prenatal Exposure to Nonpersistent Chemical Mixtures and Fetal Growth: A Population-Based Study

Author(s): Michiel A. van den Dries, Alexander P. Keil, Henning Tiemeier, Anjoeka Pronk, Suzanne Spaan, Susana Santos, Alexandros G. Asimakopoulos, Kurunthachalam Kannan, Romy Gaillard, Mònica Guxens, Leonardo Trasande, Vincent W.V. Jaddoe, and Kelly K. Ferguson
Published in: Environmental Health Perspectives, Issue 129 (11), 2021, ISSN 0091-6765
Publisher: US Department of Health and Human Services
DOI: 10.1289/ehp9178

Fetal phthalates and bisphenols and childhood lipid and glucose metabolism. A population-based prospective cohort study

Author(s): Chalana M. Sol, Susana Santos, Liesbeth Duijts, Alexandros G. Asimakopoulos, Maria-Pilar Martinez-Moral, Kurunthachalam Kannan, Vincent W.V. Jaddoe, Leonardo Trasande
Published in: Environment International, Issue 144, 2020, Page(s) 106063, ISSN 0160-4120
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.envint.2020.106063

Prenatal Exposure to Chemical Mixtures and Metabolic Syndrome Risk in Children

Author(s): Nuria Güil-Oumrait, Nikos Stratakis, Léa Maitre, Augusto Anguita-Ruiz, Jose Urquiza, Lorenzo Fabbri, Xavier Basagaña, Barbara Heude, Line Småstuen Haug, Amrit Kaur Sakhi, Nina Iszatt, Hector C. Keun, John Wright, Leda Chatzi, Marina Vafeiadi, Mariona Bustamante, Regina Grazuleviciene, Sandra Andrušaitytė, Rémy Slama, Rosemary McEachan, Maribel Casas, Martine Vrijheid
Published in: JAMA Network Open, Issue 7, 2024, Page(s) e2412040, ISSN 2574-3805
Publisher: American Medical Association
DOI: 10.1001/jamanetworkopen.2024.12040

Modelling socioeconomic position as a driver of the exposome in the first 18 months of life of the NINFEA birth cohort children

Author(s): Chiara Moccia, Costanza Pizzi, Giovenale Moirano, Maja Popovic, Daniela Zugna, Antonio d'Errico, Elena Isaevska, Serena Fossati, Mark J. Nieuwenhuijsen, Piero Fariselli, Tiziana Sanavia, Lorenzo Richiardi, Milena Maule
Published in: Environment International, Issue 173, 2024, Page(s) 107864, ISSN 0160-4120
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.envint.2023.107864

Maternal hemoglobin and iron status in early pregnancy and risk of respiratory tract infections in childhood: A population‐based prospective cohort study

Author(s): Hugo G. Quezada‐Pinedo, Evelien R. van Meel, Irwin K. Reiss, Vincent Jaddoe, Marijn J. Vermeulen, Liesbeth Duijts
Published in: Pediatric Allergy and Immunology, Issue 34, 2023, ISSN 0905-6157
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/pai.14025

Nutritional Modulation of Associations between Prenatal Exposure to Persistent Organic Pollutants and Childhood Obesity: A Prospective Cohort Study

Author(s): German Cano-Sancho, Charline Warembourg, Nuria Güil, Nikos Stratakis, Aitana Lertxundi, Amaia Irizar, Sabrina Llop, Maria-Jose Lopez-Espinosa, Xavier Basagaña, Juan Ramon González, Xavier Coumoul, Sílvia Fernández-Barrés, Jean-Philippe Antignac, Martine Vrijheid, Maribel Casas
Published in: Environmental Health Perspectives, Issue 131, 2023, ISSN 0091-6765
Publisher: US Department of Health and Human Services
DOI: 10.1289/ehp11258

Genetic regulation of newborn telomere length is mediated and modified by DNA methylation

Author(s): Wang, Congrong; Alfano, Rossella; Reimann, Brigitte; Hogervorst, Janneke; Bustamante Pineda, Mariona; De Vivo, Immaculata; Plusquin, Michelle; Nawrot, Tim S.; Martens, Dries S.
Published in: Frontiers in Genetics, Issue 13, 2022, ISSN 1664-8021
Publisher: Frontiers Media
DOI: 10.3389/fgene.2022.934277

DNA methylation changes associated with prenatal mercury exposure: A meta-analysis of prospective cohort studies from PACE consortium

Author(s): Manuel Lozano, Paul Yousefi, Karin Broberg, Raquel Soler-Blasco, Chihiro Miyashita, Giancarlo Pesce, Woo Jin Kim, Mohammad Rahman, Kelly M. Bakulski, Line S. Haug, Atsuko Ikeda-Araki, Guy Huel, Jaehyun Park, Caroline Relton, Martine Vrijheid, Sheryl Rifas-Shiman, Emily Oken, John F. Dou, Reiko Kishi, Kristine B. Gutzkow, Isabella Annesi-Maesano, Sungho Won, Marie-France Hivert, M. Daniele Fallin,
Published in: Environmental Research, Issue 204, 2023, Page(s) 112093, ISSN 0013-9351
Publisher: Academic Press
DOI: 10.1016/j.envres.2021.112093

Software Application Profile: ShinyDataSHIELD—an R Shiny application to perform federated non-disclosive data analysis in multicohort studies

Author(s): Xavier Escribà-Montagut, Yannick Marcon, Demetris Avraam, Soumya Banerjee, Tom R P Bishop, Paul Burton, Juan R González
Published in: International Journal of Epidemiology, Issue 52(1), 2022, ISSN 0300-5771
Publisher: Oxford University Press
DOI: 10.1093/ije/dyac201

Beyond the single-outcome approach: A comparison of outcome-wide analysis methods for exposome research

Author(s): Augusto Anguita-Ruiz, Ines Amine, Nikos Stratakis, Lea Maitre, Jordi Julvez, Jose Urquiza, Chongliang Luo, Mark Nieuwenhuijsen, Cathrine Thomsen, Regina Grazuleviciene, Barbara Heude, Rosemary McEachan, Marina Vafeiadi, Leda Chatzi, John Wright, Tiffany C. Yang, Rémy Slama, Valérie Siroux, Martine Vrijheid, Xavier Basagaña
Published in: Environment International, Issue 182, 2024, Page(s) 108344, ISSN 0160-4120
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.envint.2023.108344

Prenatal exposure to multiple persistent organic pollutants in association with adiposity markers and blood pressure in preadolescents

Author(s): Elke Rouxel, Nathalie Costet, Christine Monfort, Karine Audouze, Lourdes Cirugeda, Eric Gaudreau, Joan O. Grimalt, Jesus Ibarluzea, Fabrice Lainé, Sabrina Llop, Maria-Jose Lopez-Espinosa, Florence Rouget, Loreto Santa-Marina, Martine Vrijheid, Cécile Chevrier, Maribel Casas, Charline Warembourg
Published in: Environment International, Issue 178, 2024, Page(s) 108056, ISSN 0160-4120
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.envint.2023.108056

Prenatal exposure to mixtures of phthalates and phenols and body mass index and blood pressure in Spanish preadolescents

Author(s): Nuria Güil-Oumrait; German Cano-Sancho; Parisa Montazeri; Nikos Stratakis; Charline Warembourg; Maria-Jose Lopez-Espinosa; Jesús Vioque; Loreto Santa-Marina; Alba Jimeno-Romero; Rosa Ventura; Nuria Monfort; Martine Vrijheid; Maribel Casas
Published in: Environment International, Issue 63, 2022, ISSN 0160-4120
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.envint.2022.107527

Urinary metabolite quantitative trait loci in children and their interaction with dietary factors

Author(s): Beatriz Calvo-Serra, Léa Maitre, Chung-Ho E Lau, Alexandros P Siskos, Kristine B Gützkow, Sandra Andrušaitytė, Maribel Casas, Solène Cadiou, Leda Chatzi, Juan R González, Regina Grazuleviciene, Rosemary McEachan, Rémy Slama, Marina Vafeiadi, John Wright, Murieann Coen, Martine Vrijheid, Hector C Keun, Geòrgia Escaramís, Mariona Bustamante
Published in: Human Molecular Genetics, Issue 29/23, 2020, Page(s) 3830-3844, ISSN 0964-6906
Publisher: Oxford University Press
DOI: 10.1093/hmg/ddaa257

Fetal exposure to phthalates and bisphenols and childhood general and organ fat. A population-based prospective cohort study

Author(s): Chalana M. Sol, Susana Santos, Liesbeth Duijts, Alexandros G. Asimakopoulos, Maria-Pilar Martinez-Moral, Kurunthachalam Kannan, Elise M. Philips, Leonardo Trasande, Vincent W. V. Jaddoe
Published in: International Journal of Obesity, Issue 44/11, 2020, Page(s) 2225-2235, ISSN 0307-0565
Publisher: Nature Publishing Group
DOI: 10.1038/s41366-020-00672-7

Maternal phthalate urine concentrations, fetal growth and adverse birth outcomes. A population-based prospective cohort study

Author(s): Susana Santos, Chalana M. Sol, Charissa van Zwol – Janssens, Elise M. Philips, Alexandros G. Asimakopoulos, Maria-Pilar Martinez-Moral, Kurunthachalam Kannan, Vincent W.V. Jaddoe, Leonardo Trasande
Published in: Environment International, Issue 151, 2021, Page(s) 106443, ISSN 0160-4120
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.envint.2021.106443

Body composition and respiratory outcomes in children: a population-based prospective cohort study

Author(s): Tong Wu, Susana Santos, Hugo G Quezada‐Pinedo, Meike W. Vernooij, Vincent W.V. Jaddoe, Stefan Klein, Liesbeth Duijts, Edwin H.G. Oei
Published in: Thorax, Issue 79, 2024, Page(s) 448-456, ISSN 0040-6376
Publisher: BMJ Publishing Group
DOI: 10.1136/thorax-2023-220014

Association of Fish Consumption and Mercury Exposure During Pregnancy With Metabolic Health and Inflammatory Biomarkers in Children

Author(s): Nikos Stratakis, David V. Conti, Eva Borras, Eduardo Sabido, Theano Roumeliotaki, Eleni Papadopoulou, Lydiane Agier, Xavier Basagana, Mariona Bustamante, Maribel Casas, Shohreh F. Farzan, Serena Fossati, Juan R. Gonzalez, Regina Grazuleviciene, Barbara Heude, Lea Maitre, Rosemary R. C. McEachan, Ioannis Theologidis, Jose Urquiza, Marina Vafeiadi, Jane West, John Wright, Rob McConnell, Anne-Lise Br
Published in: JAMA Network Open, Issue 3/3, 2020, Page(s) e201007, ISSN 2574-3805
Publisher: Americal Medical Association
DOI: 10.1001/jamanetworkopen.2020.1007

Maternal Iron Status in Pregnancy and Child Health Outcomes after Birth: A Systematic Review and Meta-Analysis.

Author(s): Hugo G. Quezada-Pinedo; Florian Cassel; L. Duijts; Martina U. Muckenthaler; Max Gassmann; Max Gassmann; Vincent W. V. Jaddoe; Irwin K M Reiss; Marijn J. Vermeulen
Published in: urn:issn:2072-6643, Issue 13(7), 2021, ISSN 2072-6643
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/nu13072221

Prenatal Exposure to PM2.5 Oxidative Potential and Lung Function in Infants and Preschool- Age Children: A Prospective Study

Author(s): Anouk Marsal, Rémy Slama, Sarah Lyon-Caen, Lucille Joanna S. Borlaza, Jean-Luc Jaffrezo, Anne Boudier, Sophie Darfeuil, Rhabira Elazzouzi, Yoann Gioria, Johanna Lepeule, Ryan Chartier, Isabelle Pin, Joane Quentin, Sam Bayat, Gaëlle Uzu, Valérie Siroux, null null
Published in: Environmental Health Perspectives, Issue 131, 2023, ISSN 0091-6765
Publisher: US Department of Health and Human Services
DOI: 10.1289/ehp11155

Associations of Plasma Fatty Acid Patterns during Pregnancy with Respiratory and Allergy Outcomes at School Age.

Author(s): Sara M. Mensink-Bout; Trudy Voortman; Marsela Dervishaj; Irwin K.M. Reiss; Johan C. de Jongste; Vincent W. V. Jaddoe; Liesbeth Duijts
Published in: Nutrients, Issue 12(10), 2020, ISSN 2072-6643
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/nu12103057

In utero and childhood exposure to tobacco smoke and multi-layer molecular signatures in children

Author(s): Marta Vives-Usano, Carles Hernandez-Ferrer, Léa Maitre, Carlos Ruiz-Arenas, Sandra Andrusaityte, Eva Borràs, Ángel Carracedo, Maribel Casas, Leda Chatzi, Muireann Coen, Xavier Estivill, Juan R. González, Regina Grazuleviciene, Kristine B. Gutzkow, Hector C. Keun, Chung-Ho E. Lau, Solène Cadiou, Johanna Lepeule, Dan Mason, Inés Quintela, Oliver Robinson, Eduard Sabidó, Gillian Santorelli, Pe
Published in: BMC Medicine, Issue 18/1, 2020, ISSN 1741-7015
Publisher: BioMed Central
DOI: 10.1186/s12916-020-01686-8

Association between mediterranean diet and metal(loid) exposure in 4-5-year-old children living in Spain.

Author(s): L. Notario-Barandiaran, A. Irizar, M. Begoña-Zubero, R. Soler-Blasco, G. Riutort-Mayol, A. Fernández-Somoano, A. Tardón, M. Casas, M. Vrijheid, A. Meharg, M. Carey, C. Meharg, K. Ralphs, C. McCreanor, J.O. Grimalt, J. Vioque, A.J. Signes-Pastor
Published in: Environmental Research, Issue 233, 2023, Page(s) 116508, ISSN 0013-9351
Publisher: Academic Press
DOI: 10.1016/j.envres.2023.116508

Influence of perinatal and childhood exposure to tobacco and mercury in children’s gut microbiota

Author(s): Sonia Pérez-Castro, Giuseppe D’Auria, Maria Llambrich, Sílvia Fernández-Barrés, Maria-Jose Lopez-Espinosa, Sabrina Llop, Benito Regueiro, Mariona Bustamante, M. Pilar Francino, Martine Vrijheid, Léa Maitre
Published in: Frontiers in Microbiology, Issue 14, 2024, ISSN 1664-302X
Publisher: Frontiers Media
DOI: 10.3389/fmicb.2023.1258988

Genome-Wide Association Study of Blood Mercury in European Pregnant Women and Children

Author(s): Kyle Dack, Mariona Bustamante, Caroline M. Taylor, Sabrina Llop, Manuel Lozano, Paul Yousefi, Regina Gražulevičienė, Kristine Bjerve Gutzkow, Anne Lise Brantsæter, Dan Mason, Georgia Escaramís, Sarah J. Lewis
Published in: Genes, Issue 14, 2023, Page(s) 2123, ISSN 2073-4425
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/genes14122123

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