Advancing Tools for Human Early Lifecourse Exposome Research and Translation

Leistungen

E-learning materials, R packages and shiny apps for exposome and cross-omics data analysis

E-learning materials, R packages and shiny apps for exposome and cross-omics data analysis as developed by task 3.6

DataSHIELD platform for exposome and omic data analysis

Co-lead UNEW and ISGlobal.DataSHIELD platform for exposome and omic data analysis as developed by task 3.5

Co-lead Bettair and ISGlobal.This deliverable contains the App that study participants can install on their own phones for geolocalisation and physical activity data collection (task 2.3.1).

Harmonization mapping system

Harmonization mapping system – project members can define and share interoperability algorithms.This report will describe all harmonisation protocols developed for the ATHLETE cohort data.

Report describing strategies for exposome-health statistical analyses

This report will contain the statistical strategies and protocols developed by task 3.1 and 3.2.

Report comparing advanced statistical data integration strategies for cross-omics analysis

Co-Lead CNRS and USC.This task will contain the statistical strategies and protocols developed by task 3.3.

Data access protocols

D1.5 Data access protocols – cohorts and other data providers can make their data securely accessible. This deliverable will describe the data access approaches and procedures within and outside the consortium.

Intervention priorities and briefing notes for policy makers

Intervention priorities and briefing notes for policy makers with prioritised interventions.This deliverable will report the priorities resulting from task 7.4 with briefing notes.

Dissemination and engagement plan

This document will contain a guide on how to disseminate activities and outcomes in clear and accessible formats to reach the scientific, environmental health, urban and transport planning, clinical and public health community, and the general public.

Publication policy

This document will contain the publication policy for the whole project during the first year, agreed between all partners of the consortium. It will contain open access guidelines, authorship policy, and a pipeline to obtain the centralised funding for publications.

AOPs and aggregate exposure variables for use in analyses

AOPs and aggregate exposure variables for use in analyses linking the exposome to health outcomes.This report will describe the AOP methods used and indices developed by task 4.5.

Report describing strategies for incorporating external knowledge

Co-Lead ISGlobal and CNRS.This report will contain the statistical strategies and protocols developed by task 3.4.

Policy strategy

Update Joint policy strategy for the network

Data Management Plan

Co-lead ISGlobal and UMCG. This report will contain: 1) handling of research data during and after the end of the project, 2) what data will be collected, processed or generated, 3) which methodology and standards will be applied, 4) whether data will be shared/made open access and, 5) how data will be curated and preserved (including after the end of the project).

Veröffentlichungen

Applying the exposome concept in birth cohort research: a review of statistical approaches

Autoren: Susana Santos, Léa Maitre, Charline Warembourg, Lydiane Agier, Lorenzo Richiardi, Xavier Basagaña, Martine Vrijheid
Veröffentlicht in: European Journal of Epidemiology, Ausgabe 35/3, 2020, Seite(n) 193-204, ISSN 0393-2990
Herausgeber: Kluwer Academic Publishers
DOI: 10.1007/s10654-020-00625-4

Prenatal environmental exposures associated with sex differences in childhood obesity and neurodevelopment

Autoren: Alejandro Cáceres, Natàlia Carreras-Gallo, Sandra Andrusaityte, Mariona Bustamante, Ángel Carracedo, Leda Chatzi, Varun B. Dwaraka, Regina Grazuleviciene, Kristine Bjerve Gutzkow, Johanna Lepeule, Léa Maitre, Tavis L. Mendez, Mark Nieuwenhuijsen, Remy Slama, Ryan Smith, Nikos Stratakis, Cathrine Thomsen, Jose Urquiza, Hannah Went, John Wright, Tiffany Yang, Maribel Casas, Martine Vrijheid, Jua
Veröffentlicht in: BMC Medicine, Ausgabe 21, 2023, ISSN 1741-7015
Herausgeber: BioMed Central
DOI: 10.1186/s12916-023-02815-9

Childhood exposure to non-persistent endocrine disrupting chemicals and multi-omic profiles: A panel study

Autoren: Lorenzo Fabbri, Ronan Garlantézec, Karine Audouze, Mariona Bustamante, Ángel Carracedo, Leda Chatzi, Juan Ramón González, Regina Gražulevičienė, Hector Keun, Chung-Ho E Lau, Eduard Sabidó, Alexandros P Siskos, Rémy Slama, Cathrine Thomsen, John Wright, Wen Lun Yuan, Maribel Casas, Martine Vrijheid, Léa Maitre
Veröffentlicht in: Environment International, Ausgabe 173, 2024, Seite(n) 107856, ISSN 0160-4120
Herausgeber: Pergamon Press Ltd.
DOI: 10.1016/j.envint.2023.107856

First trimester fetal proportion volumetric measurements using a Virtual Reality approach.

Autoren: Clarissa J. Wiertsema; Jan S. Erkamp; A. Mulders; Eric A.P. Steegers; Liesbeth Duijts; Anton H. J. Koning; Anton H. J. Koning; Romy Gaillard; Vincent W. V. Jaddoe
Veröffentlicht in: Prenatal Diagnosis, Ausgabe 41(7), 2021, ISSN 0197-3851
Herausgeber: John Wiley & Sons Inc.
DOI: 10.1002/pd.5947

Multi-omics signatures of the human early life exposome

Autoren: Léa Maitre, Mariona Bustamante, Carles Hernández-Ferrer, Denise Thiel, Chung-Ho E. Lau, Alexandros P. Siskos, Marta Vives-Usano, Carlos Ruiz-Arenas, Dolors Pelegrí-Sisó, Oliver Robinson, Dan Mason, John Wright, Solène Cadiou, Rémy Slama, Barbara Heude, Maribel Casas, Jordi Sunyer, Eleni Z. Papadopoulou, Kristine B. Gutzkow, Sandra Andrusaityte, Regina Grazuleviciene, Marina Vafeiadi, Leda Ch
Veröffentlicht in: Nature Communications, Ausgabe 13:7024, 2022, ISSN 2041-1723
Herausgeber: Nature Publishing Group
DOI: 10.1038/s41467-022-34422-2

Bisphenol and phthalate exposure during pregnancy and the development of childhood lung function and asthma. The Generation R Study

Autoren: Tarik Karramass, Chalana Sol, Kurunthachalam Kannan, Leonardo Trasande, Vincent Jaddoe, Liesbeth Duijts
Veröffentlicht in: Environmental Pollution, Ausgabe 332, 2023, Seite(n) 121853, ISSN 0269-7491
Herausgeber: Pergamon Press Ltd.
DOI: 10.1016/j.envpol.2023.121853

Nitrogen dioxide exposure, attentional function, and working memory in children from 4 to 8 years: Periods of susceptibility from pregnancy to childhood

Autoren: Kellie L.H.A. Crooijmans, Carmen Iñiguez, Kristina W. Withworth, Marisa Estarlich, Aitana Lertxundi, Ana Fernández-Somoano, Adonina Tardón, Jesús Ibarluzea, Jordi Sunyer, Mònica Guxens, Anne-Claire Binter
Veröffentlicht in: Environment International, Ausgabe 186, 2024, Seite(n) 108604, ISSN 0160-4120
Herausgeber: Pergamon Press Ltd.
DOI: 10.1016/j.envint.2024.108604

State-of-the-Art Methods for Exposure-Health Studies: results from the Exposome Data Challenge Event

Autoren: Maitre, Léa; Guimbaud, Jean-Baptiste; Warembourg, Charline; Güil-Oumrait, Nuria; Consortium, The Exposome Data Challenge Participant; Petrone, Paula Marcela; Chadeau-Hyam, Marc; Vrijheid, Martine; Gonzalez, Juan R.; Basagaña, Xavier
Veröffentlicht in: Environment International, Ausgabe 168, 2022, ISSN 0160-4120
Herausgeber: Pergamon Press Ltd.
DOI: 10.48550/arxiv.2202.01680

A host–gut microbial amino acid co-metabolite, <i>p</i>-cresol glucuronide, promotes blood–brain barrier integrity <i>in vivo</i>

Autoren: Andrew V. Stachulski; Tobias B-A Knausenberger; Sita N. Shah; Lesley Hoyles; Simon McArthur
Veröffentlicht in: Tissue Barriers, Ausgabe 11(1), 2022, ISSN 2168-8362
Herausgeber: Taylor & Francis
DOI: 10.1080/21688370.2022.2073175

Fully exploiting SNP arrays: a systematic review on the tools to extract underlying genomic structure

Autoren: Laura Balagué-Dobón, Alejandro Cáceres, Juan R González
Veröffentlicht in: Briefings in Bioinformatics, Ausgabe bbac043, 2022, ISSN 1467-5463
Herausgeber: Oxford University Press
DOI: 10.1093/bib/bbac043

Integrating -omics approaches into population-based studies of endocrine disrupting chemicals: A scoping review

Autoren: Léa Maitre, Paulina Jedynak, Marta Gallego, Laura Ciaran, Karine Audouze, Maribel Casas, Martine Vrijheid
Veröffentlicht in: Environmental Research, Ausgabe 228, 2023, Seite(n) 115788, ISSN 0013-9351
Herausgeber: Academic Press
DOI: 10.1016/j.envres.2023.115788

Associations of physical condition with lung function and asthma in adolescents from the general population

Autoren: Sara M. Mensink‐Bout, Marc R. Jahangir, Johan C. de Jongste, Hein Raat, Vincent W. V. Jaddoe, Liesbeth Duijts
Veröffentlicht in: Pediatric Allergy and Immunology, Ausgabe 33, 2023, ISSN 0905-6157
Herausgeber: Blackwell Publishing Inc.
DOI: 10.1111/pai.13811

A case study of neurodevelopmental risks from combined exposures to lead, methyl-mercury, inorganic arsenic, polychlorinated biphenyls, polybrominated diphenyl ethers and fluoride

Autoren: Corinne Sprong, Jan Dirk te Biesebeek, Mousumi Chatterjee, Gerrit Wolterink, Annick van den Brand, Urska Blaznik, Despo Christodoulou, Amélie Crépet, Bodil Hamborg Jensen, Darja Sokolić, Elke Rauscher-Gabernig, Jiri Ruprich, Andreas Kortenkamp, Jacob van Klaveren
Veröffentlicht in: International Journal of Hygiene and Environmental Health, Ausgabe 251, 2023, Seite(n) 114167, ISSN 1438-4639
Herausgeber: Elsevier BV
DOI: 10.1016/j.ijheh.2023.114167

Common genetic variants associated with urinary phthalate levels in children: A genome-wide study

Autoren: Mariona Bustamante, Laura Balagué-Dobón, Zsanett Buko, Amrit Kaur Sakhi, Maribel Casas, Lea Maitre, Sandra Andrusaityte, Regina Grazuleviciene, Kristine B. Gützkow, Anne-Lise Brantsæter, Barbara Heude, Claire Philippat, Leda Chatzi, Marina Vafeiadi, Tiffany C. Yang, John Wright, Amy Hough, Carlos Ruiz-Arenas, Ramil N. Nurtdinov, Geòrgia Escaramís, Juan R. González, Cathrine Thomsen, Martine
Veröffentlicht in: Environment International, Ausgabe 190, 2024, Seite(n) 108845, ISSN 0160-4120
Herausgeber: Pergamon Press Ltd.
DOI: 10.1016/j.envint.2024.108845

Association of exposure to mixture of chemicals during pregnancy with cognitive abilities and fine motor function of children

Autoren: Pavla Brennan Kearns, Michiel A. van den Dries, Jordi Julvez, Mariza Kampouri, Mónica López-Vicente, Lea Maitre, Claire Philippat, Line Småstuen Haug, Marina Vafeiadi, Cathrine Thomsen, Tiffany C Yang, Martine Vrijheid, Henning Tiemeier, Mònica Guxens
Veröffentlicht in: Environment International, Ausgabe 185, 2024, Seite(n) 108490, ISSN 0160-4120
Herausgeber: Pergamon Press Ltd.
DOI: 10.1016/j.envint.2024.108490

A Deterministic Approach for Protecting Privacy in Sensitive Personal Data

Autoren: Demetris Avraam; Elinor Jones; Paul Burton
Veröffentlicht in: BMC Medical Informatics and Decision Making, Ausgabe 22(24), 2022, ISSN 1472-6947
Herausgeber: BioMed Central
DOI: 10.21203/rs.3.rs-344334/v1

Maternal bisphenol urine concentrations, fetal growth and adverse birth outcomes: A population-based prospective cohort

Autoren: Chalana M. Sol, Charissa van Zwol - Janssens, Elise M. Philips, Alexandros G. Asimakopoulos, Maria-Pilar Martinez-Moral, Kurunthachalam Kannan, Vincent W. V. Jaddoe, Leonardo Trasande, Susana Santos
Veröffentlicht in: Environmental Health, Ausgabe 20/1, 2021, ISSN 1476-069X
Herausgeber: BioMed Central
DOI: 10.1186/s12940-021-00747-6

Prenatal Urban Environment and Blood Pressure Trajectories From Childhood to Early Adulthood

Autoren: Ana Gonçalves Soares, Susana Santos, Emie Seyve, Rozenn Nedelec, Soile Puhakka, Aino-Maija Eloranta, Santtu Mikkonen, Wen Lun Yuan, Deborah A. Lawlor, Jon Heron, Martine Vrijheid, Johanna Lepeule, Mark Nieuwenhuijsen, Serena Fossati, Vincent W.V. Jaddoe, Timo Lakka, Sylvain Sebert, Barbara Heude, Janine F. Felix, Ahmed Elhakeem, Nicholas J. Timpson
Veröffentlicht in: JACC: Advances, Ausgabe 3, 2024, Seite(n) 100808, ISSN 2772-963X
Herausgeber: Elsevier
DOI: 10.1016/j.jacadv.2023.100808

Integrating Multi-Omics with environmental data for precision health: A novel analytic framework and case study on prenatal mercury induced childhood fatty liver disease

Autoren: Jesse A. Goodrich, Hongxu Wang, Qiran Jia, Nikos Stratakis, Yinqi Zhao, Léa Maitre, Mariona Bustamante, Marina Vafeiadi, Max Aung, Sandra Andrušaitytė, Xavier Basagana, Shohreh F. Farzan, Barbara Heude, Hector Keun, Rob McConnell, Tiffany C. Yang, Alexandros P. Siskos, Jose Urquiza, Damaskini Valvi, Nerea Varo, Line Småstuen Haug, Bente M. Oftedal, Regina Gražulevičienė, Claire Philippat, J
Veröffentlicht in: Environment International, Ausgabe 190, 2024, Seite(n) 108930, ISSN 0160-4120
Herausgeber: Pergamon Press Ltd.
DOI: 10.1016/j.envint.2024.108930

Performance of approaches relying on multidimensional intermediary data to decipher causal relationships between the exposome and health: A simulation study under various causal structures

Autoren: Solène Cadiou, Xavier Basagaña, Juan R. Gonzalez, Johanna Lepeule, Martine Vrijheid, Valérie Siroux, Rémy Slama
Veröffentlicht in: Environment International, Ausgabe 153, 2021, Seite(n) 106509, ISSN 0160-4120
Herausgeber: Pergamon Press Ltd.
DOI: 10.1016/j.envint.2021.106509

Prenatal exposure to common plasticizers: a longitudinal study on phthalates, brain volumetric measures, and IQ in youth

Autoren: Akhgar Ghassabian, Michiel van den Dries, Leonardo Trasande, Sander Lamballais, Suzanne Spaan, Maria-Pilar Martinez-Moral, Kurunthachalam Kannan, Vincent W. V. Jaddoe, Stephanie M. Engel, Anjoeka Pronk, Tonya White, Henning Tiemeier, Mònica Guxens
Veröffentlicht in: Molecular Psychiatry, Ausgabe 28, 2024, Seite(n) 4814-4822, ISSN 1359-4184
Herausgeber: Nature Publishing Group
DOI: 10.1038/s41380-023-02225-6

Interventions to Reduce Exposure to Synthetic Phenols and Phthalates from Dietary Intake and Personal Care Products: a Scoping Review

Autoren: Tiffany C. Yang, Nicolas Jovanovic, Felisha Chong, Meegan Worcester, Amrit K. Sakhi, Cathrine Thomsen, Ronan Garlantézec, Cécile Chevrier, Génon Jensen, Natacha Cingotti, Maribel Casas, Rosemary RC McEachan, Martine Vrijheid, Claire Philippat
Veröffentlicht in: Current Environmental Health Reports, Ausgabe 10, 2023, Seite(n) 184-214, ISSN 2196-5412
Herausgeber: Springer
DOI: 10.1007/s40572-023-00394-8

Associations of Early Pregnancy Metabolite Profiles with Gestational Blood Pressure Development

Autoren: Sophia M. Blaauwendraad; Rama J. Wahab; Bas B. van Rijn; Berthold Koletzko; Vincent W. V. Jaddoe; Romy Gaillard
Veröffentlicht in: Metabolites, Ausgabe 12(12), 2022, ISSN 2218-1989
Herausgeber: MDPI
DOI: 10.3390/metabo12121169

The effects of heavy metal exposure on brain and gut microbiota: A systematic review of animal studies

Autoren: Simona Porru, Ana Esplugues, Sabrina Llop, Juana María Delgado-Saborit
Veröffentlicht in: Environmental Pollution, Ausgabe 348, 2024, Seite(n) 123732, ISSN 0269-7491
Herausgeber: Pergamon Press Ltd.
DOI: 10.1016/j.envpol.2024.123732

Green spaces and respiratory, cardiometabolic, and neurodevelopmental outcomes: An individual-participant data meta-analysis of >35.000 European children

Autoren: Amanda Fernandes, Demetris Avraam, Tim Cadman, Payam Dadvand, Mònica Guxens, Anne-Claire Binter, Angela Pinot de Moira, Mark Nieuwenhuijsen, Liesbeth Duijts, Jordi Julvez, Montserrat De Castro, Serena Fossati, Sandra Márquez, Tanja Vrijkotte, Ahmed Elhakeem, Rosemary McEachan, Tiffany Yang, Marie Pedersen, Johan Vinther, Johanna Lepeule, Barbara Heude, Vincent W.V. Jaddoe, Susana Santos, Marieke
Veröffentlicht in: Environment International, Ausgabe 190, 2024, Seite(n) 108853, ISSN 0160-4120
Herausgeber: Pergamon Press Ltd.
DOI: 10.1016/j.envint.2024.108853

Maternal iron status in early pregnancy and childhood body fat measures and cardiometabolic risk factors: A population-based prospective cohort

Autoren: Hugo G. Quezada-Pinedo, Vincent Jaddoe, Liesbeth Duijts, Taulant Muka, Marijn J. Vermeulen, Irwin K.M. Reiss, Susana Santos
Veröffentlicht in: The American Journal of Clinical Nutrition, Ausgabe 117, 2024, Seite(n) 191-198, ISSN 0002-9165
Herausgeber: American Society for Clinical Nutrition, Inc.
DOI: 10.1016/j.ajcnut.2022.10.006

Urban environment during pregnancy and childhood and white matter microstructure in preadolescence in two European birth cohorts

Autoren: Anne-Claire Binter, Laura Granés, Elise Bannier, Montserrat de Castro, Sami Petricola, Serena Fossati, Martine Vrijheid, Cécile Chevrier, Hanan El Marroun, Mark Nieuwenhuijsen, Dave Saint-Amour, Henning Tiemeier, Mònica Guxens
Veröffentlicht in: Environmental Pollution, Ausgabe 346, 2024, Seite(n) 123612, ISSN 0269-7491
Herausgeber: Pergamon Press Ltd.
DOI: 10.1016/j.envpol.2024.123612

Association of prenatal exposure to phthalates and synthetic phenols with pubertal development in three European cohorts

Autoren: Carmen Freire, Francesca Castiello, Izaro Babarro, Augusto Anguita-Ruiz, Maribel Casas, Martine Vrijheid, Blanca Sarzo, Andrea Beneito, Manik Kadawathagedara, Claire Philippat, Cathrine Thomsen, Amrit Kaur Sakhi, Maria-Jose Lopez-Espinosa
Veröffentlicht in: International Journal of Hygiene and Environmental Health, Ausgabe 261, 2024, Seite(n) 114418, ISSN 1438-4639
Herausgeber: Elsevier BV
DOI: 10.1016/j.ijheh.2024.114418

Urinary metabolic biomarkers of diet quality in European children are associated with metabolic health

Autoren: Nikos Stratakis, Alexandros P Siskos, Eleni Papadopoulou, Anh N Nguyen, Yinqi Zhao, Katerina Margetaki, Chung-Ho E Lau, Muireann Coen, Lea Maitre, Silvia Fernández-Barrés, Lydiane Agier, Sandra Andrusaityte, Xavier Basagaña, Anne Lise Brantsaeter, Maribel Casas, Serena Fossati, Regina Grazuleviciene, Barbara Heude, Rosemary RC McEachan, Helle Margrete Meltzer, Christopher Millett, Fernanda Raub
Veröffentlicht in: eLife, Ausgabe 11, 2022, ISSN 2050-084X
Herausgeber: eLife Sciences Publications
DOI: 10.7554/elife.71332

Blurred lines: Crossing the boundaries between the chemical exposome and the metabolome

Autoren: Cristina Balcells, Yitao Xu, Rubén Gil-Solsona, Léa Maitre, Pablo Gago-Ferrero, Hector C. Keun
Veröffentlicht in: Current Opinion in Chemical Biology, Ausgabe 78, 2024, Seite(n) 102407, ISSN 1367-5931
Herausgeber: Elsevier BV
DOI: 10.1016/j.cbpa.2023.102407

Influence of genetic polymorphisms on arsenic methylation efficiency during pregnancy: Evidence from a Spanish birth cohort

Autoren: Raquel Soler-Blasco, Florencia Harari, Gabriel Riutort-Mayol, Mario Murcia, Manuel Lozano, Amaia Irizar, Loreto Santa Marina, Miren Begoña Zubero, Nora Fernández-Jimenez, Simone Braeuer, Ferran Ballester, Sabrina Llop
Veröffentlicht in: Science of The Total Environment, Ausgabe 900, 2024, Seite(n) 165740, ISSN 0048-9697
Herausgeber: Elsevier BV
DOI: 10.1016/j.scitotenv.2023.165740

Privacy preserving data visualizations

Autoren: Demetris Avraam, Rebecca Wilson, Oliver Butters, Thomas Burton, Christos Nicolaides, Elinor Jones, Andy Boyd, Paul Burton
Veröffentlicht in: EPJ Data Science, Ausgabe 10/1, 2021, ISSN 2193-1127
Herausgeber: Springer
DOI: 10.1140/epjds/s13688-020-00257-4

Associations of green and blue space exposure in pregnancy with epigenetic gestational age acceleration

Autoren: Irene Marques, Susana Santos, Giulietta S. Monasso, Serena Fossati, Martine Vrijheid, Mark Nieuwenhuijsen, Vincent W. V. Jaddoe, Janine F. Felix
Veröffentlicht in: Epigenetics, Ausgabe 18, 2023, ISSN 1559-2294
Herausgeber: Landes Bioscience
DOI: 10.1080/15592294.2023.2165321

Green space exposure and blood DNA methylation at birth and in childhood – A multi-cohort study

Autoren: Sofia Aguilar-Lacasaña, Irene Fontes Marques, Montserrat de Castro, Payam Dadvand, Xavier Escribà, Serena Fossati, Juan R González, Mark Nieuwenhuijsen, Rossella Alfano, Isabella Annesi-Maesano, Sonia Brescianini, Kimberley Burrows, Lucinda Calas, Ahmed Elhakeem, Barbara Heude, Amy Hough, Elena Isaevska, Vincent W V Jaddoe, Deborah A Lawlor, Genevieve Monaghan, Tim Nawrot, Michelle Plusquin, Lo
Veröffentlicht in: Environment International, Ausgabe 188, 2024, Seite(n) 108684, ISSN 0160-4120
Herausgeber: Pergamon Press Ltd.
DOI: 10.1016/j.envint.2024.108684

Prenatal exposure to PM10 and changes in DNA methylation and telomere length in cord blood

Autoren: Elena Isaevska, Valentina Fiano, Federica Asta, Massimo Stafoggia, Giovenale Moirano, Maja Popovic, Costanza Pizzi, Morena Trevisan, Laura De Marco, Silvia Polidoro, Luigi Gagliardi, Franca Rusconi, Sonia Brescianini, Lorenza Nistico, Maria Antonietta Stazi, Luca Ronfani, Daniela Porta, Lorenzo Richiardi
Veröffentlicht in: Environmental Research, Ausgabe 209: 112717, 2022, ISSN 0013-9351
Herausgeber: Academic Press
DOI: 10.1016/j.envres.2022.112717

The Exposome Approach to Decipher the Role of Multiple Environmental and Lifestyle Determinants in Asthma

Autoren: Alicia Guillien, Solène Cadiou, Rémy Slama, Valérie Siroux
Veröffentlicht in: International Journal of Environmental Research and Public Health, Ausgabe 18/3, 2021, Seite(n) 1138, ISSN 1660-4601
Herausgeber: MDPI
DOI: 10.3390/ijerph18031138

Identification of autosomal cis expression quantitative trait methylation (cis eQTMs) in children’s blood

Autoren: Carlos Ruiz-Arenas; Carles Hernandez-Ferrer; Marta Vives-Usano; Sergi Mari; Inés Quintela; Dan Mason; Solène Cadiou; Maribel Casas; Sandra Andrusaityte; Kristine B. Gutzkow; Marina Vafeiadi; John Wright; Johanna Lepeule; Regina Grazuleviciene; Leda Chatzi; Angel Carracedo; Xavier Estivill; Eulàlia Martí; Geòrgia Escaramís; Martine Vrijheid; Juan R. González; Mariona Bustamante
Veröffentlicht in: eLife, Ausgabe 11:e65310, 2022, ISSN 2050-084X
Herausgeber: eLife Sciences Publications
DOI: 10.1101/2020.11.05.368076

Associations between synthetic phenols, phthalates, and placental growth/function: a longitudinal cohort with exposure assessment in early pregnancy

Autoren: Nicolas Jovanovic, Vicente Mustieles, Marc Althuser, Sarah Lyon-Caen, Nadia Alfaidy, Cathrine Thomsen, Amrit Kaur Sakhi, Azemira Sabaredzovic, Sam Bayat, Anne Couturier-Tarrade, Rémy Slama, Claire Philippat
Veröffentlicht in: Human Reproduction Open, Ausgabe 2024, 2024, ISSN 2399-3529
Herausgeber: Oxford Academic
DOI: 10.1093/hropen/hoae018

Associations of four biological age markers with child development: A multi-omic analysis in the European HELIX cohort

Autoren: Oliver Robinson, ChungHo E Lau, Sungyeon Joo, Sandra Andrusaityte, Eva Borras, Paula de Prado-Bert, Lida Chatzi, Hector C Keun, Regina Grazuleviciene, Kristine B Gutzkow, Lea Maitre, Dries S Martens, Eduard Sabido, Valérie Siroux, Jose Urquiza, Marina Vafeiadi, John Wright, Tim S Nawrot, Mariona Bustamante, Martine Vrijheid
Veröffentlicht in: eLife, Ausgabe 12, 2023, ISSN 2050-084X
Herausgeber: eLife Sciences Publications
DOI: 10.7554/elife.85104

Availability, accessibility, and use of green spaces and cognitive development in primary school children

Autoren: Amanda Fernandes, Norun Hjertager Krog, Rosemary McEachan, Mark Nieuwenhuijsen, Jordi Julvez, Sandra Márquez, Montserrat de Castro, José Urquiza, Barbara Heude, Marina Vafeiadi, Regina Gražulevičienė, Rémy Slama, Audrius Dedele, Gunn Marit Aasvang, Jorunn Evandt, Sandra Andrusaityte, Mariza Kampouri, Martine Vrijheid
Veröffentlicht in: Environmental Pollution, Ausgabe 334, 2024, Seite(n) 122143, ISSN 0269-7491
Herausgeber: Pergamon Press Ltd.
DOI: 10.1016/j.envpol.2023.122143

Socioeconomic position, family context, and child cognitive development

Autoren: Llúcia González, Maja Popovic, Marisa Rebagliato, Marisa Estarlich, Giovenale Moirano, Florencia Barreto-Zarza, Lorenzo Richiardi, Enrique Arranz, Loreto Santa-Marina, Daniela Zugna, Jesús Ibarluzea, Costanza Pizzi
Veröffentlicht in: European Journal of Pediatrics, Ausgabe 183, 2024, Seite(n) 2571-2585, ISSN 1432-1076
Herausgeber: Springer
DOI: 10.1007/s00431-024-05482-x

Associations of maternal phthalate and bisphenol urine concentrations during pregnancy with childhood blood pressure in a population-based prospective cohort study

Autoren: Chalana M. Sol, Susana Santos, Alexandros G. Asimakopoulos, Maria-Pilar Martinez-Moral, Liesbeth Duijts, Kurunthachalam Kannan, Leonardo Trasande, Vincent W.V. Jaddoe
Veröffentlicht in: Environment International, Ausgabe 138, 2020, Seite(n) 105677, ISSN 0160-4120
Herausgeber: Pergamon Press Ltd.
DOI: 10.1016/j.envint.2020.105677

Cadmium exposures and deteriorations of cognitive abilities: estimation of a reference dose for mixture risk assessments based on a systematic review and confidence rating.

Autoren: Andreas Kortenkamp; Mousumi Chatterjee
Veröffentlicht in: Environmental Health, Ausgabe 9, 2022, ISSN 1476-069X
Herausgeber: BioMed Central
DOI: 10.1186/s12940-022-00881-9

A population-based study on associations of stool microbiota with atopic diseases in school-age children

Autoren: Chen Hu; Evelien R. van Meel; Carolina Medina-Gomez; Robert Kraaij; Monica Barroso; Jessica C. Kiefte-de Jong; Jessica C. Kiefte-de Jong; Djawad Radjabzadeh; Suzanne G.M.A. Pasmans; Nicolette W. de Jong; Johan C. de Jongste; Henriëtte A. Moll; Tamar Nijsten; Fernando Rivadeneira; Luba M. Pardo; Liesbeth Duijts
Veröffentlicht in: The Journal of Allergy and Clinical Immunology, Ausgabe 10, 2021, ISSN 0091-6749
Herausgeber: Mosby Inc.
DOI: 10.1016/j.jaci.2021.04.001

Associations between combined urban and lifestyle factors and respiratory health in European children

Autoren: Alicia Guillien, Rémy Slama, Sandra Andrusaityte, Maribel Casas, Leda Chatzi, Montserrat de Castro, Blandine de Lauzon-Guillain, Berit Granum, Regina Grazuleviciene, Jordi Julvez, Norun Hjertager Krog, Johanna Lepeule, Léa Maitre, Rosemary McEachan, Mark Nieuwenhuijsen, Bente Oftedal, Jose Urquiza, Marina Vafeiadi, John Wright, Martine Vrijheid, Xavier Basagaña, Valérie Siroux
Veröffentlicht in: Environmental Research, Ausgabe 242, 2024, Seite(n) 117774, ISSN 0013-9351
Herausgeber: Academic Press
DOI: 10.1016/j.envres.2023.117774

Orchestrating privacy-protected big data analyses of data from different resources with R and DataSHIELD

Autoren: Yannick Marcon, Tom Bishop, Demetris Avraam, Xavier Escriba-Montagut, Patricia Ryser-Welch, Stuart Wheater, Paul Burton, Juan R. González
Veröffentlicht in: PLOS Computational Biology, Ausgabe 17/3, 2021, Seite(n) e1008880, ISSN 1553-7358
Herausgeber: PLOS
DOI: 10.1371/journal.pcbi.1008880

Association between household cleaning product profiles evaluated by the Ménag’Score® index and asthma symptoms among women from the SEPAGES cohort

Autoren: Lemire, Pierre; Chevallier, Emmanuel; Lyon-Caen, Sarah; Sévin, Etienne; Boudier, Anne; da Silva, Emilie Pacheco; de Thuin, Christian; Slama, Rémy; Dumas, Orianne; Siroux, Valérie; Le Moual, Nicole
Veröffentlicht in: International Archives of Occupational and Environmental Health, Ausgabe 95, 2022, ISSN 1432-1246
Herausgeber: Springer
DOI: 10.1007/s00420-022-01860-w

Urban environment during pregnancy and lung function, wheezing, and asthma in school-age children. The generation R study

Autoren: Alicia Abellan, Charline Warembourg, Sara M. Mensink-Bout, Albert Ambros, Montserrat de Castro, Serena Fossati, Mònica Guxens, Vincent WV. Jaddoe, Mark J. Nieuwenhuijsen, Martine Vrijheid, Susana Santos, Maribel Casas, Liesbeth Duijts
Veröffentlicht in: Environmental Pollution, Ausgabe 344, 2024, Seite(n) 123345, ISSN 0269-7491
Herausgeber: Pergamon Press Ltd.
DOI: 10.1016/j.envpol.2024.123345

Ambient air temperature exposure and foetal size and growth in three European birth cohorts

Autoren: Esmée Essers, Laura Granés, Scott Delaney, Joan Ballester, Susana Santos, Sami Petricola, Tiffany C Yang, Ana Fernández-Somoano, Ainhoa Bereziartua, Ferran Ballester, Adonina Tardón, Martine Vrijheid, Aitana Lertxundi, Rosemary R.C. McEachan, Hanan El Marroun, Henning Tiemeier, Carmen Iñiguez, Mònica Guxens
Veröffentlicht in: Environment International, Ausgabe 186, 2024, Seite(n) 108619, ISSN 0160-4120
Herausgeber: Pergamon Press Ltd.
DOI: 10.1016/j.envint.2024.108619

Pre-natal exposure to NO2 and PM2.5 and newborn lung function: An approach based on repeated personal exposure measurements

Autoren: Johanna Lepeule, Isabelle Pin, Anne Boudier, Joane Quentin, Sarah Lyon-Caen, Karine Supernant, Emie Seyve, Ryan Chartier, Remy Slama, Valérie Siroux
Veröffentlicht in: Environmental Research, Ausgabe 226, 2024, Seite(n) 115656, ISSN 0013-9351
Herausgeber: Academic Press
DOI: 10.1016/j.envres.2023.115656

Study of the combined effect of maternal tobacco smoking and polygenic risk scores on birth weight and body mass index in childhood

Autoren: Georgina Fuentes-Paez; Geòrgia Escaramís; Sofía Aguilar-Lacasaña; Sandra Andrusaityte; Anne Lise Brantsæter; Maribel Casas; Marie-Aline Charles; Leda Chatzi; Johanna Lepeule; Regina Grazuleviciene; Kristine B. Gützkow; Barbara Heude; Léa Maitre; Carlos Ruiz-Arenas; Jordi Sunyer; Jose Urquiza; Tiffany C. Yang; John Wright; Martine Vrijheid; Natàlia Vilor-Tejedor; Mariona Bustamante
Veröffentlicht in: Frontiers in Genetics, Ausgabe 13, 2022, ISSN 1664-8021
Herausgeber: Frontiers Media
DOI: 10.3389/fgene.2022.867611

Software application profile: exposomeShiny—a toolbox for exposome data analysis

Autoren: Xavier Escriba-Montagut; Xavier Basagaña; Martine Vrijheid; Juan R. González
Veröffentlicht in: International Journal of Epidemiology, Ausgabe 51(1), 2021, ISSN 0300-5771
Herausgeber: Oxford University Press
DOI: 10.1093/ije/dyab220

A plausibility database summarizing the level of evidence regarding the hazards induced by the exposome on children health

Autoren: Colzin Stacy, Crépet Amélie, Wies Blanche, Rocabois Audrey, Sanchez Margaux, Perreau Simon, Jean Julien, Redaelli Matteo, Kortenkamp Andreas, Rousselle Christophe, Vrijheid Martine, Nieuwenhuijsen Mark, Slama Rémy, Angeli Karine
Veröffentlicht in: International Journal of Hygiene and Environmental Health, Ausgabe 256, 2024, Seite(n) 114311, ISSN 1438-4639
Herausgeber: Elsevier BV
DOI: 10.1016/j.ijheh.2023.114311

A review of statistical strategies to integrate biomarkers of chemical exposure with biomarkers of effect applied in omic-scale environmental epidemiology

Autoren: Étienne Babin, German Cano-Sancho, Evelyne Vigneau, Jean-Philippe Antignac
Veröffentlicht in: Environmental Pollution, Ausgabe 330, 2023, Seite(n) 121741, ISSN 0269-7491
Herausgeber: Pergamon Press Ltd.
DOI: 10.1016/j.envpol.2023.121741

Machine learning-based health environmental-clinical risk scores in European children

Autoren: Jean-Baptiste Guimbaud, Alexandros P. Siskos, Amrit Kaur Sakhi, Barbara Heude, Eduard Sabidó, Eva Borràs, Hector Keun, John Wright, Jordi Julvez, Jose Urquiza, Kristine Bjerve Gützkow, Leda Chatzi, Maribel Casas, Mariona Bustamante, Mark Nieuwenhuijsen, Martine Vrijheid, Mónica López-Vicente, Montserrat de Castro Pascual, Nikos Stratakis, Oliver Robinson, Regina Grazuleviciene, Remy Slama, Si
Veröffentlicht in: Communications Medicine, Ausgabe 4, 2024, ISSN 2730-664X
Herausgeber: Springer Nature
DOI: 10.1038/s43856-024-00513-y

Early life exposure to mercury and relationships with telomere length and mitochondrial DNA content in European children

Autoren: Manuel Lozano, Rosemary R.C. McEachan, John Wright, Tiffany C. Yang, Courtney Dow, Manik Kadawathagedara, Johanna Lepeule, Mariona Bustamante, Lea Maitre, Martine Vrijheid, Anne Lise Brantsæter, Helle Margrete Meltzer, Vasiliki Bempi, Theano Roumeliotaki, Cathrine Thomsen, Tim Nawrot, Karin Broberg, Sabrina Llop
Veröffentlicht in: Science of The Total Environment, Ausgabe 932, 2024, Seite(n) 173014, ISSN 0048-9697
Herausgeber: Elsevier BV
DOI: 10.1016/j.scitotenv.2024.173014

Statistical Approaches to Study Exposome-Health Associations in the Context of Repeated Exposure Data: A Simulation Study

Autoren: Charline Warembourg, Augusto Anguita-Ruiz, Valérie Siroux, Rémy Slama, Martine Vrijheid, Lorenzo Richiardi, Xavier Basagaña
Veröffentlicht in: Environmental Science & Technology, Ausgabe 57, 2023, Seite(n) 16232-16243, ISSN 0013-936X
Herausgeber: American Chemical Society
DOI: 10.1021/acs.est.3c04805

Maternal pesticides exposure in pregnancy and the risk of wheezing in infancy: A prospective cohort study

Autoren: Silvia Maritano; Giovenale Moirano; Maja Popovic; Antonio D'Errico; Franca Rusconi; Milena Maule; Lorenzo Richiardi
Veröffentlicht in: Environment International, Ausgabe 163, 2022, ISSN 0160-4120
Herausgeber: Pergamon Press Ltd.
DOI: 10.1016/j.envint.2022.107229

Environmental exposures in early-life and general health in childhood

Autoren: Ines Amine, Alicia Guillien, Claire Philippat, Augusto Anguita-Ruiz, Maribel Casas, Montserrat de Castro, Audrius Dedele, Judith Garcia-Aymerich, Berit Granum, Regina Grazuleviciene, Barbara Heude, Line Småstuen Haug, Jordi Julvez, Mónica López-Vicente, Léa Maitre, Rosemary McEachan, Mark Nieuwenhuijsen, Nikos Stratakis, Marina Vafeiadi, John Wright, Tiffany Yang, Wen Lun Yuan, Xavier Basagañ
Veröffentlicht in: Environmental Health, Ausgabe 22, 2023, ISSN 1476-069X
Herausgeber: BioMed Central
DOI: 10.1186/s12940-023-01001-x

A roadmap to advance exposomics through federation of data

Autoren: Charles P Schmitt, Jeanette A Stingone, Arcot Rajasekar, Yuxia Cui, Xiuxia Du, Chris Duncan, Michelle Heacock, Hui Hu, Juan R Gonzalez, Paul D Juarez, Alex I Smirnov
Veröffentlicht in: Exposome, Ausgabe 3, 2024, ISSN 2635-2265
Herausgeber: Oxford
DOI: 10.1093/exposome/osad010

Blood miRNA levels associated with ADHD traits in children across six European birth cohorts

Autoren: Lene B. Dypås, Nur Duale, Ann-Karin Olsen, Mariona Bustamante, Lea Maitre, Geòrgia Escaramis, Jordi Julvez, Sofia Aguilar-Lacasaña, Sandra Andrusaityte, Maribel Casas, Marina Vafeiadi, Regina Grazuleviciene, Barbara Heude, Johanna Lepeule, Jose Urquiza, John Wright, Tiffany C. Yang, Martine Vrijheid, Kristine B. Gützkow
Veröffentlicht in: BMC Psychiatry, Ausgabe 23, 2023, ISSN 1471-244X
Herausgeber: BioMed Central
DOI: 10.1186/s12888-023-05199-5

The exposome concept: how has it changed our understanding of environmental causes of chronic respiratory diseases?

Autoren: Alicia Guillien, Manosij Ghosh, Thomas Gille, Orianne Dumas
Veröffentlicht in: Breathe, Ausgabe 19, 2023, Seite(n) 230044, ISSN 1810-6838
Herausgeber: European Respiratory Society
DOI: 10.1183/20734735.0044-2023

The early-life exposome modulates the effect of polymorphic inversions on DNA methylation

Autoren: Natàlia Carreras-Gallo; Alejandro Cáceres; Laura Balagué-Dobón; Carlos Ruiz-Arenas; Sandra Andrusaityte; Ángel Carracedo; Maribel Casas; Leda Chatzi; Regina Grazuleviciene; Kristine Bjerve Gutzkow; Johanna Lepeule; Léa Maitre; Mark Nieuwenhuijsen; Remy Slama; Nikos Stratakis; Cathrine Thomsen; Jose Urquiza; John Wright; Tiffany Yang; Geòrgia Escaramís; Mariona Bustamante; Martine Vrijheid;
Veröffentlicht in: Communications Biology, Ausgabe 455, 2022, ISSN 2399-3642
Herausgeber: Springer Nature
DOI: 10.1038/s42003-022-03380-2

Urban environment in pregnancy and postpartum depression: An individual participant data meta-analysis of 12 European birth cohorts

Autoren: Tim Cadman, Katrine Strandberg-Larsen, Lucinda Calas, Malina Christiansen, Iryna Culpin, Payam Dadvand, Montserrat de Castro, Maria Foraster, Serena Fossati, Mònica Guxens, Jennifer R. Harris, Manon Hillegers, Vincent Jaddoe, Yunsung Lee, Johanna Lepeule, Hanan el Marroun, Milena Maule, Rosie McEachen, Chiara Moccia, Johanna Nader, Mark Nieuwenhuijsen, Anne-Marie Nybo Andersen, Rebecca Pearson, M
Veröffentlicht in: Environment International, Ausgabe 185, 2024, Seite(n) 108453, ISSN 0160-4120
Herausgeber: Pergamon Press Ltd.
DOI: 10.1016/j.envint.2024.108453

Prenatal maternal smoke, DNA methylation, and multi-omics of tissues and child health

Autoren: Marta Cosin-Tomas; Ariadna Cilleros-Portet; Sofía Aguilar-Lacasaña; Nora Fernandez-Jimenez; Mariona Bustamante
Veröffentlicht in: Current Environmental Health Reports, Ausgabe 9, 2022, ISSN 2196-5412
Herausgeber: Springer
DOI: 10.1007/s40572-022-00361-9

Fetal Organophosphate Pesticide Exposure and Child Adiposity Measures at 10 Years of Age in the General Dutch Population

Autoren: Sophia M. Blaauwendraad, Danielle R. Stevens, Michiel A. van den Dries, Romy Gaillard, Anjoeka Pronk, Suzanne Spaan, Kelly K. Ferguson, Vincent W.V. Jaddoe
Veröffentlicht in: Environmental Health Perspectives, Ausgabe 131, 2023, ISSN 0091-6765
Herausgeber: US Department of Health and Human Services
DOI: 10.1289/ehp12267

Towards an Interoperable Ecosystem of Research Cohort andReal-world Data Catalogues Enabling Multi-center Studies

Autoren: Morris Swertz, Esther van Enckevort , José Luis Oliveira , Isabel Fortier , Julie Bergeron , Nicolas H. Thurin , Eleanor Hyde , Alexander Kellmann , Romin Pahoueshnja , Miriam Sturkenboom , Marianne Cunnington , Anne-Marie Nybo Andersen , Yannick Marcon , Gonçalo Gonçalves , Rosa Gini
Veröffentlicht in: Yearbook of medical informatics, Ausgabe 31(01), 2022, ISSN 2364-0502
Herausgeber: Thieme Medical Publishers Inc.
DOI: 10.1055/s-0042-1742522

Variability of multi-omics profiles in a population-based child cohort

Autoren: Marta Gallego-Paüls, Carles Hernández-Ferrer, Mariona Bustamante, Xavier Basagaña, Jose Barrera-Gómez, Chung-Ho E. Lau, Alexandros P. Siskos, Marta Vives-Usano, Carlos Ruiz-Arenas, John Wright, Remy Slama, Barbara Heude, Maribel Casas, Regina Grazuleviciene, Leda Chatzi, Eva Borràs, Eduard Sabidó, Ángel Carracedo, Xavier Estivill, Jose Urquiza, Muireann Coen, Hector C. Keun, Juan R. Gonzál
Veröffentlicht in: BMC Medicine, Ausgabe 19/1, 2021, ISSN 1741-7015
Herausgeber: BioMed Central
DOI: 10.1186/s12916-021-02027-z

Lifestyle patterns in European preschoolers: Associations with socio‐demographic factors and body mass index

Autoren: Alexandra Descarpentrie, Lucinda Calas, Maxime Cornet, Barbara Heude, Marie‐Aline Charles, Demetris Avraam, Sonia Brescianini, Tim Cadman, Ahmed Elhakeem, Sílvia Fernández‐Barrés, Jennifer R. Harris, Hazel Inskip, Jordi Julvez, Sabrina Llop, Katerina Margetaki, Silvia Maritano, Johanna Lucia Thorbjornsrud Nader, Theano Roumeliotaki, Theodosia Salika, Mikel Subiza‐Pérez, Marina Vafeiadi,
Veröffentlicht in: Pediatric Obesity, Ausgabe 18, 2023, ISSN 2047-6310
Herausgeber: Wiley-Blackwell for the International Association for the Study of Obesity
DOI: 10.1111/ijpo.13079

Abdominal fat and risk of impaired lung function and asthma in children: A population‐based prospective cohort study

Autoren: Tong Wu, Tarik Karramass, Vincent W. V. Jaddoe, Stefan Klein, Edwin H. G. Oei, Liesbeth Duijts
Veröffentlicht in: Pediatric Allergy and Immunology, Ausgabe 35, 2024, ISSN 0905-6157
Herausgeber: Blackwell Publishing Inc.
DOI: 10.1111/pai.14079

School‐Based Interventions to Support Healthy Indoor and Outdoor Environments for Children: A Systematic Review

Autoren: Amanda Fernandes, Mònica Ubalde-López, Tiffany C Yang, Rosemary R C McEachan, Rukhsana Rashid, Léa Maitre, Mark J Nieuwenhuijsen, Martine Vrijheid
Veröffentlicht in: International Journal of Environmental Research and Public Health, Ausgabe 20(3), 2023, ISSN 1660-4601
Herausgeber: MDPI
DOI: 10.3390/ijerph20031746

In utero exposure to bisphenols and asthma, wheeze, and lung function in school-age children: a prospective meta-analysis of 8 European birth cohorts

Autoren: Alicia Abellan, Sara M Mensink-Bout, Raquel Garcia-Esteban, Andrea Beneito, Leda Chatzi, Talita Duarte-Salles, Mariana F Fernandez, Judith Garcia-Aymerich, Berit Granum, Carmen Iñiguez, Vincent W V Jaddoe, Kurunthachalam Kannan, Aitana Lertxundi, Maria-Jose Lopez-Espinosa, Claire Philippat, Amrit K Sakhi, Susana Santos, Valérie Siroux, Jordi Sunyer, Leonardo Trasande, Marina Vafeiadi, Fernando V
Veröffentlicht in: Environment International, Ausgabe 162, 2022, ISSN 0160-4120
Herausgeber: Pergamon Press Ltd.
DOI: 10.1016/j.envint.2022.107178

The impact of prenatal mercury on neurobehavioral functioning longitudinally assessed from a young age to pre-adolescence in a Spanish birth cohort

Autoren: Blanca Sarzo, Ferran Ballester, Raquel Soler-Blasco, Jordi Sunyer, Maria-Jose Lopez-Espinosa, Jesus Ibarluzea, Manuel Lozano, Jordi Julvez, Gorka Iriarte, Mikel Subiza-Perez, Llúcia González-Safont, Ana Fernández-Somoano, Jorge Vallejo-Ortega, Mònica Guxens, Ulises-Alfredo López-González, Isolina Riaño-Galán, Gabriel Riutort-Mayol, Mario Murcia, Sabrina Llop
Veröffentlicht in: Environmental Research, Ausgabe 252, 2024, Seite(n) 118954, ISSN 0013-9351
Herausgeber: Academic Press
DOI: 10.1016/j.envres.2024.118954

Prenatal Exposure to Multiple Endocrine-Disrupting Chemicals and Childhood BMI Trajectories in the INMA Cohort Study

Autoren: Parisa Montazeri, Nuria Güil-Oumrait, Sandra Marquez, Lourdes Cirugeda, Andrea Beneito, Mònica Guxens, Aitana Lertxundi, Maria-Jose Lopez-Espinosa, Loreto Santa-Marina, Jordi Sunyer, Maribel Casas, Martine Vrijheid
Veröffentlicht in: Environmental Health Perspectives, Ausgabe 131, 2023, ISSN 0091-6765
Herausgeber: US Department of Health and Human Services
DOI: 10.1289/ehp11103

Concentrations of per- and polyfluoroalkyl substances (PFAS) in paired tap water and blood samples during pregnancy

Autoren: Dora Cserbik, Maribel Casas, Cintia Flores, Alexandra Paraian, Line Småstuen Haug, Ioar Rivas, Mariona Bustamante, Payam Dadvand, Jordi Sunyer, Martine Vrijheid, Cristina M. Villanueva
Veröffentlicht in: Journal of Exposure Science & Environmental Epidemiology, Ausgabe 34, 2024, Seite(n) 90-96, ISSN 1559-0631
Herausgeber: Nature Publishing Group
DOI: 10.1038/s41370-023-00581-7

The early-life exposome and epigenetic age acceleration in children

Autoren: Paula de Prado-Bert, Carlos Ruiz-Arenas, Marta Vives-Usano, Sandra Andrusaityte, Solène Cadiou, Ángel Carracedo, Maribel Casas, Leda Chatzi, Payam Dadvand, Juan R. González, Regina Grazuleviciene, Kristine B. Gutzkow, Line S. Haug, Carles Hernandez-Ferrer, Hector C. Keun, Johanna Lepeule, Léa Maitre, Rosie McEachan, Mark J. Nieuwenhuijsen, Dolors Pelegrí, Oliver Robinson, Rémy Slama, Marina
Veröffentlicht in: Environment International, Ausgabe 155, 2021, Seite(n) 106683, ISSN 0160-4120
Herausgeber: Pergamon Press Ltd.
DOI: 10.1016/j.envint.2021.106683

Advancing tools for human early lifecourse exposome research and translation (ATHLETE)

Autoren: Vrijheid, Martine; Basagaña, Xavier; Gonzalez, Juan; Jaddoe, Vincent; Jensen, Genon; Keun, Hector; Mceachan, Rosemary; Porcel, Joana; Siroux, Valerie; Swertz, Morris; Thomsen, Cathrine; Aasvang, Gunn Marit; Andrušaitytė, Sandra; Angeli, Karine; Avraam, Demetris; Ballester, Ferran; Burton, Paul; Bustamante, Mariona; Casas, Maribel; Chatzi, Leda; Chevrier, Cécile; Cingotti, Natacha; Conti, David
Veröffentlicht in: Environmental Epidemiology, Ausgabe 5 (5), 2021, ISSN 2474-7882
Herausgeber: Lippincott
DOI: 10.1097/ee9.0000000000000166

Arterial Health Markers in Relation to Behavior and Cognitive Outcomes at School Age

Autoren: Romy Gonçalves, Romy Gaillard, Charlotte Cecil, Serena Defina, Eric. A. P. Steegers, Vincent W. V. Jaddoe
Veröffentlicht in: Journal of the American Heart Association, Ausgabe 13, 2024, ISSN 2047-9980
Herausgeber: Wiley-Blackwell
DOI: 10.1161/jaha.123.029771

Regulation of blood–brain barrier integrity by microbiome-associated methylamines and cognition by trimethylamine N-oxide

Autoren: Lesley Hoyles, Matthew G. Pontifex, Ildefonso Rodriguez-Ramiro, M. Areeb Anis-Alavi, Khadija S. Jelane, Tom Snelling, Egle Solito, Sonia Fonseca, Ana L. Carvalho, Simon R. Carding, Michael Müller, Robert C. Glen, David Vauzour & Simon McArthur
Veröffentlicht in: Microbiome, Ausgabe 9:235, 2021, ISSN 2049-2618
Herausgeber: BioMed Central
DOI: 10.1186/s40168-021-01181-z

Short- and medium-term air pollution exposure, plasmatic protein levels and blood pressure in children

Autoren: Paula de Prado-Bert; Charline Warembourg; Audrius Dedele; Barbara Heude; Eva Borràs; Eduard Sabidó; Gunn Marit Aasvang; Johanna Lepeule; John Wright; Jose Urquiza; Kristine B. Gützkow; Léa Maitre; Leda Chatzi; Maribel Casas; Marina Vafeiadi; Mark J. Nieuwenhuijsen; Montserrat de Castro; Regina Grazuleviciene; Rosemary R.C. McEachan; Xavier Basagaña; Martine Vrijheid; Jordi Sunyer; Mariona Bus
Veröffentlicht in: Environmental Research, Ausgabe 2011, 2022, ISSN 0013-9351
Herausgeber: Academic Press
DOI: 10.1016/j.envres.2022.113109

Latent Childhood Exposure to Mixtures of Metals and Neurodevelopmental Outcomes in 4–5-Year-Old Children Living in Spain

Autoren: L. Notario-Barandiaran, S. Díaz-Coto, N. Jimenez-Redondo, M. Guxens, M. Vrijheid, A. Andiarena, A. Irizar, I. Riaño-Galan, A. Fernández-Somoano, S. Llop, M. Lozano, M. R. Karagas, A. Meharg, M. Carey, C. Meharg, K. Ralphs, C. McCreanor, J. Vioque, P. Martinez-Camblor, A. J. Signes-Pastor
Veröffentlicht in: Exposure and Health, Ausgabe 16, 2024, Seite(n) 1053-1066, ISSN 2451-9766
Herausgeber: Springer Nature
DOI: 10.1007/s12403-023-00610-8

Neuronal differentiation pathways and compound-induced developmental neurotoxicity in the human neural progenitor cell test (hNPT) revealed by RNA-seq

Autoren: Victoria C. de Leeuw, Conny T.M. van Oostrom, Paul F.K. Wackers, Jeroen L.A. Pennings, Hennie M. Hodemaekers, Aldert H. Piersma, Ellen V.S. Hessel
Veröffentlicht in: Chemosphere, Ausgabe 304: 135298, 2022, ISSN 0045-6535
Herausgeber: Pergamon Press Ltd.
DOI: 10.1016/j.chemosphere.2022.135298

Prenatal Exposure to Nonpersistent Chemical Mixtures and Fetal Growth: A Population-Based Study

Autoren: Michiel A. van den Dries, Alexander P. Keil, Henning Tiemeier, Anjoeka Pronk, Suzanne Spaan, Susana Santos, Alexandros G. Asimakopoulos, Kurunthachalam Kannan, Romy Gaillard, Mònica Guxens, Leonardo Trasande, Vincent W.V. Jaddoe, and Kelly K. Ferguson
Veröffentlicht in: Environmental Health Perspectives, Ausgabe 129 (11), 2021, ISSN 0091-6765
Herausgeber: US Department of Health and Human Services
DOI: 10.1289/ehp9178

Fetal phthalates and bisphenols and childhood lipid and glucose metabolism. A population-based prospective cohort study

Autoren: Chalana M. Sol, Susana Santos, Liesbeth Duijts, Alexandros G. Asimakopoulos, Maria-Pilar Martinez-Moral, Kurunthachalam Kannan, Vincent W.V. Jaddoe, Leonardo Trasande
Veröffentlicht in: Environment International, Ausgabe 144, 2020, Seite(n) 106063, ISSN 0160-4120
Herausgeber: Pergamon Press Ltd.
DOI: 10.1016/j.envint.2020.106063

Prenatal Exposure to Chemical Mixtures and Metabolic Syndrome Risk in Children

Autoren: Nuria Güil-Oumrait, Nikos Stratakis, Léa Maitre, Augusto Anguita-Ruiz, Jose Urquiza, Lorenzo Fabbri, Xavier Basagaña, Barbara Heude, Line Småstuen Haug, Amrit Kaur Sakhi, Nina Iszatt, Hector C. Keun, John Wright, Leda Chatzi, Marina Vafeiadi, Mariona Bustamante, Regina Grazuleviciene, Sandra Andrušaitytė, Rémy Slama, Rosemary McEachan, Maribel Casas, Martine Vrijheid
Veröffentlicht in: JAMA Network Open, Ausgabe 7, 2024, Seite(n) e2412040, ISSN 2574-3805
Herausgeber: American Medical Association
DOI: 10.1001/jamanetworkopen.2024.12040

Modelling socioeconomic position as a driver of the exposome in the first 18 months of life of the NINFEA birth cohort children

Autoren: Chiara Moccia, Costanza Pizzi, Giovenale Moirano, Maja Popovic, Daniela Zugna, Antonio d'Errico, Elena Isaevska, Serena Fossati, Mark J. Nieuwenhuijsen, Piero Fariselli, Tiziana Sanavia, Lorenzo Richiardi, Milena Maule
Veröffentlicht in: Environment International, Ausgabe 173, 2024, Seite(n) 107864, ISSN 0160-4120
Herausgeber: Pergamon Press Ltd.
DOI: 10.1016/j.envint.2023.107864

Maternal hemoglobin and iron status in early pregnancy and risk of respiratory tract infections in childhood: A population‐based prospective cohort study

Autoren: Hugo G. Quezada‐Pinedo, Evelien R. van Meel, Irwin K. Reiss, Vincent Jaddoe, Marijn J. Vermeulen, Liesbeth Duijts
Veröffentlicht in: Pediatric Allergy and Immunology, Ausgabe 34, 2023, ISSN 0905-6157
Herausgeber: Blackwell Publishing Inc.
DOI: 10.1111/pai.14025

Nutritional Modulation of Associations between Prenatal Exposure to Persistent Organic Pollutants and Childhood Obesity: A Prospective Cohort Study

Autoren: German Cano-Sancho, Charline Warembourg, Nuria Güil, Nikos Stratakis, Aitana Lertxundi, Amaia Irizar, Sabrina Llop, Maria-Jose Lopez-Espinosa, Xavier Basagaña, Juan Ramon González, Xavier Coumoul, Sílvia Fernández-Barrés, Jean-Philippe Antignac, Martine Vrijheid, Maribel Casas
Veröffentlicht in: Environmental Health Perspectives, Ausgabe 131, 2023, ISSN 0091-6765
Herausgeber: US Department of Health and Human Services
DOI: 10.1289/ehp11258

Genetic regulation of newborn telomere length is mediated and modified by DNA methylation

Autoren: Wang, Congrong; Alfano, Rossella; Reimann, Brigitte; Hogervorst, Janneke; Bustamante Pineda, Mariona; De Vivo, Immaculata; Plusquin, Michelle; Nawrot, Tim S.; Martens, Dries S.
Veröffentlicht in: Frontiers in Genetics, Ausgabe 13, 2022, ISSN 1664-8021
Herausgeber: Frontiers Media
DOI: 10.3389/fgene.2022.934277

DNA methylation changes associated with prenatal mercury exposure: A meta-analysis of prospective cohort studies from PACE consortium

Autoren: Manuel Lozano, Paul Yousefi, Karin Broberg, Raquel Soler-Blasco, Chihiro Miyashita, Giancarlo Pesce, Woo Jin Kim, Mohammad Rahman, Kelly M. Bakulski, Line S. Haug, Atsuko Ikeda-Araki, Guy Huel, Jaehyun Park, Caroline Relton, Martine Vrijheid, Sheryl Rifas-Shiman, Emily Oken, John F. Dou, Reiko Kishi, Kristine B. Gutzkow, Isabella Annesi-Maesano, Sungho Won, Marie-France Hivert, M. Daniele Fallin,
Veröffentlicht in: Environmental Research, Ausgabe 204, 2023, Seite(n) 112093, ISSN 0013-9351
Herausgeber: Academic Press
DOI: 10.1016/j.envres.2021.112093

Software Application Profile: ShinyDataSHIELD—an R Shiny application to perform federated non-disclosive data analysis in multicohort studies

Autoren: Xavier Escribà-Montagut, Yannick Marcon, Demetris Avraam, Soumya Banerjee, Tom R P Bishop, Paul Burton, Juan R González
Veröffentlicht in: International Journal of Epidemiology, Ausgabe 52(1), 2022, ISSN 0300-5771
Herausgeber: Oxford University Press
DOI: 10.1093/ije/dyac201

Beyond the single-outcome approach: A comparison of outcome-wide analysis methods for exposome research

Autoren: Augusto Anguita-Ruiz, Ines Amine, Nikos Stratakis, Lea Maitre, Jordi Julvez, Jose Urquiza, Chongliang Luo, Mark Nieuwenhuijsen, Cathrine Thomsen, Regina Grazuleviciene, Barbara Heude, Rosemary McEachan, Marina Vafeiadi, Leda Chatzi, John Wright, Tiffany C. Yang, Rémy Slama, Valérie Siroux, Martine Vrijheid, Xavier Basagaña
Veröffentlicht in: Environment International, Ausgabe 182, 2024, Seite(n) 108344, ISSN 0160-4120
Herausgeber: Pergamon Press Ltd.
DOI: 10.1016/j.envint.2023.108344

Prenatal exposure to multiple persistent organic pollutants in association with adiposity markers and blood pressure in preadolescents

Autoren: Elke Rouxel, Nathalie Costet, Christine Monfort, Karine Audouze, Lourdes Cirugeda, Eric Gaudreau, Joan O. Grimalt, Jesus Ibarluzea, Fabrice Lainé, Sabrina Llop, Maria-Jose Lopez-Espinosa, Florence Rouget, Loreto Santa-Marina, Martine Vrijheid, Cécile Chevrier, Maribel Casas, Charline Warembourg
Veröffentlicht in: Environment International, Ausgabe 178, 2024, Seite(n) 108056, ISSN 0160-4120
Herausgeber: Pergamon Press Ltd.
DOI: 10.1016/j.envint.2023.108056

Prenatal exposure to mixtures of phthalates and phenols and body mass index and blood pressure in Spanish preadolescents

Autoren: Nuria Güil-Oumrait; German Cano-Sancho; Parisa Montazeri; Nikos Stratakis; Charline Warembourg; Maria-Jose Lopez-Espinosa; Jesús Vioque; Loreto Santa-Marina; Alba Jimeno-Romero; Rosa Ventura; Nuria Monfort; Martine Vrijheid; Maribel Casas
Veröffentlicht in: Environment International, Ausgabe 63, 2022, ISSN 0160-4120
Herausgeber: Pergamon Press Ltd.
DOI: 10.1016/j.envint.2022.107527

Urinary metabolite quantitative trait loci in children and their interaction with dietary factors

Autoren: Beatriz Calvo-Serra, Léa Maitre, Chung-Ho E Lau, Alexandros P Siskos, Kristine B Gützkow, Sandra Andrušaitytė, Maribel Casas, Solène Cadiou, Leda Chatzi, Juan R González, Regina Grazuleviciene, Rosemary McEachan, Rémy Slama, Marina Vafeiadi, John Wright, Murieann Coen, Martine Vrijheid, Hector C Keun, Geòrgia Escaramís, Mariona Bustamante
Veröffentlicht in: Human Molecular Genetics, Ausgabe 29/23, 2020, Seite(n) 3830-3844, ISSN 0964-6906
Herausgeber: Oxford University Press
DOI: 10.1093/hmg/ddaa257

Fetal exposure to phthalates and bisphenols and childhood general and organ fat. A population-based prospective cohort study

Autoren: Chalana M. Sol, Susana Santos, Liesbeth Duijts, Alexandros G. Asimakopoulos, Maria-Pilar Martinez-Moral, Kurunthachalam Kannan, Elise M. Philips, Leonardo Trasande, Vincent W. V. Jaddoe
Veröffentlicht in: International Journal of Obesity, Ausgabe 44/11, 2020, Seite(n) 2225-2235, ISSN 0307-0565
Herausgeber: Nature Publishing Group
DOI: 10.1038/s41366-020-00672-7

Maternal phthalate urine concentrations, fetal growth and adverse birth outcomes. A population-based prospective cohort study

Autoren: Susana Santos, Chalana M. Sol, Charissa van Zwol – Janssens, Elise M. Philips, Alexandros G. Asimakopoulos, Maria-Pilar Martinez-Moral, Kurunthachalam Kannan, Vincent W.V. Jaddoe, Leonardo Trasande
Veröffentlicht in: Environment International, Ausgabe 151, 2021, Seite(n) 106443, ISSN 0160-4120
Herausgeber: Pergamon Press Ltd.
DOI: 10.1016/j.envint.2021.106443

Body composition and respiratory outcomes in children: a population-based prospective cohort study

Autoren: Tong Wu, Susana Santos, Hugo G Quezada‐Pinedo, Meike W. Vernooij, Vincent W.V. Jaddoe, Stefan Klein, Liesbeth Duijts, Edwin H.G. Oei
Veröffentlicht in: Thorax, Ausgabe 79, 2024, Seite(n) 448-456, ISSN 0040-6376
Herausgeber: BMJ Publishing Group
DOI: 10.1136/thorax-2023-220014

Association of Fish Consumption and Mercury Exposure During Pregnancy With Metabolic Health and Inflammatory Biomarkers in Children

Autoren: Nikos Stratakis, David V. Conti, Eva Borras, Eduardo Sabido, Theano Roumeliotaki, Eleni Papadopoulou, Lydiane Agier, Xavier Basagana, Mariona Bustamante, Maribel Casas, Shohreh F. Farzan, Serena Fossati, Juan R. Gonzalez, Regina Grazuleviciene, Barbara Heude, Lea Maitre, Rosemary R. C. McEachan, Ioannis Theologidis, Jose Urquiza, Marina Vafeiadi, Jane West, John Wright, Rob McConnell, Anne-Lise Br
Veröffentlicht in: JAMA Network Open, Ausgabe 3/3, 2020, Seite(n) e201007, ISSN 2574-3805
Herausgeber: Americal Medical Association
DOI: 10.1001/jamanetworkopen.2020.1007

Maternal Iron Status in Pregnancy and Child Health Outcomes after Birth: A Systematic Review and Meta-Analysis.

Autoren: Hugo G. Quezada-Pinedo; Florian Cassel; L. Duijts; Martina U. Muckenthaler; Max Gassmann; Max Gassmann; Vincent W. V. Jaddoe; Irwin K M Reiss; Marijn J. Vermeulen
Veröffentlicht in: urn:issn:2072-6643, Ausgabe 13(7), 2021, ISSN 2072-6643
Herausgeber: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/nu13072221

Prenatal Exposure to PM2.5 Oxidative Potential and Lung Function in Infants and Preschool- Age Children: A Prospective Study

Autoren: Anouk Marsal, Rémy Slama, Sarah Lyon-Caen, Lucille Joanna S. Borlaza, Jean-Luc Jaffrezo, Anne Boudier, Sophie Darfeuil, Rhabira Elazzouzi, Yoann Gioria, Johanna Lepeule, Ryan Chartier, Isabelle Pin, Joane Quentin, Sam Bayat, Gaëlle Uzu, Valérie Siroux, null null
Veröffentlicht in: Environmental Health Perspectives, Ausgabe 131, 2023, ISSN 0091-6765
Herausgeber: US Department of Health and Human Services
DOI: 10.1289/ehp11155

Associations of Plasma Fatty Acid Patterns during Pregnancy with Respiratory and Allergy Outcomes at School Age.

Autoren: Sara M. Mensink-Bout; Trudy Voortman; Marsela Dervishaj; Irwin K.M. Reiss; Johan C. de Jongste; Vincent W. V. Jaddoe; Liesbeth Duijts
Veröffentlicht in: Nutrients, Ausgabe 12(10), 2020, ISSN 2072-6643
Herausgeber: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/nu12103057

In utero and childhood exposure to tobacco smoke and multi-layer molecular signatures in children

Autoren: Marta Vives-Usano, Carles Hernandez-Ferrer, Léa Maitre, Carlos Ruiz-Arenas, Sandra Andrusaityte, Eva Borràs, Ángel Carracedo, Maribel Casas, Leda Chatzi, Muireann Coen, Xavier Estivill, Juan R. González, Regina Grazuleviciene, Kristine B. Gutzkow, Hector C. Keun, Chung-Ho E. Lau, Solène Cadiou, Johanna Lepeule, Dan Mason, Inés Quintela, Oliver Robinson, Eduard Sabidó, Gillian Santorelli, Pe
Veröffentlicht in: BMC Medicine, Ausgabe 18/1, 2020, ISSN 1741-7015
Herausgeber: BioMed Central
DOI: 10.1186/s12916-020-01686-8

Association between mediterranean diet and metal(loid) exposure in 4-5-year-old children living in Spain.

Autoren: L. Notario-Barandiaran, A. Irizar, M. Begoña-Zubero, R. Soler-Blasco, G. Riutort-Mayol, A. Fernández-Somoano, A. Tardón, M. Casas, M. Vrijheid, A. Meharg, M. Carey, C. Meharg, K. Ralphs, C. McCreanor, J.O. Grimalt, J. Vioque, A.J. Signes-Pastor
Veröffentlicht in: Environmental Research, Ausgabe 233, 2023, Seite(n) 116508, ISSN 0013-9351
Herausgeber: Academic Press
DOI: 10.1016/j.envres.2023.116508

Influence of perinatal and childhood exposure to tobacco and mercury in children’s gut microbiota

Autoren: Sonia Pérez-Castro, Giuseppe D’Auria, Maria Llambrich, Sílvia Fernández-Barrés, Maria-Jose Lopez-Espinosa, Sabrina Llop, Benito Regueiro, Mariona Bustamante, M. Pilar Francino, Martine Vrijheid, Léa Maitre
Veröffentlicht in: Frontiers in Microbiology, Ausgabe 14, 2024, ISSN 1664-302X
Herausgeber: Frontiers Media
DOI: 10.3389/fmicb.2023.1258988

Genome-Wide Association Study of Blood Mercury in European Pregnant Women and Children

Autoren: Kyle Dack, Mariona Bustamante, Caroline M. Taylor, Sabrina Llop, Manuel Lozano, Paul Yousefi, Regina Gražulevičienė, Kristine Bjerve Gutzkow, Anne Lise Brantsæter, Dan Mason, Georgia Escaramís, Sarah J. Lewis
Veröffentlicht in: Genes, Ausgabe 14, 2023, Seite(n) 2123, ISSN 2073-4425
Herausgeber: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/genes14122123

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