Project description
Developing next-gen tools for early lifecourse exposome research
Defined as the measure of all of an individual’s exposures in a lifetime and how these affect their health, the exposome can help discover the key exposures responsible for chronic diseases. To aid this discovery, the EU-funded ATHLETE project aims to develop a toolbox of advanced, next-generation exposome tools and a prospective exposome cohort. This will be used to systematically quantify the effects of a wide range of environmental risk factors on mental, cardiometabolic and respiratory health outcomes and associated biological pathways during the first 20 years of life. The project’s achievements will aid in the implementation of acceptable and feasible exposome interventions; moreover, they could inform policy recommendations and prevention strategies.
Objective
ATHLETE aims to develop a toolbox of advanced, next-generation, exposome tools and a prospective exposome cohort, which will be used to systematically quantify the effects of a wide range of community-level and individual-level environmental risk factors on mental, cardiometabolic, and respiratory health outcomes and associated biological pathways during the first 2 decades of life, to implement acceptable and feasible exposome interventions, and to translate the resulting evidence to policy recommendations and prevention strategies.
ATHLETE will establish a prospective exposome cohort, including FAIR data infrastructure, building on Europe’s most comprehensive already existing exposome data (18 cohorts in 12 European countries). ATHLETE will systematically characterise the effects of the exposome on early organ development, health trajectories, and biological pathways (metagenomic, metabolomic, epigenetic, ageing, and stress pathways), longitudinally from early pregnancy through adolescence. Innovative tool development will focus on: 1) complete and accurate measurement of multiple environmental risk factors (external/urban, chemical, physical, behavioural, social) through new targeted and untargeted exposure science approaches, 2) development of advanced statistical and toxicological strategies to analyse complex multi-dimensional exposome data, 3) development of interventions to reduce personal exposures, co-produced with the community, and 4) estimation of the societal impact of the exposome by calculating costs and child health impacts.
ATHLETE’s strong focus on the vulnerable early stages of the life course, widespread general population exposures and common non-communicable diseases, its use of a large body of existing exposome data and expertise, its strong emphasis on knowledge translation, its development of an open online toolbox and its close collaboration in the European Human Exposome Network ensure that the objectives are achievable and highly relevant for future research and policy.
ATHLETE is part of the European Human Exposome Network comprised of 9 projects selected from this same call.
Fields of science
Keywords
Programme(s)
Funding Scheme
RIA - Research and Innovation actionCoordinator
08036 Barcelona
Spain
See on map
Participants (27)
Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.
46010 Valencia
See on map
75654 Paris
See on map
0456 Oslo
See on map
3015 GD Rotterdam
See on map
SW7 2AZ LONDON
See on map
BD9 6RJ Bradford
See on map
9713 GZ Groningen
See on map
1210 Saint-Josse-Ten-Noode
See on map
3721 MA Bilthoven
See on map
74100 Rethimno
See on map
LT-44248 Kaunas
See on map
3500 Hasselt
See on map
10124 Torino
See on map
08950 Esplugues De Llobregat
See on map
Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.
08950 Esplugues De Llobregat
See on map
75794 Paris
See on map
Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.
91192 Gif Sur Yvette
See on map
08907 HOSPITALET DE LLOBREGAT
See on map
The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
NG1 4FQ Nottingham
See on map
90089 5013 Los Angeles Ca
See on map
UB8 3PH Uxbridge
See on map
NE1 7RU Newcastle Upon Tyne
See on map
94700 Maisons Alfort
See on map
1165 Kobenhavn
See on map
601 77 Brno
See on map
4050-600 PORTO
See on map
The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
L69 7ZX Liverpool
See on map