Electrochemically-enabled high-throughput peptidomics for next-generation precision medicine

CORDIS fournit des liens vers les livrables publics et les publications des projets HORIZON.

Les liens vers les livrables et les publications des projets du 7e PC, ainsi que les liens vers certains types de résultats spécifiques tels que les jeux de données et les logiciels, sont récupérés dynamiquement sur OpenAIRE .

Livrables

µ-array proof on concept evaluation

UCPH will evaluate the µ-array immunosensor device (deliverable3.5) to establish the technology breakthrough proof-of-concept (deliverable 3.6) by benchmarking it to other traditional or commercial µ-arrays and by validating the performance (binding) against existing assay technology. Combinations of several MHC molecules (from recombinant libraries) and corresponding peptide sequences from (UCPH) verified T cell epitopes extracted from cases of viral infections (yellow fever, EBV, CMV) will be used26. The obtained data will be used to foresee the future application for cancer treatments.This deliverable integrates also the former 2.6, with an evaluation of our sensors to interact with proteins like antibodies and MHC molecules.

Project website

The coordinator will set up a web page (and logo) where to publish the public results of the project including the information of peer-reviewed articles, press notes...

Chemical library and protocl B

Data from the deliverable Chemical library and protocol that do not need confidentiality will be publish in our web presented in congresses andor published in peer reviewed articles

Promotion materials

The consortium will provide promotion materials including a logo leaflets as described in the impact section of the narrative

Reactor proof of concept B

Data from the deliverable Reactor proof of concept that do not need confidentiality will be publish in our web presented in congresses andor published in peer reviewed articles

Data management plan

The coordinator will set up a plan for data management including storing internal sharing and internal dissemination of relevant data from the project

µ-array proof of concept

LIST with the rest of the partners will integrate in a single prototype µ-array device (deliverable 3.5) the multiplexed FinFET sensor chip (deliverable 3.2) with the multiplexed EPS chip (deliverable 3.3) and µ-fluidic system (deliverable 1.2), updating accordingly the software.In this deliverable we will also provide the evaluation of the EPS foreseen in the original deliverable 1.9, as it will be more easy with the information from the sensors.

Publications

Acid-Modulated Peptide Synthesis for Application on Oxide Biosensor Interfaces

Auteurs: Cristóbal-Lecina, E.; El-Maiss, J.; Figueras, E.; Singh, A.C.; Krishnamoorthy, S.; Østerbye, T.; Pascual García, C.; Andreu, D.
Publié dans: Nanomaterials, Numéro 13 (24), 2023, Page(s) 3092, ISSN 2079-4991
Éditeur: MPDI
DOI: 10.3390/nano13243092

Comprehensive Analytical Modelling of an Absolute pH Sensor

Auteurs: Medina-Bailon, C.; Kumar, N.; Dhar, R.P.S.; Todorova, I.; Lenoble, D.; Georgiev, V.P.; Pascual García, C.
Publié dans: Sensors, Numéro 14248220, 2021, Page(s) 5190, ISSN 1424-8220
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/s21155190

Charge dynamics of amino acids fingerprints and the effect of density on FinFET-based Electrolyte-gated sensor

Auteurs: Kumar, N., García, C.P., Dixit, A., Rezaei, A. and Georgiev, V.
Publié dans: Solid-State Electronics, Numéro 210, 2023, Page(s) 108789, ISSN 0038-1101
Éditeur: Pergamon Press Ltd.
DOI: 10.1016/j.sse.2023.108789

Discovery of amphoteric fingerprints of amino acids with field-effect transistors

Auteurs: Kumar, N., Dhar, R. P., El Maiss, J., Georgiev, V., and Pascual García, C.
Publié dans: IEEE Access, 2024, ISSN 2169-3536
Éditeur: Institute of Electrical and Electronics Engineers Inc.
DOI: 10.1109/access.2024.3411168

Planar Junctionless Field-Effect Transistor for Detecting Biomolecular Interactions

Auteurs: Shukla, R.P.; Bomer, J.G.; Wijnperle, D.; Kumar, N.; Georgiev, V.P.; Singh, A.C.; Krishnamoorthy, S.; Pascual García, C.; Pud, S.; Olthuis, W
Publié dans: Sensors, Numéro 14248220, 2022, Page(s) 5783, ISSN 1424-8220
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/s22155783

Combinations of Analytical and Machine Learning Methods in a Single Simulation Framework for Amphoteric Molecules Detection

Auteurs: Kumar, N. , Aleksandrov, P. , Gao, Y., Macdonald, C. , Pascual García, C. and Georgiev, V.
Publié dans: IEEE Sensors Letters, 2024, ISSN 2475-1472
Éditeur: Institute of Electrical and Electronics Engineers
DOI: 10.1109/lsens.2024.3408101

Simulation and Modeling of Novel Electronic Device Architectures with NESS (Nano-Electronic Simulation Software): A Modular Nano TCAD Simulation Framework

Auteurs: Medina-Bailon, C., Dutta, T. , Rezaei, A. , Nagy, D. , Adamu-Lema, F., Georgiev, V. P. and Asenov, A.
Publié dans: Micromachines, Numéro 12, 2021, Page(s) 680, ISSN 2072-666X
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/mi12060680

Assessing the Effect of Scaling High-Aspect-Ratio ISFET with Physical Model Interface for Nano-Biosensing Application

Auteurs: R. P. S. Dhar, N. Kumar, C. Pascual. García and V. P. Georgiev
Publié dans: Solid-State Electronics, Numéro 00381101, 2022, ISSN 0038-1101
Éditeur: Pergamon Press Ltd.
DOI: 10.1016/j.sse.2022.108374

Miniaturized Control of Acidity in Multiplexed Microreactors

Auteurs: Divya Balakrishnan, Janwa El Maiss, Wouter Olthuis, and César Pascual García
Publié dans: ACS Omega, Numéro 8 (8), 2023, Page(s) 7587–7594, ISSN 2470-1343
Éditeur: American chemical Society
DOI: 10.1021/acsomega.2c06897

Deriving a novel methodology for nano-BioFETs and analysing the effect of high-k oxides on the amino-acids sensing application

Auteurs: Dhar, R., Kumar, N., Garcia, C.P. and Georgiev, V.
Publié dans: Solid-State Electronics, Numéro 200, 2023, Page(s) 108525, ISSN 0038-1101
Éditeur: Pergamon Press Ltd.
DOI: 10.1016/j.sse.2022.108525

Universal control of proton concentration using an electrochemically generated acid compatible with miniaturization

Auteurs: Janwa El-Maiss; Divya Balakrishnan; César Pascual García
Publié dans: https://www.electromed.eu/fileadmin/files/Articles/Universal_control_of_acidity.pdf, Numéro 25160230, 2022, Page(s) 3233-3242, ISSN 2516-0230
Éditeur: Royal Society of Chemistry
DOI: 10.1039/d2na00275b

(Invited) A Novel Computational Framework for Simulations of Bio-Field Effect Transistors

Auteurs: Kumar, N., Dhar, R., Garcia, C.P. and Georgiev, V.P
Publié dans: ECS Transactions, Numéro 111,1, 2023, Page(s) 249, ISSN 1938-5862
Éditeur: Electrochemical Society, Inc.
DOI: 10.1149/11101.0249ecst

Combining Chemical Functionalization and FinFET Geometry for Field Effect Sensors as Accessible Technology to Optimize pH Sensing.

Auteurs: Rani, D.; Rollo, S.; Olthuis, W.; Krishnamoorthy, S.; Pascual García, C.
Publié dans: Chemosensors, Numéro 22279040, 2021, Page(s) 20, ISSN 2227-9040
Éditeur: MDPI
DOI: 10.3390/chemosensors9020020

Novel Detection Methodology of Milk-Oligopeptides Fingerprints using Ion-Sensitive BioFET

Auteurs: Naveen Kumar; César Pascual García; Ankit Dixit; Ali Rezaei; Vihar Georgiev
Publié dans: 2023 IEEE BioSensors Conference (BioSensors), 2023, ISBN 979-8-3503-4604-6
Éditeur: IEEE
DOI: 10.1109/biosensors58001.2023.10281172

TCAD Simulations of High-Aspect-Ratio Nano-biosensor for Label-Free Sensing Application

Auteurs: R. P. S. Dhar, N. Kumar, C. Medina-Bailon, C. Pascual García and V. P. Georgiev
Publié dans: Joint International EUROSOI Workshop and International Conference on Ultimate Integration on Silicon (EuroSOI-ULIS), 2021, Page(s) 1-4, ISBN 978-1-6654-3746-2
Éditeur: IEEE
DOI: 10.1109/eurosoi-ulis53016.2021.9560701

Insights into the Ultra-Steep Subthreshold Slope Gate-all-around Feedback-FET for memory and sensing applications

Auteurs: Naveen Kumar; Ankit Dixit; Ali Rezaei; Tapas Dutta; César Pascual García; Vihar Georgiev
Publié dans: 2023 IEEE Nanotechnology Materials and Devices Conference, Numéro NMDC 2023, 2023, Page(s) 617-620, ISBN 979-8-3503-3546-0
Éditeur: IEEE Xplore
DOI: 10.1109/nmdc57951.2023.10343913

Electrolyte-Gated FET-based Sensing of Immobilized Amphoteric Molecules Including the Variability in Affinity of the Reactive Sites

Auteurs: Naveen Kumar; César Pascual García; Ali Rezaei; Ankit Dixit; Asen Asenov; Vihar Georgiev
Publié dans: 2023 International Conference on Simulation of Semiconductor Processes and Devices (SISPAD), 2023, ISBN 979-8-3503-1368-0
Éditeur: IEEE Xplore
DOI: 10.23919/sispad57422.2023.10319578

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