Electrochemically-enabled high-throughput peptidomics for next-generation precision medicine

Project Information

ElectroMed

Grant agreement ID: 862539

DOI 10.3030/862539

Project closed

EC signature date 3 September 2019

Start date 1 January 2020

End date 31 December 2023

Funded under

• EXCELLENT SCIENCE - Future and Emerging Technologies (FET)

Total cost € 2 999 167,50

EU contribution € 2 999 167,50

Coordinated by

LUXEMBOURG INSTITUTE OF SCIENCE AND TECHNOLOGY
Luxembourg

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Documents, reports (1)

µ-array proof on concept evaluation

UCPH will evaluate the µ-array immunosensor device (deliverable3.5) to establish the technology breakthrough proof-of-concept (deliverable 3.6) by benchmarking it to other traditional or commercial µ-arrays and by validating the performance (binding) against existing assay technology. Combinations of several MHC molecules (from recombinant libraries) and corresponding peptide sequences from (UCPH) verified T cell epitopes extracted from cases of viral infections (yellow fever, EBV, CMV) will be used26. The obtained data will be used to foresee the future application for cancer treatments.This deliverable integrates also the former 2.6, with an evaluation of our sensors to interact with proteins like antibodies and MHC molecules.

Websites, patent fillings, videos etc. (4)

Project website

The coordinator will set up a web page (and logo) where to publish the public results of the project including the information of peer-reviewed articles, press notes...

Chemical library and protocl B

Data from the deliverable Chemical library and protocol that do not need confidentiality will be publish in our web presented in congresses andor published in peer reviewed articles

Promotion materials

The consortium will provide promotion materials including a logo leaflets as described in the impact section of the narrative

Reactor proof of concept B

Data from the deliverable Reactor proof of concept that do not need confidentiality will be publish in our web presented in congresses andor published in peer reviewed articles

Open Research Data Pilot (1)

Data management plan

The coordinator will set up a plan for data management including storing internal sharing and internal dissemination of relevant data from the project

Demonstrators, pilots, prototypes (1)

µ-array proof of concept

LIST with the rest of the partners will integrate in a single prototype µ-array device (deliverable 3.5) the multiplexed FinFET sensor chip (deliverable 3.2) with the multiplexed EPS chip (deliverable 3.3) and µ-fluidic system (deliverable 1.2), updating accordingly the software.In this deliverable we will also provide the evaluation of the EPS foreseen in the original deliverable 1.9, as it will be more easy with the information from the sensors.

Publications

Peer reviewed articles (13)

Acid-Modulated Peptide Synthesis for Application on Oxide Biosensor Interfaces

Author(s): Cristóbal-Lecina, E.; El-Maiss, J.; Figueras, E.; Singh, A.C.; Krishnamoorthy, S.; Østerbye, T.; Pascual García, C.; Andreu, D.
Published in: Nanomaterials, Issue 13 (24), 2023, Page(s) 3092, ISSN 2079-4991
Publisher: MPDI
DOI: 10.3390/nano13243092

Comprehensive Analytical Modelling of an Absolute pH Sensor

Author(s): Medina-Bailon, C.; Kumar, N.; Dhar, R.P.S.; Todorova, I.; Lenoble, D.; Georgiev, V.P.; Pascual García, C.
Published in: Sensors, Issue 14248220, 2021, Page(s) 5190, ISSN 1424-8220
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/s21155190

Charge dynamics of amino acids fingerprints and the effect of density on FinFET-based Electrolyte-gated sensor

Author(s): Kumar, N., García, C.P., Dixit, A., Rezaei, A. and Georgiev, V.
Published in: Solid-State Electronics, Issue 210, 2023, Page(s) 108789, ISSN 0038-1101
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.sse.2023.108789

Discovery of amphoteric fingerprints of amino acids with field-effect transistors

Author(s): Kumar, N., Dhar, R. P., El Maiss, J., Georgiev, V., and Pascual García, C.
Published in: IEEE Access, 2024, ISSN 2169-3536
Publisher: Institute of Electrical and Electronics Engineers Inc.
DOI: 10.1109/access.2024.3411168

Planar Junctionless Field-Effect Transistor for Detecting Biomolecular Interactions

Author(s): Shukla, R.P.; Bomer, J.G.; Wijnperle, D.; Kumar, N.; Georgiev, V.P.; Singh, A.C.; Krishnamoorthy, S.; Pascual García, C.; Pud, S.; Olthuis, W
Published in: Sensors, Issue 14248220, 2022, Page(s) 5783, ISSN 1424-8220
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/s22155783

Combinations of Analytical and Machine Learning Methods in a Single Simulation Framework for Amphoteric Molecules Detection

Author(s): Kumar, N. , Aleksandrov, P. , Gao, Y., Macdonald, C. , Pascual García, C. and Georgiev, V.
Published in: IEEE Sensors Letters, 2024, ISSN 2475-1472
Publisher: Institute of Electrical and Electronics Engineers
DOI: 10.1109/lsens.2024.3408101

Simulation and Modeling of Novel Electronic Device Architectures with NESS (Nano-Electronic Simulation Software): A Modular Nano TCAD Simulation Framework

Author(s): Medina-Bailon, C., Dutta, T. , Rezaei, A. , Nagy, D. , Adamu-Lema, F., Georgiev, V. P. and Asenov, A.
Published in: Micromachines, Issue 12, 2021, Page(s) 680, ISSN 2072-666X
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/mi12060680

Assessing the Effect of Scaling High-Aspect-Ratio ISFET with Physical Model Interface for Nano-Biosensing Application

Author(s): R. P. S. Dhar, N. Kumar, C. Pascual. García and V. P. Georgiev
Published in: Solid-State Electronics, Issue 00381101, 2022, ISSN 0038-1101
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.sse.2022.108374

Miniaturized Control of Acidity in Multiplexed Microreactors

Author(s): Divya Balakrishnan, Janwa El Maiss, Wouter Olthuis, and César Pascual García
Published in: ACS Omega, Issue 8 (8), 2023, Page(s) 7587–7594, ISSN 2470-1343
Publisher: American chemical Society
DOI: 10.1021/acsomega.2c06897

Deriving a novel methodology for nano-BioFETs and analysing the effect of high-k oxides on the amino-acids sensing application

Author(s): Dhar, R., Kumar, N., Garcia, C.P. and Georgiev, V.
Published in: Solid-State Electronics, Issue 200, 2023, Page(s) 108525, ISSN 0038-1101
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.sse.2022.108525

Universal control of proton concentration using an electrochemically generated acid compatible with miniaturization

Author(s): Janwa El-Maiss; Divya Balakrishnan; César Pascual García
Published in: https://www.electromed.eu/fileadmin/files/Articles/Universal_control_of_acidity.pdf, Issue 25160230, 2022, Page(s) 3233-3242, ISSN 2516-0230
Publisher: Royal Society of Chemistry
DOI: 10.1039/d2na00275b

(Invited) A Novel Computational Framework for Simulations of Bio-Field Effect Transistors

Author(s): Kumar, N., Dhar, R., Garcia, C.P. and Georgiev, V.P
Published in: ECS Transactions, Issue 111,1, 2023, Page(s) 249, ISSN 1938-5862
Publisher: Electrochemical Society, Inc.
DOI: 10.1149/11101.0249ecst

Combining Chemical Functionalization and FinFET Geometry for Field Effect Sensors as Accessible Technology to Optimize pH Sensing.

Author(s): Rani, D.; Rollo, S.; Olthuis, W.; Krishnamoorthy, S.; Pascual García, C.
Published in: Chemosensors, Issue 22279040, 2021, Page(s) 20, ISSN 2227-9040
Publisher: MDPI
DOI: 10.3390/chemosensors9020020

Conference proceedings (4)

Novel Detection Methodology of Milk-Oligopeptides Fingerprints using Ion-Sensitive BioFET

Author(s): Naveen Kumar; César Pascual García; Ankit Dixit; Ali Rezaei; Vihar Georgiev
Published in: 2023 IEEE BioSensors Conference (BioSensors), 2023, ISBN 979-8-3503-4604-6
Publisher: IEEE
DOI: 10.1109/biosensors58001.2023.10281172

TCAD Simulations of High-Aspect-Ratio Nano-biosensor for Label-Free Sensing Application

Author(s): R. P. S. Dhar, N. Kumar, C. Medina-Bailon, C. Pascual García and V. P. Georgiev
Published in: Joint International EUROSOI Workshop and International Conference on Ultimate Integration on Silicon (EuroSOI-ULIS), 2021, Page(s) 1-4, ISBN 978-1-6654-3746-2
Publisher: IEEE
DOI: 10.1109/eurosoi-ulis53016.2021.9560701

Insights into the Ultra-Steep Subthreshold Slope Gate-all-around Feedback-FET for memory and sensing applications

Author(s): Naveen Kumar; Ankit Dixit; Ali Rezaei; Tapas Dutta; César Pascual García; Vihar Georgiev
Published in: 2023 IEEE Nanotechnology Materials and Devices Conference, Issue NMDC 2023, 2023, Page(s) 617-620, ISBN 979-8-3503-3546-0
Publisher: IEEE Xplore
DOI: 10.1109/nmdc57951.2023.10343913

Electrolyte-Gated FET-based Sensing of Immobilized Amphoteric Molecules Including the Variability in Affinity of the Reactive Sites

Author(s): Naveen Kumar; César Pascual García; Ali Rezaei; Ankit Dixit; Asen Asenov; Vihar Georgiev
Published in: 2023 International Conference on Simulation of Semiconductor Processes and Devices (SISPAD), 2023, ISBN 979-8-3503-1368-0
Publisher: IEEE Xplore
DOI: 10.23919/sispad57422.2023.10319578