System omics to unravel the gut-kidney axis in Chronic Kidney Disease.

Project Information

STRATEGY-CKD

Grant agreement ID: 860329

DOI 10.3030/860329

Project closed

EC signature date 5 February 2020

Start date 1 February 2020

End date 31 July 2024

Funded under

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Total cost € 3 363 591,24

EU contribution € 3 363 591,24

Coordinated by

UNIVERSITEIT GENT
Belgium

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Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Documents, reports (2)

ESR recruitment call for distribution
List of awarded doctoral degrees

Publications

Peer reviewed articles (37)

Microbiome in Chronic Kidney Disease (CKD): An Omics Perspective

Author(s): Sonnal Lohia, Antonia Vlahou, Jerome Zoidakis
Published in: Toxins, 2022, ISSN 2072-6651
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/toxins14030176

Integration of Urinary Peptidome and Fecal Microbiome to Explore Patient Clustering in Chronic Kidney Disease

Author(s): Mavrogeorgis E, Valkenburg S, Siwy J, Latosinska A, Glorieux G, Mischak H, Jankowski J
Published in: Proteomes, 2024, ISSN 2227-7382
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/proteomes12020011

Food-Derived Uremic Toxins in Chronic Kidney Disease

Author(s): Mara Lauriola; Ricard Farré; Pieter Evenepoel; Saskia Adriana Overbeek; Björn Meijers
Published in: Toxins, 2023, ISSN 2072-6651
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/toxins15020116

Glycosylation Analysis of Urinary Peptidome Highlights IGF2 Glycopeptides in Association with CKD

Author(s): Sonnal Lohia; Agnieszka Latosinska; Jerome Zoidakis; Manousos Makridakis; Harald Mischak; Griet Glorieux; Antonia Vlahou; Vera Jankowski
Published in: International Journal of Molecular Sciences, 2023, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms24065402

Gut–Kidney Axis Investigations in Animal Models of Chronic Kidney Disease

Author(s): Piotr Bartochowski; Nathalie Gayrard; Stéphanie Bornes; Céline Druart; Angel Argilés; Magali Cordaillat-Simmons; Flore Duranton
Published in: Toxins, 2022, ISSN 2072-6651
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/toxins14090626

Alterations of the peptidomic composition of peripheral plasma after portal hypertension correction by transjugular intrahepatic portosystemic shunt

Author(s): Giulia Ilaria Bagarolo, Shruti Bhargava, Robert Schierwagen, Wenyi Gu, Vera Jankowski, Josefin Soppert, Emona Barzakova, Federica Cascone, Olaf Tyc, Christiane Kuhl, Heidi Noels, Jonel Trebicka, Joachim Jankowski
Published in: npj Gut and Liver, Issue 1, 2024, ISSN 3004-9806
Publisher: Springer Nature
DOI: 10.1038/s44355-024-00001-z

Impact of Uremic Toxins on Endothelial Dysfunction in Chronic Kidney Disease: A Systematic Review

Author(s): Harlacher, Eva, Julia Wollenhaupt, Constance C. F. M. J. Baaten, and Heidi Noels
Published in: International Journal of Molecular Sciences, 2022, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms23010531

Investigation of the human-gut-kidney axis by fecal proteomics, highlights molecular mechanisms affected in CKD

Author(s): Lohia S, Valkenburg S, Stroggilos R, Lygirou V, Makridakis M, Zoidakis J, Verbeke F, Glorieux G, Vlahou A
Published in: Heliyon, 2024, ISSN 2405-8440
Publisher: Cell Press
DOI: 10.1016/j.heliyon.2024.e32828

Urinary peptide analysis to predict the response to blood pressure medication

Author(s): Mayra Alejandra Jaimes Campos; Emmanouil Mavrogeorgis; Agnieszka Latosinska; Susanne Eder; Lukas Buchwinkler; Harald Mischak; Justyna Siwy; Peter Rossing; Gert Mayer; Joachim Jankowski
Published in: Nephrology Dialysis Transplantation, 2024, ISSN 0931-0509
Publisher: Oxford University Press
DOI: 10.1093/ndt/gfad223

Probiotics for kidney disease

Author(s): Chiara Favero, Alberto Ortiz, Maria D Sanchez-Niño
Published in: Clinical Kidney Journal, 2022, ISSN 2048-8505
Publisher: Oxford University Press
DOI: 10.1093/ckj/sfac056

Gene Expression Monotonicity across Bladder Cancer Stages Informs on the Molecular Pathogenesis and Identifies a Prognostic Eight-Gene Signature

Author(s): Rafael Stroggilos; Maria Frantzi; Jerome Zoidakis; Marika Mokou; Napoleon Moulavasilis; Emmanouil Mavrogeorgis; Anna Melidi; Manousos Makridakis; Konstantinos Stravodimos; Maria G. Roubelakis; Harald Mischak; Antonia Vlahou
Published in: Cancers, 2022, ISSN 2072-6694
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers14102542

Uremic Toxin Lanthionine Induces Endothelial Cell Mineralization In Vitro

Author(s): Annapaola Coppola, Carmela Vigorito, Patrizia Lombari, Yuselys García Martínez, Margherita Borriello, Francesco Trepiccione, Diego Ingrosso, Alessandra F. Perna
Published in: Biomedicines, 2022, ISSN 2227-9059
Publisher: MDPI
DOI: 10.3390/biomedicines10020444

Multiple urinary peptides display distinct sex-specific distribution

Author(s): Mina IK, Mavrogeorgis E, Siwy J, Stojanov R, Mischak H, Latosinska A, Jankowski V
Published in: Proteomics, 2024, ISSN 1613-6810
Publisher: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1002/pmic.202300227

Exploratory Study Analyzing the Urinary Peptidome of T2DM Patients Suggests Changes in ECM but Also Inflammatory and Metabolic Pathways Following GLP-1R Agonist Treatment

Author(s): Sonnal Lohia; Justyna Siwy; Emmanouil Mavrogeorgis; Susanne Eder; Stefanie Thöni; Gert Mayer; Harald Mischak; Antonia Vlahou; Vera Jankowski
Published in: International Journal of Molecular Sciences, 2023, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms241713540

The Gut Microbiota in Kidney Transplantation: A Target for Personalized Therapy?

Author(s): García-Martínez, Yuselys; Borriello, Margherita; Capolongo, Giovanna; Ingrosso, Diego; Perna, Alessandra
Published in: Biology, 2023, ISSN 2079-7737
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/biology12020163

Gut-Derived Metabolites and Their Role in Immune Dysfunction in Chronic Kidney Disease.

Author(s): Griet Glorieux; Tessa Gryp; Alessandra F. Perna
Published in: Toxins, Issue 1, 2020, ISSN 2072-6651
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/toxins12040245

Microbial-Derived Tryptophan Catabolites, Kidney Disease and Gut Inflammation

Author(s): Madella, Avra Melina, Jeroen Van Bergenhenegouwen, Johan Garssen, Rosalinde Masereeuw, and Saskia Adriana Overbeek
Published in: Toxins, 2022, ISSN 2072-6651
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/toxins14090645

Microphysiological Systems to Recapitulate the Gut–Kidney Axis

Author(s): Laura Giordano, Silvia Maria Mihaila, Hossein Eslami Amirabadi, Rosalinde Masereeuw
Published in: Trends in Biotechnology, 2021, ISSN 0167-7799
Publisher: Elsevier BV
DOI: 10.1016/j.tibtech.2020.12.001

Integrating single-cell multi-omics and prior biological knowledge for a functional characterization of the immune system

Author(s): Schäfer, Philipp Sven Lars; Dimitrov, Daniel; Villablanca, Eduardo; Saez-Rodriguez, Julio
Published in: Nat Immunol, 2023, ISSN 1529-2908
Publisher: Nature Publishing Group
DOI: 10.1038/s41590-024-01768-2

Postbiotics and Kidney Disease

Author(s): Favero, Chiara; Giordano, Laura; Mihaila, Silvia Maria; Masereeuw, Rosalinde; Ortiz, Alberto; Sanchez-Niño, Maria Dolores; Afd Pharmacology; Pharmacology
Published in: Toxins, 2022, ISSN 2072-6651
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/toxins14090623

Homeostasis in the Gut Microbiota in Chronic Kidney Disease

Author(s): Shruti Bhargava; Erik Merckelbach; Heidi Noels; Ashima Vohra; Joachim Jankowski
Published in: Toxins, 2022, ISSN 2072-6651
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/toxins14100648

Reproducibility Evaluation of Urinary Peptide Detection Using CE-MS

Author(s): Emmanouil Mavrogeorgis; Harald Mischak; Agnieszka Latosinska; Justyna Siwy; Vera Jankowski; Joachim Jankowski
Published in: Molecules, Issue 2, 2021, ISSN 1420-3049
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules26237260

Combining LIANA and Tensor-cell2cell to decipher cell-cell communication across multiple samples

Author(s): Hratch Baghdassarian; Daniel Dimitrov; Erick Armingol; Julio Saez-Rodriguez; Nathan E. Lewis
Published in: Cell Rep Methods, 2024, ISSN 2667-2375
Publisher: Elsevier BV
DOI: 10.1016/j.crmeth.2024.100758

Comparison of methods and resources for cell-cell communication inference from single-cell RNA-Seq data

Author(s): Daniel Dimitrov; Dénes Türei; Martin Garrido-Rodriguez; Paul L. Burmedi; James S. Nagai; Charlotte Boys; Ricardo O. Ramirez Flores; Hyojin Kim; Bence Szalai; Ivan G. Costa; Alberto Valdeolivas; Aurélien Dugourd; Julio Saez-Rodriguez
Published in: Nature Communications, 2022, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-022-30755-0

Multicellular factor analysis of single-cell data for a tissue-centric understanding of disease

Author(s): Ricardo O. Ramirez Flores; Jan D. Lanzer; Daniel Dimitrov; Britta Velten; Julio Saez-Rodriguez
Published in: eLife, 2023, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.93161

Gut Microbiota and Their Derived Metabolites, a Search for Potential Targets to Limit Accumulation of Protein-Bound Uremic Toxins in Chronic Kidney Disease

Author(s): Mieke Steenbeke, Sophie Valkenburg, Tessa Gryp, Wim Van Biesen, Joris R. Delanghe, Marijn M. Speeckaert, Griet Glorieux
Published in: Toxins, 2021, ISSN 2072-6651
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/toxins13110809

Urinary peptidomic liquid biopsy for non-invasive differential diagnosis of chronic kidney disease

Author(s): Emmanouil Mavrogeorgis; Tianlin He; Harald Mischak; Agnieszka Latosinska; Antonia Vlahou; Joost P Schanstra; Lorenzo Catanese; Kerstin Amann; Tobias B Huber; Joachim Beige; Harald D Rupprecht; Justyna Siwy
Published in: Nephrology Dialysis Transplantation, 2024, ISSN 0931-0509
Publisher: Oxford University Press
DOI: 10.1093/ndt/gfad200

Phosphate, Microbiota and CKD

Author(s): Chiara Favero; Sol Carriazo; Leticia Cuarental; Raul Fernandez-Prado; Elena Gomá-Garcés; Maria Vanessa Perez-Gomez; Alberto Ortiz; Beatriz Fernandez-Fernandez; Maria Dolores Sanchez-Niño
Published in: Nutrients, Issue 2, 2021, ISSN 2072-6643
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/nu13041273

decoupleR: ensemble of computational methods to infer biological activities from omics data

Author(s): Pau Badia-i-Mompel, Jesús Vélez Santiago, Jana Braunger, Celina Geiss, Daniel Dimitrov, Sophia Müller-Dott, Petr Taus, Aurelien Dugourd, Christian H Holland, Ricardo O Ramirez Flores, Julio Saez-Rodriguez
Published in: Bioinformatics Advances, 2022, ISSN 2635-0041
Publisher: Oxford University Press
DOI: 10.1093/bioadv/vbac016

Blood Endotoxin Levels as Biomarker of Nonalcoholic Fatty Liver Disease: A Systematic Review and Meta-analysis

Author(s): Josefin Soppert, Elisa Fabiana Brandt, Nicole Maria Heussen, Emona Barzakova, Lars Mathias Blank, Lars Kuepfer, Mathias Walter Hornef, Jonel Trebicka, Joachim Jankowski, Marie-Luise Berres, Heidi Noels
Published in: Clinical Gastroenterology and Hepatology, Issue 21, 2023, Page(s) 2746-2758, ISSN 1542-3565
Publisher: W. B. Saunders Co., Ltd.
DOI: 10.1016/j.cgh.2022.11.030

How will artificial intelligence and bioinformatics change our understanding of IgA Nephropathy in the next decade

Author(s): Roman D. Bülow; Daniel Dimitrov; Peter Boor; Julio Saez-Rodriguez
Published in: Seminars in Immunopathology, Issue 1, 2021, ISSN 1863-2300
Publisher: Springer
DOI: 10.1007/s00281-021-00847-y

Butyrate promotes kidney resilience through a coordinated kidney protective response in tubular cells

Author(s): Favero C, Pintor-Chocano A, Sanz A, Ortiz A, Sanchez-Niño MD
Published in: Biochemical Pharmacology, 2024, ISSN 0006-2952
Publisher: Elsevier BV
DOI: 10.1016/j.bcp.2024.116203

Prognosis and Personalized In Silico Prediction of Treatment Efficacy in Cardiovascular and Chronic Kidney Disease: A Proof-of-Concept Study

Author(s): Jaimes Campos MA, Andújar I, Keller F, Mayer G, Rossing P, Staessen JA, Delles C, Beige J, Glorieux G, Clark AL, et al.
Published in: Pharmaceuticals, 2023, ISSN 1424-8247
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ph16091298

Urine Peptidome Analysis Identifies Common and Stage-Specific Markers in Early Versus Advanced CKD

Author(s): Sam Hobson; Emmanouil Mavrogeorgis; Tianlin He; Justyna Siwy; Thomas Ebert; Karolina Kublickiene; Peter Stenvinkel; Harald Mischak
Published in: Proteomes, 2023, ISSN 2227-7382
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/proteomes11030025

Uremic Toxins and Cardiovascular System

Author(s): Sophie Valkenburg, Griet Glorieux, Raymond Vanholder
Published in: Cardiology Clinics, 2021, ISSN 0733-8651
Publisher: W. B. Saunders Co., Ltd.
DOI: 10.1016/j.ccl.2021.04.002

Collagen-Derived Peptides in CKD: A Link to Fibrosis

Author(s): Emmanouil Mavrogeorgis; Harald Mischak; Agnieszka Latosinska; Antonia Vlahou; Joost P. Schanstra; Justyna Siwy; Vera Jankowski; Joachim Beige; Joachim Jankowski
Published in: Toxins; Volume 14; Issue 1; Pages: 10, Issue 2, 2021, ISSN 2072-6651
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/toxins14010010

What If Not All Metabolites from the Uremic Toxin Generating Pathways Are Toxic? A Hypothesis

Author(s): Raymond Vanholder; Sanjay K. Nigam; Stéphane Burtey; Griet Glorieux
Published in: Toxins, 2022, ISSN 2072-6651
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/toxins14030221