Secretion, Autophagy and their role in Neurodegeneration

Resultado final

Generate a website for SAND where all beneficiaries are listed and a short description of the projects shall be presented. All ESRs will also be listed there and well as all news related to the project

Recruitment of Project Manager

We will recruit a manager to help assist the coordinator with the administrative aspects of SAND

Publicaciones

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)<sup>1</sup>

Autores: Daniel J. Klionsky, Amal Kamal Abdel-Aziz, Sara Abdelfatah, Mahmoud Abdellatif, Asghar Abdoli, Steffen Abel, Hagai Abeliovich, Marie H. Abildgaard, Yakubu Princely Abudu, Abraham Acevedo-Arozena, Iannis E. Adamopoulos, Khosrow Adeli, Timon E. Adolph, Annagrazia Adornetto, Elma Aflaki, Galila Agam, Anupam Agarwal, Bharat B. Aggarwal, Maria Agnello, Patrizia Agostinis, Javed N. Agrewala, Alexander A
Publicado en: Autophagy, Edición 17, 2023, Página(s) 1-382, ISSN 1554-8627
Editor: Landes Bioscience
DOI: 10.1080/15548627.2020.1797280

Inhibition of Autophagy Alters Intracellular Transport of <scp>APP</scp> Resulting in Increased <scp>APP</scp> Processing

Autores: Johanna Mayer, Dominik Boeck, Michelle Werner, Daniela Frankenhauser, Stephan Geley, Hesso Farhan, Makoto Shimozawa, Per Nilsson
Publicado en: Traffic, Edición 25, 2024, ISSN 1398-9219
Editor: Blackwell Publishing Inc.
DOI: 10.1111/tra.12934

The pleiotropic roles of autophagy in Alzheimer's disease: From pathophysiology to therapy

Autores: Beatrice Paola Festa, Antonio Daniel Barbosa, Matea Rob, David C. Rubinsztein
Publicado en: Current Opinion in Pharmacology, Edición 60, 2021, Página(s) 149-157, ISSN 1471-4892
Editor: Elsevier BV
DOI: 10.1016/j.coph.2021.07.011

IER3IP1-mutations cause microcephaly by selective inhibition of ER-Golgi transport

Autores: Mihaela Anitei, Francesca Bruno, Christina Valkova, Therese Dau, Emilio Cirri, Iván Mestres, Federico Calegari, Christoph Kaether
Publicado en: Cellular and Molecular Life Sciences, Edición 81, 2024, ISSN 1420-682X
Editor: Birkhauser Verlag
DOI: 10.1007/s00018-024-05386-x

Neuronal Circuit Dysfunction in Amyotrophic Lateral Sclerosis

Autores: Andrea Salzinger, Vidya Ramesh, Shreya Das Sharma, Siddharthan Chandran, Bhuvaneish Thangaraj Selvaraj
Publicado en: Cells, Edición 13, 2024, Página(s) 792, ISSN 2073-4409
Editor: Academic Open Access Publishing
DOI: 10.3390/cells13100792

Insights into the structure and function of the RNA ligase RtcB

Autores: Matthieu Moncan, Hassan Rakhsh-Khorshid, Leif A. Eriksson, Afshin Samali, Adrienne M. Gorman
Publicado en: Cellular and Molecular Life Sciences, Edición 80, 2023, ISSN 1420-682X
Editor: Birkhauser Verlag
DOI: 10.1007/s00018-023-05001-5

Autophagy Impairment in App Knock-in Alzheimer’s Model Mice

Autores: Richeng Jiang, Makoto Shimozawa, Johanna Mayer, Simone Tambaro, Rakesh Kumar, Axel Abelein, Bengt Winblad, Nenad Bogdanovic, Per Nilsson
Publicado en: Frontiers in Aging Neuroscience, Edición 14, 2022, ISSN 1663-4365
Editor: Frontiers Research Foundation
DOI: 10.3389/fnagi.2022.878303

PolyGA targets the ER stress-adaptive response by impairing GRP75 function at the MAM in C9ORF72-ALS/FTD

Autores: Federica Pilotto, Alexander Schmitz, Niran Maharjan, Rim Diab, Adolfo Odriozola, Priyanka Tripathi, Alfred Yamoah, Olivier Scheidegger, Angelina Oestmann, Cassandra N. Dennys, Shrestha Sinha Ray, Rochelle Rodrigo, Stephen Kolb, Eleonora Aronica, Stefano Di Santo, Hans Rudolf Widmer, Nicolas Charlet-Berguerand, Bhuvaneish T Selvaraj, Siddharthan Chandran, Kathrin Meyer, Benoît Zuber, Anand Goswami
Publicado en: Acta Neuropathologica, Edición 144, 2022, Página(s) 939-966, ISSN 0001-6322
Editor: Springer Verlag
DOI: 10.1007/s00401-022-02494-5

C9ORF72 Deficiency Results in Neurodegeneration in the Zebrafish Retina

Autores: Natalia Jaroszynska, Andrea Salzinger, Themistoklis M. Tsarouchas, Catherina G. Becker, Thomas Becker, David A. Lyons, Ryan B. MacDonald, Marcus Keatinge
Publicado en: The Journal of Neuroscience, Edición 44, 2024, Página(s) e2128232024, ISSN 0270-6474
Editor: Society for Neuroscience
DOI: 10.1523/jneurosci.2128-23.2024

An App knock-in rat model for Alzheimer’s disease exhibiting Aβ and tau pathologies, neuronal death and cognitive impairments

Autores: Keliang Pang, Richeng Jiang, Wei Zhang, Zhengyi Yang, Lin-Lin Li, Makoto Shimozawa, Simone Tambaro, Johanna Mayer, Baogui Zhang, Man Li, Jiesi Wang, Hang Liu, Ailing Yang, Xi Chen, Jiazheng Liu, Bengt Winblad, Hua Han, Tianzi Jiang, Weiwen Wang, Per Nilsson, Wei Guo, Bai Lu
Publicado en: Cell Research, Edición 32, 2023, Página(s) 157-175, ISSN 1001-0602
Editor: Kexue Chubaneshe/Science Press
DOI: 10.1038/s41422-021-00582-x

Early molecular layer interneuron hyperactivity triggers Purkinje neuron degeneration in SCA1

Autores: Federica Pilotto, Christopher Douthwaite, Rim Diab, XiaoQian Ye, Zahraa Al qassab, Christoph Tietje, Meriem Mounassir, Adolfo Odriozola, Aishwarya Thapa, Ronald A.M. Buijsen, Sophie Lagache, Anne-Christine Uldry, Manfred Heller, Stefan Müller, Willeke M.C. van Roon-Mom, Benoît Zuber, Sabine Liebscher, Smita Saxena
Publicado en: Neuron, Edición 111, 2024, Página(s) 2523-2543.e10, ISSN 0896-6273
Editor: Cell Press
DOI: 10.1016/j.neuron.2023.05.016

Stress-induced phase separation of ERES components into Sec bodies precedes ER exit inhibition in mammalian cells

Autores: Wessel van Leeuwen, Dan T. M. Nguyen, Rianne Grond, Tineke Veenendaal, Catherine Rabouille, Ginny G. Farías
Publicado en: Journal of Cell Science, 2022, ISSN 0021-9533
Editor: The Company of Biologists Ltd.
DOI: 10.1242/jcs.260294

Spatial proteomics reveals secretory pathway disturbances caused by neuropathy-associated TECPR2

Autores: Karsten Nalbach, Martina Schifferer, Debjani Bhattacharya, Hung Ho-Xuan, Wei Chou Tseng, Luis A. Williams, Alexandra Stolz, Stefan F. Lichtenthaler, Zvulun Elazar, Christian Behrends
Publicado en: Nature Communications, Edición 14, 2023, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-023-36553-6

ALS’ Perfect Storm: C9orf72-Associated Toxic Dipeptide Repeats as Potential Multipotent Disruptors of Protein Homeostasis

Autores: Paulien H. Smeele, Giuliana Cesare, Thomas Vaccari
Publicado en: Cells, Edición 13, 2024, Página(s) 178, ISSN 2073-4409
Editor: MDPI Open Access Journals
DOI: 10.3390/cells13020178

Autophagy and neurodegeneration: Unraveling the role of C9ORF72 in the regulation of autophagy and its relationship to ALS-FTD pathology

Autores: Rim Diab, Federica Pilotto, Smita Saxena
Publicado en: Frontiers in Cellular Neuroscience, Edición 17, 2023, ISSN 1662-5102
Editor: Frontiers Research Foundation
DOI: 10.3389/fncel.2023.1086895

Generation and enrichment of cerebellar GABAergic interneurons from human induced pluripotent stem cells and intracellular calcium measurements

Autores: Federica Pilotto, Rim Diab, Zahraa Al Qassab, Smita Saxena
Publicado en: STAR Protocols, Edición 5, 2024, Página(s) 102936, ISSN 2666-1667
Editor: Cell Press
DOI: 10.1016/j.xpro.2024.102936

Systematic, comprehensive, evidence-based approach to identify neuroprotective interventions for motor neuron disease: using systematic reviews to inform expert consensus

Autores: Charis Wong, Jenna M Gregory, Jing Liao, Kieren Egan, Hanna M Vesterinen, Aimal Ahmad Khan, Maarij Anwar, Caitlin Beagan, Fraser S Brown, John Cafferkey, Alessandra Cardinali, Jane Yi Chiam, Claire Chiang, Victoria Collins, Joyce Dormido, Elizabeth Elliott, Peter Foley, Yu Cheng Foo, Lily Fulton-Humble, Angus B Gane, Stella A Glasmacher, Áine Heffernan, Kiran Jayaprakash, Nimesh Jayasuriya, Amina
Publicado en: BMJ Open, Edición 13, 2023, Página(s) e064169, ISSN 2044-6055
Editor: BMJ Publishing Group
DOI: 10.1136/bmjopen-2022-064169

Cell-autonomous immune dysfunction driven by disrupted autophagy in <i>C9orf72</i> -ALS iPSC-derived microglia contributes to neurodegeneration

Autores: Poulomi Banerjee, Arpan R. Mehta, Raja S. Nirujogi, James Cooper, Owen G. James, Jyoti Nanda, James Longden, Karen Burr, Karina McDade, Andrea Salzinger, Evdokia Paza, Judith Newton, David Story, Suvankar Pal, Colin Smith, Dario R. Alessi, Bhuvaneish T. Selvaraj, Josef Priller, Siddharthan Chandran
Publicado en: Science Advances, Edición 9, 2024, ISSN 2375-2548
Editor: American Association for the Advancement of Science
DOI: 10.1126/sciadv.abq0651

Microglial-to-neuronal CCR5 signaling regulates autophagy in neurodegeneration

Autores: Beatrice Paola Festa, Farah H. Siddiqi, Maria Jimenez-Sanchez, Hyeran Won, Matea Rob, Alvin Djajadikerta, Eleanna Stamatakou, David C. Rubinsztein
Publicado en: Neuron, Edición 111, 2023, Página(s) 2021-2037.e12, ISSN 0896-6273
Editor: Cell Press
DOI: 10.1016/j.neuron.2023.04.006

Axonal endoplasmic reticulum tubules control local translation via P180/RRBP1-mediated ribosome interactions

Autores: Max Koppers, Nazmiye Özkan, Ha H. Nguyen, Daphne Jurriens, Janine McCaughey, Dan T.M. Nguyen, Chun Hei Li, Riccardo Stucchi, Maarten Altelaar, Harold D. MacGillavry, Lukas C. Kapitein, Casper C. Hoogenraad, Ginny G. Farías
Publicado en: Developmental Cell, Edición 59, 2024, Página(s) 2053-2068.e9, ISSN 1534-5807
Editor: Cell Press
DOI: 10.1016/j.devcel.2024.05.005

Cortical Hyperexcitability in the Driver’s Seat in ALS

Autores: Zeynep I. Gunes, Vanessa W. Y. Kan, Shenyi Jiang, Evgeny Logunov, XiaoQian Ye, Sabine Liebscher
Publicado en: Clinical and Translational Neuroscience, Edición 6, 2024, Página(s) 5, ISSN 2514-183X
Editor: MDPI Open Access Journals
DOI: 10.3390/ctn6010005

Snapshots from within the cell: Novel trafficking and non trafficking functions of Snap29 during tissue morphogenesis

Autores: Paulien H. Smeele, Thomas Vaccari
Publicado en: Seminars in Cell & Developmental Biology, Edición 133, 2024, Página(s) 42-52, ISSN 1084-9521
Editor: Academic Press
DOI: 10.1016/j.semcdb.2022.02.024

When Separation Causes Activation: Biophysical Control of Bulk Autophagy Initiation

Autores: Debjani Bhattacharya, Christian Behrends
Publicado en: Molecular Cell, Edición 78, 2020, Página(s) 379-381, ISSN 1097-2765
Editor: Cell Press
DOI: 10.1016/j.molcel.2020.04.015

Endoplasmic reticulum – condensate interactions in protein synthesis and secretion

Autores: Dan T.M. Nguyen, Max Koppers, Ginny G. Farías
Publicado en: Current Opinion in Cell Biology, Edición 88, 2024, Página(s) 102357, ISSN 0955-0674
Editor: Elsevier BV
DOI: 10.1016/j.ceb.2024.102357

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