Secretion, Autophagy and their role in Neurodegeneration

Rezultaty

Generate a website for SAND where all beneficiaries are listed and a short description of the projects shall be presented. All ESRs will also be listed there and well as all news related to the project

Recruitment of Project Manager

We will recruit a manager to help assist the coordinator with the administrative aspects of SAND

Publikacje

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)<sup>1</sup>

Autorzy: Daniel J. Klionsky, Amal Kamal Abdel-Aziz, Sara Abdelfatah, Mahmoud Abdellatif, Asghar Abdoli, Steffen Abel, Hagai Abeliovich, Marie H. Abildgaard, Yakubu Princely Abudu, Abraham Acevedo-Arozena, Iannis E. Adamopoulos, Khosrow Adeli, Timon E. Adolph, Annagrazia Adornetto, Elma Aflaki, Galila Agam, Anupam Agarwal, Bharat B. Aggarwal, Maria Agnello, Patrizia Agostinis, Javed N. Agrewala, Alexander A
Opublikowane w: Autophagy, Numer 17, 2023, Strona(/y) 1-382, ISSN 1554-8627
Wydawca: Landes Bioscience
DOI: 10.1080/15548627.2020.1797280

Inhibition of Autophagy Alters Intracellular Transport of <scp>APP</scp> Resulting in Increased <scp>APP</scp> Processing

Autorzy: Johanna Mayer, Dominik Boeck, Michelle Werner, Daniela Frankenhauser, Stephan Geley, Hesso Farhan, Makoto Shimozawa, Per Nilsson
Opublikowane w: Traffic, Numer 25, 2024, ISSN 1398-9219
Wydawca: Blackwell Publishing Inc.
DOI: 10.1111/tra.12934

The pleiotropic roles of autophagy in Alzheimer's disease: From pathophysiology to therapy

Autorzy: Beatrice Paola Festa, Antonio Daniel Barbosa, Matea Rob, David C. Rubinsztein
Opublikowane w: Current Opinion in Pharmacology, Numer 60, 2021, Strona(/y) 149-157, ISSN 1471-4892
Wydawca: Elsevier BV
DOI: 10.1016/j.coph.2021.07.011

IER3IP1-mutations cause microcephaly by selective inhibition of ER-Golgi transport

Autorzy: Mihaela Anitei, Francesca Bruno, Christina Valkova, Therese Dau, Emilio Cirri, Iván Mestres, Federico Calegari, Christoph Kaether
Opublikowane w: Cellular and Molecular Life Sciences, Numer 81, 2024, ISSN 1420-682X
Wydawca: Birkhauser Verlag
DOI: 10.1007/s00018-024-05386-x

Neuronal Circuit Dysfunction in Amyotrophic Lateral Sclerosis

Autorzy: Andrea Salzinger, Vidya Ramesh, Shreya Das Sharma, Siddharthan Chandran, Bhuvaneish Thangaraj Selvaraj
Opublikowane w: Cells, Numer 13, 2024, Strona(/y) 792, ISSN 2073-4409
Wydawca: Academic Open Access Publishing
DOI: 10.3390/cells13100792

Insights into the structure and function of the RNA ligase RtcB

Autorzy: Matthieu Moncan, Hassan Rakhsh-Khorshid, Leif A. Eriksson, Afshin Samali, Adrienne M. Gorman
Opublikowane w: Cellular and Molecular Life Sciences, Numer 80, 2023, ISSN 1420-682X
Wydawca: Birkhauser Verlag
DOI: 10.1007/s00018-023-05001-5

Autophagy Impairment in App Knock-in Alzheimer’s Model Mice

Autorzy: Richeng Jiang, Makoto Shimozawa, Johanna Mayer, Simone Tambaro, Rakesh Kumar, Axel Abelein, Bengt Winblad, Nenad Bogdanovic, Per Nilsson
Opublikowane w: Frontiers in Aging Neuroscience, Numer 14, 2022, ISSN 1663-4365
Wydawca: Frontiers Research Foundation
DOI: 10.3389/fnagi.2022.878303

PolyGA targets the ER stress-adaptive response by impairing GRP75 function at the MAM in C9ORF72-ALS/FTD

Autorzy: Federica Pilotto, Alexander Schmitz, Niran Maharjan, Rim Diab, Adolfo Odriozola, Priyanka Tripathi, Alfred Yamoah, Olivier Scheidegger, Angelina Oestmann, Cassandra N. Dennys, Shrestha Sinha Ray, Rochelle Rodrigo, Stephen Kolb, Eleonora Aronica, Stefano Di Santo, Hans Rudolf Widmer, Nicolas Charlet-Berguerand, Bhuvaneish T Selvaraj, Siddharthan Chandran, Kathrin Meyer, Benoît Zuber, Anand Goswami
Opublikowane w: Acta Neuropathologica, Numer 144, 2022, Strona(/y) 939-966, ISSN 0001-6322
Wydawca: Springer Verlag
DOI: 10.1007/s00401-022-02494-5

C9ORF72 Deficiency Results in Neurodegeneration in the Zebrafish Retina

Autorzy: Natalia Jaroszynska, Andrea Salzinger, Themistoklis M. Tsarouchas, Catherina G. Becker, Thomas Becker, David A. Lyons, Ryan B. MacDonald, Marcus Keatinge
Opublikowane w: The Journal of Neuroscience, Numer 44, 2024, Strona(/y) e2128232024, ISSN 0270-6474
Wydawca: Society for Neuroscience
DOI: 10.1523/jneurosci.2128-23.2024

An App knock-in rat model for Alzheimer’s disease exhibiting Aβ and tau pathologies, neuronal death and cognitive impairments

Autorzy: Keliang Pang, Richeng Jiang, Wei Zhang, Zhengyi Yang, Lin-Lin Li, Makoto Shimozawa, Simone Tambaro, Johanna Mayer, Baogui Zhang, Man Li, Jiesi Wang, Hang Liu, Ailing Yang, Xi Chen, Jiazheng Liu, Bengt Winblad, Hua Han, Tianzi Jiang, Weiwen Wang, Per Nilsson, Wei Guo, Bai Lu
Opublikowane w: Cell Research, Numer 32, 2023, Strona(/y) 157-175, ISSN 1001-0602
Wydawca: Kexue Chubaneshe/Science Press
DOI: 10.1038/s41422-021-00582-x

Early molecular layer interneuron hyperactivity triggers Purkinje neuron degeneration in SCA1

Autorzy: Federica Pilotto, Christopher Douthwaite, Rim Diab, XiaoQian Ye, Zahraa Al qassab, Christoph Tietje, Meriem Mounassir, Adolfo Odriozola, Aishwarya Thapa, Ronald A.M. Buijsen, Sophie Lagache, Anne-Christine Uldry, Manfred Heller, Stefan Müller, Willeke M.C. van Roon-Mom, Benoît Zuber, Sabine Liebscher, Smita Saxena
Opublikowane w: Neuron, Numer 111, 2024, Strona(/y) 2523-2543.e10, ISSN 0896-6273
Wydawca: Cell Press
DOI: 10.1016/j.neuron.2023.05.016

Stress-induced phase separation of ERES components into Sec bodies precedes ER exit inhibition in mammalian cells

Autorzy: Wessel van Leeuwen, Dan T. M. Nguyen, Rianne Grond, Tineke Veenendaal, Catherine Rabouille, Ginny G. Farías
Opublikowane w: Journal of Cell Science, 2022, ISSN 0021-9533
Wydawca: The Company of Biologists Ltd.
DOI: 10.1242/jcs.260294

Spatial proteomics reveals secretory pathway disturbances caused by neuropathy-associated TECPR2

Autorzy: Karsten Nalbach, Martina Schifferer, Debjani Bhattacharya, Hung Ho-Xuan, Wei Chou Tseng, Luis A. Williams, Alexandra Stolz, Stefan F. Lichtenthaler, Zvulun Elazar, Christian Behrends
Opublikowane w: Nature Communications, Numer 14, 2023, ISSN 2041-1723
Wydawca: Nature Publishing Group
DOI: 10.1038/s41467-023-36553-6

ALS’ Perfect Storm: C9orf72-Associated Toxic Dipeptide Repeats as Potential Multipotent Disruptors of Protein Homeostasis

Autorzy: Paulien H. Smeele, Giuliana Cesare, Thomas Vaccari
Opublikowane w: Cells, Numer 13, 2024, Strona(/y) 178, ISSN 2073-4409
Wydawca: MDPI Open Access Journals
DOI: 10.3390/cells13020178

Autophagy and neurodegeneration: Unraveling the role of C9ORF72 in the regulation of autophagy and its relationship to ALS-FTD pathology

Autorzy: Rim Diab, Federica Pilotto, Smita Saxena
Opublikowane w: Frontiers in Cellular Neuroscience, Numer 17, 2023, ISSN 1662-5102
Wydawca: Frontiers Research Foundation
DOI: 10.3389/fncel.2023.1086895

Generation and enrichment of cerebellar GABAergic interneurons from human induced pluripotent stem cells and intracellular calcium measurements

Autorzy: Federica Pilotto, Rim Diab, Zahraa Al Qassab, Smita Saxena
Opublikowane w: STAR Protocols, Numer 5, 2024, Strona(/y) 102936, ISSN 2666-1667
Wydawca: Cell Press
DOI: 10.1016/j.xpro.2024.102936

Systematic, comprehensive, evidence-based approach to identify neuroprotective interventions for motor neuron disease: using systematic reviews to inform expert consensus

Autorzy: Charis Wong, Jenna M Gregory, Jing Liao, Kieren Egan, Hanna M Vesterinen, Aimal Ahmad Khan, Maarij Anwar, Caitlin Beagan, Fraser S Brown, John Cafferkey, Alessandra Cardinali, Jane Yi Chiam, Claire Chiang, Victoria Collins, Joyce Dormido, Elizabeth Elliott, Peter Foley, Yu Cheng Foo, Lily Fulton-Humble, Angus B Gane, Stella A Glasmacher, Áine Heffernan, Kiran Jayaprakash, Nimesh Jayasuriya, Amina
Opublikowane w: BMJ Open, Numer 13, 2023, Strona(/y) e064169, ISSN 2044-6055
Wydawca: BMJ Publishing Group
DOI: 10.1136/bmjopen-2022-064169

Cell-autonomous immune dysfunction driven by disrupted autophagy in <i>C9orf72</i> -ALS iPSC-derived microglia contributes to neurodegeneration

Autorzy: Poulomi Banerjee, Arpan R. Mehta, Raja S. Nirujogi, James Cooper, Owen G. James, Jyoti Nanda, James Longden, Karen Burr, Karina McDade, Andrea Salzinger, Evdokia Paza, Judith Newton, David Story, Suvankar Pal, Colin Smith, Dario R. Alessi, Bhuvaneish T. Selvaraj, Josef Priller, Siddharthan Chandran
Opublikowane w: Science Advances, Numer 9, 2024, ISSN 2375-2548
Wydawca: American Association for the Advancement of Science
DOI: 10.1126/sciadv.abq0651

Microglial-to-neuronal CCR5 signaling regulates autophagy in neurodegeneration

Autorzy: Beatrice Paola Festa, Farah H. Siddiqi, Maria Jimenez-Sanchez, Hyeran Won, Matea Rob, Alvin Djajadikerta, Eleanna Stamatakou, David C. Rubinsztein
Opublikowane w: Neuron, Numer 111, 2023, Strona(/y) 2021-2037.e12, ISSN 0896-6273
Wydawca: Cell Press
DOI: 10.1016/j.neuron.2023.04.006

Axonal endoplasmic reticulum tubules control local translation via P180/RRBP1-mediated ribosome interactions

Autorzy: Max Koppers, Nazmiye Özkan, Ha H. Nguyen, Daphne Jurriens, Janine McCaughey, Dan T.M. Nguyen, Chun Hei Li, Riccardo Stucchi, Maarten Altelaar, Harold D. MacGillavry, Lukas C. Kapitein, Casper C. Hoogenraad, Ginny G. Farías
Opublikowane w: Developmental Cell, Numer 59, 2024, Strona(/y) 2053-2068.e9, ISSN 1534-5807
Wydawca: Cell Press
DOI: 10.1016/j.devcel.2024.05.005

Cortical Hyperexcitability in the Driver’s Seat in ALS

Autorzy: Zeynep I. Gunes, Vanessa W. Y. Kan, Shenyi Jiang, Evgeny Logunov, XiaoQian Ye, Sabine Liebscher
Opublikowane w: Clinical and Translational Neuroscience, Numer 6, 2024, Strona(/y) 5, ISSN 2514-183X
Wydawca: MDPI Open Access Journals
DOI: 10.3390/ctn6010005

Snapshots from within the cell: Novel trafficking and non trafficking functions of Snap29 during tissue morphogenesis

Autorzy: Paulien H. Smeele, Thomas Vaccari
Opublikowane w: Seminars in Cell & Developmental Biology, Numer 133, 2024, Strona(/y) 42-52, ISSN 1084-9521
Wydawca: Academic Press
DOI: 10.1016/j.semcdb.2022.02.024

When Separation Causes Activation: Biophysical Control of Bulk Autophagy Initiation

Autorzy: Debjani Bhattacharya, Christian Behrends
Opublikowane w: Molecular Cell, Numer 78, 2020, Strona(/y) 379-381, ISSN 1097-2765
Wydawca: Cell Press
DOI: 10.1016/j.molcel.2020.04.015

Endoplasmic reticulum – condensate interactions in protein synthesis and secretion

Autorzy: Dan T.M. Nguyen, Max Koppers, Ginny G. Farías
Opublikowane w: Current Opinion in Cell Biology, Numer 88, 2024, Strona(/y) 102357, ISSN 0955-0674
Wydawca: Elsevier BV
DOI: 10.1016/j.ceb.2024.102357

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