A high-dimensional approach for unwinding immune-metabolic causes of cardiovascular disease-depression multimorbidities

Risultati finali

Identification of multiplex disease network and markers linked to multimorbidity and disease outcomes.
Enrichment of reference and bespoke datasets on inflammatory markers and construction of gene networks to support causal inference.
Dissemination plan
Molecular QTL analyses in relevant healthy and diseased cells and tissues (M30). Written report
Identification of driver nodes in disease networks
Tissue pleiotropic effects of depression and cardiovascular disease

Web presence and visual identity

Pubblicazioni

Characteristics of peripheral blood cells are independently related to major adverse cardiovascular events after carotid endarterectomy

Autori: L. Malin Overmars, Joost M. Mekke, Wouter W. van Solinge, Saskia C.A. De Jager, Cornelia A.R. Hulsbergen-Veelken, Imo E. Hoefer, Dominique P.V. de Kleijn, Gert J. de Borst, Sander W. van der Laan, Saskia Haitjema
Pubblicato in: Atherosclerosis Plus, Numero 52, 2023, Pagina/e 32-40, ISSN 2667-0895
Editore: Elsevier B.V.
DOI: 10.1016/j.athplu.2023.05.003

Genomics-based identification of a potential causal role for acylcarnitine metabolism in depression

Autori: Yuri Milaneschi; Matthias Arnold; Gabi Kastenmüller; Siamak Mahmoudian Dehkordi; Ranga R. Krishnan; Boadie W. Dunlop; A. John Rush; Brenda W.J.H. Penninx; Rima Kaddurah-Daouk
Pubblicato in: Journal of Affective Disorders, Numero 18, 2022, ISSN 0165-0327
Editore: Elsevier BV
DOI: 10.1016/j.jad.2022.03.070

The Applications of Single-Cell RNA Sequencing in Atherosclerotic Disease

Autori: Lotte Slenders; Daniëlle E. Tessels; Sander W. van der Laan; Gerard Pasterkamp; Michal Mokry; Michal Mokry
Pubblicato in: Frontiers in Cardiovascular Medicine, Vol 9 (2022), Numero 21, 2022, ISSN 2297-055X
Editore: Frontiers
DOI: 10.3389/fcvm.2022.826103

A network analysis of depressive symptoms and metabolomics

Autori: Arja O. Rydin, Yuri Milaneschi, Rick Quax, Jie Li, Jos A. Bosch, Robert A. Schoevers, Erik J. Giltay, Brenda W. J. H. Penninx, Femke Lamers
Pubblicato in: Psychological Medicine, Numero 53, 2024, Pagina/e 7385-7394, ISSN 0033-2917
Editore: Cambridge University Press
DOI: 10.1017/s0033291723001009

Plasma Lipoprotein Lipase Is Associated with Risk of Future Major Adverse Cardiovascular Events in Patients Following Carotid Endarterectomy

Autori: Joost M. Mekke, Maarten C. Verwer, Erik S.G. Stroes, Jeffrey Kroon, Leo Timmers, Gerard Pasterkamp, Gert J. de Borst, Sander W. van der Laan, Dominique P.V. de Kleijn
Pubblicato in: European Journal of Vascular and Endovascular Surgery, Numero 65, 2023, Pagina/e 700-709, ISSN 1078-5884
Editore: W. B. Saunders Co., Ltd.
DOI: 10.1016/j.ejvs.2023.01.035

Antithrombin, Protein C, and Protein S: Genome and Transcriptome-Wide Association Studies Identify 7 Novel Loci Regulating Plasma Levels

Autori: Yuekai Ji, Gerard Temprano-Sagrera, Lori A. Holle, Allison Bebo, Jennifer A. Brody, Ngoc-Quynh Le, Kadri Kangro, Michael R. Brown, Angel Martinez-Perez, Colleen M. Sitlani, Pierre Suchon, Marcus E. Kleber, David B. Emmert, Ayse Bilge Ozel, Dre’Von A. Dobson, Weihong Tang, Dolors Llobet, Russell P. Tracy, Jean-François Deleuze, Graciela E. Delgado, Martin Gögele, Kerri L. Wiggins, Juan Carlos S
Pubblicato in: Arteriosclerosis, Thrombosis, and Vascular Biology, Numero 43, 2024, ISSN 1079-5642
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/atvbaha.122.318213

Gut microbiome-wide association study of depressive symptoms

Autori: Djawad Radjabzadeh; Jos A. Bosch; André G. Uitterlinden; Aeilko H. Zwinderman; M. Arfan Ikram; Joyce B. J. van Meurs; Annemarie I. Luik; Max Nieuwdorp; Anja Lok; Cornelia M. van Duijn; Robert Kraaij; Najaf Amin
Pubblicato in: Nature Communications, Numero 18, 2022, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-022-34502-3

The Effects of FABP4 on Cardiovascular Disease in the Aging Population

Autori: Ellen M. van der Ark-Vonk, Mike V. Puijk, Gerard Pasterkamp, Sander W. van der Laan
Pubblicato in: Current Atherosclerosis Reports, Numero 26, 2024, Pagina/e 163-175, ISSN 1523-3804
Editore: Current Science Inc.
DOI: 10.1007/s11883-024-01196-5

Gene set analysis of transcriptomics data identifies new biological processes associated with early markers of atherosclerosis but not with those of osteoporosis : Atherosclerosis-osteoporosis co/multimorbidity study in the Young Finns Study

Autori: Binisha H. Mishra; Harri Sievänen; Emma Raitoharju; Nina Mononen; Jorma Viikari; Markus Juonala; Marika Laaksonen; Nina Hutri-Kähönen; Mika Kähönen; Olli T. Raitakari; Terho Lehtimäki; Pashupati P. Mishra
Pubblicato in: Atherosclerosis, Numero 26, 2022, ISSN 0021-9150
Editore: Elsevier BV
DOI: 10.1016/j.atherosclerosis.2022.10.005

Assessment of plasma ceramides as predictor for subclinical atherosclerosis

Autori: Pashupati P. Mishra; Binisha H. Mishra; Leo-Pekka Lyytikäinen; Mika Hilvo; Markus Juonala; Markus Juonala; Mika Kähönen; Nina Hutri-Kähönen; Dimitrios I. Fotiadis; Dimitrios I. Fotiadis; Olli T. Raitakari; Olli T. Raitakari; Reijo Laaksonen; Terho Lehtimäki
Pubblicato in: Atherosclerosis Plus, Numero 1, 2021, ISSN 2667-0895
Editore: Elsevier BV
DOI: 10.1016/j.athplu.2021.09.005

Multi-ancestry genetic analysis of gene regulation in coronary arteries prioritizes disease risk loci

Autori: Chani J. Hodonsky, Adam W. Turner, Mohammad Daud Khan, Nelson B. Barrientos, Ruben Methorst, Lijiang Ma, Nicolas G. Lopez, Jose Verdezoto Mosquera, Gaëlle Auguste, Emily Farber, Wei Feng Ma, Doris Wong, Suna Onengut-Gumuscu, Maryam Kavousi, Patricia A. Peyser, Sander W. van der Laan, Nicholas J. Leeper, Jason C. Kovacic, Johan L.M. Björkegren, Clint L. Miller
Pubblicato in: Cell Genomics, Numero 4, 2024, Pagina/e 100465, ISSN 2666-979X
Editore: Cell Press
DOI: 10.1016/j.xgen.2023.100465

Genome-wide association meta-analysis identifies risk loci for abdominal aortic aneurysm and highlights PCSK9 as a therapeutic target

Autori: Tanmoy Roychowdhury, Derek Klarin, Michael G. Levin, Joshua M. Spin, Yae Hyun Rhee, Alicia Deng, Colwyn A. Headley, Noah L. Tsao, Corry Gellatly, Verena Zuber, Fred Shen, Whitney E. Hornsby, Ina Holst Laursen, Shefali S. Verma, Adam E. Locke, Gudmundur Einarsson, Gudmar Thorleifsson, Sarah E. Graham, Ozan Dikilitas, Jack W. Pattee, Renae L. Judy, Ferran Pauls-Verges, Jonas B. Nielsen, Brooke N. Wo
Pubblicato in: Nature Genetics, Numero 55, 2023, Pagina/e 1831-1842, ISSN 1061-4036
Editore: Nature Publishing Group
DOI: 10.1038/s41588-023-01510-y

Integrative single-cell meta-analysis reveals disease-relevant vascular cell states and markers in human atherosclerosis

Autori: Jose Verdezoto Mosquera, Gaëlle Auguste, Doris Wong, Adam W. Turner, Chani J. Hodonsky, Astrid Catalina Alvarez-Yela, Yipei Song, Qi Cheng, Christian L. Lino Cardenas, Konstantinos Theofilatos, Maxime Bos, Maryam Kavousi, Patricia A. Peyser, Manuel Mayr, Jason C. Kovacic, Johan L.M. Björkegren, Rajeev Malhotra, P. Todd Stukenberg, Aloke V. Finn, Sander W. van der Laan, Chongzhi Zang, Nathan C. S
Pubblicato in: Cell Reports, Numero 42, 2024, Pagina/e 113380, ISSN 2211-1247
Editore: Cell Press
DOI: 10.1016/j.celrep.2023.113380

The accumulation of erythrocytes quantified and visualized by Glycophorin C in carotid atherosclerotic plaque reflects intraplaque hemorrhage and pre-procedural neurological symptoms

Autori: Joost M. Mekke, Tim R. Sakkers, Maarten C. Verwer, Noortje A. M. van den Dungen, Yipei Song, Clint L. Miller, Aloke V. Finn, Gerard Pasterkamp, Michal Mokry, Hester M. den Ruijter, Aryan Vink, Dominique P. V. de Kleijn, Gert J. de Borst, Saskia Haitjema, Sander W. van der Laan
Pubblicato in: Scientific Reports, Numero 13, 2023, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-023-43369-3

The gut microbiota and depressive symptoms across ethnic groups

Autori: Jos A. Bosch; Max Nieuwdorp; Aeilko H. Zwinderman; Mélanie Deschasaux; Djawad Radjabzadeh; Robert Kraaij; Mark Davids; Susanne R. de Rooij; Anja Lok
Pubblicato in: Nature Communications, Numero 19, 2022, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-022-34504-1

Notch signaling in adipose tissue macrophages prevents diet‐induced inflammation and metabolic dysregulation

Autori: Eleni Siouti, Maria Salagianni, Maria Manioudaki, Eleftherios Pavlos, Apostolos Klinakis, Ioanna‐Evdokia Galani, Evangelos Andreakos
Pubblicato in: European Journal of Immunology, Numero 54, 2024, ISSN 0014-2980
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/eji.202350669

Effect of tissue-grouped regulatory variants associated to type 2 diabetes in related secondary outcomes

Autori: Daiane Hemerich, Roelof A. J. Smit, Michael Preuss, Lauren Stalbow, Sander W. van der Laan, Folkert W. Asselbergs, Jessica van Setten, Vinicius Tragante
Pubblicato in: Scientific Reports, Numero 13, 2023, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-023-30369-6

Multi-Omics Integration in a Twin Cohort and Predictive Modeling of Blood Pressure Values

Autori: Gabin Drouard; Miina Ollikainen; Juha Mykkänen; Olli Raitakari; Terho Lehtimäki; Mika Kähönen; Pashupati P. Mishra; Xiaoling Wang; Jaakko Kaprio
Pubblicato in: OMICS: A journal of integrative biology, Numero 28, 2022, ISSN 1536-2310
Editore: Mary Ann Liebert Inc.
DOI: 10.1089/omi.2021.0201

PolarMorphism enables discovery of shared genetic variants across multiple traits from GWAS summary statistics.

Autori: Joanna von Berg; Michelle ten Dam; Sander W van der Laan; Jeroen de Ridder
Pubblicato in: Bioinformatics, Numero 23, 2022, ISSN 1367-4803
Editore: Oxford University Press
DOI: 10.1101/2022.01.14.476302

Sex and statin-related genetic associations at the PCSK9 gene locus: results of genome-wide association meta-analysis

Autori: Janne Pott, Azin Kheirkhah, Jesper R. Gadin, Marcus E. Kleber, Graciela E. Delgado, Holger Kirsten, Lukas Forer, Stefanie M. Hauck, Ralph Burkhardt, Hubert Scharnagl, Markus Loeffler, Winfried März, Joachim Thiery, Christian Gieger, Annette Peters, Angela Silveira, Ferdinand van’t Hooft, Florian Kronenberg, Markus Scholz
Pubblicato in: Biology of Sex Differences, Numero 15, 2024, ISSN 2042-6410
Editore: BMC
DOI: 10.1186/s13293-024-00602-6

Metabolomics signatures of depression: the role of symptom profiles

Autori: Hilde de Kluiver, Rick Jansen, Brenda W. J. H. Penninx, Erik J. Giltay, Robert A. Schoevers, Yuri Milaneschi
Pubblicato in: Translational Psychiatry, Numero 13, 2023, ISSN 2158-3188
Editore: Nature Publishing Group
DOI: 10.1038/s41398-023-02484-5

Lowering of Circulating Sclerostin May Increase Risk of Atherosclerosis and Its Risk Factors: Evidence From a <scp>Genome‐Wide</scp> Association <scp>Meta‐Analysis</scp> Followed by Mendelian Randomization

Autori: Jie Zheng, Eleanor Wheeler, Maik Pietzner, Till F. M. Andlauer, Michelle S. Yau, April E. Hartley, Ben Michael Brumpton, Humaira Rasheed, John P. Kemp, Monika Frysz, Jamie Robinson, Sjur Reppe, Vid Prijatelj, Kaare M. Gautvik, Louise Falk, Winfried Maerz, Ingrid Gergei, Patricia A. Peyser, Maryam Kavousi, Paul S. de Vries, Clint L. Miller, Maxime Bos, Sander W. van der Laan, Rajeev Malhotra, Marku
Pubblicato in: Arthritis & Rheumatology, Numero 75, 2023, Pagina/e 1781-1792, ISSN 2326-5191
Editore: Wiley & Sons
DOI: 10.1002/art.42538

How location and cellular signaling combine to activate the NLRP3 inflammasome

Autori: Anil Akbal; Alesja Dernst; Marta Lovotti; Matthew S. J. Mangan; Róisín M. McManus; Eicke Latz
Pubblicato in: Cellular and molecular immunology, Numero 19, 2022, ISSN 1672-7681
Editore: Nature Publishing Group
DOI: 10.1038/s41423-022-00922-w

AI-Enhanced Predictive Modeling for Identifying Depression and Delirium in Cardiovascular Patients Scheduled for Cardiac Surgery

Autori: Karina Nowakowska, Antonis Sakellarios, Jakub Kaźmierski, Dimitrios I. Fotiadis, Vasileios C. Pezoulas
Pubblicato in: Diagnostics, Numero 14, 2023, Pagina/e 67, ISSN 2075-4418
Editore: MDPI
DOI: 10.3390/diagnostics14010067

An automatic entropy method to efficiently mask histology whole-slide images

Autori: Yipei Song, Francesco Cisternino, Joost M. Mekke, Gert J. de Borst, Dominique P. V. de Kleijn, Gerard Pasterkamp, Aryan Vink, Craig A. Glastonbury, Sander W. van der Laan, Clint L. Miller
Pubblicato in: Scientific Reports, Numero 13, 2023, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-023-29638-1

Identification of gene networks jointly associated with depressive symptoms and cardiovascular health metrics using whole blood transcriptome in the Young Finns Study

Autori: Binisha H. Mishra, Emma Raitoharju, Nina Mononen, Aino Saarinen, Jorma Viikari, Markus Juonala, Nina Hutri-Kähönen, Mika Kähönen, Olli T. Raitakari, Terho Lehtimäki, Pashupati P. Mishra
Pubblicato in: Frontiers in Psychiatry, Numero 15, 2024, ISSN 1664-0640
Editore: Frontiers Research Foundation
DOI: 10.3389/fpsyt.2024.1345159

LoFTK: a framework for fully automated calculation of predicted Loss-of-Function variants

Autori: Folkert W. Asselbergs; Folkert W. Asselbergs; Jason H. Moore; Brendan J. Keating; A. Alasiri; A. Alasiri; S.W. Van Der Laan; Brian S. Cole; J. van Setten; Bao-Li Loza; Konrad J. Karczewski; Konrad J. Karczewski
Pubblicato in: BioData Mining, Numero 15, 2023, ISSN 1756-0381
Editore: BioMed Central
DOI: 10.1101/2021.08.09.455694

High genetic risk for depression as an independent risk factor for mortality in patients referred for coronary angiography

Autori: Robert M. Krämer, Angela P. Moissl, Stefan Lorkowski, Bernhard K. Krämer, Terho Lehtimäki, Binisha H. Mishra, Pashupati P. Mishra, Jan Leipe, Winfried März, Marcus E. Kleber, Bertram Müller-Myhsok, Graciela E. Delgado
Pubblicato in: Frontiers in Cardiovascular Medicine, Numero 10, 2023, ISSN 2297-055X
Editore: Frontiers Media SA
DOI: 10.3389/fcvm.2023.1125151

Druggable proteins influencing cardiac structure and function: implications for heart failure therapies and cancer related cardiotoxicity

Autori: Amand Schmidt; Mimount Bourfiss; Abdulrahman Alasiri; Sandesh Chopade; Esther Puyol-Anton; Marion van Vugt; Sander van der Laan; Anneline ter Riele; Birgitta Velthuis; Nora Franceschini; Bram Ruijsink; Aroon Hingorani; Pim van der Harst; Christian Gross; Chris Clarkson; Albert Henry; R Lumbers; Joshua Bis; Folkert Asselbergs; Jessica van Setten; Chris Finan
Pubblicato in: Science Advances, Numero 30, 2023, ISSN 2375-2548
Editore: AAAS
DOI: 10.21203/rs.3.rs-1305500/v1

Platelet Reactivity and Cardiovascular Mortality Risk in the LURIC Study

Autori: Martin Berger, Alexander Dressel, Marcus E. Kleber, Winfried März, Peter Hellstern, Nikolaus Marx, Katharina Schütt
Pubblicato in: Journal of Clinical Medicine, Numero 12, 2023, Pagina/e 1913, ISSN 2077-0383
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/jcm12051913

Sphingomyelin d18:1/14:0 activates TLR4 in metaflammation

Autori: Eicke Latz; Friederike Gorki; Lenka Dohnalová; Christoph Thaiss; Jelena Zurkovic; Anette Christ; Umeharu Ohto; Jan Marzinek; Peter J. Bond; Eike Geißmar; Santu Singha; Arslan Hamid; Mohamed Yaghmour; Kyra de Goede; Maximilian Rothe; Katarzyna Placek; Amin Polzin; Philipp Wollnitzke; Bodo Levkau; Michael Fitzgerald; Joost Rutten; Mihai Netea; Niels Riksen; Christoph Thiele; Andreas Pfeiffer; Pete
Pubblicato in: Research Square, Numero 14, 2023, ISSN 2693-5015
Editore: Research Square
DOI: 10.21203/rs.3.rs-2792338/v1

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