A high-dimensional approach for unwinding immune-metabolic causes of cardiovascular disease-depression multimorbidities

Resultado final

Identification of multiplex disease network and markers linked to multimorbidity and disease outcomes.
Enrichment of reference and bespoke datasets on inflammatory markers and construction of gene networks to support causal inference.
Dissemination plan
Molecular QTL analyses in relevant healthy and diseased cells and tissues (M30). Written report
Identification of driver nodes in disease networks
Tissue pleiotropic effects of depression and cardiovascular disease

Web presence and visual identity

Publicaciones

Characteristics of peripheral blood cells are independently related to major adverse cardiovascular events after carotid endarterectomy

Autores: L. Malin Overmars, Joost M. Mekke, Wouter W. van Solinge, Saskia C.A. De Jager, Cornelia A.R. Hulsbergen-Veelken, Imo E. Hoefer, Dominique P.V. de Kleijn, Gert J. de Borst, Sander W. van der Laan, Saskia Haitjema
Publicado en: Atherosclerosis Plus, Edición 52, 2023, Página(s) 32-40, ISSN 2667-0895
Editor: Elsevier B.V.
DOI: 10.1016/j.athplu.2023.05.003

Genomics-based identification of a potential causal role for acylcarnitine metabolism in depression

Autores: Yuri Milaneschi; Matthias Arnold; Gabi Kastenmüller; Siamak Mahmoudian Dehkordi; Ranga R. Krishnan; Boadie W. Dunlop; A. John Rush; Brenda W.J.H. Penninx; Rima Kaddurah-Daouk
Publicado en: Journal of Affective Disorders, Edición 18, 2022, ISSN 0165-0327
Editor: Elsevier BV
DOI: 10.1016/j.jad.2022.03.070

The Applications of Single-Cell RNA Sequencing in Atherosclerotic Disease

Autores: Lotte Slenders; Daniëlle E. Tessels; Sander W. van der Laan; Gerard Pasterkamp; Michal Mokry; Michal Mokry
Publicado en: Frontiers in Cardiovascular Medicine, Vol 9 (2022), Edición 21, 2022, ISSN 2297-055X
Editor: Frontiers
DOI: 10.3389/fcvm.2022.826103

A network analysis of depressive symptoms and metabolomics

Autores: Arja O. Rydin, Yuri Milaneschi, Rick Quax, Jie Li, Jos A. Bosch, Robert A. Schoevers, Erik J. Giltay, Brenda W. J. H. Penninx, Femke Lamers
Publicado en: Psychological Medicine, Edición 53, 2024, Página(s) 7385-7394, ISSN 0033-2917
Editor: Cambridge University Press
DOI: 10.1017/s0033291723001009

Plasma Lipoprotein Lipase Is Associated with Risk of Future Major Adverse Cardiovascular Events in Patients Following Carotid Endarterectomy

Autores: Joost M. Mekke, Maarten C. Verwer, Erik S.G. Stroes, Jeffrey Kroon, Leo Timmers, Gerard Pasterkamp, Gert J. de Borst, Sander W. van der Laan, Dominique P.V. de Kleijn
Publicado en: European Journal of Vascular and Endovascular Surgery, Edición 65, 2023, Página(s) 700-709, ISSN 1078-5884
Editor: W. B. Saunders Co., Ltd.
DOI: 10.1016/j.ejvs.2023.01.035

Antithrombin, Protein C, and Protein S: Genome and Transcriptome-Wide Association Studies Identify 7 Novel Loci Regulating Plasma Levels

Autores: Yuekai Ji, Gerard Temprano-Sagrera, Lori A. Holle, Allison Bebo, Jennifer A. Brody, Ngoc-Quynh Le, Kadri Kangro, Michael R. Brown, Angel Martinez-Perez, Colleen M. Sitlani, Pierre Suchon, Marcus E. Kleber, David B. Emmert, Ayse Bilge Ozel, Dre’Von A. Dobson, Weihong Tang, Dolors Llobet, Russell P. Tracy, Jean-François Deleuze, Graciela E. Delgado, Martin Gögele, Kerri L. Wiggins, Juan Carlos S
Publicado en: Arteriosclerosis, Thrombosis, and Vascular Biology, Edición 43, 2024, ISSN 1079-5642
Editor: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/atvbaha.122.318213

Gut microbiome-wide association study of depressive symptoms

Autores: Djawad Radjabzadeh; Jos A. Bosch; André G. Uitterlinden; Aeilko H. Zwinderman; M. Arfan Ikram; Joyce B. J. van Meurs; Annemarie I. Luik; Max Nieuwdorp; Anja Lok; Cornelia M. van Duijn; Robert Kraaij; Najaf Amin
Publicado en: Nature Communications, Edición 18, 2022, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-022-34502-3

The Effects of FABP4 on Cardiovascular Disease in the Aging Population

Autores: Ellen M. van der Ark-Vonk, Mike V. Puijk, Gerard Pasterkamp, Sander W. van der Laan
Publicado en: Current Atherosclerosis Reports, Edición 26, 2024, Página(s) 163-175, ISSN 1523-3804
Editor: Current Science Inc.
DOI: 10.1007/s11883-024-01196-5

Gene set analysis of transcriptomics data identifies new biological processes associated with early markers of atherosclerosis but not with those of osteoporosis : Atherosclerosis-osteoporosis co/multimorbidity study in the Young Finns Study

Autores: Binisha H. Mishra; Harri Sievänen; Emma Raitoharju; Nina Mononen; Jorma Viikari; Markus Juonala; Marika Laaksonen; Nina Hutri-Kähönen; Mika Kähönen; Olli T. Raitakari; Terho Lehtimäki; Pashupati P. Mishra
Publicado en: Atherosclerosis, Edición 26, 2022, ISSN 0021-9150
Editor: Elsevier BV
DOI: 10.1016/j.atherosclerosis.2022.10.005

Assessment of plasma ceramides as predictor for subclinical atherosclerosis

Autores: Pashupati P. Mishra; Binisha H. Mishra; Leo-Pekka Lyytikäinen; Mika Hilvo; Markus Juonala; Markus Juonala; Mika Kähönen; Nina Hutri-Kähönen; Dimitrios I. Fotiadis; Dimitrios I. Fotiadis; Olli T. Raitakari; Olli T. Raitakari; Reijo Laaksonen; Terho Lehtimäki
Publicado en: Atherosclerosis Plus, Edición 1, 2021, ISSN 2667-0895
Editor: Elsevier BV
DOI: 10.1016/j.athplu.2021.09.005

Multi-ancestry genetic analysis of gene regulation in coronary arteries prioritizes disease risk loci

Autores: Chani J. Hodonsky, Adam W. Turner, Mohammad Daud Khan, Nelson B. Barrientos, Ruben Methorst, Lijiang Ma, Nicolas G. Lopez, Jose Verdezoto Mosquera, Gaëlle Auguste, Emily Farber, Wei Feng Ma, Doris Wong, Suna Onengut-Gumuscu, Maryam Kavousi, Patricia A. Peyser, Sander W. van der Laan, Nicholas J. Leeper, Jason C. Kovacic, Johan L.M. Björkegren, Clint L. Miller
Publicado en: Cell Genomics, Edición 4, 2024, Página(s) 100465, ISSN 2666-979X
Editor: Cell Press
DOI: 10.1016/j.xgen.2023.100465

Genome-wide association meta-analysis identifies risk loci for abdominal aortic aneurysm and highlights PCSK9 as a therapeutic target

Autores: Tanmoy Roychowdhury, Derek Klarin, Michael G. Levin, Joshua M. Spin, Yae Hyun Rhee, Alicia Deng, Colwyn A. Headley, Noah L. Tsao, Corry Gellatly, Verena Zuber, Fred Shen, Whitney E. Hornsby, Ina Holst Laursen, Shefali S. Verma, Adam E. Locke, Gudmundur Einarsson, Gudmar Thorleifsson, Sarah E. Graham, Ozan Dikilitas, Jack W. Pattee, Renae L. Judy, Ferran Pauls-Verges, Jonas B. Nielsen, Brooke N. Wo
Publicado en: Nature Genetics, Edición 55, 2023, Página(s) 1831-1842, ISSN 1061-4036
Editor: Nature Publishing Group
DOI: 10.1038/s41588-023-01510-y

Integrative single-cell meta-analysis reveals disease-relevant vascular cell states and markers in human atherosclerosis

Autores: Jose Verdezoto Mosquera, Gaëlle Auguste, Doris Wong, Adam W. Turner, Chani J. Hodonsky, Astrid Catalina Alvarez-Yela, Yipei Song, Qi Cheng, Christian L. Lino Cardenas, Konstantinos Theofilatos, Maxime Bos, Maryam Kavousi, Patricia A. Peyser, Manuel Mayr, Jason C. Kovacic, Johan L.M. Björkegren, Rajeev Malhotra, P. Todd Stukenberg, Aloke V. Finn, Sander W. van der Laan, Chongzhi Zang, Nathan C. S
Publicado en: Cell Reports, Edición 42, 2024, Página(s) 113380, ISSN 2211-1247
Editor: Cell Press
DOI: 10.1016/j.celrep.2023.113380

The accumulation of erythrocytes quantified and visualized by Glycophorin C in carotid atherosclerotic plaque reflects intraplaque hemorrhage and pre-procedural neurological symptoms

Autores: Joost M. Mekke, Tim R. Sakkers, Maarten C. Verwer, Noortje A. M. van den Dungen, Yipei Song, Clint L. Miller, Aloke V. Finn, Gerard Pasterkamp, Michal Mokry, Hester M. den Ruijter, Aryan Vink, Dominique P. V. de Kleijn, Gert J. de Borst, Saskia Haitjema, Sander W. van der Laan
Publicado en: Scientific Reports, Edición 13, 2023, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-023-43369-3

The gut microbiota and depressive symptoms across ethnic groups

Autores: Jos A. Bosch; Max Nieuwdorp; Aeilko H. Zwinderman; Mélanie Deschasaux; Djawad Radjabzadeh; Robert Kraaij; Mark Davids; Susanne R. de Rooij; Anja Lok
Publicado en: Nature Communications, Edición 19, 2022, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-022-34504-1

Notch signaling in adipose tissue macrophages prevents diet‐induced inflammation and metabolic dysregulation

Autores: Eleni Siouti, Maria Salagianni, Maria Manioudaki, Eleftherios Pavlos, Apostolos Klinakis, Ioanna‐Evdokia Galani, Evangelos Andreakos
Publicado en: European Journal of Immunology, Edición 54, 2024, ISSN 0014-2980
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/eji.202350669

Effect of tissue-grouped regulatory variants associated to type 2 diabetes in related secondary outcomes

Autores: Daiane Hemerich, Roelof A. J. Smit, Michael Preuss, Lauren Stalbow, Sander W. van der Laan, Folkert W. Asselbergs, Jessica van Setten, Vinicius Tragante
Publicado en: Scientific Reports, Edición 13, 2023, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-023-30369-6

Multi-Omics Integration in a Twin Cohort and Predictive Modeling of Blood Pressure Values

Autores: Gabin Drouard; Miina Ollikainen; Juha Mykkänen; Olli Raitakari; Terho Lehtimäki; Mika Kähönen; Pashupati P. Mishra; Xiaoling Wang; Jaakko Kaprio
Publicado en: OMICS: A journal of integrative biology, Edición 28, 2022, ISSN 1536-2310
Editor: Mary Ann Liebert Inc.
DOI: 10.1089/omi.2021.0201

PolarMorphism enables discovery of shared genetic variants across multiple traits from GWAS summary statistics.

Autores: Joanna von Berg; Michelle ten Dam; Sander W van der Laan; Jeroen de Ridder
Publicado en: Bioinformatics, Edición 23, 2022, ISSN 1367-4803
Editor: Oxford University Press
DOI: 10.1101/2022.01.14.476302

Sex and statin-related genetic associations at the PCSK9 gene locus: results of genome-wide association meta-analysis

Autores: Janne Pott, Azin Kheirkhah, Jesper R. Gadin, Marcus E. Kleber, Graciela E. Delgado, Holger Kirsten, Lukas Forer, Stefanie M. Hauck, Ralph Burkhardt, Hubert Scharnagl, Markus Loeffler, Winfried März, Joachim Thiery, Christian Gieger, Annette Peters, Angela Silveira, Ferdinand van’t Hooft, Florian Kronenberg, Markus Scholz
Publicado en: Biology of Sex Differences, Edición 15, 2024, ISSN 2042-6410
Editor: BMC
DOI: 10.1186/s13293-024-00602-6

Metabolomics signatures of depression: the role of symptom profiles

Autores: Hilde de Kluiver, Rick Jansen, Brenda W. J. H. Penninx, Erik J. Giltay, Robert A. Schoevers, Yuri Milaneschi
Publicado en: Translational Psychiatry, Edición 13, 2023, ISSN 2158-3188
Editor: Nature Publishing Group
DOI: 10.1038/s41398-023-02484-5

Lowering of Circulating Sclerostin May Increase Risk of Atherosclerosis and Its Risk Factors: Evidence From a <scp>Genome‐Wide</scp> Association <scp>Meta‐Analysis</scp> Followed by Mendelian Randomization

Autores: Jie Zheng, Eleanor Wheeler, Maik Pietzner, Till F. M. Andlauer, Michelle S. Yau, April E. Hartley, Ben Michael Brumpton, Humaira Rasheed, John P. Kemp, Monika Frysz, Jamie Robinson, Sjur Reppe, Vid Prijatelj, Kaare M. Gautvik, Louise Falk, Winfried Maerz, Ingrid Gergei, Patricia A. Peyser, Maryam Kavousi, Paul S. de Vries, Clint L. Miller, Maxime Bos, Sander W. van der Laan, Rajeev Malhotra, Marku
Publicado en: Arthritis & Rheumatology, Edición 75, 2023, Página(s) 1781-1792, ISSN 2326-5191
Editor: Wiley & Sons
DOI: 10.1002/art.42538

How location and cellular signaling combine to activate the NLRP3 inflammasome

Autores: Anil Akbal; Alesja Dernst; Marta Lovotti; Matthew S. J. Mangan; Róisín M. McManus; Eicke Latz
Publicado en: Cellular and molecular immunology, Edición 19, 2022, ISSN 1672-7681
Editor: Nature Publishing Group
DOI: 10.1038/s41423-022-00922-w

AI-Enhanced Predictive Modeling for Identifying Depression and Delirium in Cardiovascular Patients Scheduled for Cardiac Surgery

Autores: Karina Nowakowska, Antonis Sakellarios, Jakub Kaźmierski, Dimitrios I. Fotiadis, Vasileios C. Pezoulas
Publicado en: Diagnostics, Edición 14, 2023, Página(s) 67, ISSN 2075-4418
Editor: MDPI
DOI: 10.3390/diagnostics14010067

An automatic entropy method to efficiently mask histology whole-slide images

Autores: Yipei Song, Francesco Cisternino, Joost M. Mekke, Gert J. de Borst, Dominique P. V. de Kleijn, Gerard Pasterkamp, Aryan Vink, Craig A. Glastonbury, Sander W. van der Laan, Clint L. Miller
Publicado en: Scientific Reports, Edición 13, 2023, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-023-29638-1

Identification of gene networks jointly associated with depressive symptoms and cardiovascular health metrics using whole blood transcriptome in the Young Finns Study

Autores: Binisha H. Mishra, Emma Raitoharju, Nina Mononen, Aino Saarinen, Jorma Viikari, Markus Juonala, Nina Hutri-Kähönen, Mika Kähönen, Olli T. Raitakari, Terho Lehtimäki, Pashupati P. Mishra
Publicado en: Frontiers in Psychiatry, Edición 15, 2024, ISSN 1664-0640
Editor: Frontiers Research Foundation
DOI: 10.3389/fpsyt.2024.1345159

LoFTK: a framework for fully automated calculation of predicted Loss-of-Function variants

Autores: Folkert W. Asselbergs; Folkert W. Asselbergs; Jason H. Moore; Brendan J. Keating; A. Alasiri; A. Alasiri; S.W. Van Der Laan; Brian S. Cole; J. van Setten; Bao-Li Loza; Konrad J. Karczewski; Konrad J. Karczewski
Publicado en: BioData Mining, Edición 15, 2023, ISSN 1756-0381
Editor: BioMed Central
DOI: 10.1101/2021.08.09.455694

High genetic risk for depression as an independent risk factor for mortality in patients referred for coronary angiography

Autores: Robert M. Krämer, Angela P. Moissl, Stefan Lorkowski, Bernhard K. Krämer, Terho Lehtimäki, Binisha H. Mishra, Pashupati P. Mishra, Jan Leipe, Winfried März, Marcus E. Kleber, Bertram Müller-Myhsok, Graciela E. Delgado
Publicado en: Frontiers in Cardiovascular Medicine, Edición 10, 2023, ISSN 2297-055X
Editor: Frontiers Media SA
DOI: 10.3389/fcvm.2023.1125151

Druggable proteins influencing cardiac structure and function: implications for heart failure therapies and cancer related cardiotoxicity

Autores: Amand Schmidt; Mimount Bourfiss; Abdulrahman Alasiri; Sandesh Chopade; Esther Puyol-Anton; Marion van Vugt; Sander van der Laan; Anneline ter Riele; Birgitta Velthuis; Nora Franceschini; Bram Ruijsink; Aroon Hingorani; Pim van der Harst; Christian Gross; Chris Clarkson; Albert Henry; R Lumbers; Joshua Bis; Folkert Asselbergs; Jessica van Setten; Chris Finan
Publicado en: Science Advances, Edición 30, 2023, ISSN 2375-2548
Editor: AAAS
DOI: 10.21203/rs.3.rs-1305500/v1

Platelet Reactivity and Cardiovascular Mortality Risk in the LURIC Study

Autores: Martin Berger, Alexander Dressel, Marcus E. Kleber, Winfried März, Peter Hellstern, Nikolaus Marx, Katharina Schütt
Publicado en: Journal of Clinical Medicine, Edición 12, 2023, Página(s) 1913, ISSN 2077-0383
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/jcm12051913

Sphingomyelin d18:1/14:0 activates TLR4 in metaflammation

Autores: Eicke Latz; Friederike Gorki; Lenka Dohnalová; Christoph Thaiss; Jelena Zurkovic; Anette Christ; Umeharu Ohto; Jan Marzinek; Peter J. Bond; Eike Geißmar; Santu Singha; Arslan Hamid; Mohamed Yaghmour; Kyra de Goede; Maximilian Rothe; Katarzyna Placek; Amin Polzin; Philipp Wollnitzke; Bodo Levkau; Michael Fitzgerald; Joost Rutten; Mihai Netea; Niels Riksen; Christoph Thiele; Andreas Pfeiffer; Pete
Publicado en: Research Square, Edición 14, 2023, ISSN 2693-5015
Editor: Research Square
DOI: 10.21203/rs.3.rs-2792338/v1

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