A high-dimensional approach for unwinding immune-metabolic causes of cardiovascular disease-depression multimorbidities

Deliverables

Identification of multiplex disease network and markers linked to multimorbidity and disease outcomes.
Enrichment of reference and bespoke datasets on inflammatory markers and construction of gene networks to support causal inference.
Dissemination plan
Molecular QTL analyses in relevant healthy and diseased cells and tissues (M30). Written report
Identification of driver nodes in disease networks
Tissue pleiotropic effects of depression and cardiovascular disease

Web presence and visual identity

Publications

Characteristics of peripheral blood cells are independently related to major adverse cardiovascular events after carotid endarterectomy

Author(s): L. Malin Overmars, Joost M. Mekke, Wouter W. van Solinge, Saskia C.A. De Jager, Cornelia A.R. Hulsbergen-Veelken, Imo E. Hoefer, Dominique P.V. de Kleijn, Gert J. de Borst, Sander W. van der Laan, Saskia Haitjema
Published in: Atherosclerosis Plus, Issue 52, 2023, Page(s) 32-40, ISSN 2667-0895
Publisher: Elsevier B.V.
DOI: 10.1016/j.athplu.2023.05.003

Genomics-based identification of a potential causal role for acylcarnitine metabolism in depression

Author(s): Yuri Milaneschi; Matthias Arnold; Gabi Kastenmüller; Siamak Mahmoudian Dehkordi; Ranga R. Krishnan; Boadie W. Dunlop; A. John Rush; Brenda W.J.H. Penninx; Rima Kaddurah-Daouk
Published in: Journal of Affective Disorders, Issue 18, 2022, ISSN 0165-0327
Publisher: Elsevier BV
DOI: 10.1016/j.jad.2022.03.070

The Applications of Single-Cell RNA Sequencing in Atherosclerotic Disease

Author(s): Lotte Slenders; Daniëlle E. Tessels; Sander W. van der Laan; Gerard Pasterkamp; Michal Mokry; Michal Mokry
Published in: Frontiers in Cardiovascular Medicine, Vol 9 (2022), Issue 21, 2022, ISSN 2297-055X
Publisher: Frontiers
DOI: 10.3389/fcvm.2022.826103

A network analysis of depressive symptoms and metabolomics

Author(s): Arja O. Rydin, Yuri Milaneschi, Rick Quax, Jie Li, Jos A. Bosch, Robert A. Schoevers, Erik J. Giltay, Brenda W. J. H. Penninx, Femke Lamers
Published in: Psychological Medicine, Issue 53, 2024, Page(s) 7385-7394, ISSN 0033-2917
Publisher: Cambridge University Press
DOI: 10.1017/s0033291723001009

Plasma Lipoprotein Lipase Is Associated with Risk of Future Major Adverse Cardiovascular Events in Patients Following Carotid Endarterectomy

Author(s): Joost M. Mekke, Maarten C. Verwer, Erik S.G. Stroes, Jeffrey Kroon, Leo Timmers, Gerard Pasterkamp, Gert J. de Borst, Sander W. van der Laan, Dominique P.V. de Kleijn
Published in: European Journal of Vascular and Endovascular Surgery, Issue 65, 2023, Page(s) 700-709, ISSN 1078-5884
Publisher: W. B. Saunders Co., Ltd.
DOI: 10.1016/j.ejvs.2023.01.035

Antithrombin, Protein C, and Protein S: Genome and Transcriptome-Wide Association Studies Identify 7 Novel Loci Regulating Plasma Levels

Author(s): Yuekai Ji, Gerard Temprano-Sagrera, Lori A. Holle, Allison Bebo, Jennifer A. Brody, Ngoc-Quynh Le, Kadri Kangro, Michael R. Brown, Angel Martinez-Perez, Colleen M. Sitlani, Pierre Suchon, Marcus E. Kleber, David B. Emmert, Ayse Bilge Ozel, Dre’Von A. Dobson, Weihong Tang, Dolors Llobet, Russell P. Tracy, Jean-François Deleuze, Graciela E. Delgado, Martin Gögele, Kerri L. Wiggins, Juan Carlos S
Published in: Arteriosclerosis, Thrombosis, and Vascular Biology, Issue 43, 2024, ISSN 1079-5642
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/atvbaha.122.318213

Gut microbiome-wide association study of depressive symptoms

Author(s): Djawad Radjabzadeh; Jos A. Bosch; André G. Uitterlinden; Aeilko H. Zwinderman; M. Arfan Ikram; Joyce B. J. van Meurs; Annemarie I. Luik; Max Nieuwdorp; Anja Lok; Cornelia M. van Duijn; Robert Kraaij; Najaf Amin
Published in: Nature Communications, Issue 18, 2022, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-022-34502-3

The Effects of FABP4 on Cardiovascular Disease in the Aging Population

Author(s): Ellen M. van der Ark-Vonk, Mike V. Puijk, Gerard Pasterkamp, Sander W. van der Laan
Published in: Current Atherosclerosis Reports, Issue 26, 2024, Page(s) 163-175, ISSN 1523-3804
Publisher: Current Science Inc.
DOI: 10.1007/s11883-024-01196-5

Gene set analysis of transcriptomics data identifies new biological processes associated with early markers of atherosclerosis but not with those of osteoporosis : Atherosclerosis-osteoporosis co/multimorbidity study in the Young Finns Study

Author(s): Binisha H. Mishra; Harri Sievänen; Emma Raitoharju; Nina Mononen; Jorma Viikari; Markus Juonala; Marika Laaksonen; Nina Hutri-Kähönen; Mika Kähönen; Olli T. Raitakari; Terho Lehtimäki; Pashupati P. Mishra
Published in: Atherosclerosis, Issue 26, 2022, ISSN 0021-9150
Publisher: Elsevier BV
DOI: 10.1016/j.atherosclerosis.2022.10.005

Assessment of plasma ceramides as predictor for subclinical atherosclerosis

Author(s): Pashupati P. Mishra; Binisha H. Mishra; Leo-Pekka Lyytikäinen; Mika Hilvo; Markus Juonala; Markus Juonala; Mika Kähönen; Nina Hutri-Kähönen; Dimitrios I. Fotiadis; Dimitrios I. Fotiadis; Olli T. Raitakari; Olli T. Raitakari; Reijo Laaksonen; Terho Lehtimäki
Published in: Atherosclerosis Plus, Issue 1, 2021, ISSN 2667-0895
Publisher: Elsevier BV
DOI: 10.1016/j.athplu.2021.09.005

Multi-ancestry genetic analysis of gene regulation in coronary arteries prioritizes disease risk loci

Author(s): Chani J. Hodonsky, Adam W. Turner, Mohammad Daud Khan, Nelson B. Barrientos, Ruben Methorst, Lijiang Ma, Nicolas G. Lopez, Jose Verdezoto Mosquera, Gaëlle Auguste, Emily Farber, Wei Feng Ma, Doris Wong, Suna Onengut-Gumuscu, Maryam Kavousi, Patricia A. Peyser, Sander W. van der Laan, Nicholas J. Leeper, Jason C. Kovacic, Johan L.M. Björkegren, Clint L. Miller
Published in: Cell Genomics, Issue 4, 2024, Page(s) 100465, ISSN 2666-979X
Publisher: Cell Press
DOI: 10.1016/j.xgen.2023.100465

Genome-wide association meta-analysis identifies risk loci for abdominal aortic aneurysm and highlights PCSK9 as a therapeutic target

Author(s): Tanmoy Roychowdhury, Derek Klarin, Michael G. Levin, Joshua M. Spin, Yae Hyun Rhee, Alicia Deng, Colwyn A. Headley, Noah L. Tsao, Corry Gellatly, Verena Zuber, Fred Shen, Whitney E. Hornsby, Ina Holst Laursen, Shefali S. Verma, Adam E. Locke, Gudmundur Einarsson, Gudmar Thorleifsson, Sarah E. Graham, Ozan Dikilitas, Jack W. Pattee, Renae L. Judy, Ferran Pauls-Verges, Jonas B. Nielsen, Brooke N. Wo
Published in: Nature Genetics, Issue 55, 2023, Page(s) 1831-1842, ISSN 1061-4036
Publisher: Nature Publishing Group
DOI: 10.1038/s41588-023-01510-y

Integrative single-cell meta-analysis reveals disease-relevant vascular cell states and markers in human atherosclerosis

Author(s): Jose Verdezoto Mosquera, Gaëlle Auguste, Doris Wong, Adam W. Turner, Chani J. Hodonsky, Astrid Catalina Alvarez-Yela, Yipei Song, Qi Cheng, Christian L. Lino Cardenas, Konstantinos Theofilatos, Maxime Bos, Maryam Kavousi, Patricia A. Peyser, Manuel Mayr, Jason C. Kovacic, Johan L.M. Björkegren, Rajeev Malhotra, P. Todd Stukenberg, Aloke V. Finn, Sander W. van der Laan, Chongzhi Zang, Nathan C. S
Published in: Cell Reports, Issue 42, 2024, Page(s) 113380, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2023.113380

The accumulation of erythrocytes quantified and visualized by Glycophorin C in carotid atherosclerotic plaque reflects intraplaque hemorrhage and pre-procedural neurological symptoms

Author(s): Joost M. Mekke, Tim R. Sakkers, Maarten C. Verwer, Noortje A. M. van den Dungen, Yipei Song, Clint L. Miller, Aloke V. Finn, Gerard Pasterkamp, Michal Mokry, Hester M. den Ruijter, Aryan Vink, Dominique P. V. de Kleijn, Gert J. de Borst, Saskia Haitjema, Sander W. van der Laan
Published in: Scientific Reports, Issue 13, 2023, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-023-43369-3

The gut microbiota and depressive symptoms across ethnic groups

Author(s): Jos A. Bosch; Max Nieuwdorp; Aeilko H. Zwinderman; Mélanie Deschasaux; Djawad Radjabzadeh; Robert Kraaij; Mark Davids; Susanne R. de Rooij; Anja Lok
Published in: Nature Communications, Issue 19, 2022, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-022-34504-1

Notch signaling in adipose tissue macrophages prevents diet‐induced inflammation and metabolic dysregulation

Author(s): Eleni Siouti, Maria Salagianni, Maria Manioudaki, Eleftherios Pavlos, Apostolos Klinakis, Ioanna‐Evdokia Galani, Evangelos Andreakos
Published in: European Journal of Immunology, Issue 54, 2024, ISSN 0014-2980
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/eji.202350669

Effect of tissue-grouped regulatory variants associated to type 2 diabetes in related secondary outcomes

Author(s): Daiane Hemerich, Roelof A. J. Smit, Michael Preuss, Lauren Stalbow, Sander W. van der Laan, Folkert W. Asselbergs, Jessica van Setten, Vinicius Tragante
Published in: Scientific Reports, Issue 13, 2023, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-023-30369-6

Multi-Omics Integration in a Twin Cohort and Predictive Modeling of Blood Pressure Values

Author(s): Gabin Drouard; Miina Ollikainen; Juha Mykkänen; Olli Raitakari; Terho Lehtimäki; Mika Kähönen; Pashupati P. Mishra; Xiaoling Wang; Jaakko Kaprio
Published in: OMICS: A journal of integrative biology, Issue 28, 2022, ISSN 1536-2310
Publisher: Mary Ann Liebert Inc.
DOI: 10.1089/omi.2021.0201

PolarMorphism enables discovery of shared genetic variants across multiple traits from GWAS summary statistics.

Author(s): Joanna von Berg; Michelle ten Dam; Sander W van der Laan; Jeroen de Ridder
Published in: Bioinformatics, Issue 23, 2022, ISSN 1367-4803
Publisher: Oxford University Press
DOI: 10.1101/2022.01.14.476302

Sex and statin-related genetic associations at the PCSK9 gene locus: results of genome-wide association meta-analysis

Author(s): Janne Pott, Azin Kheirkhah, Jesper R. Gadin, Marcus E. Kleber, Graciela E. Delgado, Holger Kirsten, Lukas Forer, Stefanie M. Hauck, Ralph Burkhardt, Hubert Scharnagl, Markus Loeffler, Winfried März, Joachim Thiery, Christian Gieger, Annette Peters, Angela Silveira, Ferdinand van’t Hooft, Florian Kronenberg, Markus Scholz
Published in: Biology of Sex Differences, Issue 15, 2024, ISSN 2042-6410
Publisher: BMC
DOI: 10.1186/s13293-024-00602-6

Metabolomics signatures of depression: the role of symptom profiles

Author(s): Hilde de Kluiver, Rick Jansen, Brenda W. J. H. Penninx, Erik J. Giltay, Robert A. Schoevers, Yuri Milaneschi
Published in: Translational Psychiatry, Issue 13, 2023, ISSN 2158-3188
Publisher: Nature Publishing Group
DOI: 10.1038/s41398-023-02484-5

Lowering of Circulating Sclerostin May Increase Risk of Atherosclerosis and Its Risk Factors: Evidence From a <scp>Genome‐Wide</scp> Association <scp>Meta‐Analysis</scp> Followed by Mendelian Randomization

Author(s): Jie Zheng, Eleanor Wheeler, Maik Pietzner, Till F. M. Andlauer, Michelle S. Yau, April E. Hartley, Ben Michael Brumpton, Humaira Rasheed, John P. Kemp, Monika Frysz, Jamie Robinson, Sjur Reppe, Vid Prijatelj, Kaare M. Gautvik, Louise Falk, Winfried Maerz, Ingrid Gergei, Patricia A. Peyser, Maryam Kavousi, Paul S. de Vries, Clint L. Miller, Maxime Bos, Sander W. van der Laan, Rajeev Malhotra, Marku
Published in: Arthritis & Rheumatology, Issue 75, 2023, Page(s) 1781-1792, ISSN 2326-5191
Publisher: Wiley & Sons
DOI: 10.1002/art.42538

How location and cellular signaling combine to activate the NLRP3 inflammasome

Author(s): Anil Akbal; Alesja Dernst; Marta Lovotti; Matthew S. J. Mangan; Róisín M. McManus; Eicke Latz
Published in: Cellular and molecular immunology, Issue 19, 2022, ISSN 1672-7681
Publisher: Nature Publishing Group
DOI: 10.1038/s41423-022-00922-w

AI-Enhanced Predictive Modeling for Identifying Depression and Delirium in Cardiovascular Patients Scheduled for Cardiac Surgery

Author(s): Karina Nowakowska, Antonis Sakellarios, Jakub Kaźmierski, Dimitrios I. Fotiadis, Vasileios C. Pezoulas
Published in: Diagnostics, Issue 14, 2023, Page(s) 67, ISSN 2075-4418
Publisher: MDPI
DOI: 10.3390/diagnostics14010067

An automatic entropy method to efficiently mask histology whole-slide images

Author(s): Yipei Song, Francesco Cisternino, Joost M. Mekke, Gert J. de Borst, Dominique P. V. de Kleijn, Gerard Pasterkamp, Aryan Vink, Craig A. Glastonbury, Sander W. van der Laan, Clint L. Miller
Published in: Scientific Reports, Issue 13, 2023, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-023-29638-1

Identification of gene networks jointly associated with depressive symptoms and cardiovascular health metrics using whole blood transcriptome in the Young Finns Study

Author(s): Binisha H. Mishra, Emma Raitoharju, Nina Mononen, Aino Saarinen, Jorma Viikari, Markus Juonala, Nina Hutri-Kähönen, Mika Kähönen, Olli T. Raitakari, Terho Lehtimäki, Pashupati P. Mishra
Published in: Frontiers in Psychiatry, Issue 15, 2024, ISSN 1664-0640
Publisher: Frontiers Research Foundation
DOI: 10.3389/fpsyt.2024.1345159

LoFTK: a framework for fully automated calculation of predicted Loss-of-Function variants

Author(s): Folkert W. Asselbergs; Folkert W. Asselbergs; Jason H. Moore; Brendan J. Keating; A. Alasiri; A. Alasiri; S.W. Van Der Laan; Brian S. Cole; J. van Setten; Bao-Li Loza; Konrad J. Karczewski; Konrad J. Karczewski
Published in: BioData Mining, Issue 15, 2023, ISSN 1756-0381
Publisher: BioMed Central
DOI: 10.1101/2021.08.09.455694

High genetic risk for depression as an independent risk factor for mortality in patients referred for coronary angiography

Author(s): Robert M. Krämer, Angela P. Moissl, Stefan Lorkowski, Bernhard K. Krämer, Terho Lehtimäki, Binisha H. Mishra, Pashupati P. Mishra, Jan Leipe, Winfried März, Marcus E. Kleber, Bertram Müller-Myhsok, Graciela E. Delgado
Published in: Frontiers in Cardiovascular Medicine, Issue 10, 2023, ISSN 2297-055X
Publisher: Frontiers Media SA
DOI: 10.3389/fcvm.2023.1125151

Druggable proteins influencing cardiac structure and function: implications for heart failure therapies and cancer related cardiotoxicity

Author(s): Amand Schmidt; Mimount Bourfiss; Abdulrahman Alasiri; Sandesh Chopade; Esther Puyol-Anton; Marion van Vugt; Sander van der Laan; Anneline ter Riele; Birgitta Velthuis; Nora Franceschini; Bram Ruijsink; Aroon Hingorani; Pim van der Harst; Christian Gross; Chris Clarkson; Albert Henry; R Lumbers; Joshua Bis; Folkert Asselbergs; Jessica van Setten; Chris Finan
Published in: Science Advances, Issue 30, 2023, ISSN 2375-2548
Publisher: AAAS
DOI: 10.21203/rs.3.rs-1305500/v1

Platelet Reactivity and Cardiovascular Mortality Risk in the LURIC Study

Author(s): Martin Berger, Alexander Dressel, Marcus E. Kleber, Winfried März, Peter Hellstern, Nikolaus Marx, Katharina Schütt
Published in: Journal of Clinical Medicine, Issue 12, 2023, Page(s) 1913, ISSN 2077-0383
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/jcm12051913

Sphingomyelin d18:1/14:0 activates TLR4 in metaflammation

Author(s): Eicke Latz; Friederike Gorki; Lenka Dohnalová; Christoph Thaiss; Jelena Zurkovic; Anette Christ; Umeharu Ohto; Jan Marzinek; Peter J. Bond; Eike Geißmar; Santu Singha; Arslan Hamid; Mohamed Yaghmour; Kyra de Goede; Maximilian Rothe; Katarzyna Placek; Amin Polzin; Philipp Wollnitzke; Bodo Levkau; Michael Fitzgerald; Joost Rutten; Mihai Netea; Niels Riksen; Christoph Thiele; Andreas Pfeiffer; Pete
Published in: Research Square, Issue 14, 2023, ISSN 2693-5015
Publisher: Research Square
DOI: 10.21203/rs.3.rs-2792338/v1

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