Periodic Reporting for period 2 - MindGAP (Bridging the gap between Mind, Brain and Body: exosome role and monitoring)
Période du rapport: 2020-04-01 au 2021-09-30
MindGAP presents a radical new vision that may BRIDGE the GAP between HEALTH status and MIND/BODY interactions and lead to a paradigm shift in medicine. Overall, combining the facts that (i) the mind is related to the brain chemistry, (ii) brain-related EXOs are part of the brain chemistry and (iii) EXOs are involved in the cell communication, it becomes apparent that these EXOs may also be the messengers between Mind and Body events, thereby filling the current gap between Mind and Body interrelation.
The disruptive idea presented herein is sustained by relevant data presented in the literature: (i) exosomes circulate throughout the body as messengers of health and disease, transporting genetic data to be delivered into a recipient cell; (ii) and exosomes are implicated in brain activity, having the ability to cross the blood brain barrier. Thus, when exosomes circulate and exit the brain to peripheral cells, there is a message transported therein, which is related to its cargo inside the vesicle. Overall, we aim to know which cargo is related to health and which cargo is related to disease. Traditionally, everyone has been looking for disease indicators to detect disease.
Herein, we look for sensitive health indicators that may change under disease installation, therefore yielding an unprecedented early disease detection possibility. Moreover, the possibility of using MINDFULNESS mediation as a mind-related tool to control the cargo of exosomes is explored herein. If mediation is successful in changing the behaviour and attitudes of many people, fighting depression, etc., it means that the exosomes cargo may be changed through this process. Thus, this could be a major route to a self-healing approach before disease begins. Finally, all this knowledge opens doors to an innovative device that may be used by everyone to understand his/her health status.
Overall, MindGAP targets (i) the missing relation between the genetic data in EXOSOMES and health status; (ii) interfacing this link with MIND-related activities; (iii) and to create an INNOVATIVE and PORTABLE DEVICE that TRACKS EXOSOMES and ANALYSIS their relevant genetic data, thereby allowing each individual to correlate this information with their own HEALTH STATUS and the installation of a pro-active attitude of each one of us against disease.
The disruptive idea presented herein is sustained by relevant data presented in the literature: (i) exosomes circulate throughout the body as messengers of health and disease, transporting genetic data to be delivered into a recipient cell; (ii) and exosomes are implicated in brain activity, having the ability to cross the blood brain barrier. Thus, when exosomes circulate and exit the brain to peripheral cells, there is a message transported therein, which is related to its cargo inside the vesicle. Overall, we aim to know which cargo is related to health and which cargo is related to disease. Traditionally, everyone has been looking for disease indicators to detect disease.
Herein, we look for sensitive health indicators that may change under disease installation, therefore yielding an unprecedented early disease detection possibility. Moreover, the possibility of using MINDFULNESS mediation as a mind-related tool to control the cargo of exosomes is explored herein. If mediation is successful in changing the behaviour and attitudes of many people, fighting depression, etc., it means that the exosomes cargo may be changed through this process. Thus, this could be a major route to a self-healing approach before disease begins. Finally, all this knowledge opens doors to an innovative device that may be used by everyone to understand his/her health status.
Overall, MindGAP targets (i) the missing relation between the genetic data in EXOSOMES and health status; (ii) interfacing this link with MIND-related activities; (iii) and to create an INNOVATIVE and PORTABLE DEVICE that TRACKS EXOSOMES and ANALYSIS their relevant genetic data, thereby allowing each individual to correlate this information with their own HEALTH STATUS and the installation of a pro-active attitude of each one of us against disease.
In the course of MindGAP, there are several technical approaches being developed, each of these bringing additional innovation into the current state-of-art. Exosomes have been characterized by different methods and approaches. New plastic antibodies are in due course and new devices targeting miRNA are being envisioned. This is being interfaced with simulation and specific microfluidic approaches.
All deliverables and milestones in this period have been achieved. The website of the project is https://mindgap-fet-open.eu/. Public activities are available in https://mindgap-fet-open.eu/news-%26-media.
Overall, the working is progressing towards the objectives identified, as planned, with the exception of impact out coming from COVID-19 pandemics.
All deliverables and milestones in this period have been achieved. The website of the project is https://mindgap-fet-open.eu/. Public activities are available in https://mindgap-fet-open.eu/news-%26-media.
Overall, the working is progressing towards the objectives identified, as planned, with the exception of impact out coming from COVID-19 pandemics.
Overall, it is expected that MindGAP may lead to the FOUNDATION of a NOVEL APPROACH towards DISEASE DIAGNOSIS and medical , yielding a new line of research, which in a long term may change the current paradigm in medicine, while helping to understand how our mind may interact with health and disease installation and progression. The impact of this new field is tremendous. It is also expected that MindGAP may lead to the (2) implementation of NEW MEDICAL PROCEDURES in disease management that include meditation.
Overall, the end of implementation of MindGAP is expected to produce a series of results that can be exploited individually, by each partner, or as part of the joint effort of the whole consortium or several partners, as detailed in D7.
Overall, the end of implementation of MindGAP is expected to produce a series of results that can be exploited individually, by each partner, or as part of the joint effort of the whole consortium or several partners, as detailed in D7.