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Interdisciplinary training network for advancing Organ-on-a-chip technology in Europe

Descripción del proyecto

Hacia la siguiente generación de la tecnología de órgano en un chip

Los órganos en un chip son sistemas de microingeniería que permiten el cultivo «in vitro» de células en un entorno tridimensional. Utilizan microfluídica y andamiaje basado en polímeros para sintetizar en detalle las propiedades fisiológicas del microentorno y la estructura del órgano correspondiente. La tecnología de órgano en un chip ha revolucionado el descubrimiento de fármacos y permite obtener datos fiables sobre la eficacia y toxicidad de los medicamentos. El objetivo del proyecto EUROoC, financiado con fondos europeos, es impartir una formación multidisciplinaria a jóvenes investigadores para impulsar su carrera en el ámbito de la fabricación de órganos en un chip. Desde una perspectiva experimental, los alumnos se proponen construir dispositivos de órganos en un chip de siguiente generación que repliquen los intestinos, el hígado, los huesos, el corazón, la retina y el tejido adiposo.

Objetivo

EUROoC will create a trans-European network of industrially oriented specialists fully trained in development and application of the emerging Organ-on-a-chip (OoC) technology. OoC technology is advancing at breath taking pace due to its potential impact in drug development and personalised treatments of disease. New researchers entering this field must be equipped with a multidisciplinary background ranging from biology to microfluidic chip engineering. EUROoC will offer the first complete and coherent European training program on OoC by gathering multidisciplinary participants (biologists, physicists, chemists, engineers) in a multi-sectoral network composed of 4 companies (3 SMEs), 2 regulation entities and 10 academic institutions. EUROoC will qualify the next generation of interdisciplinary scientists for all aspects of OoC development and utilisation, including understanding of commercialisation pathways and regulatory aspects. EUROoC furthermore comprises a collection of innovative research projects addressing the development of advanced OoC systems with higher physiological significance going beyond current in vitro testing. The EUROoC project will create advanced OoCs, which closely recapitulate properties of the respective organ tissues in vivo regarding cell types, microenvironment, organ-specific tissue structure and function as well as concepts for the interconnection of individual OoCs. The various OoC models to be developed comprise heart-on-a-chip, bone-on-a-chip, retina-on-a-chip, lung-on-a-chip, adipose- on-a-chip, gut-on-a-chip to liver-on-a-chip. The OoC systems will be able to monitor and analyse tissue functionality and response in situ by integrating various novel sensing elements. The OoCs developed will be pre-validated with the regulatory partners through in vitro-in vivo correlations. The research and training program planned will increase European competitiveness sustainably in this emerging key technology.

Coordinador

NATURWISSENSCHAFTLICHES UND MEDIZINISCHES INSTITUT AN DER UNIVERSITAET TUEBINGEN
Aportación neta de la UEn
€ 182 569,40
Dirección
MARKWIESENSTRASSE 55
72770 Reutlingen
Alemania

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Región
Baden-Württemberg Tübingen Reutlingen
Tipo de actividad
Research Organisations
Enlaces
Coste total
€ 182 569,40

Participantes (12)

Socios (10)