Integrated nanoparticle isolation and detection system for complete on-chip analysis of exosomes

Risultati finali

Project dedicated web site

Publishing of the project dedicated website.

Data management plan

Generation of a Data Management Plan to follow the Horizon 2020 Open Research Data Pilot guidelines

Updated data management plan

Update of the Data Management Plan

Intermediate dissemination and exploitation report

This document will report on the plan envisaged by the consortium for project results dissemination and exploitation

Report on exosome-specific Ab selection

This document will report on the selection of the panel of antibodies for on-chip exosome immuno- phenotyping

Final dissemination and exploitation report

This document will report on the dissemination activities held during the project and on the possibility of exploitation of results and deliverables for translation of inventions obtained during the project.

Report on clinical demonstration

This document will report on the results obtained using the newly developed instrumentation with selected clinical samples

Report on criteria for system demonstration

This report will provide the specifications on the requested performance of the systems and the criteria that will be used for system demonstration at the end of the project.

Pubblicazioni

Computational nanosensing from defocus in single particle interferometric reflectance microscopy

Autori: Yurdakul, C., M.S., Ünlü
Pubblicato in: OpticsLetters, 2020
Editore: OpticsLetters
DOI: 10.1364/ol.409458

Separation of Extracellular Vesicles by DNA-Directed Immunocapturing Followed by Enzymatic Release

Autori: Brambilla, D., Sola, L., Chiodi, E., Zarovni, N., Fortunato, D., Criscuoli, M., Dolo, V., Giusti, I., Murdica, V., Vago, R., Chiari, M.
Pubblicato in: ChemRxiv, 2020
Editore: ChemRxiv
DOI: 10.26434/chemrxiv.12234683.v1

Multiplexed affinity measurements of extracellular vesicles binding kinetics

Autori: Chiodi, E.; Daaboul, G.; Marn, A.M.; Ünlü, M.S.
Pubblicato in: ChemRxiv, 2021
Editore: ChemRxiv
DOI: 10.26434/chemrxiv.13547459.v1

A Bi-Functional Polymeric Coating for the Co-Imobilization of Proteins and Peptides on Microarray Substrates

Autori: Laura Sola, Dario Brambilla, Alessandro Mussida, Roberto Consonni, Francesco Damin, Marina Cretich, Alessandro Gori, Marcella Chiari
Pubblicato in: ChemRxiv, 2020
Editore: ChemRxiv
DOI: 10.26434/chemrxiv.13135769.v1

Simultaneous Evaluation of Multiple Microarray Surface Chemistries Through Real-Time Interferometric Imaging.

Autori: Chiodi, Elisa; Sola, Laura; Brambilla, Dario; Cretich, Marina; Marn, Allison; Ünlü, M. Selim; et al.
Pubblicato in: Chemrxiv, 2019
Editore: Chemrxiv
DOI: 10.26434/chemrxiv.8976347.v1

Advantageous Antibody Microarray Fabrication Through DNA-Directed Immobilization: A Step Toward Use of Extracellular Vesicles in Diagnostics

Autori: Dario Brambilla; Laura Sola; Marcella Chiari
Pubblicato in: Chemrxiv, Numero 1, 2020
Editore: Chemrxiv
DOI: 10.26434/chemrxiv.12227255.v1

Author Correction: Label-free detection of nanoparticles using depth scanning correlation interferometric microscopy

Autori: Ugur Aygun, Hakan Urey, Ayca Yalcin Ozkumur
Pubblicato in: Scientific Reports, Numero 9/1, 2019, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-019-53131-3

Small evs-associated dna as complementary biomarker to circulating tumor dna in plasma of metastatic colorectal cancer patients

Autori: Silvia Galbiati, Francesco Damin, Dario Brambilla, Lucia Ferraro, Nadia Soriani, Anna Maria Ferretti, Valentina Burgio, Monica Ronzoni, Riccardo Vago, Laura Sola. Marcella Chiari,
Pubblicato in: Pharmaceuticals, 2021, ISSN 1424-8247
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ph14020128

Extracellular Vesicles Analysis in the COVID-19 Era: Insights on Serum Inactivation Protocols Towards Downstream Isolation and Analysis

Autori: Roberto Frigerio, Angelo Musicò, Marco Brucale, Andrea Ridolfi, Silvia Galbiati, Riccardo Vago, Greta Bergamaschi, Anna Ferretti, Marcella Chiari, Francesco Valle, Alessandro Gori, Marina Cretich
Pubblicato in: Cells 2021, Numero 10, 2021, Pagina/e 544, ISSN 2073-4409
Editore: MDPI
DOI: 10.3390/cells10030544

High-Throughput, High-Resolution Interferometric Light Microscopy of Biological Nanoparticles

Autori: Celalettin Yurdakul, Oguzhan Avci, Alex Matlock, Alexander J. Devaux, Maritza V. Quintero, Ekmel Ozbay, Robert A. Davey, John H. Connor, W. Clem Karl, Lei Tian, M. Selim Ünlü
Pubblicato in: ACS Nano, Numero 14/2, 2020, Pagina/e 2002-2013, ISSN 1936-0851
Editore: American Chemical Society
DOI: 10.1021/acsnano.9b08512

The Role of Surface Chemistry in the Efficacy of Protein and DNA Microarrays for Label-Free Detection: An Overview

Autori: Elisa Chiodi, Allison M. Marn, Matthew T. Geib, M. Selim Ünlü
Pubblicato in: Polymers, Numero 13/7, 2021, Pagina/e 1026, ISSN 2073-4360
Editore: MDPI
DOI: 10.3390/polym13071026

Microarray Approach Combined with ddPCR: An Useful Pipeline for the Detection and Quantification of Circulating Tumour dna Mutations

Autori: Galbiati, Damin, Ferraro, Soriani, Burgio, Ronzoni, Gianni, Ferrari, Chiari
Pubblicato in: Cells, Numero 8/8, 2019, Pagina/e 769, ISSN 2073-4409
Editore: MDPI
DOI: 10.3390/cells8080769

Analysis of KRAS, NRAS and BRAF mutational profile by combination of in-tube hybridization and universal tag-microarray in tumor tissue and plasma of colorectal cancer patients

Autori: Francesco Damin, Silvia Galbiati, Nadia Soriani, Valentina Burgio, Monica Ronzoni, Maurizio Ferrari, Marcella Chiari
Pubblicato in: PLOS ONE, Numero 13/12, 2018, Pagina/e e0207876, ISSN 1932-6203
Editore: Public Library of Science
DOI: 10.1371/journal.pone.0207876

Membrane‐binding peptides for extracellular vesicles on‐chip analysis

Autori: Alessandro Gori, Alessandro Romanato, Greta Bergamaschi, Alessandro Strada, Paola Gagni, Roberto Frigerio, Dario Brambilla, Riccardo Vago, Silvia Galbiati, Silvia Picciolini, Marzia Bedoni, George G. Daaboul, Marcella Chiari, Marina Cretich
Pubblicato in: Journal of Extracellular Vesicles, Numero 9/1, 2020, Pagina/e 1751428, ISSN 2001-3078
Editore: Taylor&Francis
DOI: 10.1080/20013078.2020.1751428

Computational Analysis of Dengue Virus Envelope Protein (E) Reveals an Epitope with Flavivirus Immunodiagnostic Potential in Peptide Microarrays

Autori: Greta Bergamaschi, Enrico M. A. Fassi, Alessandro Romanato, Ilda D'Annessa, Maria Teresa Odinolfi, Dario Brambilla, Francesco Damin, Marcella Chiari, Alessandro Gori, Giorgio Colombo, Marina Cretich
Pubblicato in: International Journal of Molecular Sciences, Numero 20/8, 2019, Pagina/e 1921, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms20081921

A Reliable, Label Free Quality Control Method for the Production of DNA Microarrays with Clinical Applications

Autori: Elisa Chiodi, Francesco Damin,*,Laura Sola*, Lucia Ferraro, Dario Brambilla, M. Selim Ünlü and Marcella Chiari
Pubblicato in: Polymers, 2021, ISSN 2073-4360
Editore: MDPI
DOI: 10.3390/polym13030340

Interferometric Detection and Enumeration of Viral Particles using Si-Based Microfluidics

Autori: Ayca Yalcin Ozkumur, Fulya Ekiz Kanik, Jacob T. Trueb, Celalettin Yurdakul, M. Selim Unlu
Pubblicato in: IEEE Journal of Selected Topics in Quantum Electronics, Numero 25/1, 2019, Pagina/e 1-7, ISSN 1077-260X
Editore: Institute of Electrical and Electronics Engineers
DOI: 10.1109/jstqe.2018.2854548

High-visibility detection of exosomes by interferometric reflectance imaging

Autori: Unlu, Selim; Yurdakul, Celalettin; Yalcin-Ozkumur, Ayca; Chiari, Marcella; Ekiz-Kanik, Fulya; et al.
Pubblicato in: Journal of Extracellular Vesicles, 2018, Pagina/e 248, ISSN 2001-3078
Editore: Taylor&Francis

Diritti di proprietà intellettuale

METHOD FOR THE ISOLATION OF INTACT EXTRACELLULAR VESICLES

Numero candidatura/pubblicazione: 20 200476
Data: 2020-10-07

Risultati finali

Pubblicazioni

Diritti di proprietà intellettuale

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