Integrated nanoparticle isolation and detection system for complete on-chip analysis of exosomes

Livrables

Project dedicated web site

Publishing of the project dedicated website.

Data management plan

Generation of a Data Management Plan to follow the Horizon 2020 Open Research Data Pilot guidelines

Updated data management plan

Update of the Data Management Plan

Intermediate dissemination and exploitation report

This document will report on the plan envisaged by the consortium for project results dissemination and exploitation

Report on exosome-specific Ab selection

This document will report on the selection of the panel of antibodies for on-chip exosome immuno- phenotyping

Final dissemination and exploitation report

This document will report on the dissemination activities held during the project and on the possibility of exploitation of results and deliverables for translation of inventions obtained during the project.

Report on clinical demonstration

This document will report on the results obtained using the newly developed instrumentation with selected clinical samples

Report on criteria for system demonstration

This report will provide the specifications on the requested performance of the systems and the criteria that will be used for system demonstration at the end of the project.

Publications

Computational nanosensing from defocus in single particle interferometric reflectance microscopy

Auteurs: Yurdakul, C., M.S., Ünlü
Publié dans: OpticsLetters, 2020
Éditeur: OpticsLetters
DOI: 10.1364/ol.409458

Separation of Extracellular Vesicles by DNA-Directed Immunocapturing Followed by Enzymatic Release

Auteurs: Brambilla, D., Sola, L., Chiodi, E., Zarovni, N., Fortunato, D., Criscuoli, M., Dolo, V., Giusti, I., Murdica, V., Vago, R., Chiari, M.
Publié dans: ChemRxiv, 2020
Éditeur: ChemRxiv
DOI: 10.26434/chemrxiv.12234683.v1

Multiplexed affinity measurements of extracellular vesicles binding kinetics

Auteurs: Chiodi, E.; Daaboul, G.; Marn, A.M.; Ünlü, M.S.
Publié dans: ChemRxiv, 2021
Éditeur: ChemRxiv
DOI: 10.26434/chemrxiv.13547459.v1

A Bi-Functional Polymeric Coating for the Co-Imobilization of Proteins and Peptides on Microarray Substrates

Auteurs: Laura Sola, Dario Brambilla, Alessandro Mussida, Roberto Consonni, Francesco Damin, Marina Cretich, Alessandro Gori, Marcella Chiari
Publié dans: ChemRxiv, 2020
Éditeur: ChemRxiv
DOI: 10.26434/chemrxiv.13135769.v1

Simultaneous Evaluation of Multiple Microarray Surface Chemistries Through Real-Time Interferometric Imaging.

Auteurs: Chiodi, Elisa; Sola, Laura; Brambilla, Dario; Cretich, Marina; Marn, Allison; Ünlü, M. Selim; et al.
Publié dans: Chemrxiv, 2019
Éditeur: Chemrxiv
DOI: 10.26434/chemrxiv.8976347.v1

Advantageous Antibody Microarray Fabrication Through DNA-Directed Immobilization: A Step Toward Use of Extracellular Vesicles in Diagnostics

Auteurs: Dario Brambilla; Laura Sola; Marcella Chiari
Publié dans: Chemrxiv, Numéro 1, 2020
Éditeur: Chemrxiv
DOI: 10.26434/chemrxiv.12227255.v1

Author Correction: Label-free detection of nanoparticles using depth scanning correlation interferometric microscopy

Auteurs: Ugur Aygun, Hakan Urey, Ayca Yalcin Ozkumur
Publié dans: Scientific Reports, Numéro 9/1, 2019, ISSN 2045-2322
Éditeur: Nature Publishing Group
DOI: 10.1038/s41598-019-53131-3

Small evs-associated dna as complementary biomarker to circulating tumor dna in plasma of metastatic colorectal cancer patients

Auteurs: Silvia Galbiati, Francesco Damin, Dario Brambilla, Lucia Ferraro, Nadia Soriani, Anna Maria Ferretti, Valentina Burgio, Monica Ronzoni, Riccardo Vago, Laura Sola. Marcella Chiari,
Publié dans: Pharmaceuticals, 2021, ISSN 1424-8247
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ph14020128

Extracellular Vesicles Analysis in the COVID-19 Era: Insights on Serum Inactivation Protocols Towards Downstream Isolation and Analysis

Auteurs: Roberto Frigerio, Angelo Musicò, Marco Brucale, Andrea Ridolfi, Silvia Galbiati, Riccardo Vago, Greta Bergamaschi, Anna Ferretti, Marcella Chiari, Francesco Valle, Alessandro Gori, Marina Cretich
Publié dans: Cells 2021, Numéro 10, 2021, Page(s) 544, ISSN 2073-4409
Éditeur: MDPI
DOI: 10.3390/cells10030544

High-Throughput, High-Resolution Interferometric Light Microscopy of Biological Nanoparticles

Auteurs: Celalettin Yurdakul, Oguzhan Avci, Alex Matlock, Alexander J. Devaux, Maritza V. Quintero, Ekmel Ozbay, Robert A. Davey, John H. Connor, W. Clem Karl, Lei Tian, M. Selim Ünlü
Publié dans: ACS Nano, Numéro 14/2, 2020, Page(s) 2002-2013, ISSN 1936-0851
Éditeur: American Chemical Society
DOI: 10.1021/acsnano.9b08512

The Role of Surface Chemistry in the Efficacy of Protein and DNA Microarrays for Label-Free Detection: An Overview

Auteurs: Elisa Chiodi, Allison M. Marn, Matthew T. Geib, M. Selim Ünlü
Publié dans: Polymers, Numéro 13/7, 2021, Page(s) 1026, ISSN 2073-4360
Éditeur: MDPI
DOI: 10.3390/polym13071026

Microarray Approach Combined with ddPCR: An Useful Pipeline for the Detection and Quantification of Circulating Tumour dna Mutations

Auteurs: Galbiati, Damin, Ferraro, Soriani, Burgio, Ronzoni, Gianni, Ferrari, Chiari
Publié dans: Cells, Numéro 8/8, 2019, Page(s) 769, ISSN 2073-4409
Éditeur: MDPI
DOI: 10.3390/cells8080769

Analysis of KRAS, NRAS and BRAF mutational profile by combination of in-tube hybridization and universal tag-microarray in tumor tissue and plasma of colorectal cancer patients

Auteurs: Francesco Damin, Silvia Galbiati, Nadia Soriani, Valentina Burgio, Monica Ronzoni, Maurizio Ferrari, Marcella Chiari
Publié dans: PLOS ONE, Numéro 13/12, 2018, Page(s) e0207876, ISSN 1932-6203
Éditeur: Public Library of Science
DOI: 10.1371/journal.pone.0207876

Membrane‐binding peptides for extracellular vesicles on‐chip analysis

Auteurs: Alessandro Gori, Alessandro Romanato, Greta Bergamaschi, Alessandro Strada, Paola Gagni, Roberto Frigerio, Dario Brambilla, Riccardo Vago, Silvia Galbiati, Silvia Picciolini, Marzia Bedoni, George G. Daaboul, Marcella Chiari, Marina Cretich
Publié dans: Journal of Extracellular Vesicles, Numéro 9/1, 2020, Page(s) 1751428, ISSN 2001-3078
Éditeur: Taylor&Francis
DOI: 10.1080/20013078.2020.1751428

Computational Analysis of Dengue Virus Envelope Protein (E) Reveals an Epitope with Flavivirus Immunodiagnostic Potential in Peptide Microarrays

Auteurs: Greta Bergamaschi, Enrico M. A. Fassi, Alessandro Romanato, Ilda D'Annessa, Maria Teresa Odinolfi, Dario Brambilla, Francesco Damin, Marcella Chiari, Alessandro Gori, Giorgio Colombo, Marina Cretich
Publié dans: International Journal of Molecular Sciences, Numéro 20/8, 2019, Page(s) 1921, ISSN 1422-0067
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms20081921

A Reliable, Label Free Quality Control Method for the Production of DNA Microarrays with Clinical Applications

Auteurs: Elisa Chiodi, Francesco Damin,*,Laura Sola*, Lucia Ferraro, Dario Brambilla, M. Selim Ünlü and Marcella Chiari
Publié dans: Polymers, 2021, ISSN 2073-4360
Éditeur: MDPI
DOI: 10.3390/polym13030340

Interferometric Detection and Enumeration of Viral Particles using Si-Based Microfluidics

Auteurs: Ayca Yalcin Ozkumur, Fulya Ekiz Kanik, Jacob T. Trueb, Celalettin Yurdakul, M. Selim Unlu
Publié dans: IEEE Journal of Selected Topics in Quantum Electronics, Numéro 25/1, 2019, Page(s) 1-7, ISSN 1077-260X
Éditeur: Institute of Electrical and Electronics Engineers
DOI: 10.1109/jstqe.2018.2854548

High-visibility detection of exosomes by interferometric reflectance imaging

Auteurs: Unlu, Selim; Yurdakul, Celalettin; Yalcin-Ozkumur, Ayca; Chiari, Marcella; Ekiz-Kanik, Fulya; et al.
Publié dans: Journal of Extracellular Vesicles, 2018, Page(s) 248, ISSN 2001-3078
Éditeur: Taylor&Francis

Droits de propriété intellectuelle

METHOD FOR THE ISOLATION OF INTACT EXTRACELLULAR VESICLES

Numéro de demande/publication: 20 200476
Date: 2020-10-07

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Publications

Droits de propriété intellectuelle

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