Novel therapeutic approaches for the treatment of cystic fibrosis based on small molecule transmembrane anion transporters

Livrables

Physiology of normal and cystic fibrosis bronchial epithelium; Imaging assay

pH-insensitive Cl- sensor assay
iPS cells from G551D patients
Lung epithelial cells from F508del patients
iPS cells from F508del patients
Correlation of anion transport activity with mucin release in Calu-3 CFTR wt and mutant sensor cell lines
Calu-3 mutant CFTR F508del and G551D cells
Intestinal organoids from G551D patients
Anionophores in F508del and G551D mouse models
Lung epithelial cells from G551D patients
Biophysical and pharmacological characterisation of the anionophores
Intestinal organoids from F508del patients

Project Website

Publications

Anion-Transport Mechanism of a Triazole-Bearing Derivative of Prodigiosine: A Candidate for Cystic Fibrosis Therapy

Auteurs: Claudia Cossu, Michele Fiore, Debora Baroni, Valeria Capurro, Emanuela Caci, Maria Garcia-Valverde, Roberto Quesada, Oscar Moran
Publié dans: Frontiers in Pharmacology, Numéro 9, 2018, ISSN 1663-9812
Éditeur: Frontiers Media S.A.
DOI: 10.3389/fphar.2018.00852

Small molecule anionophores promote transmembrane anion permeation matching CFTR activity

Auteurs: Elsa Hernando, Valeria Capurro, Claudia Cossu, Michele Fiore, María García-Valverde, Vanessa Soto-Cerrato, Ricardo Pérez-Tomás, Oscar Moran, Olga Zegarra-Moran, Roberto Quesada
Publié dans: Scientific Reports, Numéro 8/1, 2018, ISSN 2045-2322
Éditeur: Nature Publishing Group
DOI: 10.1038/s41598-018-20708-3

Generation of two induced pluripotent stem cell (iPSC) lines from p.F508del Cystic Fibrosis patients

Auteurs: Aarne Fleischer, Iván M. Lorenzo, Esther Palomino, Trond Aasen, Fernando Gómez, Miguel Servera, Víctor J. Asensio, Víctor Gálvez, Juan Carlos Izpisúa-Belmonte, Daniel Bachiller
Publié dans: Stem Cell Research, Numéro 29, 2018, Page(s) 1-5, ISSN 1873-5061
Éditeur: Elsevier
DOI: 10.1016/j.scr.2018.03.004

5th TAT-CF Newsletter

Auteurs: Ángel del Pozo, Roberto Quesada
Publié dans: 2018
Éditeur: TAT-CF consortium

3rd TAT-CF Newsletter

Auteurs: Ángel del Pozo, Roberto Quesada, Oscar Moran, Emanuela Caci
Publié dans: 2018
Éditeur: TAT-CF consortium

4th TAT-CF Newsletter

Auteurs: Ángel del Pozo, Roberto Quesada, Manfred Frey
Publié dans: 2018
Éditeur: TAT-CF consortium

6th TAT-CF Newsletter

Auteurs: Ángel del Pozo, Roberto Quesada, Oscar Moran, Emanuela Caci, Manfred Frey, Daniel Bachiller, Anette Mullertz, Laszlo Puskas
Publié dans: 2018
Éditeur: TAT-CF consortium

1st TAT-CF Newsletter

Auteurs: Ángel del Pozo, Roberto Quesada
Publié dans: 2016
Éditeur: TAT-CF consortium

2nd TAT-CF Newsletter

Auteurs: Ángel del Pozo, Daniel Bachiller, Oscar Moran, Roberto Quesada
Publié dans: 2017
Éditeur: TAT-CF consortium

Biologically Active Transmembrane Anion Transporters

Auteurs: Roberto Quesada, Elsa Hernando, Francisco Ciruela, Vanesa Soto-Cerrato, Ricardo Pérez-Tomás, and Rosa Farràs.
Publié dans: Abstract book of the III Biennial Meeting of the Chemical Biology Group / XII Carbohydrate Symposium, 2016
Éditeur: Royal Society of Chemistry of Spain (RSEQ)

Phospholipids vesicles as convenient models to study transmembrane ion transport

Auteurs: Sandra Díaz, Elsa Hernando and Roberto Quesada
Publié dans: Abstract book of the 6th Early Stage Researchers Workshop in Nanoscience, 2016
Éditeur: Instituto IMDEA nanociencia

Bromination of 2, 7' bi-indolyls and quinazolin-7-ones as a key step in the synthesis of macrocyclic tetra-indolyls

Auteurs: Marcin Mielczarek, Mohan Bhadbhade, Rui Chen, Naresh Kumar, David St. C. Black
Publié dans: Abstract book of the 3rd ERC Grantees Conference, 2016
Éditeur: University of Groningen

An UGI/Intramolecular cyclization sequence for the synthesis of nitrogen-based heterocycles

Auteurs: Pablo Peña-Calleja, Pablo Pertejo, Roberto Quesada, María García-Valverde
Publié dans: Abstract book of the 17th Tetrahedron Symposium, 2016
Éditeur: Elsevier

New transmembrane anion transporters based on tetraheterocycle structures

Auteurs: Israel Carreira-Barral, Elsa Hernando, Roberto Quesada.
Publié dans: Abstract book of the 6th EuCheMS Chemistry Congress, 2016
Éditeur: The National Chemists Association of Spain (ANQUE)

Directed differentiation and genetic modification of novel iPS cell lines from CF patients

Auteurs: Daniel Bachiller, Aarne Fleischer, Esther Palomino, Ivan Lorenzo, Victor Galvez, Trond Aasen, Juan Carlos Izpisua-Belmonte, Fernando Gomez
Publié dans: Abstract book of the ECFS Basic Science Conference 2017, 2017
Éditeur: European Cystic Fibrosis Society

TAT:CF: Novel therapeutic approaches for the treatment of cystic fibrosis based on small molecule transmembrane anion transporters through open innovation

Auteurs: Angel del Pozo, Marta Pastor, Roberto Quesada, Yolanda Gil, TAT-CF Consortium
Publié dans: Abstract book of the the 3rd International Rare Diseases Research Consortium (IRDiRC) Conference, 2017
Éditeur: International Rare Diseases Research Consortium

Facilitated transmembrane transport, a viable therapeutic approach for channelopathies?

Auteurs: Roberto Quesada, Israel Carreira, Marcin Mielczarek, María García-Valverde, Olga Zegarra, Oscar Morán, Angel del Pozo, Laszlo Puskas, Anette Mullertz, Manfred Fey and Daniel Bachiller
Publié dans: Abstract book of the 3rd International Rare Diseases Research Consortium (IRDiRC) Conference, 2017
Éditeur: International Rare Diseases Research Consortium

Anion transport mechanisms through lipid bilayers by synthetic ionophores: towards a cystic fibrosis therapy

Auteurs: Claudia Cossu, Michele Fiore, Olga Zegarra-Moran, Valeria Capurro, Elsa Henando, Roberto Quesada and Oscar Moran
Publié dans: Abstract book for the XXIII Congresso Nazionale Società Italiana di Biofisica Pura e Applicata, 2016
Éditeur: Società Italiana di Biofisica Pura e Applicata

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