Novel therapeutic approaches for the treatment of cystic fibrosis based on small molecule transmembrane anion transporters

Rezultaty

Physiology of normal and cystic fibrosis bronchial epithelium; Imaging assay

pH-insensitive Cl- sensor assay
iPS cells from G551D patients
Lung epithelial cells from F508del patients
iPS cells from F508del patients
Correlation of anion transport activity with mucin release in Calu-3 CFTR wt and mutant sensor cell lines
Calu-3 mutant CFTR F508del and G551D cells
Intestinal organoids from G551D patients
Anionophores in F508del and G551D mouse models
Lung epithelial cells from G551D patients
Biophysical and pharmacological characterisation of the anionophores
Intestinal organoids from F508del patients

Project Website

Publikacje

Anion-Transport Mechanism of a Triazole-Bearing Derivative of Prodigiosine: A Candidate for Cystic Fibrosis Therapy

Autorzy: Claudia Cossu, Michele Fiore, Debora Baroni, Valeria Capurro, Emanuela Caci, Maria Garcia-Valverde, Roberto Quesada, Oscar Moran
Opublikowane w: Frontiers in Pharmacology, Numer 9, 2018, ISSN 1663-9812
Wydawca: Frontiers Media S.A.
DOI: 10.3389/fphar.2018.00852

Small molecule anionophores promote transmembrane anion permeation matching CFTR activity

Autorzy: Elsa Hernando, Valeria Capurro, Claudia Cossu, Michele Fiore, María García-Valverde, Vanessa Soto-Cerrato, Ricardo Pérez-Tomás, Oscar Moran, Olga Zegarra-Moran, Roberto Quesada
Opublikowane w: Scientific Reports, Numer 8/1, 2018, ISSN 2045-2322
Wydawca: Nature Publishing Group
DOI: 10.1038/s41598-018-20708-3

Generation of two induced pluripotent stem cell (iPSC) lines from p.F508del Cystic Fibrosis patients

Autorzy: Aarne Fleischer, Iván M. Lorenzo, Esther Palomino, Trond Aasen, Fernando Gómez, Miguel Servera, Víctor J. Asensio, Víctor Gálvez, Juan Carlos Izpisúa-Belmonte, Daniel Bachiller
Opublikowane w: Stem Cell Research, Numer 29, 2018, Strona(/y) 1-5, ISSN 1873-5061
Wydawca: Elsevier
DOI: 10.1016/j.scr.2018.03.004

5th TAT-CF Newsletter

Autorzy: Ángel del Pozo, Roberto Quesada
Opublikowane w: 2018
Wydawca: TAT-CF consortium

3rd TAT-CF Newsletter

Autorzy: Ángel del Pozo, Roberto Quesada, Oscar Moran, Emanuela Caci
Opublikowane w: 2018
Wydawca: TAT-CF consortium

4th TAT-CF Newsletter

Autorzy: Ángel del Pozo, Roberto Quesada, Manfred Frey
Opublikowane w: 2018
Wydawca: TAT-CF consortium

6th TAT-CF Newsletter

Autorzy: Ángel del Pozo, Roberto Quesada, Oscar Moran, Emanuela Caci, Manfred Frey, Daniel Bachiller, Anette Mullertz, Laszlo Puskas
Opublikowane w: 2018
Wydawca: TAT-CF consortium

1st TAT-CF Newsletter

Autorzy: Ángel del Pozo, Roberto Quesada
Opublikowane w: 2016
Wydawca: TAT-CF consortium

2nd TAT-CF Newsletter

Autorzy: Ángel del Pozo, Daniel Bachiller, Oscar Moran, Roberto Quesada
Opublikowane w: 2017
Wydawca: TAT-CF consortium

Biologically Active Transmembrane Anion Transporters

Autorzy: Roberto Quesada, Elsa Hernando, Francisco Ciruela, Vanesa Soto-Cerrato, Ricardo Pérez-Tomás, and Rosa Farràs.
Opublikowane w: Abstract book of the III Biennial Meeting of the Chemical Biology Group / XII Carbohydrate Symposium, 2016
Wydawca: Royal Society of Chemistry of Spain (RSEQ)

Phospholipids vesicles as convenient models to study transmembrane ion transport

Autorzy: Sandra Díaz, Elsa Hernando and Roberto Quesada
Opublikowane w: Abstract book of the 6th Early Stage Researchers Workshop in Nanoscience, 2016
Wydawca: Instituto IMDEA nanociencia

Bromination of 2, 7' bi-indolyls and quinazolin-7-ones as a key step in the synthesis of macrocyclic tetra-indolyls

Autorzy: Marcin Mielczarek, Mohan Bhadbhade, Rui Chen, Naresh Kumar, David St. C. Black
Opublikowane w: Abstract book of the 3rd ERC Grantees Conference, 2016
Wydawca: University of Groningen

An UGI/Intramolecular cyclization sequence for the synthesis of nitrogen-based heterocycles

Autorzy: Pablo Peña-Calleja, Pablo Pertejo, Roberto Quesada, María García-Valverde
Opublikowane w: Abstract book of the 17th Tetrahedron Symposium, 2016
Wydawca: Elsevier

New transmembrane anion transporters based on tetraheterocycle structures

Autorzy: Israel Carreira-Barral, Elsa Hernando, Roberto Quesada.
Opublikowane w: Abstract book of the 6th EuCheMS Chemistry Congress, 2016
Wydawca: The National Chemists Association of Spain (ANQUE)

Directed differentiation and genetic modification of novel iPS cell lines from CF patients

Autorzy: Daniel Bachiller, Aarne Fleischer, Esther Palomino, Ivan Lorenzo, Victor Galvez, Trond Aasen, Juan Carlos Izpisua-Belmonte, Fernando Gomez
Opublikowane w: Abstract book of the ECFS Basic Science Conference 2017, 2017
Wydawca: European Cystic Fibrosis Society

TAT:CF: Novel therapeutic approaches for the treatment of cystic fibrosis based on small molecule transmembrane anion transporters through open innovation

Autorzy: Angel del Pozo, Marta Pastor, Roberto Quesada, Yolanda Gil, TAT-CF Consortium
Opublikowane w: Abstract book of the the 3rd International Rare Diseases Research Consortium (IRDiRC) Conference, 2017
Wydawca: International Rare Diseases Research Consortium

Facilitated transmembrane transport, a viable therapeutic approach for channelopathies?

Autorzy: Roberto Quesada, Israel Carreira, Marcin Mielczarek, María García-Valverde, Olga Zegarra, Oscar Morán, Angel del Pozo, Laszlo Puskas, Anette Mullertz, Manfred Fey and Daniel Bachiller
Opublikowane w: Abstract book of the 3rd International Rare Diseases Research Consortium (IRDiRC) Conference, 2017
Wydawca: International Rare Diseases Research Consortium

Anion transport mechanisms through lipid bilayers by synthetic ionophores: towards a cystic fibrosis therapy

Autorzy: Claudia Cossu, Michele Fiore, Olga Zegarra-Moran, Valeria Capurro, Elsa Henando, Roberto Quesada and Oscar Moran
Opublikowane w: Abstract book for the XXIII Congresso Nazionale Società Italiana di Biofisica Pura e Applicata, 2016
Wydawca: Società Italiana di Biofisica Pura e Applicata

Rezultaty

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