Novel therapeutic approaches for the treatment of cystic fibrosis based on small molecule transmembrane anion transporters

Deliverables

Physiology of normal and cystic fibrosis bronchial epithelium; Imaging assay

pH-insensitive Cl- sensor assay
iPS cells from G551D patients
Lung epithelial cells from F508del patients
iPS cells from F508del patients
Correlation of anion transport activity with mucin release in Calu-3 CFTR wt and mutant sensor cell lines
Calu-3 mutant CFTR F508del and G551D cells
Intestinal organoids from G551D patients
Anionophores in F508del and G551D mouse models
Lung epithelial cells from G551D patients
Biophysical and pharmacological characterisation of the anionophores
Intestinal organoids from F508del patients

Project Website

Publications

Anion-Transport Mechanism of a Triazole-Bearing Derivative of Prodigiosine: A Candidate for Cystic Fibrosis Therapy

Author(s): Claudia Cossu, Michele Fiore, Debora Baroni, Valeria Capurro, Emanuela Caci, Maria Garcia-Valverde, Roberto Quesada, Oscar Moran
Published in: Frontiers in Pharmacology, Issue 9, 2018, ISSN 1663-9812
Publisher: Frontiers Media S.A.
DOI: 10.3389/fphar.2018.00852

Small molecule anionophores promote transmembrane anion permeation matching CFTR activity

Author(s): Elsa Hernando, Valeria Capurro, Claudia Cossu, Michele Fiore, María García-Valverde, Vanessa Soto-Cerrato, Ricardo Pérez-Tomás, Oscar Moran, Olga Zegarra-Moran, Roberto Quesada
Published in: Scientific Reports, Issue 8/1, 2018, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-018-20708-3

Generation of two induced pluripotent stem cell (iPSC) lines from p.F508del Cystic Fibrosis patients

Author(s): Aarne Fleischer, Iván M. Lorenzo, Esther Palomino, Trond Aasen, Fernando Gómez, Miguel Servera, Víctor J. Asensio, Víctor Gálvez, Juan Carlos Izpisúa-Belmonte, Daniel Bachiller
Published in: Stem Cell Research, Issue 29, 2018, Page(s) 1-5, ISSN 1873-5061
Publisher: Elsevier
DOI: 10.1016/j.scr.2018.03.004

5th TAT-CF Newsletter

Author(s): Ángel del Pozo, Roberto Quesada
Published in: 2018
Publisher: TAT-CF consortium

3rd TAT-CF Newsletter

Author(s): Ángel del Pozo, Roberto Quesada, Oscar Moran, Emanuela Caci
Published in: 2018
Publisher: TAT-CF consortium

4th TAT-CF Newsletter

Author(s): Ángel del Pozo, Roberto Quesada, Manfred Frey
Published in: 2018
Publisher: TAT-CF consortium

6th TAT-CF Newsletter

Author(s): Ángel del Pozo, Roberto Quesada, Oscar Moran, Emanuela Caci, Manfred Frey, Daniel Bachiller, Anette Mullertz, Laszlo Puskas
Published in: 2018
Publisher: TAT-CF consortium

1st TAT-CF Newsletter

Author(s): Ángel del Pozo, Roberto Quesada
Published in: 2016
Publisher: TAT-CF consortium

2nd TAT-CF Newsletter

Author(s): Ángel del Pozo, Daniel Bachiller, Oscar Moran, Roberto Quesada
Published in: 2017
Publisher: TAT-CF consortium

Biologically Active Transmembrane Anion Transporters

Author(s): Roberto Quesada, Elsa Hernando, Francisco Ciruela, Vanesa Soto-Cerrato, Ricardo Pérez-Tomás, and Rosa Farràs.
Published in: Abstract book of the III Biennial Meeting of the Chemical Biology Group / XII Carbohydrate Symposium, 2016
Publisher: Royal Society of Chemistry of Spain (RSEQ)

Phospholipids vesicles as convenient models to study transmembrane ion transport

Author(s): Sandra Díaz, Elsa Hernando and Roberto Quesada
Published in: Abstract book of the 6th Early Stage Researchers Workshop in Nanoscience, 2016
Publisher: Instituto IMDEA nanociencia

Bromination of 2, 7' bi-indolyls and quinazolin-7-ones as a key step in the synthesis of macrocyclic tetra-indolyls

Author(s): Marcin Mielczarek, Mohan Bhadbhade, Rui Chen, Naresh Kumar, David St. C. Black
Published in: Abstract book of the 3rd ERC Grantees Conference, 2016
Publisher: University of Groningen

An UGI/Intramolecular cyclization sequence for the synthesis of nitrogen-based heterocycles

Author(s): Pablo Peña-Calleja, Pablo Pertejo, Roberto Quesada, María García-Valverde
Published in: Abstract book of the 17th Tetrahedron Symposium, 2016
Publisher: Elsevier

New transmembrane anion transporters based on tetraheterocycle structures

Author(s): Israel Carreira-Barral, Elsa Hernando, Roberto Quesada.
Published in: Abstract book of the 6th EuCheMS Chemistry Congress, 2016
Publisher: The National Chemists Association of Spain (ANQUE)

Directed differentiation and genetic modification of novel iPS cell lines from CF patients

Author(s): Daniel Bachiller, Aarne Fleischer, Esther Palomino, Ivan Lorenzo, Victor Galvez, Trond Aasen, Juan Carlos Izpisua-Belmonte, Fernando Gomez
Published in: Abstract book of the ECFS Basic Science Conference 2017, 2017
Publisher: European Cystic Fibrosis Society

TAT:CF: Novel therapeutic approaches for the treatment of cystic fibrosis based on small molecule transmembrane anion transporters through open innovation

Author(s): Angel del Pozo, Marta Pastor, Roberto Quesada, Yolanda Gil, TAT-CF Consortium
Published in: Abstract book of the the 3rd International Rare Diseases Research Consortium (IRDiRC) Conference, 2017
Publisher: International Rare Diseases Research Consortium

Facilitated transmembrane transport, a viable therapeutic approach for channelopathies?

Author(s): Roberto Quesada, Israel Carreira, Marcin Mielczarek, María García-Valverde, Olga Zegarra, Oscar Morán, Angel del Pozo, Laszlo Puskas, Anette Mullertz, Manfred Fey and Daniel Bachiller
Published in: Abstract book of the 3rd International Rare Diseases Research Consortium (IRDiRC) Conference, 2017
Publisher: International Rare Diseases Research Consortium

Anion transport mechanisms through lipid bilayers by synthetic ionophores: towards a cystic fibrosis therapy

Author(s): Claudia Cossu, Michele Fiore, Olga Zegarra-Moran, Valeria Capurro, Elsa Henando, Roberto Quesada and Oscar Moran
Published in: Abstract book for the XXIII Congresso Nazionale Società Italiana di Biofisica Pura e Applicata, 2016
Publisher: Società Italiana di Biofisica Pura e Applicata

Deliverables

Publications

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